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Items: 20


Venous malformations: PIK3CA mutations guide new treatments.

Dbouk HA.

Oncotarget. 2016 Aug 2;7(31):48852-48853. doi: 10.18632/oncotarget.9252. No abstract available.


Hypertension: the missing WNKs.

Dbouk HA, Huang CL, Cobb MH.

Am J Physiol Renal Physiol. 2016 Jul 1;311(1):F16-27. doi: 10.1152/ajprenal.00358.2015. Epub 2016 Mar 23. Review.


Identification of the Rab5 binding site in p110β: assays for PI3Kβ binding to Rab5.

Salamon RS, Dbouk HA, Collado D, Lopiccolo J, Bresnick AR, Backer JM.

Methods Mol Biol. 2015;1298:271-81. doi: 10.1007/978-1-4939-2569-8_23.


Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31.


G protein-coupled receptors and the regulation of autophagy.

Wauson EM, Dbouk HA, Ghosh AB, Cobb MH.

Trends Endocrinol Metab. 2014 May;25(5):274-82. doi: 10.1016/j.tem.2014.03.006. Epub 2014 Apr 18. Review.


Molecular determinants of PI3Kγ-mediated activation downstream of G-protein-coupled receptors (GPCRs).

Vadas O, Dbouk HA, Shymanets A, Perisic O, Burke JE, Abi Saab WF, Khalil BD, Harteneck C, Bresnick AR, Nürnberg B, Backer JM, Williams RL.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18862-7. doi: 10.1073/pnas.1304801110. Epub 2013 Nov 4.


Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: role of β-catenin/connexin43 association.

Talhouk RS, Fares MB, Rahme GJ, Hariri HH, Rayess T, Dbouk HA, Bazzoun D, Al-Labban D, El-Sabban ME.

Exp Cell Res. 2013 Dec 10;319(20):3065-80. doi: 10.1016/j.yexcr.2013.10.002. Epub 2013 Oct 10.


Characterization of a tumor-associated activating mutation of the p110β PI 3-kinase.

Dbouk HA, Khalil BD, Wu H, Shymanets A, Nürnberg B, Backer JM.

PLoS One. 2013 May 29;8(5):e63833. doi: 10.1371/journal.pone.0063833. Print 2013.


Class IA PI3K p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation.

Dou Z, Pan JA, Dbouk HA, Ballou LM, DeLeon JL, Fan Y, Chen JS, Liang Z, Li G, Backer JM, Lin RZ, Zong WX.

Mol Cell. 2013 Apr 11;50(1):29-42. doi: 10.1016/j.molcel.2013.01.022. Epub 2013 Feb 21.


Novel approaches to inhibitor design for the p110β phosphoinositide 3-kinase.

Dbouk HA, Backer JM.

Trends Pharmacol Sci. 2013 Mar;34(3):149-53. doi: 10.1016/ Epub 2013 Feb 12. Review.


PI3Kβ downstream of GPCRs - crucial partners in oncogenesis.

Dbouk HA, Vadas O, Williams RL, Backer JM.

Oncotarget. 2012 Dec;3(12):1485-6. No abstract available.


G protein-coupled receptor-mediated activation of p110β by Gβγ is required for cellular transformation and invasiveness.

Dbouk HA, Vadas O, Shymanets A, Burke JE, Salamon RS, Khalil BD, Barrett MO, Waldo GL, Surve C, Hsueh C, Perisic O, Harteneck C, Shepherd PR, Harden TK, Smrcka AV, Taussig R, Bresnick AR, Nürnberg B, Williams RL, Backer JM.

Sci Signal. 2012 Dec 4;5(253):ra89. doi: 10.1126/scisignal.2003264.


A beta version of life: p110β takes center stage.

Dbouk HA, Backer JM.

Oncotarget. 2010 Dec;1(8):729-33. Review.


A biochemical mechanism for the oncogenic potential of the p110beta catalytic subunit of phosphoinositide 3-kinase.

Dbouk HA, Pang H, Fiser A, Backer JM.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19897-902. doi: 10.1073/pnas.1008739107. Epub 2010 Oct 28.


Somatic mutations in p85alpha promote tumorigenesis through class IA PI3K activation.

Jaiswal BS, Janakiraman V, Kljavin NM, Chaudhuri S, Stern HM, Wang W, Kan Z, Dbouk HA, Peters BA, Waring P, Dela Vega T, Kenski DM, Bowman KK, Lorenzo M, Li H, Wu J, Modrusan Z, Stinson J, Eby M, Yue P, Kaminker JS, de Sauvage FJ, Backer JM, Seshagiri S.

Cancer Cell. 2009 Dec 8;16(6):463-74. doi: 10.1016/j.ccr.2009.10.016.


Time course of alterations in pre- and post-synaptic chemoreceptor function during developmental hyperoxia.

Donnelly DF, Bavis RW, Kim I, Dbouk HA, Carroll JL.

Respir Physiol Neurobiol. 2009 Sep 30;168(3):189-97. doi: 10.1016/j.resp.2009.05.005. Epub 2009 May 22.


Connexins: a myriad of functions extending beyond assembly of gap junction channels.

Dbouk HA, Mroue RM, El-Sabban ME, Talhouk RS.

Cell Commun Signal. 2009 Mar 12;7:4. doi: 10.1186/1478-811X-7-4.


Significance of CEA and VEGF as Diagnostic Markers of Colorectal Cancer in Lebanese Patients.

Dbouk HA, Tawil A, Nasr F, Kandakarjian L, Abou-Merhi R.

Open Clin Cancer J. 2007 Nov 8;1:1-5. doi: 10.2174/1874189400701010001.


An overview of familial Mediterranean fever with emphasis on pyrin and colchicine.

Dbouk HA, Uthman IW.

J Med Liban. 2008 Jan-Mar;56(1):35-41. Review.


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