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Items: 1 to 50 of 2083

1.

New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections.

De Clercq E.

Chem Asian J. 2019 Aug 7. doi: 10.1002/asia.201900841. [Epub ahead of print] Review.

PMID:
31389664
2.

Design, synthesis and biological evaluation of 3-hydroxyquinazoline-2,4(1H,3H)-diones as dual inhibitors of HIV-1 reverse transcriptase-associated RNase H and integrase.

Gao P, Cheng X, Sun L, Song S, Álvarez M, Luczkowiak J, Pannecouque C, De Clercq E, Menéndez-Arias L, Zhan P, Liu X.

Bioorg Med Chem. 2019 Sep 1;27(17):3836-3845. doi: 10.1016/j.bmc.2019.07.011. Epub 2019 Jul 6.

PMID:
31324562
3.

The conceptual understanding of pediatric palliative care: a Swiss healthcare perspective.

De Clercq E, Rost M, Rakic M, Ansari M, Brazzola P, Wangmo T, Elger BS.

BMC Palliat Care. 2019 Jul 11;18(1):55. doi: 10.1186/s12904-019-0438-1.

4.

"Undoing" Capacity: The Capability Approach in Pediatrics.

De Clercq E, Streuli J, Ruhe K, Elger BS.

Perspect Biol Med. 2019;62(2):319-336. doi: 10.1353/pbm.2019.0016.

PMID:
31281124
5.

An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice.

Eyer L, Nougairède A, Uhlířová M, Driouich JS, Zouharová D, Valdés JJ, Haviernik J, Gould EA, De Clercq E, de Lamballerie X, Ruzek D.

J Virol. 2019 Jul 30;93(16). pii: e00367-19. doi: 10.1128/JVI.00367-19. Print 2019 Aug 15.

PMID:
31142664
6.

Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains.

Sang Y, Han S, Han S, Pannecouque C, De Clercq E, Zhuang C, Chen F.

Bioorg Chem. 2019 Aug;89:102974. doi: 10.1016/j.bioorg.2019.102974. Epub 2019 May 4.

PMID:
31102693
7.

Synthesis and biological evaluation of dihydroquinazoline-2-amines as potent non-nucleoside reverse transcriptase inhibitors of wild-type and mutant HIV-1 strains.

Jin K, Sang Y, Han S, De Clercq E, Pannecouque C, Meng G, Chen F.

Eur J Med Chem. 2019 Aug 15;176:11-20. doi: 10.1016/j.ejmech.2019.05.011. Epub 2019 May 10.

PMID:
31091477
8.

Overview of Recent Strategic Advances in Medicinal Chemistry.

Wu G, Zhao T, Kang D, Zhang J, Song Y, Namasivayam V, Kongsted J, Pannecouque C, De Clercq E, Poongavanam V, Liu X, Zhan P.

J Med Chem. 2019 May 28. doi: 10.1021/acs.jmedchem.9b00359. [Epub ahead of print]

PMID:
31050421
9.

Modelling the distribution of Rhipicephalus microplus and R. decoloratus in Zimbabwe.

Sungirai M, Moyo DZ, De Clercq P, Madder M, Vanwambeke SO, De Clercq EM.

Vet Parasitol Reg Stud Reports. 2018 Dec;14:41-49. doi: 10.1016/j.vprsr.2018.08.006. Epub 2018 Aug 29.

PMID:
31014735
10.

Fifty Years in Search of Selective Antiviral Drugs.

De Clercq E.

J Med Chem. 2019 Apr 12. doi: 10.1021/acs.jmedchem.9b00175. [Epub ahead of print]

PMID:
30939009
11.

Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus.

Zhou Z, Liu T, Wu G, Kang D, Fu Z, Wang Z, De Clercq E, Pannecouque C, Zhan P, Liu X.

Org Biomol Chem. 2019 Mar 20;17(12):3202-3217. doi: 10.1039/c9ob00032a.

PMID:
30839042
12.

Mozobil® (Plerixafor, AMD3100), 10 years after its approval by the US Food and Drug Administration.

De Clercq E.

Antivir Chem Chemother. 2019 Jan-Dec;27:2040206619829382. doi: 10.1177/2040206619829382. Review.

13.

Exploiting the Tolerant Region I of the Non-Nucleoside Reverse Transcriptase Inhibitor (NNRTI) Binding Pocket: Discovery of Potent Diarylpyrimidine-Typed HIV-1 NNRTIs against Wild-Type and E138K Mutant Virus with Significantly Improved Water Solubility and Favorable Safety Profiles.

Huang B, Chen W, Zhao T, Li Z, Jiang X, Ginex T, Vílchez D, Luque FJ, Kang D, Gao P, Zhang J, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

J Med Chem. 2019 Feb 28;62(4):2083-2098. doi: 10.1021/acs.jmedchem.8b01729. Epub 2019 Feb 20.

PMID:
30721060
14.

Continuous Deep Sedation and Euthanasia in Pediatrics: Does One Really Exclude the Other for Terminally Ill Patients?

Badarau DO, De Clercq E, Elger BS.

J Med Philos. 2019 Jan 14;44(1):50-70. doi: 10.1093/jmp/jhy033.

PMID:
30649451
15.

Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.

Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, Murugan NA, Steitz TA, Zhan P, Liu X.

J Med Chem. 2019 Feb 14;62(3):1484-1501. doi: 10.1021/acs.jmedchem.8b01656. Epub 2019 Jan 18.

PMID:
30624934
16.

Design, synthesis and biological evaluation of novel acetamide-substituted doravirine and its prodrugs as potent HIV-1 NNRTIs.

Wang Z, Yu Z, Kang D, Zhang J, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Bioorg Med Chem. 2019 Feb 1;27(3):447-456. doi: 10.1016/j.bmc.2018.12.039. Epub 2018 Dec 30. Review.

PMID:
30606670
17.

Design, synthesis, and biologic evaluation of novel galloyl derivatives as HIV-1 RNase H inhibitors.

Gao P, Wang X, Sun L, Cheng X, Poongavanam V, Kongsted J, Álvarez M, Luczkowiak J, Pannecouque C, De Clercq E, Lee KH, Chen CH, Liu H, Menéndez-Arias L, Liu X, Zhan P.

Chem Biol Drug Des. 2019 Apr;93(4):582-589. doi: 10.1111/cbdd.13455. Epub 2019 Jan 24.

PMID:
30560566
18.

Palliative care initiation in pediatric oncology patients: A systematic review.

Cheng BT, Rost M, De Clercq E, Arnold L, Elger BS, Wangmo T.

Cancer Med. 2019 Jan;8(1):3-12. doi: 10.1002/cam4.1907. Epub 2018 Dec 7. Review.

19.

Power stabilization of a diode laser with an acousto-optic modulator.

Tricot F, Phung DH, Lours M, Guérandel S, de Clercq E.

Rev Sci Instrum. 2018 Nov;89(11):113112. doi: 10.1063/1.5046852.

PMID:
30501318
20.

Discovery of potent HIV-1 non-nucleoside reverse transcriptase inhibitors by exploring the structure-activity relationship of solvent-exposed regions I.

Kang D, Wang Z, Chen M, Feng D, Wu G, Zhou Z, Jing L, Zuo X, Jiang X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Chem Biol Drug Des. 2019 Apr;93(4):430-437. doi: 10.1111/cbdd.13429. Epub 2019 Feb 22.

PMID:
30381875
21.

Design and synthesis of a novel series of non-nucleoside HIV-1 inhibitors bearing pyrimidine and N-substituted aromatic piperazine.

Jin K, Sang Y, De Clercq E, Pannecouque C, Meng G.

Bioorg Med Chem Lett. 2018 Dec 1;28(22):3491-3495. doi: 10.1016/j.bmcl.2018.10.010. Epub 2018 Oct 9.

PMID:
30318436
22.

The Best Interest Standard: An Exhaustive Guide for Medical Decision Making in Pediatrics?

De Clercq E, Ruhe K.

Am J Bioeth. 2018 Aug;18(8):69-71. doi: 10.1080/15265161.2018.1485767. No abstract available.

PMID:
30133406
23.

Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.

Wang Z, Kang D, Chen M, Wu G, Feng D, Zhao T, Zhou Z, Huo Z, Jing L, Zuo X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Chem Biol Drug Des. 2018 Dec;92(6):2009-2021. doi: 10.1111/cbdd.13373. Epub 2018 Aug 26.

PMID:
30079476
24.

5-Hydroxypyrido[2,3-b]pyrazin-6(5H)-one derivatives as novel dual inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H and integrase.

Sun L, Gao P, Dong G, Zhang X, Cheng X, Ding X, Wang X, Daelemans D, De Clercq E, Pannecouque C, Menéndez-Arias L, Zhan P, Liu X.

Eur J Med Chem. 2018 Jul 15;155:714-724. doi: 10.1016/j.ejmech.2018.06.036. Epub 2018 Jun 18.

PMID:
29940462
25.

Composite laser-pulses spectroscopy for high-accuracy optical clocks: a review of recent progress and perspectives.

Zanon-Willette T, Lefevre R, Metzdorff R, Sillitoe N, Almonacil S, Minissale M, de Clercq E, Taichenachev AV, Yudin VI, Arimondo E.

Rep Prog Phys. 2018 Sep;81(9):094401. doi: 10.1088/1361-6633/aac9e9. Epub 2018 Jun 4.

PMID:
29862989
26.

Tanovea® for the treatment of lymphoma in dogs.

De Clercq E.

Biochem Pharmacol. 2018 Aug;154:265-269. doi: 10.1016/j.bcp.2018.05.010. Epub 2018 May 17. Review.

27.

Discovery of Novel Diarylpyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the "NNRTI Adjacent" Binding Site.

Huo Z, Zhang H, Kang D, Zhou Z, Wu G, Desta S, Zuo X, Wang Z, Jing L, Ding X, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

ACS Med Chem Lett. 2018 Feb 27;9(4):334-338. doi: 10.1021/acsmedchemlett.7b00524. eCollection 2018 Apr 12.

28.

Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus.

Tian Y, Liu Z, Liu J, Huang B, Kang D, Zhang H, De Clercq E, Daelemans D, Pannecouque C, Lee KH, Chen CH, Zhan P, Liu X.

Eur J Med Chem. 2018 May 10;151:339-350. doi: 10.1016/j.ejmech.2018.03.059. Epub 2018 Mar 23.

29.

The discovery of novel diarylpyri(mi)dine derivatives with high level activity against a wide variety of HIV-1 strains as well as against HIV-2.

Lu X, Yang J, Kang D, Gao P, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Bioorg Med Chem. 2018 May 1;26(8):2051-2060. doi: 10.1016/j.bmc.2018.03.003. Epub 2018 Mar 3.

PMID:
29559197
30.

West African Cattle Farmers' Perception of Tick-Borne Diseases.

Adehan SB, Adakal H, Gbinwoua D, Yokossi D, Zoungrana S, Toé P, Ouedraogo M, Gbaguidi AM, Adoligbé C, Fandohan AB, Hounmanou G, Glèlè Kakaï R, Farougou S, De Clercq EM.

Ecohealth. 2018 Jun;15(2):437-449. doi: 10.1007/s10393-018-1323-8. Epub 2018 Mar 13.

PMID:
29536206
31.

First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain.

Huang B, Liu X, Tian Y, Kang D, Zhou Z, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Bioorg Med Chem Lett. 2018 May 1;28(8):1348-1351. doi: 10.1016/j.bmcl.2018.03.012. Epub 2018 Mar 5.

PMID:
29534929
32.

Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses.

Eyer L, Nencka R, de Clercq E, Seley-Radtke K, Růžek D.

Antivir Chem Chemother. 2018 Jan-Dec;26:2040206618761299. doi: 10.1177/2040206618761299. Review.

33.

SYNTHESIS AND CYTOTOXIC EVALUATION OF SOME 2-{4-[(2-OXO-1,2-DIHYDRO-3H-INDOL-3-YLIDENE)METHYL] PHENOXY}-N-PHENYLACETAMIDE.

Bhadauria VS, Sravanthi V, Kumar S, DAS D, DE Clercq E, Schols D, Tokuda H, Karki SS.

Acta Pol Pharm. 2017 Jan;74(1):137-145.

34.

Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1.

Jin K, Yin H, De Clercq E, Pannecouque C, Meng G, Chen F.

Eur J Med Chem. 2018 Feb 10;145:726-734. doi: 10.1016/j.ejmech.2018.01.016. Epub 2018 Jan 8.

PMID:
29353724
35.

Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".

Zhou Z, Liu T, Kang D, Huo Z, Wu G, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Org Biomol Chem. 2018 Feb 7;16(6):1014-1028. doi: 10.1039/c7ob02828h.

PMID:
29349445
36.

Spatial multi-criteria decision analysis for modelling suitable habitats of Ornithodoros soft ticks in the Western Palearctic region.

Vial L, Ducheyne E, Filatov S, Gerilovych A, McVey DS, Sindryakova I, Morgunov S, Pérez de León AA, Kolbasov D, De Clercq EM.

Vet Parasitol. 2018 Jan 15;249:2-16. doi: 10.1016/j.vetpar.2017.10.022. Epub 2017 Nov 2.

PMID:
29279082
37.

Education and Reproductive Autonomy: The Case of Married Nigerian Women.

Princewill CW, De Clercq E, Riecher-Rössler A, Jegede AS, Wangmo T, Elger BS.

Narrat Inq Bioeth. 2017;7(3):231-244. doi: 10.1353/nib.2017.0071.

PMID:
29249717
38.

Role of tenofovir alafenamide (TAF) in the treatment and prophylaxis of HIV and HBV infections.

De Clercq E.

Biochem Pharmacol. 2018 Jul;153:2-11. doi: 10.1016/j.bcp.2017.11.023. Epub 2017 Dec 7. Review.

PMID:
29225131
39.

Global risk mapping for major diseases transmitted by Aedes aegypti and Aedes albopictus.

Leta S, Beyene TJ, De Clercq EM, Amenu K, Kraemer MUG, Revie CW.

Int J Infect Dis. 2018 Feb;67:25-35. doi: 10.1016/j.ijid.2017.11.026. Epub 2017 Nov 28.

40.

Discovery of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs Targeting the Tolerant Region I of NNIBP.

Kang D, Ding X, Wu G, Huo Z, Zhou Z, Zhao T, Feng D, Wang Z, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

ACS Med Chem Lett. 2017 Oct 19;8(11):1188-1193. doi: 10.1021/acsmedchemlett.7b00361. eCollection 2017 Nov 9.

41.

Design, synthesis and anti-HIV evaluation of novel diarylpyridine derivatives as potent HIV-1 NNRTIs.

Liu Z, Tian Y, Liu J, Huang B, Kang D, De Clercq E, Daelemans D, Pannecouque C, Zhan P, Liu X.

Eur J Med Chem. 2017 Nov 10;140:383-391. doi: 10.1016/j.ejmech.2017.07.012. Epub 2017 Jul 18.

PMID:
28987601
42.

Decision making in pediatric oncology: Views of parents and physicians in two European countries.

Badarau DO, Ruhe K, Kühne T, De Clercq E, Colita A, Elger BS, Wangmo T.

AJOB Empir Bioeth. 2017 Jan-Mar;8(1):21-31. doi: 10.1080/23294515.2016.1234519. Epub 2016 Sep 22.

PMID:
28949870
43.

Better to know than to imagine: Including children in their health care.

Wangmo T, De Clercq E, Ruhe KM, Beck-Popovic M, Rischewski J, Angst R, Ansari M, Elger BS.

AJOB Empir Bioeth. 2017 Jan-Mar;8(1):11-20. doi: 10.1080/23294515.2016.1207724. Epub 2016 Jul 1.

PMID:
28949869
44.

Escape of Tick-Borne Flavivirus from 2'-C-Methylated Nucleoside Antivirals Is Mediated by a Single Conservative Mutation in NS5 That Has a Dramatic Effect on Viral Fitness.

Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D.

J Virol. 2017 Oct 13;91(21). pii: e01028-17. doi: 10.1128/JVI.01028-17. Print 2017 Nov 1.

45.

Discovery of novel DAPY-IAS hybrid derivatives as potential HIV-1 inhibitors using molecular hybridization based on crystallographic overlays.

Huang B, Wang X, Liu X, Chen Z, Li W, Sun S, Liu H, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

Bioorg Med Chem. 2017 Aug 15;25(16):4397-4406. doi: 10.1016/j.bmc.2017.06.022. Epub 2017 Jun 15.

PMID:
28659246
46.

Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.

Kang D, Fang Z, Huang B, Lu X, Zhang H, Xu H, Huo Z, Zhou Z, Yu Z, Meng Q, Wu G, Ding X, Tian Y, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X.

J Med Chem. 2017 May 25;60(10):4424-4443. doi: 10.1021/acs.jmedchem.7b00332. Epub 2017 May 15.

PMID:
28481112
47.

Is decision-making capacity an "essentially contested" concept in pediatrics?

De Clercq E, Ruhe K, Rost M, Elger B.

Med Health Care Philos. 2017 Sep;20(3):425-433. doi: 10.1007/s11019-017-9768-z.

PMID:
28382518
48.

Antiviral activity of the adenosine analogue BCX4430 against West Nile virus and tick-borne flaviviruses.

Eyer L, Zouharová D, Širmarová J, Fojtíková M, Štefánik M, Haviernik J, Nencka R, de Clercq E, Růžek D.

Antiviral Res. 2017 Jun;142:63-67. doi: 10.1016/j.antiviral.2017.03.012. Epub 2017 Mar 21.

PMID:
28336346
49.

Returning Results: Let's Be Honest!

Elger BS, De Clercq E.

Genet Test Mol Biomarkers. 2017 Mar;21(3):134-139. doi: 10.1089/gtmb.2016.0395. Epub 2017 Feb 24.

50.

Discovery of uracil-bearing DAPYs derivatives as novel HIV-1 NNRTIs via crystallographic overlay-based molecular hybridization.

Zhang H, Tian Y, Kang D, Huo Z, Zhou Z, Liu H, De Clercq E, Pannecouque C, Zhan P, Liu X.

Eur J Med Chem. 2017 Apr 21;130:209-222. doi: 10.1016/j.ejmech.2017.02.047. Epub 2017 Feb 21.

PMID:
28254696

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