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Items: 44


Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation.

Gu Z, Wang H, Xia J, Yang Y, Jin Z, Xu H, Shi J, De Domenico I, Tricot G, Zhan F.

Cancer Res. 2015 Jun 1;75(11):2211-21. doi: 10.1158/0008-5472.CAN-14-3804. Epub 2015 Apr 8.


Autophagy is a key feature in the pathogenesis of systemic sclerosis.

Frech T, De Domenico I, Murtaugh MA, Revelo MP, Li DY, Sawitzke AD, Drakos S.

Rheumatol Int. 2014 Mar;34(3):435-9. doi: 10.1007/s00296-013-2827-8. Epub 2013 Aug 11.


Murine macrophages response to iron.

Polati R, Castagna A, Bossi AM, Alberio T, De Domenico I, Kaplan J, Timperio AM, Zolla L, Gevi F, D'Alessandro A, Brunch R, Olivieri O, Girelli D.

J Proteomics. 2012 Dec 5;76 Spec No.:10-27. doi: 10.1016/j.jprot.2012.07.018. Epub 2012 Jul 23.


The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin.

De Domenico I, Lo E, Yang B, Korolnek T, Hamza I, Ward DM, Kaplan J.

Cell Metab. 2011 Nov 2;14(5):635-46. doi: 10.1016/j.cmet.2011.09.008. Epub 2011 Oct 20. Retraction in: Cell Metab. 2012 Jun 6;15(6):927.


Hepcidin and ferroportin: the new players in iron metabolism.

De Domenico I, Ward DM, Kaplan J.

Semin Liver Dis. 2011 Aug;31(3):272-9. doi: 10.1055/s-0031-1286058. Epub 2011 Sep 7. Review.


The molecular basis of iron overload disorders and iron-linked anemias.

Kaplan J, Ward DM, De Domenico I.

Int J Hematol. 2011 Jan;93(1):14-20. doi: 10.1007/s12185-010-0760-0. Epub 2011 Jan 7. Review.


Decoupling ferritin synthesis from free cytosolic iron results in ferritin secretion.

De Domenico I, Vaughn MB, Paradkar PN, Lo E, Ward DM, Kaplan J.

Cell Metab. 2011 Jan 5;13(1):57-67. doi: 10.1016/j.cmet.2010.12.003. Retraction in: Cell Metab. 2012 Jun 6;15(6):927.


Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux.

Troadec MB, Ward DM, Lo E, Kaplan J, De Domenico I.

Blood. 2010 Nov 25;116(22):4657-64. doi: 10.1182/blood-2010-04-278614. Epub 2010 Aug 5.


Reconstitution of normal hepcidin expression in Hfe-deficient mice after liver transplantation: a new role of HFE in Kupffer cells?

De Domenico I, Kushner JP.

Gastroenterology. 2010 Jul;139(1):25-7. doi: 10.1053/j.gastro.2010.05.020. No abstract available.


Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice.

De Domenico I, Zhang TY, Koening CL, Branch RW, London N, Lo E, Daynes RA, Kushner JP, Li D, Ward DM, Kaplan J.

J Clin Invest. 2010 Jul;120(7):2395-405. doi: 10.1172/JCI42011. Epub 2010 Jun 7.


Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice.

Gao J, Chen J, De Domenico I, Koeller DM, Harding CO, Fleming RE, Koeberl DD, Enns CA.

Blood. 2010 Apr 22;115(16):3374-81. doi: 10.1182/blood-2009-09-245209. Epub 2010 Feb 22.


Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation.

De Domenico I, Lo E, Ward DM, Kaplan J.

Blood. 2010 Apr 8;115(14):2956-9. doi: 10.1182/blood-2009-10-251306. Epub 2010 Feb 2.


Autophagy, ferritin and iron chelation.

De Domenico I, Ward DM, Kaplan J.

Autophagy. 2010 Jan;6(1):157. Epub 2010 Jan 10. No abstract available.


Hepcidin is elevated in mice injected with Mycoplasma arthritidis.

Koening CL, Mu HH, Van Schelt A, Lo E, Ward DM, Kaplan J, De Domenico I.

J Inflamm (Lond). 2009 Nov 24;6:33. doi: 10.1186/1476-9255-6-33.


A new wrinkle in the fold: hepcidin links inflammation to the unfolded protein response.

De Domenico I, Kaplan J.

Cell Metab. 2009 Oct;10(4):245-6. doi: 10.1016/j.cmet.2009.09.005.


Specific iron chelators determine the route of ferritin degradation.

De Domenico I, Ward DM, Kaplan J.

Blood. 2009 Nov 12;114(20):4546-51. doi: 10.1182/blood-2009-05-224188. Epub 2009 Aug 11.


Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi.

Koening CL, Miller JC, Nelson JM, Ward DM, Kushner JP, Bockenstedt LK, Weis JJ, Kaplan J, De Domenico I.

Blood. 2009 Aug 27;114(9):1913-8. doi: 10.1182/blood-2009-03-209577. Epub 2009 Jul 8.


The molecular basis of hepcidin-resistant hereditary hemochromatosis.

Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E.

Blood. 2009 Jul 9;114(2):437-43. doi: 10.1182/blood-2008-03-146134. Epub 2009 Apr 21.


Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.

De Domenico I, Lo E, Ward DM, Kaplan J.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3800-5. doi: 10.1073/pnas.0900453106. Epub 2009 Feb 20. Erratum in: Proc Natl Acad Sci U S A. 2012 May 8;109(19):7583-6.


Serum ferritin regulates blood vessel formation: a role beyond iron storage.

De Domenico I, Ward DM, Kaplan J.

Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1683-4. doi: 10.1073/pnas.0813318106. Epub 2009 Feb 4. No abstract available.


The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin.

Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C.

Cell Metab. 2008 Dec;8(6):502-11. doi: 10.1016/j.cmet.2008.09.012. Epub 2008 Oct 30.


Clinical, pathological, and molecular correlates in ferroportin disease: a study of two novel mutations.

Girelli D, De Domenico I, Bozzini C, Campostrini N, Busti F, Castagna A, Soriani N, Cremonesi L, Ferrari M, Colombari R, McVey Ward D, Kaplan J, Corrocher R.

J Hepatol. 2008 Oct;49(4):664-71. doi: 10.1016/j.jhep.2008.05.028. Epub 2008 Jul 17.


The hepcidin-binding site on ferroportin is evolutionarily conserved.

De Domenico I, Nemeth E, Nelson JM, Phillips JD, Ajioka RS, Kay MS, Kushner JP, Ganz T, Ward DM, Kaplan J.

Cell Metab. 2008 Aug;8(2):146-56. doi: 10.1016/j.cmet.2008.07.002. Retraction in: Cell Metab. 2014 Jun 3;19(6):1067.


Two distinct modes of ESCRT-III recognition are required for VPS4 functions in lysosomal protein targeting and HIV-1 budding.

Kieffer C, Skalicky JJ, Morita E, De Domenico I, Ward DM, Kaplan J, Sundquist WI.

Dev Cell. 2008 Jul;15(1):62-73. doi: 10.1016/j.devcel.2008.05.014.


Iron depletion limits intracellular bacterial growth in macrophages.

Paradkar PN, De Domenico I, Durchfort N, Zohn I, Kaplan J, Ward DM.

Blood. 2008 Aug 1;112(3):866-74. doi: 10.1182/blood-2007-12-126854. Epub 2008 Mar 27.


A heme export protein is required for red blood cell differentiation and iron homeostasis.

Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, Knoblaugh S, Kingsley PD, De Domenico I, Vaughn MB, Kaplan J, Palis J, Abkowitz JL.

Science. 2008 Feb 8;319(5864):825-8. doi: 10.1126/science.1151133.


Chediak-Higashi syndrome.

Kaplan J, De Domenico I, Ward DM.

Curr Opin Hematol. 2008 Jan;15(1):22-9. Review.


Regulation of iron acquisition and storage: consequences for iron-linked disorders.

De Domenico I, McVey Ward D, Kaplan J.

Nat Rev Mol Cell Biol. 2008 Jan;9(1):72-81. Review.


Zebrafish as a model for defining the functional impact of mammalian ferroportin mutations.

De Domenico I, Vaughn MB, Yoon D, Kushner JP, Ward DM, Kaplan J.

Blood. 2007 Nov 15;110(10):3780-3. Epub 2007 Aug 28. Erratum in: Blood. 2012 May 31;119(22):5340.


Hepcidin regulation: ironing out the details.

De Domenico I, Ward DM, Kaplan J.

J Clin Invest. 2007 Jul;117(7):1755-8.


Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin.

De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, Musci G, Kaplan J.

EMBO J. 2007 Jun 20;26(12):2823-31. Epub 2007 May 31.


The molecular mechanism of hepcidin-mediated ferroportin down-regulation.

De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J.

Mol Biol Cell. 2007 Jul;18(7):2569-78. Epub 2007 May 2.


The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease.

Zohn IE, De Domenico I, Pollock A, Ward DM, Goodman JF, Liang X, Sanchez AJ, Niswander L, Kaplan J.

Blood. 2007 May 15;109(10):4174-80. Epub 2007 Feb 8.


Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome.

De Domenico I, Vaughn MB, Li L, Bagley D, Musci G, Ward DM, Kaplan J.

EMBO J. 2006 Nov 15;25(22):5396-404. Epub 2006 Nov 2.


Evidence for the multimeric structure of ferroportin.

De Domenico I, Ward DM, Musci G, Kaplan J.

Blood. 2007 Mar 1;109(5):2205-9. Epub 2006 Oct 31.


Human ESCRT-II complex and its role in human immunodeficiency virus type 1 release.

Langelier C, von Schwedler UK, Fisher RD, De Domenico I, White PL, Hill CP, Kaplan J, Ward D, Sundquist WI.

J Virol. 2006 Oct;80(19):9465-80.


Molecular and clinical correlates in iron overload associated with mutations in ferroportin.

De Domenico I, McVey Ward D, Nemeth E, Ganz T, Corradini E, Ferrara F, Musci G, Pietrangelo A, Kaplan J.

Haematologica. 2006 Aug;91(8):1092-5.


Iron overload due to mutations in ferroportin.

De Domenico I, Ward DM, Musci G, Kaplan J.

Haematologica. 2006 Jan;91(1):92-5. Review.


Purification and characterization of recombinant Caulobacter crescentus Cu,Zn superoxide dismutase.

De Domenico I, Lania A, Bonaccorsi di Patti MC, Battistoni A, Musci G, Desideri A.

Biochim Biophys Acta. 2006 Jan;1764(1):105-9. Epub 2005 Sep 13.


Specific aspartate residues in FET3 control high-affinity iron transport in Saccharomyces cerevisiae.

Bonaccorsi di Patti MC, Felice MR, De Domenico I, Lania A, Alaleona F, Musci G.

Yeast. 2005 Jul 15;22(9):677-87.


The molecular basis of ferroportin-linked hemochromatosis.

De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J.

Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8955-60. Epub 2005 Jun 13.


Post-transcriptional regulation of the yeast high affinity iron transport system.

Felice MR, De Domenico I, Li L, Ward DM, Bartok B, Musci G, Kaplan J.

J Biol Chem. 2005 Jun 10;280(23):22181-90. Epub 2005 Apr 7.


Intestinal conduit urinary diversion in children.

Ray P, De Domenico I.

Br J Urol. 1972 Jun;44(3):345-50. No abstract available.


Periureteral fibrosis.


Can J Surg. 1958 Jan;1(2):162-6. No abstract available.


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