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Items: 1 to 50 of 2093

1.

Fragment hopping-based discovery of novel sulfinylacetamide-diarylpyrimidines (DAPYs) as HIV-1 nonnucleoside reverse transcriptase inhibitors.

Han S, Sang Y, Wu Y, Tao Y, Pannecouque C, De Clercq E, Zhuang C, Chen FE.

Eur J Med Chem. 2020 Jan 1;185:111874. doi: 10.1016/j.ejmech.2019.111874. Epub 2019 Nov 10.

PMID:
31735575
2.

Ligand-based design of nondimethylphenyl-diarylpyrimidines with improved metabolic stability, safety and oral pharmacokinetic profiles.

Sang Y, Han S, Pannecouque C, De Clercq E, Zhuang C, Chen F.

J Med Chem. 2019 Nov 12. doi: 10.1021/acs.jmedchem.9b01446. [Epub ahead of print]

PMID:
31714780
3.

Access to paediatric palliative care in children and adolescents with complex chronic conditions: a retrospective hospital-based study in Brussels, Belgium.

Friedel M, Gilson A, Bouckenaere D, Brichard B, Fonteyne C, Wojcik T, De Clercq E, Guillet A, Mahboub A, Lahaye M, Aujoulat I.

BMJ Paediatr Open. 2019 Sep 29;3(1):e000547. doi: 10.1136/bmjpo-2019-000547. eCollection 2019.

4.

Molecular Hybridization-Inspired Optimization of Diarylbenzopyrimidines as HIV-1 Nonnucleoside Reverse Transcriptase Inhibitors with Improved Activity against K103N and E138K Mutants and Pharmacokinetic Profiles.

Han S, Sang Y, Wu Y, Tao Y, Pannecouque C, De Clercq E, Zhuang C, Chen FE.

ACS Infect Dis. 2019 Oct 24. doi: 10.1021/acsinfecdis.9b00229. [Epub ahead of print]

PMID:
31599568
5.

Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment.

Wang Y, De Clercq E, Li G.

Expert Opin Drug Metab Toxicol. 2019 Oct;15(10):813-829. doi: 10.1080/17425255.2019.1673367. Epub 2019 Oct 17. Review.

PMID:
31556749
6.

Barriers to Palliative Care in Pediatric Oncology in Switzerland: A Focus Group Study.

Rost M, De Clercq E, Rakic M, Wangmo T, Elger B.

J Pediatr Oncol Nurs. 2020 Jan/Feb;37(1):35-45. doi: 10.1177/1043454219871082. Epub 2019 Sep 3.

PMID:
31478463
7.

Special Parents for "Special" Children? The Narratives of Health Care Providers and Parents of Intersex Children.

De Clercq E, Streuli J.

Narrat Inq Bioeth. 2019;9(2):133-147. doi: 10.1353/nib.2019.0026.

PMID:
31447452
8.

Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.

Zhao T, Meng Q, Kang D, Ji J, De Clercq E, Pannecouque C, Liu X, Zhan P.

Eur J Med Chem. 2019 Nov 15;182:111619. doi: 10.1016/j.ejmech.2019.111619. Epub 2019 Aug 14.

PMID:
31434039
9.

Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors.

Sang Y, Han S, Pannecouque C, De Clercq E, Zhuang C, Chen F.

Eur J Med Chem. 2019 Nov 15;182:111603. doi: 10.1016/j.ejmech.2019.111603. Epub 2019 Aug 8.

PMID:
31421633
10.

New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections.

De Clercq E.

Chem Asian J. 2019 Nov 18;14(22):3962-3968. doi: 10.1002/asia.201900841. Epub 2019 Aug 7. Review.

PMID:
31389664
11.

Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.

Gao P, Cheng X, Sun L, Song S, Álvarez M, Luczkowiak J, Pannecouque C, De Clercq E, Menéndez-Arias L, Zhan P, Liu X.

Bioorg Med Chem. 2019 Sep 1;27(17):3836-3845. doi: 10.1016/j.bmc.2019.07.011. Epub 2019 Jul 6.

PMID:
31324562
12.

The conceptual understanding of pediatric palliative care: a Swiss healthcare perspective.

De Clercq E, Rost M, Rakic M, Ansari M, Brazzola P, Wangmo T, Elger BS.

BMC Palliat Care. 2019 Jul 11;18(1):55. doi: 10.1186/s12904-019-0438-1.

13.

"Undoing" Capacity: The Capability Approach in Pediatrics.

De Clercq E, Streuli J, Ruhe K, Elger BS.

Perspect Biol Med. 2019;62(2):319-336. doi: 10.1353/pbm.2019.0016.

PMID:
31281124
14.

An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice.

Eyer L, Nougairède A, Uhlířová M, Driouich JS, Zouharová D, Valdés JJ, Haviernik J, Gould EA, De Clercq E, de Lamballerie X, Ruzek D.

J Virol. 2019 Jul 30;93(16). pii: e00367-19. doi: 10.1128/JVI.00367-19. Print 2019 Aug 15.

PMID:
31142664
15.

Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains.

Sang Y, Han S, Han S, Pannecouque C, De Clercq E, Zhuang C, Chen F.

Bioorg Chem. 2019 Aug;89:102974. doi: 10.1016/j.bioorg.2019.102974. Epub 2019 May 4.

PMID:
31102693
16.

Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains.

Jin K, Sang Y, Han S, De Clercq E, Pannecouque C, Meng G, Chen F.

Eur J Med Chem. 2019 Aug 15;176:11-20. doi: 10.1016/j.ejmech.2019.05.011. Epub 2019 May 10.

PMID:
31091477
17.

Overview of Recent Strategic Advances in Medicinal Chemistry.

Wu G, Zhao T, Kang D, Zhang J, Song Y, Namasivayam V, Kongsted J, Pannecouque C, De Clercq E, Poongavanam V, Liu X, Zhan P.

J Med Chem. 2019 Nov 14;62(21):9375-9414. doi: 10.1021/acs.jmedchem.9b00359. Epub 2019 May 28.

PMID:
31050421
18.

Modelling the distribution of Rhipicephalus microplus and R. decoloratus in Zimbabwe.

Sungirai M, Moyo DZ, De Clercq P, Madder M, Vanwambeke SO, De Clercq EM.

Vet Parasitol Reg Stud Reports. 2018 Dec;14:41-49. doi: 10.1016/j.vprsr.2018.08.006. Epub 2018 Aug 29.

PMID:
31014735
19.

Molecular design opportunities presented by solvent-exposed regions of target proteins.

Jiang X, Yu J, Zhou Z, Kongsted J, Song Y, Pannecouque C, De Clercq E, Kang D, Poongavanam V, Liu X, Zhan P.

Med Res Rev. 2019 Nov;39(6):2194-2238. doi: 10.1002/med.21581. Epub 2019 Apr 19. Review.

PMID:
31002405
20.

Fifty Years in Search of Selective Antiviral Drugs.

De Clercq E.

J Med Chem. 2019 Aug 22;62(16):7322-7339. doi: 10.1021/acs.jmedchem.9b00175. Epub 2019 Apr 12.

PMID:
30939009
21.

Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus.

Zhou Z, Liu T, Wu G, Kang D, Fu Z, Wang Z, De Clercq E, Pannecouque C, Zhan P, Liu X.

Org Biomol Chem. 2019 Mar 20;17(12):3202-3217. doi: 10.1039/c9ob00032a.

PMID:
30839042
22.

Mozobil® (Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration.

De Clercq E.

Antivir Chem Chemother. 2019 Jan-Dec;27:2040206619829382. doi: 10.1177/2040206619829382. Review.

23.

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

Huang B, Chen W, Zhao T, Li Z, Jiang X, Ginex T, Vílchez D, Luque FJ, Kang D, Gao P, Zhang J, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

J Med Chem. 2019 Feb 28;62(4):2083-2098. doi: 10.1021/acs.jmedchem.8b01729. Epub 2019 Feb 20.

PMID:
30721060
24.

Continuous Deep Sedation and Euthanasia in Pediatrics: Does One Really Exclude the Other for Terminally Ill Patients?

Badarau DO, De Clercq E, Elger BS.

J Med Philos. 2019 Jan 14;44(1):50-70. doi: 10.1093/jmp/jhy033.

PMID:
30649451
25.

Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, Murugan NA, Steitz TA, Zhan P, Liu X.

J Med Chem. 2019 Feb 14;62(3):1484-1501. doi: 10.1021/acs.jmedchem.8b01656. Epub 2019 Jan 18.

PMID:
30624934
26.

Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.

Wang Z, Yu Z, Kang D, Zhang J, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Bioorg Med Chem. 2019 Feb 1;27(3):447-456. doi: 10.1016/j.bmc.2018.12.039. Epub 2018 Dec 30. Review.

PMID:
30606670
27.

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors.

Gao P, Wang X, Sun L, Cheng X, Poongavanam V, Kongsted J, Álvarez M, Luczkowiak J, Pannecouque C, De Clercq E, Lee KH, Chen CH, Liu H, Menéndez-Arias L, Liu X, Zhan P.

Chem Biol Drug Des. 2019 Apr;93(4):582-589. doi: 10.1111/cbdd.13455. Epub 2019 Jan 24.

PMID:
30560566
28.

Palliative care initiation in pediatric oncology patients: A systematic review.

Cheng BT, Rost M, De Clercq E, Arnold L, Elger BS, Wangmo T.

Cancer Med. 2019 Jan;8(1):3-12. doi: 10.1002/cam4.1907. Epub 2018 Dec 7. Review.

29.

Power stabilization of a diode laser with an acousto-optic modulator.

Tricot F, Phung DH, Lours M, Guérandel S, de Clercq E.

Rev Sci Instrum. 2018 Nov;89(11):113112. doi: 10.1063/1.5046852.

PMID:
30501318
30.

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I.

Kang D, Wang Z, Chen M, Feng D, Wu G, Zhou Z, Jing L, Zuo X, Jiang X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Chem Biol Drug Des. 2019 Apr;93(4):430-437. doi: 10.1111/cbdd.13429. Epub 2019 Feb 22.

PMID:
30381875
31.

Design and synthesis of a novel series of non-nucleoside HIV-1 inhibitors bearing pyrimidine and N-substituted aromatic piperazine.

Jin K, Sang Y, De Clercq E, Pannecouque C, Meng G.

Bioorg Med Chem Lett. 2018 Dec 1;28(22):3491-3495. doi: 10.1016/j.bmcl.2018.10.010. Epub 2018 Oct 9.

PMID:
30318436
32.

The Best Interest Standard: An Exhaustive Guide for Medical Decision Making in Pediatrics?

De Clercq E, Ruhe K.

Am J Bioeth. 2018 Aug;18(8):69-71. doi: 10.1080/15265161.2018.1485767. No abstract available.

PMID:
30133406
33.

Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.

Wang Z, Kang D, Chen M, Wu G, Feng D, Zhao T, Zhou Z, Huo Z, Jing L, Zuo X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Chem Biol Drug Des. 2018 Dec;92(6):2009-2021. doi: 10.1111/cbdd.13373. Epub 2018 Aug 26.

PMID:
30079476
34.

5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.

Sun L, Gao P, Dong G, Zhang X, Cheng X, Ding X, Wang X, Daelemans D, De Clercq E, Pannecouque C, Menéndez-Arias L, Zhan P, Liu X.

Eur J Med Chem. 2018 Jul 15;155:714-724. doi: 10.1016/j.ejmech.2018.06.036. Epub 2018 Jun 18.

PMID:
29940462
35.

Composite laser-pulses spectroscopy for high-accuracy optical clocks: a review of recent progress and perspectives.

Zanon-Willette T, Lefevre R, Metzdorff R, Sillitoe N, Almonacil S, Minissale M, de Clercq E, Taichenachev AV, Yudin VI, Arimondo E.

Rep Prog Phys. 2018 Sep;81(9):094401. doi: 10.1088/1361-6633/aac9e9. Epub 2018 Jun 4.

PMID:
29862989
36.

Tanovea® for the treatment of lymphoma in dogs.

De Clercq E.

Biochem Pharmacol. 2018 Aug;154:265-269. doi: 10.1016/j.bcp.2018.05.010. Epub 2018 May 17. Review.

37.

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.

Huo Z, Zhang H, Kang D, Zhou Z, Wu G, Desta S, Zuo X, Wang Z, Jing L, Ding X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

ACS Med Chem Lett. 2018 Feb 27;9(4):334-338. doi: 10.1021/acsmedchemlett.7b00524. eCollection 2018 Apr 12.

38.

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

Tian Y, Liu Z, Liu J, Huang B, Kang D, Zhang H, De Clercq E, Daelemans D, Pannecouque C, Lee KH, Chen CH, Zhan P, Liu X.

Eur J Med Chem. 2018 May 10;151:339-350. doi: 10.1016/j.ejmech.2018.03.059. Epub 2018 Mar 23.

39.

The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2.

Lu X, Yang J, Kang D, Gao P, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Bioorg Med Chem. 2018 May 1;26(8):2051-2060. doi: 10.1016/j.bmc.2018.03.003. Epub 2018 Mar 3.

PMID:
29559197
40.

West African Cattle Farmers' Perception of Tick-Borne Diseases.

Adehan SB, Adakal H, Gbinwoua D, Yokossi D, Zoungrana S, Toé P, Ouedraogo M, Gbaguidi AM, Adoligbé C, Fandohan AB, Hounmanou G, Glèlè Kakaï R, Farougou S, De Clercq EM.

Ecohealth. 2018 Jun;15(2):437-449. doi: 10.1007/s10393-018-1323-8. Epub 2018 Mar 13.

PMID:
29536206
41.

First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain.

Huang B, Liu X, Tian Y, Kang D, Zhou Z, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Bioorg Med Chem Lett. 2018 May 1;28(8):1348-1351. doi: 10.1016/j.bmcl.2018.03.012. Epub 2018 Mar 5.

PMID:
29534929
42.

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses.

Eyer L, Nencka R, de Clercq E, Seley-Radtke K, Růžek D.

Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618761299. doi: 10.1177/2040206618761299. Review.

43.

SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME 2-{4-[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL] PHENOXY}-N-PHENYLACETAMIDE.

Bhadauria VS, Sravanthi V, Kumar S, DAS D, DE Clercq E, Schols D, Tokuda H, Karki SS.

Acta Pol Pharm. 2017 Jan;74(1):137-145.

44.

Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1.

Jin K, Yin H, De Clercq E, Pannecouque C, Meng G, Chen F.

Eur J Med Chem. 2018 Feb 10;145:726-734. doi: 10.1016/j.ejmech.2018.01.016. Epub 2018 Jan 8.

PMID:
29353724
45.

Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".

Zhou Z, Liu T, Kang D, Huo Z, Wu G, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Org Biomol Chem. 2018 Feb 7;16(6):1014-1028. doi: 10.1039/c7ob02828h.

PMID:
29349445
46.

Spatial multi-criteria decision analysis for modelling suitable habitats of Ornithodoros soft ticks in the Western Palearctic region.

Vial L, Ducheyne E, Filatov S, Gerilovych A, McVey DS, Sindryakova I, Morgunov S, Pérez de León AA, Kolbasov D, De Clercq EM.

Vet Parasitol. 2018 Jan 15;249:2-16. doi: 10.1016/j.vetpar.2017.10.022. Epub 2017 Nov 2.

PMID:
29279082
47.

Education and Reproductive Autonomy: The Case of Married Nigerian Women.

Princewill CW, De Clercq E, Riecher-Rössler A, Jegede AS, Wangmo T, Elger BS.

Narrat Inq Bioeth. 2017;7(3):231-244. doi: 10.1353/nib.2017.0071.

PMID:
29249717
48.

Role of tenofovir alafenamide (TAF) in the treatment and prophylaxis of HIV and HBV infections.

De Clercq E.

Biochem Pharmacol. 2018 Jul;153:2-11. doi: 10.1016/j.bcp.2017.11.023. Epub 2017 Dec 7. Review.

PMID:
29225131
49.

Global risk mapping for major diseases transmitted by Aedes aegypti and Aedes albopictus.

Leta S, Beyene TJ, De Clercq EM, Amenu K, Kraemer MUG, Revie CW.

Int J Infect Dis. 2018 Feb;67:25-35. doi: 10.1016/j.ijid.2017.11.026. Epub 2017 Nov 28.

50.

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

Kang D, Ding X, Wu G, Huo Z, Zhou Z, Zhao T, Feng D, Wang Z, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

ACS Med Chem Lett. 2017 Oct 19;8(11):1188-1193. doi: 10.1021/acsmedchemlett.7b00361. eCollection 2017 Nov 9.

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