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Route of Infection Strongly Impacts the Host-Pathogen Relationship.

Demars A, Lison A, Machelart A, Van Vyve M, Potemberg G, Vanderwinden JM, De Bolle X, Letesson JJ, Muraille E.

Front Immunol. 2019 Jul 11;10:1589. doi: 10.3389/fimmu.2019.01589. eCollection 2019.


Localized incorporation of outer membrane components in the pathogen Brucella abortus.

Vassen V, Valotteau C, Feuillie C, Formosa-Dague C, Dufrêne YF, De Bolle X.

EMBO J. 2019 Mar 1;38(5). pii: e100323. doi: 10.15252/embj.2018100323. Epub 2019 Jan 11.


Transposon Sequencing of Brucella abortus Uncovers Essential Genes for Growth In Vitro and Inside Macrophages.

Sternon JF, Godessart P, Gonçalves de Freitas R, Van der Henst M, Poncin K, Francis N, Willemart K, Christen M, Christen B, Letesson JJ, De Bolle X.

Infect Immun. 2018 Jul 23;86(8). pii: e00312-18. doi: 10.1128/IAI.00312-18. Print 2018 Aug.


PBP2b plays a key role in both peripheral growth and septum positioning in Lactococcus lactis.

David B, Duchêne MC, Haustenne GL, Pérez-Núñez D, Chapot-Chartier MP, De Bolle X, Guédon E, Hols P, Hallet B.

PLoS One. 2018 May 23;13(5):e0198014. doi: 10.1371/journal.pone.0198014. eCollection 2018.


Learning from the master: targets and functions of the CtrA response regulator in Brucella abortus and other alpha-proteobacteria.

Poncin K, Gillet S, De Bolle X.

FEMS Microbiol Rev. 2018 Jul 1;42(4):500-513. doi: 10.1093/femsre/fuy019. Review.


Mitochondrial fragmentation affects neither the sensitivity to TNFα-induced apoptosis of Brucella-infected cells nor the intracellular replication of the bacteria.

Lobet E, Willemart K, Ninane N, Demazy C, Sedzicki J, Lelubre C, De Bolle X, Renard P, Raes M, Dehio C, Letesson JJ, Arnould T.

Sci Rep. 2018 Mar 26;8(1):5173. doi: 10.1038/s41598-018-23483-3.


OXA-427, a new plasmid-borne carbapenem-hydrolysing class D β-lactamase in Enterobacteriaceae.

Bogaerts P, Naas T, Saegeman V, Bonnin RA, Schuermans A, Evrard S, Bouchahrouf W, Jove T, Tande D, de Bolle X, Huang TD, Dortet L, Glupczynski Y.

J Antimicrob Chemother. 2017 Sep 1;72(9):2469-2477. doi: 10.1093/jac/dkx184.


Erythritol Availability in Bovine, Murine and Human Models Highlights a Potential Role for the Host Aldose Reductase during Brucella Infection.

Barbier T, Machelart A, Zúñiga-Ripa A, Plovier H, Hougardy C, Lobet E, Willemart K, Muraille E, De Bolle X, Van Schaftingen E, Moriyón I, Letesson JJ.

Front Microbiol. 2017 Jun 13;8:1088. doi: 10.3389/fmicb.2017.01088. eCollection 2017.


Brucella central carbon metabolism: an update.

Barbier T, Zúñiga-Ripa A, Moussa S, Plovier H, Sternon JF, Lázaro-Antón L, Conde-Álvarez R, De Bolle X, Iriarte M, Moriyón I, Letesson JJ.

Crit Rev Microbiol. 2018 Mar;44(2):182-211. doi: 10.1080/1040841X.2017.1332002. Epub 2017 Jun 12. Review.


Brucella Genital Tropism: What's on the Menu.

Letesson JJ, Barbier T, Zúñiga-Ripa A, Godfroid J, De Bolle X, Moriyón I.

Front Microbiol. 2017 Mar 28;8:506. doi: 10.3389/fmicb.2017.00506. eCollection 2017. No abstract available.


CtrA controls cell division and outer membrane composition of the pathogen Brucella abortus.

Francis N, Poncin K, Fioravanti A, Vassen V, Willemart K, Ong TA, Rappez L, Letesson JJ, Biondi EG, De Bolle X.

Mol Microbiol. 2017 Mar;103(5):780-797. doi: 10.1111/mmi.13589. Epub 2017 Jan 10.


Brucella abortus Strain 2308 Wisconsin Genome: Importance of the Definition of Reference Strains.

Suárez-Esquivel M, Ruiz-Villalobos N, Castillo-Zeledón A, Jiménez-Rojas C, Roop Ii RM, Comerci DJ, Barquero-Calvo E, Chacón-Díaz C, Caswell CC, Baker KS, Chaves-Olarte E, Thomson NR, Moreno E, Letesson JJ, De Bolle X, Guzmán-Verri C.

Front Microbiol. 2016 Sep 29;7:1557. eCollection 2016.


Phosphotransferase-dependent accumulation of (p)ppGpp in response to glutamine deprivation in Caulobacter crescentus.

Ronneau S, Petit K, De Bolle X, Hallez R.

Nat Commun. 2016 Apr 25;7:11423. doi: 10.1038/ncomms11423.


Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase.

Beaufay F, De Bolle X, Hallez R.

Commun Integr Biol. 2016 Jan 5;9(1):e1125052. doi: 10.1080/19420889.2015.1125052. eCollection 2016 Jan-Feb.


Brucella abortus Cell Cycle and Infection Are Coordinated.

De Bolle X, Crosson S, Matroule JY, Letesson JJ.

Trends Microbiol. 2015 Dec;23(12):812-821. doi: 10.1016/j.tim.2015.09.007. Epub 2015 Oct 20. Review.


A NAD-dependent glutamate dehydrogenase coordinates metabolism with cell division in Caulobacter crescentus.

Beaufay F, Coppine J, Mayard A, Laloux G, De Bolle X, Hallez R.

EMBO J. 2015 Jul 2;34(13):1786-800. doi: 10.15252/embj.201490730. Epub 2015 May 7.


On the link between cell cycle and infection of the Alphaproteobacterium Brucella abortus.

Deghelt M, Letesson JJ, De Bolle X.

Microb Cell. 2014 Sep 29;1(10):346-348. doi: 10.15698/mic2014.10.171.


Replication of Brucella abortus and Brucella melitensis in fibroblasts does not require Atg5-dependent macroautophagy.

Hamer I, Goffin E, De Bolle X, Letesson JJ, Jadot M.

BMC Microbiol. 2014 Sep 2;14:223. doi: 10.1186/s12866-014-0223-5.


G1-arrested newborn cells are the predominant infectious form of the pathogen Brucella abortus.

Deghelt M, Mullier C, Sternon JF, Francis N, Laloux G, Dotreppe D, Van der Henst C, Jacobs-Wagner C, Letesson JJ, De Bolle X.

Nat Commun. 2014 Jul 9;5:4366. doi: 10.1038/ncomms5366.


Quorum sensing and self-quorum quenching in the intracellular pathogen Brucellamelitensis.

Terwagne M, Mirabella A, Lemaire J, Deschamps C, De Bolle X, Letesson JJ.

PLoS One. 2013 Dec 11;8(12):e82514. doi: 10.1371/journal.pone.0082514. eCollection 2013.


Insights into the function of YciM, a heat shock membrane protein required to maintain envelope integrity in Escherichia coli.

Nicolaes V, El Hajjaji H, Davis RM, Van der Henst C, Depuydt M, Leverrier P, Aertsen A, Haufroid V, Ollagnier de Choudens S, De Bolle X, Ruiz N, Collet JF.

J Bacteriol. 2014 Jan;196(2):300-9. doi: 10.1128/JB.00921-13. Epub 2013 Nov 1.


The Brucella pathogens are polarized bacteria.

Van der Henst C, de Barsy M, Zorreguieta A, Letesson JJ, De Bolle X.

Microbes Infect. 2013 Dec;15(14-15):998-1004. doi: 10.1016/j.micinf.2013.10.008. Epub 2013 Oct 18. Review.


BtaE, an adhesin that belongs to the trimeric autotransporter family, is required for full virulence and defines a specific adhesive pole of Brucella suis.

Ruiz-Ranwez V, Posadas DM, Van der Henst C, Estein SM, Arocena GM, Abdian PL, Martín FA, Sieira R, De Bolle X, Zorreguieta A.

Infect Immun. 2013 Mar;81(3):996-1007. doi: 10.1128/IAI.01241-12. Epub 2013 Jan 14.


Innate immune recognition of flagellin limits systemic persistence of Brucella.

Terwagne M, Ferooz J, Rolán HG, Sun YH, Atluri V, Xavier MN, Franchi L, Núñez G, Legrand T, Flavell RA, De Bolle X, Letesson JJ, Tsolis RM.

Cell Microbiol. 2013 Jun;15(6):942-960. doi: 10.1111/cmi.12088. Epub 2013 Jan 7.


Small GTPases and Brucella entry into the endoplasmic reticulum.

de Bolle X, Letesson JJ, Gorvel JP.

Biochem Soc Trans. 2012 Dec 1;40(6):1348-52. doi: 10.1042/BST20120156.


Brucella melitensis MucR, an orthologue of Sinorhizobium meliloti MucR, is involved in resistance to oxidative, detergent, and saline stresses and cell envelope modifications.

Mirabella A, Terwagne M, Zygmunt MS, Cloeckaert A, De Bolle X, Letesson JJ.

J Bacteriol. 2013 Feb;195(3):453-65. doi: 10.1128/JB.01336-12. Epub 2012 Nov 16.


Structural analysis of Brucella abortus RicA substitutions that do not impair interaction with human Rab2 GTPase.

Nkengfac B, Pouyez J, Bauwens E, Vandenhaute J, Letesson JJ, Wouters J, De Bolle X.

BMC Biochem. 2012 Aug 14;13:16. doi: 10.1186/1471-2091-13-16.


The two-component system PrlS/PrlR of Brucella melitensis is required for persistence in mice and appears to respond to ionic strength.

Mirabella A, Yañez Villanueva RM, Delrue RM, Uzureau S, Zygmunt MS, Cloeckaert A, De Bolle X, Letesson JJ.

Microbiology. 2012 Oct;158(Pt 10):2642-51. Epub 2012 Aug 2.


The histidine kinase PdhS controls cell cycle progression of the pathogenic alphaproteobacterium Brucella abortus.

Van der Henst C, Beaufay F, Mignolet J, Didembourg C, Colinet J, Hallet B, Letesson JJ, De Bolle X.

J Bacteriol. 2012 Oct;194(19):5305-14. doi: 10.1128/JB.00699-12. Epub 2012 Jul 27.


A Brucella abortus cstA mutant is defective for association with endoplasmic reticulum exit sites and displays altered trafficking in HeLa cells.

de Barsy M, Mirabella A, Letesson JJ, De Bolle X.

Microbiology. 2012 Oct;158(Pt 10):2610-8. Epub 2012 Jul 19.


Purification, refolding and characterization of the trimeric Omp2a outer membrane porin from Brucella melitensis.

Roussel G, Matagne A, De Bolle X, Perpète EA, Michaux C.

Protein Expr Purif. 2012 Jun;83(2):198-204. doi: 10.1016/j.pep.2012.04.003. Epub 2012 Apr 17.


Polar growth in the Alphaproteobacterial order Rhizobiales.

Brown PJ, de Pedro MA, Kysela DT, Van der Henst C, Kim J, De Bolle X, Fuqua C, Brun YV.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1697-701. doi: 10.1073/pnas.1114476109. Epub 2012 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2012 Feb 21;109(8);3190.


The alkylation response protein AidB is localized at the new poles and constriction sites in Brucella abortus.

Dotreppe D, Mullier C, Letesson JJ, De Bolle X.

BMC Microbiol. 2011 Nov 23;11:257. doi: 10.1186/1471-2180-11-257.


Identification of a Brucella spp. secreted effector specifically interacting with human small GTPase Rab2.

de Barsy M, Jamet A, Filopon D, Nicolas C, Laloux G, Rual JF, Muller A, Twizere JC, Nkengfac B, Vandenhaute J, Hill DE, Salcedo SP, Gorvel JP, Letesson JJ, De Bolle X.

Cell Microbiol. 2011 Jul;13(7):1044-58. doi: 10.1111/j.1462-5822.2011.01601.x. Epub 2011 May 30.


RpoE1, an extracytoplasmic function sigma factor, is a repressor of the flagellar system in Brucella melitensis.

Ferooz J, Lemaire J, Delory M, De Bolle X, Letesson JJ.

Microbiology. 2011 May;157(Pt 5):1263-8. doi: 10.1099/mic.0.044875-0. Epub 2011 Jan 27.


Identification of the essential Brucella melitensis porin Omp2b as a suppressor of Bax-induced cell death in yeast in a genome-wide screening.

Laloux G, Deghelt M, de Barsy M, Letesson JJ, De Bolle X.

PLoS One. 2010 Oct 11;5(10):e13274. doi: 10.1371/journal.pone.0013274.


Overproduced Brucella abortus PdhS-mCherry forms soluble aggregates in Escherichia coli, partially associating with mobile foci of IbpA-YFP.

Van der Henst C, Charlier C, Deghelt M, Wouters J, Matroule JY, Letesson JJ, De Bolle X.

BMC Microbiol. 2010 Sep 28;10:248. doi: 10.1186/1471-2180-10-248.


Functional characterization of the incomplete phosphotransferase system (PTS) of the intracellular pathogen Brucella melitensis.

Dozot M, Poncet S, Nicolas C, Copin R, Bouraoui H, Mazé A, Deutscher J, De Bolle X, Letesson JJ.

PLoS One. 2010 Sep 10;5(9). pii: e12679. doi: 10.1371/journal.pone.0012679.


Brucella melitensis 16M produces a mannan and other extracellular matrix components typical of a biofilm.

Godefroid M, Svensson MV, Cambier P, Uzureau S, Mirabella A, De Bolle X, Van Cutsem P, Widmalm G, Letesson JJ.

FEMS Immunol Med Microbiol. 2010 Aug;59(3):364-77. doi: 10.1111/j.1574-695X.2010.00689.x. Epub 2010 Apr 20.


Global analysis of quorum sensing targets in the intracellular pathogen Brucella melitensis 16 M.

Uzureau S, Lemaire J, Delaive E, Dieu M, Gaigneaux A, Raes M, De Bolle X, Letesson JJ.

J Proteome Res. 2010 Jun 4;9(6):3200-17. doi: 10.1021/pr100068p.


PdhS, an old-pole-localized histidine kinase, recruits the fumarase FumC in Brucella abortus.

Mignolet J, Van der Henst C, Nicolas C, Deghelt M, Dotreppe D, Letesson JJ, De Bolle X.

J Bacteriol. 2010 Jun;192(12):3235-9. doi: 10.1128/JB.00066-10. Epub 2010 Apr 9.


Correlations between carbon metabolism and virulence in bacteria.

Poncet S, Milohanic E, Mazé A, Abdallah JN, Aké F, Larribe M, Deghmane AE, Taha MK, Dozot M, De Bolle X, Letesson JJ, Deutscher J.

Contrib Microbiol. 2009;16:88-102. doi: 10.1159/000219374. Epub 2009 Jun 2. Review.


Intracellular rescuing of a B. melitensis 16M virB mutant by co-infection with a wild type strain.

Nijskens C, Copin R, De Bolle X, Letesson JJ.

Microb Pathog. 2008 Aug;45(2):134-41. doi: 10.1016/j.micpath.2008.04.005. Epub 2008 May 2.


Mutations of the quorum sensing-dependent regulator VjbR lead to drastic surface modifications in Brucella melitensis.

Uzureau S, Godefroid M, Deschamps C, Lemaire J, De Bolle X, Letesson JJ.

J Bacteriol. 2007 Aug;189(16):6035-47. Epub 2007 Jun 8.


The asymmetric distribution of the essential histidine kinase PdhS indicates a differentiation event in Brucella abortus.

Hallez R, Mignolet J, Van Mullem V, Wery M, Vandenhaute J, Letesson JJ, Jacobs-Wagner C, De Bolle X.

EMBO J. 2007 Mar 7;26(5):1444-55. Epub 2007 Feb 15.


Gateway-based destination vectors for functional analyses of bacterial ORFeomes: application to the Min system in Brucella abortus.

Hallez R, Letesson JJ, Vandenhaute J, De Bolle X.

Appl Environ Microbiol. 2007 Feb;73(4):1375-9. Epub 2006 Dec 15.


FtcR is a new master regulator of the flagellar system of Brucella melitensis 16M with homologs in Rhizobiaceae.

Léonard S, Ferooz J, Haine V, Danese I, Fretin D, Tibor A, de Walque S, De Bolle X, Letesson JJ.

J Bacteriol. 2007 Jan;189(1):131-41. Epub 2006 Oct 20.


An RpoH-like heat shock sigma factor is involved in stress response and virulence in Brucella melitensis 16M.

Delory M, Hallez R, Letesson JJ, De Bolle X.

J Bacteriol. 2006 Nov;188(21):7707-10. Epub 2006 Aug 25.


The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB.

Dozot M, Boigegrain RA, Delrue RM, Hallez R, Ouahrani-Bettache S, Danese I, Letesson JJ, De Bolle X, Köhler S.

Cell Microbiol. 2006 Nov;8(11):1791-802. Epub 2006 Jun 27.


NnrA is required for full virulence and regulates several Brucella melitensis denitrification genes.

Haine V, Dozot M, Dornand J, Letesson JJ, De Bolle X.

J Bacteriol. 2006 Feb;188(4):1615-9.

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