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Items: 1 to 50 of 69

1.

Acute and chronic neurological consequences of early-life Zika virus infection in mice.

Nem de Oliveira Souza I, Frost PS, França JV, Nascimento-Viana JB, Neris RLS, Freitas L, Pinheiro DJLL, Nogueira CO, Neves G, Chimelli L, De Felice FG, Cavalheiro ÉA, Ferreira ST, Assunção-Miranda I, Figueiredo CP, Da Poian AT, Clarke JR.

Sci Transl Med. 2018 Jun 6;10(444). pii: eaar2749. doi: 10.1126/scitranslmed.aar2749.

PMID:
29875203
2.

Free-floating adult human brain-derived slice cultures as a model to study the neuronal impact of Alzheimer's disease-associated Aβ oligomers.

Mendes ND, Fernandes A, Almeida GM, Santos LE, Selles MC, Lyra-Silva N, Machado CM, Horta-Júnior JAC, Louzada PR, De Felice FG, Alvez-Leon S, Marcondes J, Assirati JA Jr, Matias CM, Klein WL, Garcia-Cairasco N, Ferreira ST, Neder L, Sebollela A.

J Neurosci Methods. 2018 May 31. pii: S0165-0270(18)30159-6. doi: 10.1016/j.jneumeth.2018.05.021. [Epub ahead of print]

PMID:
29859877
3.

Are Alzheimer's disease and other neurodegenerative disorders caused by impaired signalling of insulin and other hormones?

Hölscher C, De Felice FG, Greig N, Ferreira ST.

Neuropharmacology. 2018 May 18. pii: S0028-3908(18)30250-8. doi: 10.1016/j.neuropharm.2018.05.021. [Epub ahead of print] No abstract available.

PMID:
29782874
4.

Metabolic Syndrome and cognitive decline in the elderly: A systematic review.

Assuncao N, Sudo FK, Drummond C, de Felice FG, Mattos P.

PLoS One. 2018 Mar 26;13(3):e0194990. doi: 10.1371/journal.pone.0194990. eCollection 2018.

5.

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches.

Clarke JR, Ribeiro FC, Frozza RL, De Felice FG, Lourenco MV.

J Alzheimers Dis. 2018;64(s1):S405-S426. doi: 10.3233/JAD-179911.

PMID:
29562518
6.

Challenges for Alzheimer's Disease Therapy: Insights from Novel Mechanisms Beyond Memory Defects.

Frozza RL, Lourenco MV, De Felice FG.

Front Neurosci. 2018 Feb 6;12:37. doi: 10.3389/fnins.2018.00037. eCollection 2018. Review.

7.

Brain STAT5 signaling modulates learning and memory formation.

Furigo IC, Melo HM, Lyra E Silva NM, Ramos-Lobo AM, Teixeira PDS, Buonfiglio DC, Wasinski F, Lima ER, Higuti E, Peroni CN, Bartolini P, Soares CRJ, Metzger M, de Felice FG, Donato J Jr.

Brain Struct Funct. 2018 Jun;223(5):2229-2241. doi: 10.1007/s00429-018-1627-z. Epub 2018 Feb 19.

PMID:
29460051
8.

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

Batista AF, Forny-Germano L, Clarke JR, Lyra E Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Vital JF, Marques SA, Martinez AM, Gralle M, Holscher C, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG.

J Pathol. 2018 May;245(1):85-100. doi: 10.1002/path.5056. Epub 2018 Apr 2.

9.

Tau ablation in mice leads to pancreatic β cell dysfunction and glucose intolerance.

Wijesekara N, Gonçalves RA, Ahrens R, De Felice FG, Fraser PE.

FASEB J. 2018 Jun;32(6):3166-3173. doi: 10.1096/fj.201701352. Epub 2018 Jan 18.

PMID:
29401605
10.

Mesenchymal stem cells and cell-derived extracellular vesicles protect hippocampal neurons from oxidative stress and synapse damage induced by amyloid-β oligomers.

de Godoy MA, Saraiva LM, de Carvalho LRP, Vasconcelos-Dos-Santos A, Beiral HJV, Ramos AB, Silva LRP, Leal RB, Monteiro VHS, Braga CV, de Araujo-Silva CA, Sinis LC, Bodart-Santos V, Kasai-Brunswick TH, Alcantara CL, Lima APCA, da Cunha-E Silva NL, Galina A, Vieyra A, De Felice FG, Mendez-Otero R, Ferreira ST.

J Biol Chem. 2018 Feb 9;293(6):1957-1975. doi: 10.1074/jbc.M117.807180. Epub 2017 Dec 28.

PMID:
29284679
11.

Impaired peripheral glucose homeostasis and Alzheimer's disease.

Wijesekara N, Gonçalves RA, De Felice FG, Fraser PE.

Neuropharmacology. 2017 Nov 21. pii: S0028-3908(17)30536-1. doi: 10.1016/j.neuropharm.2017.11.027. [Epub ahead of print] Review.

PMID:
29169962
12.

Connecting Alzheimer's disease to diabetes: Underlying mechanisms and potential therapeutic targets.

Vieira MNN, Lima-Filho RAS, De Felice FG.

Neuropharmacology. 2017 Nov 10. pii: S0028-3908(17)30523-3. doi: 10.1016/j.neuropharm.2017.11.014. [Epub ahead of print] Review.

PMID:
29129775
13.

Neuroprotective astrocyte-derived insulin/insulin-like growth factor 1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers.

Pitt J, Wilcox KC, Tortelli V, Diniz LP, Oliveira MS, Dobbins C, Yu XW, Nandamuri S, Gomes FCA, DiNunno N, Viola KL, De Felice FG, Ferreira ST, Klein WL.

Mol Biol Cell. 2017 Oct 1;28(20):2623-2636. doi: 10.1091/mbc.E17-06-0416. Epub 2017 Aug 9.

14.

Brain infusion of α-synuclein oligomers induces motor and non-motor Parkinson's disease-like symptoms in mice.

Fortuna JTS, Gralle M, Beckman D, Neves FS, Diniz LP, Frost PS, Barros-Aragão F, Santos LE, Gonçalves RA, Romão L, Zamberlan DC, Soares FAA, Braga C, Foguel D, Gomes FCA, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP.

Behav Brain Res. 2017 Aug 30;333:150-160. doi: 10.1016/j.bbr.2017.06.047. Epub 2017 Jun 29.

PMID:
28668282
15.

Astrocyte Transforming Growth Factor Beta 1 Protects Synapses against Aβ Oligomers in Alzheimer's Disease Model.

Diniz LP, Tortelli V, Matias I, Morgado J, Bérgamo Araujo AP, Melo HM, Seixas da Silva GS, Alves-Leon SV, de Souza JM, Ferreira ST, De Felice FG, Gomes FCA.

J Neurosci. 2017 Jul 12;37(28):6797-6809. doi: 10.1523/JNEUROSCI.3351-16.2017. Epub 2017 Jun 12.

16.

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.

Kincheski GC, Valentim IS, Clarke JR, Cozachenco D, Castelo-Branco MTL, Ramos-Lobo AM, Rumjanek VMBD, Donato J Jr, De Felice FG, Ferreira ST.

Brain Behav Immun. 2017 Aug;64:140-151. doi: 10.1016/j.bbi.2017.04.007. Epub 2017 Apr 13.

PMID:
28412140
17.

Amyloid-β oligomers transiently inhibit AMP-activated kinase and cause metabolic defects in hippocampal neurons.

Seixas da Silva GS, Melo HM, Lourenco MV, Lyra E Silva NM, de Carvalho MB, Alves-Leon SV, de Souza JM, Klein WL, da-Silva WS, Ferreira ST, De Felice FG.

J Biol Chem. 2017 May 5;292(18):7395-7406. doi: 10.1074/jbc.M116.753525. Epub 2017 Mar 16.

18.

Interaction of amyloid-β (Aβ) oligomers with neurexin 2α and neuroligin 1 mediates synapse damage and memory loss in mice.

Brito-Moreira J, Lourenco MV, Oliveira MM, Ribeiro FC, Ledo JH, Diniz LP, Vital JFS, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FCA, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST.

J Biol Chem. 2017 May 5;292(18):7327-7337. doi: 10.1074/jbc.M116.761189. Epub 2017 Mar 10.

19.

Protein Tyrosine Phosphatase 1B (PTP1B): A Potential Target for Alzheimer's Therapy?

Vieira MN, Lyra E Silva NM, Ferreira ST, De Felice FG.

Front Aging Neurosci. 2017 Jan 31;9:7. doi: 10.3389/fnagi.2017.00007. eCollection 2017.

20.

Getting a "GRiP" on Hypothalamic Endoplasmic Reticulum Stress to Combat Obesity.

De Felice FG, Ferreira ST.

Diabetes. 2017 Jan;66(1):17-19. doi: 10.2337/dbi16-0057. No abstract available.

21.

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

Neves FS, Marques PT, Barros-Aragão F, Nunes JB, Venancio AM, Cozachenco D, Frozza RL, Passos GF, Costa R, de Oliveira J, Engel DF, De Bem AF, Benjamim CF, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP.

Mol Neurobiol. 2018 Jan;55(1):435-444. doi: 10.1007/s12035-016-0307-3. Epub 2016 Dec 13.

PMID:
27966074
22.

Cross Talk Between Brain Innate Immunity and Serotonin Signaling Underlies Depressive-Like Behavior Induced by Alzheimer's Amyloid-β Oligomers in Mice.

Ledo JH, Azevedo EP, Beckman D, Ribeiro FC, Santos LE, Razolli DS, Kincheski GC, Melo HM, Bellio M, Teixeira AL, Velloso LA, Foguel D, De Felice FG, Ferreira ST.

J Neurosci. 2016 Nov 30;36(48):12106-12116.

23.

Opportunities and challenges in developing relevant animal models for Alzheimer's disease.

De Felice FG, Munoz DP.

Ageing Res Rev. 2016 Mar;26:112-4. doi: 10.1016/j.arr.2016.01.006. Epub 2016 Jan 30. Review.

PMID:
26829469
24.

A Key Role of Insulin Receptors in Memory.

De Felice FG, Benedict C.

Diabetes. 2015 Nov;64(11):3653-5. doi: 10.2337/dbi15-0011. No abstract available.

25.

Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer's disease.

Ferreira ST, Lourenco MV, Oliveira MM, De Felice FG.

Front Cell Neurosci. 2015 May 26;9:191. doi: 10.3389/fncel.2015.00191. eCollection 2015. Review.

26.

Brain metabolic stress and neuroinflammation at the basis of cognitive impairment in Alzheimer's disease.

De Felice FG, Lourenco MV.

Front Aging Neurosci. 2015 May 19;7:94. doi: 10.3389/fnagi.2015.00094. eCollection 2015. Review.

27.

Neuronal stress signaling and eIF2α phosphorylation as molecular links between Alzheimer's disease and diabetes.

Lourenco MV, Ferreira ST, De Felice FG.

Prog Neurobiol. 2015 Jun;129:37-57. doi: 10.1016/j.pneurobio.2015.03.003. Epub 2015 Apr 6. Review.

PMID:
25857551
28.

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG.

EMBO Mol Med. 2015 Feb;7(2):190-210. doi: 10.15252/emmm.201404183.

29.

Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates.

Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG.

J Neurosci. 2014 Oct 8;34(41):13629-43. doi: 10.1523/JNEUROSCI.1353-14.2014.

30.

Inflammation, defective insulin signaling, and mitochondrial dysfunction as common molecular denominators connecting type 2 diabetes to Alzheimer disease.

De Felice FG, Ferreira ST.

Diabetes. 2014 Jul;63(7):2262-72. doi: 10.2337/db13-1954. Epub 2014 Jun 15. Review.

31.

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease.

Ferreira ST, Clarke JR, Bomfim TR, De Felice FG.

Alzheimers Dement. 2014 Feb;10(1 Suppl):S76-83. doi: 10.1016/j.jalz.2013.12.010. Review.

32.

How does brain insulin resistance develop in Alzheimer's disease?

De Felice FG, Lourenco MV, Ferreira ST.

Alzheimers Dement. 2014 Feb;10(1 Suppl):S26-32. doi: 10.1016/j.jalz.2013.12.004. Review.

33.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG.

Cell Metab. 2013 Dec 3;18(6):831-43. doi: 10.1016/j.cmet.2013.11.002.

34.

Connecting type 2 diabetes to Alzheimer's disease.

De Felice FG.

Expert Rev Neurother. 2013 Dec;13(12):1297-9. doi: 10.1586/14737175.2013.864824. No abstract available.

PMID:
24236899
35.

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST.

J Neurosci. 2013 Jun 5;33(23):9626-34. doi: 10.1523/JNEUROSCI.0482-13.2013.

36.

Intranasal insulin as a treatment for Alzheimer's disease: a review of basic research and clinical evidence.

Freiherr J, Hallschmid M, Frey WH 2nd, Brünner YF, Chapman CD, Hölscher C, Craft S, De Felice FG, Benedict C.

CNS Drugs. 2013 Jul;27(7):505-14. doi: 10.1007/s40263-013-0076-8. Review.

37.

Alzheimer's disease and insulin resistance: translating basic science into clinical applications.

De Felice FG.

J Clin Invest. 2013 Feb;123(2):531-9. doi: 10.1172/JCI64595. Epub 2013 Feb 1. Review.

38.

Amyloid-β oligomers link depressive-like behavior and cognitive deficits in mice.

Ledo JH, Azevedo EP, Clarke JR, Ribeiro FC, Figueiredo CP, Foguel D, De Felice FG, Ferreira ST.

Mol Psychiatry. 2013 Oct;18(10):1053-4. doi: 10.1038/mp.2012.168. Epub 2012 Nov 27. No abstract available.

39.

An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers.

Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, Ferreira ST, De Felice FG.

J Clin Invest. 2012 Apr;122(4):1339-53. doi: 10.1172/JCI57256.

40.

Amyloid-β oligomers induce differential gene expression in adult human brain slices.

Sebollela A, Freitas-Correa L, Oliveira FF, Paula-Lima AC, Saraiva LM, Martins SM, Mota LD, Torres C, Alves-Leon S, de Souza JM, Carraro DM, Brentani H, De Felice FG, Ferreira ST.

J Biol Chem. 2012 Mar 2;287(10):7436-45. doi: 10.1074/jbc.M111.298471. Epub 2012 Jan 10.

41.

Amyloid-beta oligomers increase the localization of prion protein at the cell surface.

Caetano FA, Beraldo FH, Hajj GN, Guimaraes AL, Jürgensen S, Wasilewska-Sampaio AP, Hirata PH, Souza I, Machado CF, Wong DY, De Felice FG, Ferreira ST, Prado VF, Rylett RJ, Martins VR, Prado MA.

J Neurochem. 2011 May;117(3):538-53. doi: 10.1111/j.1471-4159.2011.07225.x. Epub 2011 Mar 23.

42.

Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria.

Saraiva LM, Seixas da Silva GS, Galina A, da-Silva WS, Klein WL, Ferreira ST, De Felice FG.

PLoS One. 2010 Dec 16;5(12):e15230. doi: 10.1371/journal.pone.0015230.

43.

Activation of D1/D5 dopamine receptors protects neurons from synapse dysfunction induced by amyloid-beta oligomers.

Jürgensen S, Antonio LL, Mussi GE, Brito-Moreira J, Bomfim TR, De Felice FG, Garrido-Sanabria ER, Cavalheiro ÉA, Ferreira ST.

J Biol Chem. 2011 Feb 4;286(5):3270-6. doi: 10.1074/jbc.M110.177790. Epub 2010 Nov 29.

44.

N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers.

Decker H, Jürgensen S, Adrover MF, Brito-Moreira J, Bomfim TR, Klein WL, Epstein AL, De Felice FG, Jerusalinsky D, Ferreira ST.

J Neurochem. 2010 Dec;115(6):1520-9. doi: 10.1111/j.1471-4159.2010.07058.x. Epub 2010 Nov 11.

45.

Expression profile of rat hippocampal neurons treated with the neuroprotective compound 2,4-dinitrophenol: up-regulation of cAMP signaling genes.

Sebollela A, Freitas-Corrêa L, Oliveira FF, Mendes CT, Wasilewska-Sampaio AP, Camacho-Pereira J, Galina A, Brentani H, Passetti F, De Felice FG, Dias-Neto E, Ferreira ST.

Neurotox Res. 2010 Aug;18(2):112-23. doi: 10.1007/s12640-009-9133-y. Epub 2009 Dec 1.

PMID:
19949915
46.

Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers.

De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1971-6. doi: 10.1073/pnas.0809158106. Epub 2009 Feb 2. Erratum in: Proc Natl Acad Sci U S A. 2009 May 5;106(18):7678.

47.

Soluble oligomers from a non-disease related protein mimic Abeta-induced tau hyperphosphorylation and neurodegeneration.

Vieira MN, Forny-Germano L, Saraiva LM, Sebollela A, Martinez AM, Houzel JC, De Felice FG, Ferreira ST.

J Neurochem. 2007 Oct;103(2):736-48. Epub 2007 Aug 28.

48.

Amyloid beta oligomers induce impairment of neuronal insulin receptors.

Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL.

FASEB J. 2008 Jan;22(1):246-60. Epub 2007 Aug 24.

PMID:
17720802
49.

Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease.

De Felice FG, Wasilewska-Sampaio AP, Barbosa AC, Gomes FC, Klein WL, Ferreira ST.

Curr Alzheimer Res. 2007 Jul;4(3):263-71. Review.

PMID:
17627483
50.

Soluble protein oligomers as emerging toxins in Alzheimer's and other amyloid diseases.

Ferreira ST, Vieira MN, De Felice FG.

IUBMB Life. 2007 Apr-May;59(4-5):332-45. Review.

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