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NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis.

Zheng F, Luo S, Ouyang Z, Zhou J, Mo H, Schoonooghe S, Muyldermans S, De Baetselier P, Raes G, Wen Y.

Int J Mol Sci. 2019 Jul 8;20(13). pii: E3347. doi: 10.3390/ijms20133347.


The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages.

Scott CL, T'Jonck W, Martens L, Todorov H, Sichien D, Soen B, Bonnardel J, De Prijck S, Vandamme N, Cannoodt R, Saelens W, Vanneste B, Toussaint W, De Bleser P, Takahashi N, Vandenabeele P, Henri S, Pridans C, Hume DA, Lambrecht BN, De Baetselier P, Milling SWF, Van Ginderachter JA, Malissen B, Berx G, Beschin A, Saeys Y, Guilliams M.

Immunity. 2018 Aug 21;49(2):312-325.e5. doi: 10.1016/j.immuni.2018.07.004. Epub 2018 Jul 31.


Neutrophils enhance early Trypanosoma brucei infection onset.

Caljon G, Mabille D, Stijlemans B, De Trez C, Mazzone M, Tacchini-Cottier F, Malissen M, A Van Ginderachter J, Magez S, De Baetselier P, Van Den Abbeele J.

Sci Rep. 2018 Jul 25;8(1):11203. doi: 10.1038/s41598-018-29527-y.


African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System.

Stijlemans B, De Baetselier P, Magez S, Van Ginderachter JA, De Trez C.

Front Immunol. 2018 Feb 15;9:218. doi: 10.3389/fimmu.2018.00218. eCollection 2018. Review.


Novel half-life extended anti-MIF nanobodies protect against endotoxic shock.

Sparkes A, De Baetselier P, Brys L, Cabrito I, Sterckx YG, Schoonooghe S, Muyldermans S, Raes G, Bucala R, Vanlandschoot P, Van Ginderachter JA, Stijlemans B.

FASEB J. 2018 Jun;32(6):3411-3422. doi: 10.1096/fj.201701189R. Epub 2018 Jan 25.


Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis.

Stijlemans B, De Baetselier P, Caljon G, Van Den Abbeele J, Van Ginderachter JA, Magez S.

Front Immunol. 2017 Jun 30;8:724. doi: 10.3389/fimmu.2017.00724. eCollection 2017. Review.


Reprint of: The non-mammalian MIF superfamily.

Sparkes A, De Baetselier P, Roelants K, De Trez C, Magez S, Van Ginderachter JA, Raes G, Bucala R, Stijlemans B.

Immunobiology. 2017 Jun;222(6):858-867. doi: 10.1016/j.imbio.2017.05.004. Epub 2017 May 26. Review.


The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity.

Laoui D, Keirsse J, Morias Y, Van Overmeire E, Geeraerts X, Elkrim Y, Kiss M, Bolli E, Lahmar Q, Sichien D, Serneels J, Scott CL, Boon L, De Baetselier P, Mazzone M, Guilliams M, Van Ginderachter JA.

Nat Commun. 2016 Dec 23;7:13720. doi: 10.1038/ncomms13720.


Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity.

Wen Y, Ouyang Z, Schoonooghe S, Luo S, De Baetselier P, Lu W, Muyldermans S, Raes G, Zheng F.

Immunobiology. 2017 Jun;222(6):807-813. doi: 10.1016/j.imbio.2016.11.008. Epub 2016 Nov 18.


The non-mammalian MIF superfamily.

Sparkes A, De Baetselier P, Roelants K, De Trez C, Magez S, Van Ginderachter JA, Raes G, Bucala R, Stijlemans B.

Immunobiology. 2017 Mar;222(3):473-482. doi: 10.1016/j.imbio.2016.10.006. Epub 2016 Oct 12. Review.


Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies.

Zheng F, Perlman H, Matthys P, Wen Y, Lahoutte T, Muyldermans S, Lu S, De Baetselier P, Schoonooghe S, Devoogdt N, Raes G.

Sci Rep. 2016 Oct 25;6:35966. doi: 10.1038/srep35966.


MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis.

Stijlemans B, Brys L, Korf H, Bieniasz-Krzywiec P, Sparkes A, Vansintjan L, Leng L, Vanbekbergen N, Mazzone M, Caljon G, Van Den Abbeele J, Odongo S, De Trez C, Magez S, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P.

PLoS Pathog. 2016 Sep 15;12(9):e1005862. doi: 10.1371/journal.ppat.1005862. eCollection 2016 Sep.


Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis.

Zheng F, Sparkes A, De Baetselier P, Schoonooghe S, Stijlemans B, Muyldermans S, Flamand V, Van Ginderachter JA, Devoogdt N, Raes G, Beschin A.

Mol Imaging Biol. 2017 Feb;19(1):49-58. doi: 10.1007/s11307-016-0976-3.


Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells.

Scott CL, Zheng F, De Baetselier P, Martens L, Saeys Y, De Prijck S, Lippens S, Abels C, Schoonooghe S, Raes G, Devoogdt N, Lambrecht BN, Beschin A, Guilliams M.

Nat Commun. 2016 Jan 27;7:10321. doi: 10.1038/ncomms10321.


M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment.

Van Overmeire E, Stijlemans B, Heymann F, Keirsse J, Morias Y, Elkrim Y, Brys L, Abels C, Lahmar Q, Ergen C, Vereecke L, Tacke F, De Baetselier P, Van Ginderachter JA, Laoui D.

Cancer Res. 2016 Jan 1;76(1):35-42. doi: 10.1158/0008-5472.CAN-15-0869. Epub 2015 Nov 16.


The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome.

Goyvaerts C, Broos K, Escors D, Heirman C, Raes G, De Baetselier P, Thielemans K, Breckpot K.

Eur J Immunol. 2015 Dec;45(12):3351-61. doi: 10.1002/eji.201545559. Epub 2015 Oct 27.


E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo.

Van den Bossche J, Laoui D, Naessens T, Smits HH, Hokke CH, Stijlemans B, Grooten J, De Baetselier P, Van Ginderachter JA.

Sci Rep. 2015 Jul 31;5:12599. doi: 10.1038/srep12599.


Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A Battle/Quest for Iron.

Stijlemans B, Beschin A, Magez S, Van Ginderachter JA, De Baetselier P.

Biomed Res Int. 2015;2015:819389. doi: 10.1155/2015/819389. Epub 2015 May 18. Review.


PET Imaging of Macrophage Mannose Receptor-Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments.

Blykers A, Schoonooghe S, Xavier C, D'hoe K, Laoui D, D'Huyvetter M, Vaneycken I, Cleeren F, Bormans G, Heemskerk J, Raes G, De Baetselier P, Lahoutte T, Devoogdt N, Van Ginderachter JA, Caveliers V.

J Nucl Med. 2015 Aug;56(8):1265-71. doi: 10.2967/jnumed.115.156828. Epub 2015 Jun 11.


Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages.

Morias Y, Abels C, Laoui D, Van Overmeire E, Guilliams M, Schouppe E, Tacke F, deVries CJ, De Baetselier P, Beschin A.

PLoS Pathog. 2015 May 28;11(5):e1004873. doi: 10.1371/journal.ppat.1004873. eCollection 2015 May.


Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis.

Stijlemans B, Cnops J, Naniima P, Vaast A, Bockstal V, De Baetselier P, Magez S.

PLoS Negl Trop Dis. 2015 Mar 5;9(3):e0003561. doi: 10.1371/journal.pntd.0003561. eCollection 2015 Mar.


Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas.

Van Gassen N, Van Overmeire E, Leuckx G, Heremans Y, De Groef S, Cai Y, Elkrim Y, Gysemans C, Stijlemans B, Van de Casteele M, De Baetselier P, De Leu N, Heimberg H, Van Ginderachter JA.

Eur J Immunol. 2015 May;45(5):1482-93. doi: 10.1002/eji.201445013. Epub 2015 Mar 19.


Monitoring liver macrophages using nanobodies targeting Vsig4: concanavalin A induced acute hepatitis as paradigm.

Zheng F, Devoogdt N, Sparkes A, Morias Y, Abels C, Stijlemans B, Lahoutte T, Muyldermans S, De Baetselier P, Schoonooghe S, Beschin A, Raes G.

Immunobiology. 2015 Feb;220(2):200-9. doi: 10.1016/j.imbio.2014.09.018. Epub 2014 Oct 2.


Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression.

Laoui D, Van Overmeire E, De Baetselier P, Van Ginderachter JA, Raes G.

Front Immunol. 2014 Oct 7;5:489. doi: 10.3389/fimmu.2014.00489. eCollection 2014. Review.


MIF contributes to Trypanosoma brucei associated immunopathogenicity development.

Stijlemans B, Leng L, Brys L, Sparkes A, Vansintjan L, Caljon G, Raes G, Van Den Abbeele J, Van Ginderachter JA, Beschin A, Bucala R, De Baetselier P.

PLoS Pathog. 2014 Sep 25;10(9):e1004414. doi: 10.1371/journal.ppat.1004414. eCollection 2014 Sep.


African trypanosome control in the insect vector and mammalian host.

Beschin A, Van Den Abbeele J, De Baetselier P, Pays E.

Trends Parasitol. 2014 Nov;30(11):538-47. doi: 10.1016/ Epub 2014 Sep 19. Review.


Visceral leishmaniasis relapse in HIV patients--a role for myeloid-derived suppressor cells?

Van den Bergh R, Van Ginderachter JA, Schouppe E, Desimmie BA, Hailu A, De Baetselier P, van Griensven J.

PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3132. doi: 10.1371/journal.pntd.0003132. eCollection 2014 Sep. No abstract available.


Molecular imaging with macrophage CRIg-targeting nanobodies for early and preclinical diagnosis in a mouse model of rheumatoid arthritis.

Zheng F, Put S, Bouwens L, Lahoutte T, Matthys P, Muyldermans S, De Baetselier P, Devoogdt N, Raes G, Schoonooghe S.

J Nucl Med. 2014 May;55(5):824-9. doi: 10.2967/jnumed.113.130617. Epub 2014 Mar 31.


Immunogenicity of targeted lentivectors.

Goyvaerts C, Kurt de G, Van Lint S, Heirman C, Van Ginderachter JA, De Baetselier P, Raes G, Thielemans K, Breckpot K.

Oncotarget. 2014 Feb 15;5(3):704-15.


Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population.

Laoui D, Van Overmeire E, Di Conza G, Aldeni C, Keirsse J, Morias Y, Movahedi K, Houbracken I, Schouppe E, Elkrim Y, Karroum O, Jordan B, Carmeliet P, Gysemans C, De Baetselier P, Mazzone M, Van Ginderachter JA.

Cancer Res. 2014 Jan 1;74(1):24-30. doi: 10.1158/0008-5472.CAN-13-1196. Epub 2013 Nov 12.


A Trypanosoma brucei kinesin heavy chain promotes parasite growth by triggering host arginase activity.

De Muylder G, Daulouède S, Lecordier L, Uzureau P, Morias Y, Van Den Abbeele J, Caljon G, Hérin M, Holzmuller P, Semballa S, Courtois P, Vanhamme L, Stijlemans B, De Baetselier P, Barrett MP, Barlow JL, McKenzie AN, Barron L, Wynn TA, Beschin A, Vincendeau P, Pays E.

PLoS Pathog. 2013 Oct;9(10):e1003731. doi: 10.1371/journal.ppat.1003731. Epub 2013 Oct 31.


The role of monocytes in the development of Tuberculosis-associated Immune Reconstitution Inflammatory Syndrome.

Tran HT, Van den Bergh R, Vu TN, Laukens K, Worodria W, Loembé MM, Colebunders R, Kestens L, De Baetselier P, Raes G; TB-IRIS Study Group.

Immunobiology. 2014 Jan;219(1):37-44. doi: 10.1016/j.imbio.2013.07.004. Epub 2013 Jul 25.


Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T-cell activation events.

Schouppe E, Mommer C, Movahedi K, Laoui D, Morias Y, Gysemans C, Luyckx A, De Baetselier P, Van Ginderachter JA.

Eur J Immunol. 2013 Nov;43(11):2930-42. doi: 10.1002/eji.201343349. Epub 2013 Aug 25.


Targeting of human antigen-presenting cell subsets.

Goyvaerts C, Dingemans J, De Groeve K, Heirman C, Van Gulck E, Vanham G, De Baetselier P, Thielemans K, Raes G, Breckpot K.

J Virol. 2013 Oct;87(20):11304-8. doi: 10.1128/JVI.01498-13. Epub 2013 Jul 17.


Modulation of the complement system in monocytes contributes to tuberculosis-associated immune reconstitution inflammatory syndrome.

Tran HT, Van den Bergh R, Loembé MM, Worodria W, Mayanja-Kizza H, Colebunders R, Mascart F, Stordeur P, Kestens L, De Baetselier P, Raes G; TB-IRIS study group.

AIDS. 2013 Jul 17;27(11):1725-34. doi: 10.1097/QAD.0b013e328361648b.


SPECT imaging of joint inflammation with Nanobodies targeting the macrophage mannose receptor in a mouse model for rheumatoid arthritis.

Put S, Schoonooghe S, Devoogdt N, Schurgers E, Avau A, Mitera T, D'Huyvetter M, De Baetselier P, Raes G, Lahoutte T, Matthys P.

J Nucl Med. 2013 May;54(5):807-14. doi: 10.2967/jnumed.112.111781. Epub 2013 Feb 27.


Affinity is an important determinant of the anti-trypanosome activity of nanobodies.

Caljon G, Stijlemans B, Saerens D, Van Den Abbeele J, Muyldermans S, Magez S, De Baetselier P.

PLoS Negl Trop Dis. 2012;6(11):e1902. doi: 10.1371/journal.pntd.0001902. Epub 2012 Nov 15.


Tsetse salivary gland proteins 1 and 2 are high affinity nucleic acid binding proteins with residual nuclease activity.

Caljon G, De Ridder K, Stijlemans B, Coosemans M, Magez S, De Baetselier P, Van Den Abbeele J.

PLoS One. 2012;7(10):e47233. doi: 10.1371/journal.pone.0047233. Epub 2012 Oct 23.


Plasticity of monocytes, macrophages and dendritic cells is reflected in distinct organs and tissues.

Raes G, De Baetselier P, Van Ginderachter JA.

Immunobiology. 2012 Dec;217(12):1223-4. doi: 10.1016/j.imbio.2012.10.001. Epub 2012 Oct 4. No abstract available.


Contribution of myeloid cell subsets to liver fibrosis in parasite infection.

Beschin A, De Baetselier P, Van Ginderachter JA.

J Pathol. 2013 Jan;229(2):186-97. doi: 10.1002/path.4112. Epub 2012 Nov 20. Review.


Molecular imaging using Nanobodies: a case study.

Devoogdt N, Xavier C, Hernot S, Vaneycken I, D'Huyvetter M, De Vos J, Massa S, De Baetselier P, Caveliers V, Lahoutte T.

Methods Mol Biol. 2012;911:559-67. doi: 10.1007/978-1-61779-968-6_35.


Novel applications of nanobodies for in vivo bio-imaging of inflamed tissues in inflammatory diseases and cancer.

Schoonooghe S, Laoui D, Van Ginderachter JA, Devoogdt N, Lahoutte T, De Baetselier P, Raes G.

Immunobiology. 2012 Dec;217(12):1266-72. doi: 10.1016/j.imbio.2012.07.009. Epub 2012 Jul 21. Review.


Nanobody-based targeting of the macrophage mannose receptor for effective in vivo imaging of tumor-associated macrophages.

Movahedi K, Schoonooghe S, Laoui D, Houbracken I, Waelput W, Breckpot K, Bouwens L, Lahoutte T, De Baetselier P, Raes G, Devoogdt N, Van Ginderachter JA.

Cancer Res. 2012 Aug 15;72(16):4165-77. doi: 10.1158/0008-5472.CAN-11-2994. Epub 2012 Jun 19.


Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host.

Salmon D, Vanwalleghem G, Morias Y, Denoeud J, Krumbholz C, Lhommé F, Bachmaier S, Kador M, Gossmann J, Dias FB, De Muylder G, Uzureau P, Magez S, Moser M, De Baetselier P, Van Den Abbeele J, Beschin A, Boshart M, Pays E.

Science. 2012 Jul 27;337(6093):463-6. doi: 10.1126/science.1222753. Epub 2012 Jun 14.


Multiple myeloma induces the immunosuppressive capacity of distinct myeloid-derived suppressor cell subpopulations in the bone marrow.

Van Valckenborgh E, Schouppe E, Movahedi K, De Bruyne E, Menu E, De Baetselier P, Vanderkerken K, Van Ginderachter JA.

Leukemia. 2012 Nov;26(11):2424-8. doi: 10.1038/leu.2012.113. Epub 2012 Apr 23. No abstract available.


Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT.

Van den Bergh R, Morin S, Sass HJ, Grzesiek S, Vekemans M, Florence E, Tran HT, Imiru RG, Heyndrickx L, Vanham G, De Baetselier P, Raes G.

PLoS One. 2012;7(4):e35074. doi: 10.1371/journal.pone.0035074. Epub 2012 Apr 6.


Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes.

Van den Bossche J, Lamers WH, Koehler ES, Geuns JM, Alhonen L, Uimari A, Pirnes-Karhu S, Van Overmeire E, Morias Y, Brys L, Vereecke L, De Baetselier P, Van Ginderachter JA.

J Leukoc Biol. 2012 May;91(5):685-99. doi: 10.1189/jlb.0911453. Epub 2012 Mar 13.


Expression and extracellular release of a functional anti-trypanosome Nanobody® in Sodalis glossinidius, a bacterial symbiont of the tsetse fly.

De Vooght L, Caljon G, Stijlemans B, De Baetselier P, Coosemans M, Van den Abbeele J.

Microb Cell Fact. 2012 Feb 15;11:23. doi: 10.1186/1475-2859-11-23.


Claudin-1, claudin-2 and claudin-11 genes differentially associate with distinct types of anti-inflammatory macrophages in vitro and with parasite- and tumour-elicited macrophages in vivo.

Van den Bossche J, Laoui D, Morias Y, Movahedi K, Raes G, De Baetselier P, Van Ginderachter JA.

Scand J Immunol. 2012 Jun;75(6):588-98. doi: 10.1111/j.1365-3083.2012.02689.x.

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