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Items: 4


Organization of ATP-gated P2X1 receptor intracellular termini in apo and desensitized states.

Fryatt AG, Dayl S, Stavrou A, Schmid R, Evans RJ.

J Gen Physiol. 2019 Feb 4;151(2):146-155. doi: 10.1085/jgp.201812108. Epub 2019 Jan 9.


Mapping the Allosteric Action of Antagonists A740003 and A438079 Reveals a Role for the Left Flipper in Ligand Sensitivity at P2X7 Receptors.

Allsopp RC, Dayl S, Bin Dayel A, Schmid R, Evans RJ.

Mol Pharmacol. 2018 May;93(5):553-562. doi: 10.1124/mol.117.111021. Epub 2018 Mar 13.


Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.

Allsopp RC, Dayl S, Schmid R, Evans RJ.

Sci Rep. 2017 Apr 7;7(1):725. doi: 10.1038/s41598-017-00732-5.


Mechanistic insights from resolving ligand-dependent kinetics of conformational changes at ATP-gated P2X1R ion channels.

Fryatt AG, Dayl S, Cullis PM, Schmid R, Evans RJ.

Sci Rep. 2016 Sep 12;6:32918. doi: 10.1038/srep32918.

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