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Items: 1 to 50 of 638

1.

Targeting TNFR2 as a Novel Therapeutic Strategy for Alzheimer's Disease.

Ortí-Casañ N, Wu Y, Naudé PJW, De Deyn PP, Zuhorn IS, Eisel ULM.

Front Neurosci. 2019 Feb 4;13:49. doi: 10.3389/fnins.2019.00049. eCollection 2019.

2.

Alzheimer's disease and glaucoma: Look-alike neurodegenerative diseases.

Wostyn P, Van Dam D, De Deyn PP.

Alzheimers Dement. 2019 Jan 31. pii: S1552-5260(18)33629-X. doi: 10.1016/j.jalz.2018.12.012. [Epub ahead of print] No abstract available.

PMID:
30713020
3.

Relative cerebral flow from dynamic PIB scans as an alternative for FDG scans in Alzheimer's disease PET studies.

Peretti DE, Vállez García D, Reesink FE, van der Goot T, De Deyn PP, de Jong BM, Dierckx RAJO, Boellaard R.

PLoS One. 2019 Jan 17;14(1):e0211000. doi: 10.1371/journal.pone.0211000. eCollection 2019.

4.

The validation of Short Interspersed Nuclear Elements (SINEs) as a RT-qPCR normalization strategy in a rodent model for temporal lobe epilepsy.

Crans RAJ, Janssens J, Daelemans S, Wouters E, Raedt R, Van Dam D, De Deyn PP, Van Craenenbroeck K, Stove CP.

PLoS One. 2019 Jan 10;14(1):e0210567. doi: 10.1371/journal.pone.0210567. eCollection 2019.

5.

Intrathecal cerebrospinal fluid infusion as a potential therapeutic strategy for Alzheimer's disease.

Wostyn P, Van Dam D, De Deyn PP.

Med Hypotheses. 2019 Jan;122:57. doi: 10.1016/j.mehy.2018.10.020. Epub 2018 Oct 22. No abstract available.

PMID:
30593424
6.

Everolimus depletes plaque macrophages, abolishes intraplaque neovascularization and improves survival in mice with advanced atherosclerosis.

Kurdi A, Roth L, Van der Veken B, Van Dam D, De Deyn PP, De Doncker M, Neels H, De Meyer GRY, Martinet W.

Vascul Pharmacol. 2018 Dec 24. pii: S1537-1891(18)30300-8. doi: 10.1016/j.vph.2018.12.004. [Epub ahead of print]

PMID:
30590134
7.

Lipocalin 2 contributes to brain iron dysregulation but does not affect cognition, plaque load, and glial activation in the J20 Alzheimer mouse model.

Dekens DW, Naudé PJW, Keijser JN, Boerema AS, De Deyn PP, Eisel ULM.

J Neuroinflammation. 2018 Nov 30;15(1):330. doi: 10.1186/s12974-018-1372-5.

8.

Dilated Prelaminar Paravascular Spaces as a Possible Mechanism for Optic Disc Edema in Astronauts.

Wostyn P, De Winne F, Stern C, De Deyn PP.

Aerosp Med Hum Perform. 2018 Dec 1;89(12):1089-1091. doi: 10.3357/AMHP.5095.2018.

PMID:
30487031
9.

Episodic memory in mild cognitive impairment inversely correlates with the global modularity of the cerebral blood flow network.

Sánchez-Catasús CA, Willemsen A, Boellaard R, Juarez-Orozco LE, Samper-Noa J, Aguila-Ruiz A, De Deyn PP, Dierckx R, Medina YI, Melie-Garcia L.

Psychiatry Res Neuroimaging. 2018 Dec 30;282:73-81. doi: 10.1016/j.pscychresns.2018.11.003. Epub 2018 Nov 3.

PMID:
30419408
10.

The MMSE should not be the sole indicator of fitness to drive in mild Alzheimer's dementia.

Piersma D, Fuermaier ABM, de Waard D, De Deyn PP, Davidse RJ, de Groot J, Doumen MJA, Bredewoud RA, Claesen R, Lemstra AW, Vermeeren A, Ponds R, Verhey F, Brouwer WH, Tucha O.

Acta Neurol Belg. 2018 Dec;118(4):637-642. doi: 10.1007/s13760-018-1036-3. Epub 2018 Nov 2.

11.

[The behavioral and psychological symptoms of dementia in down syndrome (BPSD-DS) scale: comprehensive assessment of psychopathology in down syndrome].

Dekker AD, Vermeiren Y, Beugelsdijk G, Schippers M, Hassefras L, Eleveld J, Grefelman S, Fopma R, Bomer-Veenboer M, Oosterling GDE, Scholten E, Tollenaere M, Van Goethem G, Zu Eulenburg C, Coppus AMW, De Deyn PP.

Tijdschr Gerontol Geriatr. 2018 Oct;49(5):187-205. doi: 10.1007/s12439-018-0262-8. Epub 2018 Sep 20. Dutch.

PMID:
30238286
12.

Adherence to driving cessation advice given to patients with cognitive impairment and consequences for mobility.

Piersma D, Fuermaier ABM, De Waard D, Davidse RJ, De Groot J, Doumen MJA, Ponds RWHM, De Deyn PP, Brouwer WH, Tucha O.

BMC Geriatr. 2018 Sep 17;18(1):216. doi: 10.1186/s12877-018-0910-4.

13.

Crossed Cerebellar Diaschisis in Alzheimer's Disease.

Reesink FE, García DV, Sánchez-Catasús CA, Peretti DE, Willemsen AT, Boellaard R, Meles SK, Huitema RB, de Jong BM, Dierckx RA, De Deyn PP.

Curr Alzheimer Res. 2018;15(13):1267-1275. doi: 10.2174/1567205015666180913102615.

PMID:
30210001
14.

Randomized controlled trial to evaluate a prevention program for frail community-dwelling older adults: a D-SCOPE protocol.

Lambotte D, De Donder L, De Roeck EE, Hoeyberghs LJ, van der Vorst A, Duppen D, Van der Elst M, Fret B, Dury S, Smetcoren AS, Kardol MJM, Engelborghs S, De Deyn PP, De Witte N, Schols JMGA, Kempen GIJM, Zijlstra GAR, De Lepeleire J, Schoenmakers B, Verté D, Dierckx E.

BMC Geriatr. 2018 Aug 27;18(1):194. doi: 10.1186/s12877-018-0875-3.

15.

Anti-Tau Monoclonal Antibodies Derived from Soluble and Filamentous Tau Show Diverse Functional Properties in vitro and in vivo.

Vandermeeren M, Borgers M, Van Kolen K, Theunis C, Vasconcelos B, Bottelbergs A, Wintmolders C, Daneels G, Willems R, Dockx K, Delbroek L, Marreiro A, Ver Donck L, Sousa C, Nanjunda R, Lacy E, Van De Casteele T, Van Dam D, De Deyn PP, Kemp JA, Malia TJ, Mercken MH.

J Alzheimers Dis. 2018;65(1):265-281. doi: 10.3233/JAD-180404.

PMID:
30040731
16.

Intracranial pressure and glaucoma: Is there a new therapeutic perspective on the horizon?

Wostyn P, Van Dam D, De Deyn PP.

Med Hypotheses. 2018 Sep;118:98-102. doi: 10.1016/j.mehy.2018.06.026. Epub 2018 Jun 28.

PMID:
30037625
17.

The putative glymphatic signature of chronic fatigue syndrome: A new view on the disease pathogenesis and therapy.

Wostyn P, De Deyn PP.

Med Hypotheses. 2018 Sep;118:142-145. doi: 10.1016/j.mehy.2018.07.007. Epub 2018 Jul 6.

PMID:
30037603
18.

Neuroimaging of Subacute Brain Inflammation and Microstructural Changes Predicts Long-Term Functional Outcome after Experimental Traumatic Brain Injury.

Missault S, Anckaerts C, Blockx I, Deleye S, Van Dam D, Barriche N, De Pauw G, Aertgeerts S, Valkenburg F, De Deyn PP, Verhaeghe J, Wyffels L, Van der Linden A, Staelens S, Verhoye M, Dedeurwaerdere S.

J Neurotrauma. 2018 Oct 3. doi: 10.1089/neu.2018.5704. [Epub ahead of print]

PMID:
30032713
19.

No supportive evidence for TIA1 gene mutations in a European cohort of ALS-FTD spectrum patients.

Baradaran-Heravi Y, Dillen L, Nguyen HP, Van Mossevelde S, Baets J, De Jonghe P, Engelborghs S, De Deyn PP, Vandenbulcke M, Vandenberghe R, Van Damme P, Cras P, Salmon E, Synofzik M, Heutink P, Wilke C, Simon-Sanchez J, Rojas-Garcia R, Turon-Sans J, Lleó A, Illán-Gala I, Clarimón J, Borroni B, Padovani A, Pastor P, Diez-Fairen M, Aguilar M, Gelpi E, Sanchez-Valle R, Borrego-Ecija S, Matej R, Parobkova E, Nacmias B, Sorbi S, Bagnoli S, de Mendonça A, Ferreira C, Fraidakis MJ, Diehl-Schmid J, Alexopoulos P, Almeida MR, Santana I, Van Broeckhoven C, van der Zee J; BELNEU Consortium; EU EOD Consortium.

Neurobiol Aging. 2018 Sep;69:293.e9-293.e11. doi: 10.1016/j.neurobiolaging.2018.05.005. Epub 2018 May 23.

20.

Genetic screening in early-onset dementia patients with unclear phenotype: relevance for clinical diagnosis.

Perrone F, Cacace R, Van Mossevelde S, Van den Bossche T, De Deyn PP, Cras P, Engelborghs S, van der Zee J, Van Broeckhoven C.

Neurobiol Aging. 2018 Sep;69:292.e7-292.e14. doi: 10.1016/j.neurobiolaging.2018.04.015. Epub 2018 May 9.

21.

A Retrospective Belgian Multi-Center MRI Biomarker Study in Alzheimer's Disease (REMEMBER).

Niemantsverdriet E, Ribbens A, Bastin C, Benoit F, Bergmans B, Bier JC, Bladt R, Claes L, De Deyn PP, Deryck O, Hanseeuw B, Ivanoiu A, Lemper JC, Mormont E, Picard G, Salmon E, Segers K, Sieben A, Smeets D, Struyfs H, Thiery E, Tournoy J, Triau E, Vanbinst AM, Versijpt J, Bjerke M, Engelborghs S.

J Alzheimers Dis. 2018;63(4):1509-1522. doi: 10.3233/JAD-171140.

22.

Monoaminergic impairment in Down syndrome with Alzheimer's disease compared to early-onset Alzheimer's disease.

Dekker AD, Vermeiren Y, Carmona-Iragui M, Benejam B, Videla L, Gelpi E, Aerts T, Van Dam D, Fernández S, Lleó A, Videla S, Sieben A, Martin JJ; Netherlands Brain Bank, Blesa R, Fortea J, De Deyn PP.

Alzheimers Dement (Amst). 2017 Nov 23;10:99-111. doi: 10.1016/j.dadm.2017.11.001. eCollection 2018.

23.

Letter to the Editor. Low ICP and normal tension glaucoma: optic nerve damage due to barotraumatic factors, failure of CSF dynamics, or both?

Wostyn P, De Groot V, Van Dam D, Audenaert K, De Deyn PP, Killer HE.

J Neurosurg. 2018 Oct;129(4):1100-1103. doi: 10.3171/2017.11.JNS172939. Epub 2018 May 4. No abstract available.

PMID:
29726764
24.

Lower Choline and Myo-Inositol in Temporo-Parietal Cortex Is Associated With Apathy in Amnestic MCI.

Tumati S, Opmeer EM, Marsman JC, Martens S, Reesink FE, De Deyn PP, Aleman A.

Front Aging Neurosci. 2018 Apr 13;10:106. doi: 10.3389/fnagi.2018.00106. eCollection 2018.

25.

Can cerebrospinal fluid diversion be beneficial in the treatment of chronic fatigue syndrome?

Wostyn P, De Deyn PP.

Med Hypotheses. 2018 Sep;118:174. doi: 10.1016/j.mehy.2018.04.020. Epub 2018 Apr 24. No abstract available.

PMID:
29706288
26.

The Behavioral and Psychological Symptoms of Dementia in Down Syndrome (BPSD-DS) Scale: Comprehensive Assessment of Psychopathology in Down Syndrome.

Dekker AD, Sacco S, Carfi A, Benejam B, Vermeiren Y, Beugelsdijk G, Schippers M, Hassefras L, Eleveld J, Grefelman S, Fopma R, Bomer-Veenboer M, Boti M, Oosterling GDE, Scholten E, Tollenaere M, Checkley L, Strydom A, Van Goethem G, Onder G, Blesa R, Zu Eulenburg C, Coppus AMW, Rebillat AS, Fortea J, De Deyn PP.

J Alzheimers Dis. 2018;63(2):797-819. doi: 10.3233/JAD-170920.

27.

The "Ocular Glymphatic System": An Important Missing Piece in the Puzzle of Optic Disc Edema in Astronauts?

Wostyn P, De Deyn PP.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2090-2091. doi: 10.1167/iovs.17-23263. No abstract available.

PMID:
29677371
28.

Clinical variability and onset age modifiers in an extended Belgian GRN founder family.

Wauters E, Van Mossevelde S, Sleegers K, van der Zee J, Engelborghs S, Sieben A, Vandenberghe R, Philtjens S, Van den Broeck M, Peeters K, Cuijt I, De Coster W, Van Langenhove T, Santens P, Ivanoiu A, Cras P, De Bleecker JL, Versijpt J, Crols R, De Klippel N, Martin JJ, De Deyn PP, Cruts M, Van Broeckhoven C; Belgian Neurology (BELNEU) Consortium.

Neurobiol Aging. 2018 Jul;67:84-94. doi: 10.1016/j.neurobiolaging.2018.03.007. Epub 2018 Mar 10.

29.

CFAI-Plus: Adding cognitive frailty as a new domain to the comprehensive frailty assessment instrument.

De Roeck EE, Dury S, De Witte N, De Donder L, Bjerke M, De Deyn PP, Engelborghs S, Dierckx E.

Int J Geriatr Psychiatry. 2018 Jul;33(7):941-947. doi: 10.1002/gps.4875. Epub 2018 Apr 10.

PMID:
29637620
30.

Serotonergic Dysfunction in Amyotrophic Lateral Sclerosis and Parkinson's Disease: Similar Mechanisms, Dissimilar Outcomes.

Vermeiren Y, Janssens J, Van Dam D, De Deyn PP.

Front Neurosci. 2018 Mar 20;12:185. doi: 10.3389/fnins.2018.00185. eCollection 2018.

31.

Added Diagnostic Value of Cerebrospinal Fluid Biomarkers for Differential Dementia Diagnosis in an Autopsy-Confirmed Cohort.

Niemantsverdriet E, Feyen BFE, Le Bastard N, Martin JJ, Goeman J, De Deyn PP, Bjerke M, Engelborghs S.

J Alzheimers Dis. 2018;63(1):373-381. doi: 10.3233/JAD-170927.

32.

The First Histologic Evidence of a Paravascular Pathway Within the Optic Nerve.

Wostyn P, De Groot V, Van Dam D, Audenaert K, De Deyn PP, Killer HE.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1717. doi: 10.1167/iovs.17-23119. No abstract available.

PMID:
29610854
33.

An intronic VNTR affects splicing of ABCA7 and increases risk of Alzheimer's disease.

De Roeck A, Duchateau L, Van Dongen J, Cacace R, Bjerke M, Van den Bossche T, Cras P, Vandenberghe R, De Deyn PP, Engelborghs S, Van Broeckhoven C, Sleegers K; BELNEU Consortium.

Acta Neuropathol. 2018 Jun;135(6):827-837. doi: 10.1007/s00401-018-1841-z. Epub 2018 Mar 27.

34.

Diagnostic value of cerebrospinal fluid tau, neurofilament, and progranulin in definite frontotemporal lobar degeneration.

Goossens J, Bjerke M, Van Mossevelde S, Van den Bossche T, Goeman J, De Vil B, Sieben A, Martin JJ, Cras P, De Deyn PP, Van Broeckhoven C, van der Zee J, Engelborghs S.

Alzheimers Res Ther. 2018 Mar 20;10(1):31. doi: 10.1186/s13195-018-0364-0.

35.

Rare nonsynonymous variants in SORT1 are associated with increased risk for frontotemporal dementia.

Philtjens S, Van Mossevelde S, van der Zee J, Wauters E, Dillen L, Vandenbulcke M, Vandenberghe R, Ivanoiu A, Sieben A, Willems C, Benussi L, Ghidoni R, Binetti G, Borroni B, Padovani A, Pastor P, Diez-Fairen M, Aguilar M, de Mendonça A, Miltenberger-Miltényi G, Hernández I, Boada M, Ruiz A, Nacmias B, Sorbi S, Almeida MR, Santana I, Clarimón J, Lleó A, Frisoni GB, Sanchez-Valle R, Lladó A, Gómez-Tortosa E, Gelpi E, Van den Broeck M, Peeters K, Cras P, De Deyn PP, Engelborghs S, Cruts M, Van Broeckhoven C; BELNEU Consortium; EU EOD Consortium.

Neurobiol Aging. 2018 Jun;66:181.e3-181.e10. doi: 10.1016/j.neurobiolaging.2018.02.011. Epub 2018 Feb 17.

36.

Cerebrospinal fluid and serum MHPG improve Alzheimer's disease versus dementia with Lewy bodies differential diagnosis.

Janssens J, Vermeiren Y, Fransen E, Aerts T, Van Dam D, Engelborghs S, De Deyn PP.

Alzheimers Dement (Amst). 2018 Feb 6;10:172-181. doi: 10.1016/j.dadm.2018.01.002. eCollection 2018.

37.

Why Space Flight-Associated Neuro-ocular Syndrome May Differ From Idiopathic Intracranial Hypertension.

Wostyn P, De Deyn PP.

JAMA Ophthalmol. 2018 Apr 1;136(4):451-452. doi: 10.1001/jamaophthalmol.2018.0316. No abstract available.

PMID:
29543948
38.

[Apathy, depression and cognitive functioning in patients with MCI and dementia].

Vloeberghs R, Opmeer EM, De Deyn PP, Engelborghs S, De Roeck EE.

Tijdschr Gerontol Geriatr. 2018 Jun;49(3):95-102. doi: 10.1007/s12439-018-0248-6. Epub 2018 Feb 27. Dutch.

PMID:
29488192
39.

Monoaminergic Markers Across the Cognitive Spectrum of Lewy Body Disease.

van der Zee S, Vermeiren Y, Fransen E, Van Dam D, Aerts T, Gerritsen MJ, Spikman JM, van Laar T, De Deyn PP.

J Parkinsons Dis. 2018;8(1):71-84. doi: 10.3233/JPD-171228.

PMID:
29480224
40.

Detecting frail, older adults and identifying their strengths: results of a mixed-methods study.

Dury S, Dierckx E, van der Vorst A, Van der Elst M, Fret B, Duppen D, Hoeyberghs L, De Roeck E, Lambotte D, Smetcoren AS, Schols J, Kempen G, Zijlstra GAR, De Lepeleire J, Schoenmakers B, Verté D, De Witte N, Kardol T, De Deyn PP, Engelborghs S, De Donder L.

BMC Public Health. 2018 Jan 30;18(1):191. doi: 10.1186/s12889-018-5088-3.

41.

Extended FTLD pedigree segregating a Belgian GRN-null mutation: neuropathological heterogeneity in one family.

Sieben A, Van Mossevelde S, Wauters E, Engelborghs S, van der Zee J, Van Langenhove T, Santens P, Praet M, Boon P, Miatton M, Van Hoecke S, Vandenbulcke M, Vandenberghe R, Cras P, Cruts M, De Deyn PP, Van Broeckhoven C, Martin JJ.

Alzheimers Res Ther. 2018 Jan 22;10(1):7. doi: 10.1186/s13195-017-0334-y.

42.

Procarboxypeptidase U (proCPU, TAFI, proCPB2) in cerebrospinal fluid during ischemic stroke is associated with stroke progression, outcome and blood-brain barrier dysfunction.

Mertens JC, Leenaerts D, Brouns R, Engelborghs S, Ieven M, De Deyn PP, Lambeir AM, Hendriks D.

J Thromb Haemost. 2018 Feb;16(2):342-348. doi: 10.1111/jth.13914. Epub 2017 Dec 26.

PMID:
29194929
43.

Assessing Fitness to Drive in Patients With Different Types of Dementia.

Piersma D, Fuermaier ABM, De Waard D, Davidse RJ, De Groot J, Doumen MJA, Bredewoud RA, Claesen R, Lemstra AW, Scheltens P, Vermeeren A, Ponds R, Verhey F, De Deyn PP, Brouwer WH, Tucha O.

Alzheimer Dis Assoc Disord. 2018 Jan-Mar;32(1):70-75. doi: 10.1097/WAD.0000000000000221.

44.

[Detection and prevention in later life: risk profiles for physical, psychological, social and environmental frailty.]

Smetcoren AS, Dury S, De Donder L, Dierckx E, De Witte N, Engelborghs S, De Deyn PP, van der Vorst A, Van der Elst M, Lambotte D, Hoeyberghs L, Fret B, Duppen D, De Roeck E, Kardol M, Schoenmakers B, De Lepeleire J, Zijlstra GAR, Kempen GIJM, Schols JMGA, Verté D.

Tijdschr Gerontol Geriatr. 2018 Feb;49(1):1-11. doi: 10.1007/s12439-017-0241-5. Dutch.

PMID:
29181776
45.

Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer's Disease.

Geijselaers SLC, Aalten P, Ramakers IHGB, De Deyn PP, Heijboer AC, Koek HL, OldeRikkert MGM, Papma JM, Reesink FE, Smits LL, Stehouwer CDA, Teunissen CE, Verhey FRJ, van der Flier WM, Biessels GJ; Parelsnoer Institute Neurodegenerative Diseases study group.

J Alzheimers Dis. 2018;61(1):309-320. doi: 10.3233/JAD-170522.

46.

Common and rare TBK1 variants in early-onset Alzheimer disease in a European cohort.

Verheijen J, van der Zee J, Gijselinck I, Van den Bossche T, Dillen L, Heeman B, Gómez-Tortosa E, Lladó A, Sanchez-Valle R, Graff C, Pastor P, Pastor MA, Benussi L, Ghidoni R, Binetti G, Clarimon J, de Mendonça A, Gelpi E, Tsolaki M, Diehl-Schmid J, Nacmias B, Almeida MR, Borroni B, Matej R, Ruiz A, Engelborghs S, Vandenberghe R, De Deyn PP, Cruts M, Van Broeckhoven C, Sleegers K; BELNEU Consortium; EU EOD Consortium.

Neurobiol Aging. 2018 Feb;62:245.e1-245.e7. doi: 10.1016/j.neurobiolaging.2017.10.012. Epub 2017 Oct 25.

47.

Sleep and Alzheimer's disease: A pivotal role for the suprachiasmatic nucleus.

Van Erum J, Van Dam D, De Deyn PP.

Sleep Med Rev. 2018 Aug;40:17-27. doi: 10.1016/j.smrv.2017.07.005. Epub 2017 Jul 28. Review.

PMID:
29102282
48.

Dynamics of neutrophil gelatinase-associated lipocalin plasma and cerebrospinal fluid concentrations in older males.

Naudé PJW, Dekens DW, Eisel ULM, den Daas I, De Deyn PP.

Eur J Clin Invest. 2017 Dec;47(12). doi: 10.1111/eci.12853. Epub 2017 Nov 14.

PMID:
29082525
49.

Why a One-Way Ticket to Mars May Result in a One-Way Directional Glymphatic Flow to the Eye.

Wostyn P, Killer HE, De Deyn PP.

J Neuroophthalmol. 2017 Dec;37(4):462-463. doi: 10.1097/WNO.0000000000000578. No abstract available.

PMID:
28991101
50.

Alzheimer's disease and driving: review of the literature and consensus guideline from Belgian dementia experts and the Belgian road safety institute endorsed by the Belgian Medical Association.

Versijpt J, Tant M, Beyer I, Bier JC, Cras P, De Deyn PP, De Wit P, Deryck O, Hanseeuw B, Lambert M, Lemper JC, Mormont E, Petrovic M, Picard G, Salmon E, Segers K, Sieben A, Thiery E, Tournoy J, Vandewoude M, Ventura M, Verschraegen J, Engelborghs S, Goffin T, Deneyer M, Ivanoiu A.

Acta Neurol Belg. 2017 Dec;117(4):811-819. doi: 10.1007/s13760-017-0840-5. Epub 2017 Oct 5. Review.

PMID:
28983881

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