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Items: 1 to 50 of 82

1.

Zika virus replicates in adult human brain tissue and impairs synapses and memory in mice.

Figueiredo CP, Barros-Aragão FGQ, Neris RLS, Frost PS, Soares C, Souza INO, Zeidler JD, Zamberlan DC, de Sousa VL, Souza AS, Guimarães ALA, Bellio M, Marcondes de Souza J, Alves-Leon SV, Neves GA, Paula-Neto HA, Castro NG, De Felice FG, Assunção-Miranda I, Clarke JR, Da Poian AT, Ferreira ST.

Nat Commun. 2019 Sep 5;10(1):3890. doi: 10.1038/s41467-019-11866-7.

2.

Association between diabetes and mood disorders and the potential use of anti-hyperglycemic agents as antidepressants.

Grigolon RB, Brietzke E, Mansur RB, Idzikowski MA, Gerchman F, De Felice FG, McIntyre RS.

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Dec 20;95:109720. doi: 10.1016/j.pnpbp.2019.109720. Epub 2019 Jul 25. Review.

PMID:
31352032
3.

Neonatal infection leads to increased susceptibility to Aβ oligomer-induced brain inflammation, synapse loss and cognitive impairment in mice.

Frost PS, Barros-Aragão F, da Silva RT, Venancio A, Matias I, Lyra E Silva NM, Kincheski GC, Pimentel-Coelho PM, De Felice FG, Gomes FCA, Ferreira ST, Figueiredo CP, Clarke JR.

Cell Death Dis. 2019 Apr 11;10(4):323. doi: 10.1038/s41419-019-1529-x.

4.

Understanding the link between insulin resistance and Alzheimer's disease: Insights from animal models.

Lyra E Silva NM, Gonçalves RA, Boehnke SE, Forny-Germano L, Munoz DP, De Felice FG.

Exp Neurol. 2019 Jun;316:1-11. doi: 10.1016/j.expneurol.2019.03.016. Epub 2019 Mar 28. Review.

PMID:
30930096
5.

Potentials and Pitfalls of Cross-Translational Models of Cognitive Impairment.

Al Dahhan NZ, De Felice FG, Munoz DP.

Front Behav Neurosci. 2019 Mar 14;13:48. doi: 10.3389/fnbeh.2019.00048. eCollection 2019. Review.

6.

Insulin Resistance as a Shared Pathogenic Mechanism Between Depression and Type 2 Diabetes.

Lyra E Silva NM, Lam MP, Soares CN, Munoz DP, Milev R, De Felice FG.

Front Psychiatry. 2019 Feb 14;10:57. doi: 10.3389/fpsyt.2019.00057. eCollection 2019. Review.

7.

The Link Between Tau and Insulin Signaling: Implications for Alzheimer's Disease and Other Tauopathies.

Gonçalves RA, Wijesekara N, Fraser PE, De Felice FG.

Front Cell Neurosci. 2019 Feb 5;13:17. doi: 10.3389/fncel.2019.00017. eCollection 2019.

8.

Long-term consequences of the absence of leptin signaling in early life.

Ramos-Lobo AM, Teixeira PD, Furigo IC, Melo HM, de M Lyra E Silva N, De Felice FG, Donato J Jr.

Elife. 2019 Jan 29;8. pii: e40970. doi: 10.7554/eLife.40970.

9.

The Role of Leptin and Adiponectin in Obesity-Associated Cognitive Decline and Alzheimer's Disease.

Forny-Germano L, De Felice FG, Vieira MNDN.

Front Neurosci. 2019 Jan 14;12:1027. doi: 10.3389/fnins.2018.01027. eCollection 2018. Review.

10.

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.

Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, Clarke JR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG.

Nat Med. 2019 Jan;25(1):165-175. doi: 10.1038/s41591-018-0275-4. Epub 2019 Jan 7.

11.

Insulin Resistance in Alzheimer's Disease.

Ferreira LSS, Fernandes CS, Vieira MNN, De Felice FG.

Front Neurosci. 2018 Nov 13;12:830. doi: 10.3389/fnins.2018.00830. eCollection 2018. Review.

12.

Neuroprotective Actions of Glucagon-Like Peptide-1 (GLP-1) Analogues in Alzheimer's and Parkinson's Diseases.

Batista AF, Bodart-Santos V, De Felice FG, Ferreira ST.

CNS Drugs. 2019 Mar;33(3):209-223. doi: 10.1007/s40263-018-0593-6.

PMID:
30511349
13.

Expression of dopamine signaling genes in the post-mortem brain of individuals with mental illnesses is moderated by body mass index and mediated by insulin signaling genes.

Mansur RB, Fries GR, Subramaniapillai M, Frangou S, De Felice FG, Rasgon N, McEwen B, Brietzke E, McIntyre RS.

J Psychiatr Res. 2018 Dec;107:128-135. doi: 10.1016/j.jpsychires.2018.10.020. Epub 2018 Oct 27.

PMID:
30391805
14.

Acute and chronic neurological consequences of early-life Zika virus infection in mice.

Nem de Oliveira Souza I, Frost PS, França JV, Nascimento-Viana JB, Neris RLS, Freitas L, Pinheiro DJLL, Nogueira CO, Neves G, Chimelli L, De Felice FG, Cavalheiro ÉA, Ferreira ST, Assunção-Miranda I, Figueiredo CP, Da Poian AT, Clarke JR.

Sci Transl Med. 2018 Jun 6;10(444). pii: eaar2749. doi: 10.1126/scitranslmed.aar2749.

PMID:
29875203
15.

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers.

Mendes ND, Fernandes A, Almeida GM, Santos LE, Selles MC, Lyra E Silva NM, Machado CM, Horta-Júnior JAC, Louzada PR, De Felice FG, Alves-Leon S, Marcondes J, Assirati JA Jr, Matias CM, Klein WL, Garcia-Cairasco N, Ferreira ST, Neder L, Sebollela A.

J Neurosci Methods. 2018 Sep 1;307:203-209. doi: 10.1016/j.jneumeth.2018.05.021. Epub 2018 May 31.

PMID:
29859877
16.

Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

Hölscher C, De Felice FG, Greig NH, Ferreira ST.

Neuropharmacology. 2018 Jul 1;136(Pt B):159. doi: 10.1016/j.neuropharm.2018.05.021. Epub 2018 May 18. No abstract available.

17.

Metabolic Syndrome and cognitive decline in the elderly: A systematic review.

Assuncao N, Sudo FK, Drummond C, de Felice FG, Mattos P.

PLoS One. 2018 Mar 26;13(3):e0194990. doi: 10.1371/journal.pone.0194990. eCollection 2018. Review.

18.

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches.

Clarke JR, Ribeiro FC, Frozza RL, De Felice FG, Lourenco MV.

J Alzheimers Dis. 2018;64(s1):S405-S426. doi: 10.3233/JAD-179911. Review.

PMID:
29562518
19.

Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects.

Frozza RL, Lourenco MV, De Felice FG.

Front Neurosci. 2018 Feb 6;12:37. doi: 10.3389/fnins.2018.00037. eCollection 2018. Review.

20.

Brain STAT5 signaling modulates learning and memory formation.

Furigo IC, Melo HM, Lyra E Silva NM, Ramos-Lobo AM, Teixeira PDS, Buonfiglio DC, Wasinski F, Lima ER, Higuti E, Peroni CN, Bartolini P, Soares CRJ, Metzger M, de Felice FG, Donato J Jr.

Brain Struct Funct. 2018 Jun;223(5):2229-2241. doi: 10.1007/s00429-018-1627-z. Epub 2018 Feb 19.

PMID:
29460051
21.

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

Batista AF, Forny-Germano L, Clarke JR, Lyra E Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Vital JF, Marques SA, Martinez AM, Gralle M, Holscher C, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG.

J Pathol. 2018 May;245(1):85-100. doi: 10.1002/path.5056. Epub 2018 Apr 2.

22.

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance.

Wijesekara N, Gonçalves RA, Ahrens R, De Felice FG, Fraser PE.

FASEB J. 2018 Jun;32(6):3166-3173. doi: 10.1096/fj.201701352. Epub 2018 Jan 18.

PMID:
29401605
23.

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

de Godoy MA, Saraiva LM, de Carvalho LRP, Vasconcelos-Dos-Santos A, Beiral HJV, Ramos AB, Silva LRP, Leal RB, Monteiro VHS, Braga CV, de Araujo-Silva CA, Sinis LC, Bodart-Santos V, Kasai-Brunswick TH, Alcantara CL, Lima APCA, da Cunha-E Silva NL, Galina A, Vieyra A, De Felice FG, Mendez-Otero R, Ferreira ST.

J Biol Chem. 2018 Feb 9;293(6):1957-1975. doi: 10.1074/jbc.M117.807180. Epub 2017 Dec 28.

24.

Impaired peripheral glucose homeostasis and Alzheimer's disease.

Wijesekara N, Gonçalves RA, De Felice FG, Fraser PE.

Neuropharmacology. 2018 Jul 1;136(Pt B):172-181. doi: 10.1016/j.neuropharm.2017.11.027. Epub 2017 Nov 21. Review.

PMID:
29169962
25.

Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets.

Vieira MNN, Lima-Filho RAS, De Felice FG.

Neuropharmacology. 2018 Jul 1;136(Pt B):160-171. doi: 10.1016/j.neuropharm.2017.11.014. Epub 2017 Nov 10. Review.

PMID:
29129775
26.

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL.

Mol Biol Cell. 2017 Oct 1;28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416. Epub 2017 Aug 9.

27.

Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.

Fortuna JTS, Gralle M, Beckman D, Neves FS, Diniz LP, Frost PS, Barros-Aragão F, Santos LE, Gonçalves RA, Romão L, Zamberlan DC, Soares FAA, Braga C, Foguel D, Gomes FCA, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP.

Behav Brain Res. 2017 Aug 30;333:150-160. doi: 10.1016/j.bbr.2017.06.047. Epub 2017 Jun 29.

PMID:
28668282
28.

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model.

Diniz LP, Tortelli V, Matias I, Morgado J, Bérgamo Araujo AP, Melo HM, Seixas da Silva GS, Alves-Leon SV, de Souza JM, Ferreira ST, De Felice FG, Gomes FCA.

J Neurosci. 2017 Jul 12;37(28):6797-6809. doi: 10.1523/JNEUROSCI.3351-16.2017. Epub 2017 Jun 12.

29.

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.

Kincheski GC, Valentim IS, Clarke JR, Cozachenco D, Castelo-Branco MTL, Ramos-Lobo AM, Rumjanek VMBD, Donato J Jr, De Felice FG, Ferreira ST.

Brain Behav Immun. 2017 Aug;64:140-151. doi: 10.1016/j.bbi.2017.04.007. Epub 2017 Apr 13.

PMID:
28412140
30.

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.

Seixas da Silva GS, Melo HM, Lourenco MV, Lyra E Silva NM, de Carvalho MB, Alves-Leon SV, de Souza JM, Klein WL, da-Silva WS, Ferreira ST, De Felice FG.

J Biol Chem. 2017 May 5;292(18):7395-7406. doi: 10.1074/jbc.M116.753525. Epub 2017 Mar 16.

31.

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice.

Brito-Moreira J, Lourenco MV, Oliveira MM, Ribeiro FC, Ledo JH, Diniz LP, Vital JFS, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FCA, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST.

J Biol Chem. 2017 May 5;292(18):7327-7337. doi: 10.1074/jbc.M116.761189. Epub 2017 Mar 10.

32.

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?

Vieira MN, Lyra E Silva NM, Ferreira ST, De Felice FG.

Front Aging Neurosci. 2017 Jan 31;9:7. doi: 10.3389/fnagi.2017.00007. eCollection 2017.

33.

Getting a "GRiP" on Hypothalamic Endoplasmic Reticulum Stress to Combat Obesity.

De Felice FG, Ferreira ST.

Diabetes. 2017 Jan;66(1):17-19. doi: 10.2337/dbi16-0057. No abstract available.

34.

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

Neves FS, Marques PT, Barros-Aragão F, Nunes JB, Venancio AM, Cozachenco D, Frozza RL, Passos GF, Costa R, de Oliveira J, Engel DF, De Bem AF, Benjamim CF, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP.

Mol Neurobiol. 2018 Jan;55(1):435-444. doi: 10.1007/s12035-016-0307-3. Epub 2016 Dec 13.

PMID:
27966074
35.

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.

Ledo JH, Azevedo EP, Beckman D, Ribeiro FC, Santos LE, Razolli DS, Kincheski GC, Melo HM, Bellio M, Teixeira AL, Velloso LA, Foguel D, De Felice FG, Ferreira ST.

J Neurosci. 2016 Nov 30;36(48):12106-12116.

36.

Opportunities and challenges in developing relevant animal models for Alzheimer's disease.

De Felice FG, Munoz DP.

Ageing Res Rev. 2016 Mar;26:112-4. doi: 10.1016/j.arr.2016.01.006. Epub 2016 Jan 30. Review.

PMID:
26829469
37.

A Key Role of Insulin Receptors in Memory.

De Felice FG, Benedict C.

Diabetes. 2015 Nov;64(11):3653-5. doi: 10.2337/dbi15-0011. No abstract available.

38.

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.

Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG.

Front Cell Neurosci. 2015 May 26;9:191. doi: 10.3389/fncel.2015.00191. eCollection 2015. Review.

39.

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease.

De Felice FG, Lourenco MV.

Front Aging Neurosci. 2015 May 19;7:94. doi: 10.3389/fnagi.2015.00094. eCollection 2015. Review.

40.

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes.

Lourenco MV, Ferreira ST, De Felice FG.

Prog Neurobiol. 2015 Jun;129:37-57. doi: 10.1016/j.pneurobio.2015.03.003. Epub 2015 Apr 6. Review.

PMID:
25857551
41.

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG.

EMBO Mol Med. 2015 Feb;7(2):190-210. doi: 10.15252/emmm.201404183.

42.

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG.

J Neurosci. 2014 Oct 8;34(41):13629-43. doi: 10.1523/JNEUROSCI.1353-14.2014.

43.

Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease.

De Felice FG, Ferreira ST.

Diabetes. 2014 Jul;63(7):2262-72. doi: 10.2337/db13-1954. Epub 2014 Jun 15. Review.

44.

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease.

Ferreira ST, Clarke JR, Bomfim TR, De Felice FG.

Alzheimers Dement. 2014 Feb;10(1 Suppl):S76-83. doi: 10.1016/j.jalz.2013.12.010. Review.

45.

How does brain insulin resistance develop in Alzheimer's disease?

De Felice FG, Lourenco MV, Ferreira ST.

Alzheimers Dement. 2014 Feb;10(1 Suppl):S26-32. doi: 10.1016/j.jalz.2013.12.004. Review.

46.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG.

Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.

47.

Connecting type 2 diabetes to Alzheimer's disease.

De Felice FG.

Expert Rev Neurother. 2013 Dec;13(12):1297-9. doi: 10.1586/14737175.2013.864824. No abstract available.

PMID:
24236899
48.

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST.

J Neurosci. 2013 Jun 5;33(23):9626-34. doi: 10.1523/JNEUROSCI.0482-13.2013.

49.

Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence.

Freiherr J, Hallschmid M, Frey WH 2nd, Brünner YF, Chapman CD, Hölscher C, Craft S, De Felice FG, Benedict C.

CNS Drugs. 2013 Jul;27(7):505-14. doi: 10.1007/s40263-013-0076-8. Review.

50.

Alzheimer's disease and insulin resistance: translating basic science into clinical applications.

De Felice FG.

J Clin Invest. 2013 Feb;123(2):531-9. doi: 10.1172/JCI64595. Epub 2013 Feb 1. Review.

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