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Items: 1 to 20 of 102


A lower affinity to cytosolic proteins reveals VDAC3 isoform-specific role in mitochondrial biology.

Queralt-Martín M, Bergdoll L, Teijido O, Munshi N, Jacobs D, Kuszak AJ, Protchenko O, Reina S, Magrì A, De Pinto V, Bezrukov SM, Abramson J, Rostovtseva TK.

J Gen Physiol. 2020 Feb 3;152(2). pii: e201912501. doi: 10.1085/jgp.201912501.


Deletion of Voltage-Dependent Anion Channel 1 knocks mitochondria down triggering metabolic rewiring in yeast.

Magrì A, Di Rosa MC, Orlandi I, Guarino F, Reina S, Guarnaccia M, Morello G, Spampinato A, Cavallaro S, Messina A, Vai M, De Pinto V.

Cell Mol Life Sci. 2019 Oct 26. doi: 10.1007/s00018-019-03342-8. [Epub ahead of print]


Recombinant yeast VDAC2: a comparison of electrophysiological features with the native form.

Magrì A, Karachitos A, Di Rosa MC, Reina S, Conti Nibali S, Messina A, Kmita H, De Pinto V.

FEBS Open Bio. 2019 Jul;9(7):1184-1193. doi: 10.1002/2211-5463.12574. Epub 2019 Jun 17.


Folded Structure and Membrane Affinity of the N-Terminal Domain of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion-Selective Channel.

Manzo G, Serra I, Magrí A, Casu M, De Pinto V, Ceccarelli M, Scorciapino MA.

ACS Omega. 2018 Sep 30;3(9):11415-11425. doi: 10.1021/acsomega.8b01536. Epub 2018 Sep 19.


Post-translational modifications of VDAC1 and VDAC2 cysteines from rat liver mitochondria.

Saletti R, Reina S, Pittalà MGG, Magrì A, Cunsolo V, Foti S, De Pinto V.

Biochim Biophys Acta Bioenerg. 2018 Sep;1859(9):806-816. doi: 10.1016/j.bbabio.2018.06.007. Epub 2018 Jun 8.


VDAC1 as Pharmacological Target in Cancer and Neurodegeneration: Focus on Its Role in Apoptosis.

Magrì A, Reina S, De Pinto V.

Front Chem. 2018 Apr 6;6:108. doi: 10.3389/fchem.2018.00108. eCollection 2018. Review.


Hypoxic-induced truncation of voltage-dependent anion channel 1 is mediated by both asparagine endopeptidase and calpain 1 activities.

Pahima H, Reina S, Tadmor N, Dadon-Klein D, Shteinfer-Kuzmine A, Mazure NM, De Pinto V, Shoshan-Barmatz V.

Oncotarget. 2018 Jan 31;9(16):12825-12841. doi: 10.18632/oncotarget.24377. eCollection 2018 Feb 27.


yVDAC2, the second mitochondrial porin isoform of Saccharomyces cerevisiae.

Guardiani C, Magrì A, Karachitos A, Di Rosa MC, Reina S, Bodrenko I, Messina A, Kmita H, Ceccarelli M, De Pinto V.

Biochim Biophys Acta Bioenerg. 2018 Apr;1859(4):270-279. doi: 10.1016/j.bbabio.2018.01.008. Epub 2018 Feb 2.


Anti-Cancer Compounds Targeted to VDAC: Potential and Perspectives.

Reina S, De Pinto V.

Curr Med Chem. 2017;24(40):4447-4469. doi: 10.2174/0929867324666170530074039. Review.


VDAC3 As a Potential Marker of Mitochondrial Status Is Involved in Cancer and Pathology.

Reina S, Guarino F, Magrì A, De Pinto V.

Front Oncol. 2016 Dec 23;6:264. doi: 10.3389/fonc.2016.00264. eCollection 2016. Review.


High resolution mass spectrometry characterization of the oxidation pattern of methionine and cysteine residues in rat liver mitochondria voltage-dependent anion selective channel 3 (VDAC3).

Saletti R, Reina S, Pittalà MG, Belfiore R, Cunsolo V, Messina A, De Pinto V, Foti S.

Biochim Biophys Acta Biomembr. 2017 Mar;1859(3):301-311. doi: 10.1016/j.bbamem.2016.12.003. Epub 2016 Dec 16.


Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction.

Ben-Hail D, Begas-Shvartz R, Shalev M, Shteinfer-Kuzmine A, Gruzman A, Reina S, De Pinto V, Shoshan-Barmatz V.

J Biol Chem. 2016 Nov 25;291(48):24986-25003. Epub 2016 Oct 13.


Hexokinase I N-terminal based peptide prevents the VDAC1-SOD1 G93A interaction and re-establishes ALS cell viability.

Magrì A, Belfiore R, Reina S, Tomasello MF, Di Rosa MC, Guarino F, Leggio L, De Pinto V, Messina A.

Sci Rep. 2016 Oct 10;6:34802. doi: 10.1038/srep34802.


Role of cysteines in mammalian VDAC isoforms' function.

De Pinto V, Reina S, Gupta A, Messina A, Mahalakshmi R.

Biochim Biophys Acta. 2016 Aug;1857(8):1219-1227. doi: 10.1016/j.bbabio.2016.02.020. Epub 2016 Mar 4. Review.


Overexpression of human SOD1 in VDAC1-less yeast restores mitochondrial functionality modulating beta-barrel outer membrane protein genes.

Magrì A, Di Rosa MC, Tomasello MF, Guarino F, Reina S, Messina A, De Pinto V.

Biochim Biophys Acta. 2016 Jun;1857(6):789-98. doi: 10.1016/j.bbabio.2016.03.003. Epub 2016 Mar 4.


A computational study of ion current modulation in hVDAC3 induced by disulfide bonds.

Guardiani C, Leggio L, Scorciapino MA, de Pinto V, Ceccarelli M.

Biochim Biophys Acta. 2016 Apr;1858(4):813-23. doi: 10.1016/j.bbamem.2016.01.013. Epub 2016 Jan 22.


VDAC3 as a sensor of oxidative state of the intermembrane space of mitochondria: the putative role of cysteine residue modifications.

Reina S, Checchetto V, Saletti R, Gupta A, Chaturvedi D, Guardiani C, Guarino F, Scorciapino MA, Magrì A, Foti S, Ceccarelli M, Messina AA, Mahalakshmi R, Szabo I, De Pinto V.

Oncotarget. 2016 Jan 19;7(3):2249-68. doi: 10.18632/oncotarget.6850.


The N-Terminal Peptides of the Three Human Isoforms of the Mitochondrial Voltage-Dependent Anion Channel Have Different Helical Propensities.

Guardiani C, Scorciapino MA, Amodeo GF, Grdadolnik J, Pappalardo G, De Pinto V, Ceccarelli M, Casu M.

Biochemistry. 2015 Sep 15;54(36):5646-56. doi: 10.1021/acs.biochem.5b00469. Epub 2015 Aug 28.


Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance.

Checchetto V, Reina S, Magrì A, Szabo I, De Pinto V.

Cell Physiol Biochem. 2014;34(3):842-53. doi: 10.1159/000363047. Epub 2014 Aug 20.


Charged residues distribution modulates selectivity of the open state of human isoforms of the voltage dependent anion-selective channel.

Amodeo GF, Scorciapino MA, Messina A, De Pinto V, Ceccarelli M.

PLoS One. 2014 Aug 1;9(8):e103879. doi: 10.1371/journal.pone.0103879. eCollection 2014.

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