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Access to emergency department for acute events and identification of sickle cell disease in refugees.

De Franceschi L, Lux C, Piel FB, Gianesin B, Bonetti F, Casale M, Graziadei G, Lisi R, Pinto V, Putti MC, Rigano P, Rosso R, Russo G, Spadola V, Pulvirenti C, Rizzi M, Mazzi F, Ruffo G, Forni GL.

Blood. 2019 Feb 11. pii: blood-2018-09-876508. doi: 10.1182/blood-2018-09-876508. [Epub ahead of print] No abstract available.


Morphological and ultrastructural analysis of normal, injured and osteoarthritic human knee menisci.

Battistelli M, Favero M, Burini D, Trisolino G, Dallari D, De Franceschi L, Goldring SR, Goldring MB, Belluzzi E, Filardo G, Grigolo B, Falcieri E, Olivotto E.

Eur J Histochem. 2019 Feb 11;63(1). doi: 10.4081/ejh.2019.2998.


New Therapeutic Options for the Treatment of Sickle Cell Disease.

Matte A, Zorzi F, Mazzi F, Federti E, Olivieri O, De Franceschi L.

Mediterr J Hematol Infect Dis. 2019 Jan 1;11(1):e2019002. doi: 10.4084/MJHID.2019.002. eCollection 2019. Review.


Postural counseling represents a novel option in pain management of fibromyalgia patients.

Galvani C, Caramaschi P, Mura P, Paladini A, Piroli A, Arnaudo E, De Franceschi L, Evangelista M, Pari A, Ongaro G, Finco G, Ciannameo A, Carletto A, Varrassi G, Biasi D.

J Pain Res. 2019 Jan 11;12:327-337. doi: 10.2147/JPR.S164714. eCollection 2019.


Red blood cell alloimmunisation in transfusion-dependent thalassaemia: a systematic review.

Franchini M, Forni GL, Marano G, Cruciani M, Mengoli C, Pinto V, De Franceschi L, Venturelli D, Casale M, Amerini M, Capuzzo M, Grazzini G, Masiello F, Pati I, Veropalumbo E, Vaglio S, Pupella S, Liumbruno GM.

Blood Transfus. 2019 Jan;17(1):4-15. doi: 10.2450/2019.0229-18. Review.


Factor H interfers with the adhesion of sickle red cells to vascular endothelium: a novel disease modulating molecule.

Lombardi E, Matte A, Risitano AM, Ricklin D, Lambris JD, De Zanet D, Jokiranta ST, Martinelli N, Scambi C, Salvagno G, Bisoffi Z, Colato C, Siciliano A, Bortolami O, Mazzuccato M, Zorzi F, De Marco L, De Franceschi L.

Haematologica. 2019 Jan 10. pii: haematol.2018.198622. doi: 10.3324/haematol.2018.198622. [Epub ahead of print]


Resolution of sickle cell disease-associated inflammation and tissue damage with 17R-resolvin D1.

Matte A, Recchiuti A, Federti E, Koehl B, Mintz T, El Nemer W, Tharaux PL, Brousse V, Andolfo I, Lamolinara A, Weinberg O, Siciliano A, Norris PC, Riley IR, Iolascon A, Serhan CN, Brugnara C, De Franceschi L.

Blood. 2019 Jan 17;133(3):252-265. doi: 10.1182/blood-2018-07-865378. Epub 2018 Nov 7.


Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis.

Beneduce E, Matte A, De Falco L, Mbiandjeu S, Chiabrando D, Tolosano E, Federti E, Petrillo S, Mohandas N, Siciliano A, Babu W, Menon V, Ghaffari S, Iolascon A, De Franceschi L.

Am J Hematol. 2019 Jan;94(1):10-20. doi: 10.1002/ajh.25295. Epub 2018 Oct 25.


Persistent abdominal pain related to portal vein thrombosis in young adult with sickle cell disease.

Dal Zotto C, Wieczorek M, Mariottini G, Malagò R, Olivieri O, De Franceschi L.

Am J Hematol. 2018 Dec;93(12):1562-1565. doi: 10.1002/ajh.25291. Epub 2018 Oct 15. No abstract available.


Daily alternating deferasirox and deferiprone therapy successfully controls iron accumulation in untreatable transfusion-dependent thalassemia patients.

Pinto VM, Balocco M, Quintino S, Bacigalupo L, Gianesin B, Rizzi M, Malagò R, De Franceschi L, Forni GL.

Am J Hematol. 2018 Oct;93(10):E338-E340. doi: 10.1002/ajh.25222. Epub 2018 Aug 14. No abstract available.


Improvement of maternal and fetal outcomes in women with sickle cell disease treated with early prophylactic erythrocytapheresis.

Vianello A, Vencato E, Cantini M, Zanconato G, Manfrin E, Zamo A, Zorzi F, Mazzi F, Martinelli N, Cavaliere E, Monari F, Venturelli D, Ferrara F, Olivieri O, De Franceschi L.

Transfusion. 2018 Sep;58(9):2192-2201. doi: 10.1111/trf.14767. Epub 2018 Jul 8.


Microcytosis is important in screening of iron deficiency anemia.

De Franceschi L, Iolascon A, Taher A, Cappellini MD.

Eur J Intern Med. 2018 Feb;48:e39. doi: 10.1016/j.ejim.2017.08.021. Epub 2018 Feb 1. No abstract available.


Lack of correlation between heart, liver and pancreas MRI-R2*: Results from long-term follow-up in a cohort of adult β-thalassemia major patients.

Pinto VM, Bacigalupo L, Gianesin B, Balocco M, De Franceschi L, Malagò R, Wood J, Forni GL.

Am J Hematol. 2018 Mar;93(3):E79-E82. doi: 10.1002/ajh.25009. Epub 2018 Jan 9. No abstract available.


PIEZO1-R1864H rare variant accounts for a genetic phenotype-modifier role in dehydrated hereditary stomatocytosis.

Andolfo I, Manna F, De Rosa G, Rosato BE, Gambale A, Tomaiuolo G, Carciati A, Marra R, De Franceschi L, Iolascon A, Russo R.

Haematologica. 2018 Mar;103(3):e94-e97. doi: 10.3324/haematol.2017.180687. Epub 2017 Nov 30. No abstract available.


Adipocytes sustain pancreatic cancer progression through a non-canonical WNT paracrine network inducing ROR2 nuclear shuttling.

Carbone C, Piro G, Gaianigo N, Ligorio F, Santoro R, Merz V, Simionato F, Zecchetto C, Falco G, Conti G, Kamga PT, Krampera M, Di Nicolantonio F, De Franceschi L, Scarpa A, Tortora G, Melisi D.

Int J Obes (Lond). 2018 Mar;42(3):334-343. doi: 10.1038/ijo.2017.285. Epub 2017 Nov 20.


Real-life experience with hydroxyurea in sickle cell disease: A multicenter study in a cohort of patients with heterogeneous descent.

Rigano P, De Franceschi L, Sainati L, Piga A, Piel FB, Cappellini MD, Fidone C, Masera N, Palazzi G, Gianesin B, Forni GL; Italian Multicenter Study of Hydroxyurea in Sickle Cell Anemia Investigators.

Blood Cells Mol Dis. 2018 Mar;69:82-89. doi: 10.1016/j.bcmd.2017.08.017. Epub 2017 Oct 9.


Data demonstrating the role of peroxiredoxin 2 as important anti-oxidant system in lung homeostasis.

Federti E, Matte A, Ghigo A, Andolfo I, James C, Siciliano A, Leboeuf C, Janin A, Manna F, Choi SY, Iolascon A, Beneduce E, Melisi D, Kim DW, Levi S, De Franceschi L.

Data Brief. 2017 Sep 30;15:376-381. doi: 10.1016/j.dib.2017.09.062. eCollection 2017 Dec.


Treatment of hepatitis C virus infection with direct-acting antiviral drugs is safe and effective in patients with hemoglobinopathies.

Origa R, Ponti ML, Filosa A, Galeota Lanza A, Piga A, Saracco GM, Pinto V, Picciotto A, Rigano P, Madonia S, Rosso R, D'Ascola D, Cappellini MD, D'Ambrosio R, Tartaglione I, De Franceschi L, Gianesin B, Di Marco V, Forni GL; Italy for THAlassemia and hepatitis C Advance - Società Italiana Talassemie ed Emoglobinopatie (ITHACA-SITE).

Am J Hematol. 2017 Dec;92(12):1349-1355. doi: 10.1002/ajh.24911. Epub 2017 Oct 19.


Peroxiredoxin-2 plays a pivotal role as multimodal cytoprotector in the early phase of pulmonary hypertension.

Federti E, Matté A, Ghigo A, Andolfo I, James C, Siciliano A, Leboeuf C, Janin A, Manna F, Choi SY, Iolascon A, Beneduce E, Melisi D, Kim DW, Levi S, De Franceschi L.

Free Radic Biol Med. 2017 Nov;112:376-386. doi: 10.1016/j.freeradbiomed.2017.08.004. Epub 2017 Aug 9.


Peroxiredoxin-2: A Novel Regulator of Iron Homeostasis in Ineffective Erythropoiesis.

Matte A, De Falco L, Federti E, Cozzi A, Iolascon A, Levi S, Mohandas N, Zamo A, Bruno M, Lebouef C, Janin A, Siciliano A, Ganz T, Federico G, Carlomagno F, Mueller S, Silva I, Carbone C, Melisi D, Kim DW, Choi SY, De Franceschi L.

Antioxid Redox Signal. 2018 Jan 1;28(1):1-14. doi: 10.1089/ars.2017.7051. Epub 2017 Sep 6.


Data demonstrating the anti-oxidant role of hemopexin in the heart.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Data Brief. 2017 May 13;13:69-76. doi: 10.1016/j.dib.2017.05.026. eCollection 2017 Aug.


Recommendations regarding splenectomy in hereditary hemolytic anemias.

Iolascon A, Andolfo I, Barcellini W, Corcione F, Garçon L, De Franceschi L, Pignata C, Graziadei G, Pospisilova D, Rees DC, de Montalembert M, Rivella S, Gambale A, Russo R, Ribeiro L, Vives-Corrons J, Martinez PA, Kattamis A, Gulbis B, Cappellini MD, Roberts I, Tamary H; Working Study Group on Red Cells and Iron of the EHA.

Haematologica. 2017 Aug;102(8):1304-1313. doi: 10.3324/haematol.2016.161166. Epub 2017 May 26.


Clinical management of iron deficiency anemia in adults: Systemic review on advances in diagnosis and treatment.

De Franceschi L, Iolascon A, Taher A, Cappellini MD.

Eur J Intern Med. 2017 Jul;42:16-23. doi: 10.1016/j.ejim.2017.04.018. Epub 2017 May 18. Review.


Magnesium for treating sickle cell disease.

Than NN, Soe HHK, Palaniappan SK, Abas AB, De Franceschi L.

Cochrane Database Syst Rev. 2017 Apr 14;4:CD011358. doi: 10.1002/14651858.CD011358.pub2. Review.


Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress.

Ingoglia G, Sag CM, Rex N, De Franceschi L, Vinchi F, Cimino J, Petrillo S, Wagner S, Kreitmeier K, Silengo L, Altruda F, Maier LS, Hirsch E, Ghigo A, Tolosano E.

Free Radic Biol Med. 2017 Jul;108:452-464. doi: 10.1016/j.freeradbiomed.2017.04.003. Epub 2017 Apr 8.


Eighth International Chorea-Acanthocytosis Symposium: Summary of Workshop Discussion and Action Points.

Pappas SS, Bonifacino J, Danek A, Dauer WT, De M, De Franceschi L, DiPaolo G, Fuller R, Haucke V, Hermann A, Kornmann B, Landwehrmeyer B, Levin J, Neiman AM, Rudnicki DD, Sibon O, Velayos-Baeza A, Vonk JJ, Walker RH, Weisman LS, Albin RL.

Tremor Other Hyperkinet Mov (N Y). 2017 Feb 15;7:428. doi: 10.7916/D8XD127W. eCollection 2017.


Hemolytic anemia repressed hepcidin level without hepatocyte iron overload: lesson from Günther disease model.

Millot S, Delaby C, Moulouel B, Lefebvre T, Pilard N, Ducrot N, Ged C, Lettéron P, de Franceschi L, Deybach JC, Beaumont C, Gouya L, De Verneuil H, Lyoumi S, Puy H, Karim Z.

Haematologica. 2017 Feb;102(2):260-270. doi: 10.3324/haematol.2016.151621. Epub 2016 Nov 10.


Pesticide toxicogenomics across scales: in vitro transcriptome predicts mechanisms and outcomes of exposure in vivo.

Porreca I, D'Angelo F, De Franceschi L, Mattè A, Ceccarelli M, Iolascon A, Zamò A, Russo F, Ravo M, Tarallo R, Scarfò M, Weisz A, De Felice M, Mallardo M, Ambrosino C.

Sci Rep. 2016 Dec 1;6:38131. doi: 10.1038/srep38131.


Neuronal Dysfunction in iPSC-Derived Medium Spiny Neurons from Chorea-Acanthocytosis Patients Is Reversed by Src Kinase Inhibition and F-Actin Stabilization.

Stanslowsky N, Reinhardt P, Glass H, Kalmbach N, Naujock M, Hensel N, Lübben V, Pal A, Venneri A, Lupo F, De Franceschi L, Claus P, Sterneckert J, Storch A, Hermann A, Wegner F.

J Neurosci. 2016 Nov 23;36(47):12027-12043.


A new molecular link between defective autophagy and erythroid abnormalities in chorea-acanthocytosis.

Lupo F, Tibaldi E, Matte A, Sharma AK, Brunati AM, Alper SL, Zancanaro C, Benati D, Siciliano A, Bertoldi M, Zonta F, Storch A, Walker RH, Danek A, Bader B, Hermann A, De Franceschi L.

Blood. 2016 Dec 22;128(25):2976-2987. doi: 10.1182/blood-2016-07-727321. Epub 2016 Oct 14.


Blood smear, a key diagnostic tool in hematology: Lessons from two cases of acute hemolysis in previously undiagnosed G6PD deficiency.

Veneri D, Facchinelli D, Vianello A, Ambrosetti A, Cantini M, Olivieri O, Dima F, De Franceschi L.

Am J Hematol. 2016 Nov;91(11):1165-1166. doi: 10.1002/ajh.24385. Epub 2016 May 11. No abstract available.


Increased levels of ERFE-encoding FAM132B in patients with congenital dyserythropoietic anemia type II.

Russo R, Andolfo I, Manna F, De Rosa G, De Falco L, Gambale A, Bruno M, Mattè A, Ricchi P, Girelli D, De Franceschi L, Iolascon A.

Blood. 2016 Oct 6;128(14):1899-1902. doi: 10.1182/blood-2016-06-724328. Epub 2016 Aug 18. No abstract available.


Functional characterization of novel ABCB6 mutations and their clinical implications in familial pseudohyperkalemia.

Andolfo I, Russo R, Manna F, De Rosa G, Gambale A, Zouwail S, Detta N, Pardo CL, Alper SL, Brugnara C, Sharma AK, De Franceschi L, Iolascon A.

Haematologica. 2016 Aug;101(8):909-17. doi: 10.3324/haematol.2016.142372. Epub 2016 May 5.


Red Blood Cell Homeostasis: Pharmacological Interventions to Explore Biochemical, Morphological and Mechanical Properties.

Cluitmans JC, Gevi F, Siciliano A, Matte A, Leal JK, De Franceschi L, Zolla L, Brock R, Adjobo-Hermans MJ, Bosman GJ.

Front Mol Biosci. 2016 Mar 29;3:10. doi: 10.3389/fmolb.2016.00010. eCollection 2016.


Band 3 Erythrocyte Membrane Protein Acts as Redox Stress Sensor Leading to Its Phosphorylation by p (72) Syk.

Pantaleo A, Ferru E, Pau MC, Khadjavi A, Mandili G, Mattè A, Spano A, De Franceschi L, Pippia P, Turrini F.

Oxid Med Cell Longev. 2016;2016:6051093. doi: 10.1155/2016/6051093. Epub 2015 Dec 29.


NCOA4 Deficiency Impairs Systemic Iron Homeostasis.

Bellelli R, Federico G, Matte' A, Colecchia D, Iolascon A, Chiariello M, Santoro M, De Franceschi L, Carlomagno F.

Cell Rep. 2016 Jan 26;14(3):411-421. doi: 10.1016/j.celrep.2015.12.065. Epub 2016 Jan 14.


Hypoxia-reperfusion affects osteogenic lineage and promotes sickle cell bone disease.

Dalle Carbonare L, Matte' A, Valenti MT, Siciliano A, Mori A, Schweiger V, Zampieri G, Perbellini L, De Franceschi L.

Blood. 2015 Nov 12;126(20):2320-8. doi: 10.1182/blood-2015-04-641969. Epub 2015 Sep 1.


Protease inhibitors-based therapy induces acquired spherocytic-like anaemia and ineffective erythropoiesis in chronic hepatitis C virus patients.

Lupo F, Russo R, Iolascon A, Ieluzzi D, Siciliano A, Toniutto P, Matté A, Piovesan S, Raffetti E, Turrini F, Dissegna D, Donato F, Alberti A, Zuliani V, Fattovich G, De Franceschi L.

Liver Int. 2016 Jan;36(1):49-58. doi: 10.1111/liv.12900. Epub 2015 Jul 14.


The Interplay Between Peroxiredoxin-2 and Nuclear Factor-Erythroid 2 Is Important in Limiting Oxidative Mediated Dysfunction in β-Thalassemic Erythropoiesis.

Matte A, De Falco L, Iolascon A, Mohandas N, An X, Siciliano A, Leboeuf C, Janin A, Bruno M, Choi SY, Kim DW, De Franceschi L.

Antioxid Redox Signal. 2015 Dec 1;23(16):1284-97. doi: 10.1089/ars.2014.6237. Epub 2015 Jul 14.


Fentanyl Buccal Tablet: A New Breakthrough Pain Medication in Early Management of Severe Vaso-Occlusive Crisis in Sickle Cell Disease.

De Franceschi L, Mura P, Schweiger V, Vencato E, Quaglia FM, Delmonte L, Evangelista M, Polati E, Olivieri O, Finco G.

Pain Pract. 2016 Jul;16(6):680-7. doi: 10.1111/papr.12313. Epub 2015 May 26.


Dietary ω-3 fatty acids protect against vasculopathy in a transgenic mouse model of sickle cell disease.

Kalish BT, Matte A, Andolfo I, Iolascon A, Weinberg O, Ghigo A, Cimino J, Siciliano A, Hirsch E, Federti E, Puder M, Brugnara C, De Franceschi L.

Haematologica. 2015 Jul;100(7):870-80. doi: 10.3324/haematol.2015.124586. Epub 2015 May 1.


Abnormal red cell structure and function in neuroacanthocytosis.

Cluitmans JC, Tomelleri C, Yapici Z, Dinkla S, Bovee-Geurts P, Chokkalingam V, De Franceschi L, Brock R, Bosman GJ.

PLoS One. 2015 May 1;10(5):e0125580. doi: 10.1371/journal.pone.0125580. eCollection 2015.


The local complement activation on vascular bed of patients with systemic sclerosis: a hypothesis-generating study.

Scambi C, Ugolini S, Jokiranta TS, De Franceschi L, Bortolami O, La Verde V, Guarini P, Caramaschi P, Ravagnani V, Martignoni G, Colato C, Pedron S, Benedetti F, Sorio M, Poli F, Biasi D.

PLoS One. 2015 Feb 6;10(2):e0114856. doi: 10.1371/journal.pone.0114856. eCollection 2015.


The novel role of peroxiredoxin-2 in red cell membrane protein homeostasis and senescence.

Matté A, Pantaleo A, Ferru E, Turrini F, Bertoldi M, Lupo F, Siciliano A, Ho Zoon C, De Franceschi L.

Free Radic Biol Med. 2014 Nov;76:80-8. doi: 10.1016/j.freeradbiomed.2014.08.004. Epub 2014 Aug 21.


A rare disorder in an orphan disease: Kikuchi-Fujimoto disease in a young-adult patient with sickle cell anemia.

Vencato E, Manfredi R, Zamò A, Chilosi M, Beccari S, De Franceschi L.

Am J Hematol. 2014 Dec;89(12):1151-2. doi: 10.1002/ajh.23792. Epub 2014 Jul 14. No abstract available.


Development of interactive algorithm for clinical management of acute events related to sickle cell disease in emergency department.

Forni GL, Finco G, Graziadei G, Balocco M, Rigano P, Perrotta S, Olivieri O, Cappellini MD, De Franceschi L.

Orphanet J Rare Dis. 2014 Jun 23;9:91. doi: 10.1186/1750-1172-9-91.


Abnormal red cell features associated with hereditary neurodegenerative disorders: the neuroacanthocytosis syndromes.

De Franceschi L, Bosman GJ, Mohandas N.

Curr Opin Hematol. 2014 May;21(3):201-9. doi: 10.1097/MOH.0000000000000035. Review.


Oxidative stress and β-thalassemic erythroid cells behind the molecular defect.

De Franceschi L, Bertoldi M, Matte A, Santos Franco S, Pantaleo A, Ferru E, Turrini F.

Oxid Med Cell Longev. 2013;2013:985210. doi: 10.1155/2013/985210. Epub 2013 Sep 24. Review.


Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice.

Franco SS, De Falco L, Ghaffari S, Brugnara C, Sinclair DA, Matte' A, Iolascon A, Mohandas N, Bertoldi M, An X, Siciliano A, Rimmelé P, Cappellini MD, Michan S, Zoratti E, Anne J, De Franceschi L.

Haematologica. 2014 Feb;99(2):267-75. doi: 10.3324/haematol.2013.090076. Epub 2013 Aug 23.


Structural changes in senescing oilseed rape leaves at tissue and subcellular levels monitored by nuclear magnetic resonance relaxometry through water status.

Musse M, De Franceschi L, Cambert M, Sorin C, Le Caherec F, Burel A, Bouchereau A, Mariette F, Leport L.

Plant Physiol. 2013 Sep;163(1):392-406. doi: 10.1104/pp.113.223123. Epub 2013 Jul 31.

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