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Detecting autoreactive B cells in the peripheral blood of people with type 1 diabetes using ELISpot.

Powell WE, Hanna SJ, Hocter CN, Robinson E, Lewis M, Dunseath G, Luzio S, Howell A, Dayan CM, Wong FS.

J Immunol Methods. 2019 Aug;471:61-65. doi: 10.1016/j.jim.2019.05.007. Epub 2019 May 29.


Role of Hyaluronan in Human Adipogenesis: Evidence from in-Vitro and in-Vivo Studies.

Wilson N, Steadman R, Muller I, Draman M, Rees DA, Taylor P, Dayan CM, Ludgate M, Zhang L.

Int J Mol Sci. 2019 May 31;20(11). pii: E2675. doi: 10.3390/ijms20112675.


Conjugation of a peptide autoantigen to gold nanoparticles for intradermally administered antigen specific immunotherapy.

Dul M, Nikolic T, Stefanidou M, McAteer MA, Williams P, Mous J, Roep BO, Kochba E, Levin Y, Peakman M, Wong FS, Dayan CM, Tatovic D, Coulman SA, Birchall JC; EE-ASI Consortium.

Int J Pharm. 2019 May 1;562:303-312. doi: 10.1016/j.ijpharm.2019.03.041. Epub 2019 Mar 22.


Primary therapy of Graves' disease and cardiovascular morbidity and mortality: a linked-record cohort study.

Okosieme OE, Taylor PN, Evans C, Thayer D, Chai A, Khan I, Draman MS, Tennant B, Geen J, Sayers A, French R, Lazarus JH, Premawardhana LD, Dayan CM.

Lancet Diabetes Endocrinol. 2019 Apr;7(4):278-287. doi: 10.1016/S2213-8587(19)30059-2. Epub 2019 Feb 28.


Liothyronine cost and prescriptions in England.

Taylor PN, Razvi S, Muller I, Wass J, Dayan CM, Chatterjee K, Boelaert K.

Lancet Diabetes Endocrinol. 2019 Jan;7(1):11-12. doi: 10.1016/S2213-8587(18)30334-6. No abstract available.


Longitudinal Characterization of Autoantibodies to the Thyrotropin Receptor (TRAb) During Alemtuzumab Therapy: Evidence that TRAb May Precede Thyroid Dysfunction by Many Years.

Muller I, Willis M, Healy S, Nasser T, Loveless S, Butterworth S, Zhang L, Draman MS, Taylor PN, Robertson N, Dayan CM, Ludgate ME.

Thyroid. 2018 Dec;28(12):1682-1693. doi: 10.1089/thy.2018.0232. Epub 2018 Dec 4. Erratum in: Thyroid. 2019 Feb;29(2):309.


Loss of CXCR3 expression on memory B cells in individuals with long-standing type 1 diabetes.

Powell WE, Hanna SJ, Hocter CN, Robinson E, Davies J, Dunseath GJ, Luzio S, Farewell D, Wen L, Dayan CM, Price DA, Ladell K, Wong FS.

Diabetologia. 2018 Aug;61(8):1794-1803. doi: 10.1007/s00125-018-4651-x. Epub 2018 Jun 7.


Relationship between islet autoantibody status and the clinical characteristics of children and adults with incident type 1 diabetes in a UK cohort.

Bravis V, Kaur A, Walkey HC, Godsland IF, Misra S, Bingley PJ, Williams AJK, Dunger DB, Dayan CM, Peakman M, Oliver NS, Johnston DG; ADDRESS-2 Management Committee, Patient Advocate Group and Investigators.

BMJ Open. 2018 Apr 4;8(4):e020904. doi: 10.1136/bmjopen-2017-020904.


An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction.

Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC.

Thyroid. 2018 Jun;28(6):707-721. doi: 10.1089/thy.2017.0681. Epub 2018 Apr 5.


Global epidemiology of hyperthyroidism and hypothyroidism.

Taylor PN, Albrecht D, Scholz A, Gutierrez-Buey G, Lazarus JH, Dayan CM, Okosieme OE.

Nat Rev Endocrinol. 2018 May;14(5):301-316. doi: 10.1038/nrendo.2018.18. Epub 2018 Mar 23. Review.


Attitudes and perceptions of health professionals towards management of hypothyroidism in general practice: a qualitative interview study.

Dew R, King K, Okosieme OE, Pearce SH, Donovan G, Taylor PN, Hickey J, Dayan CM, Leese G, Razvi S, Wilkes S.

BMJ Open. 2018 Feb 21;8(2):e019970. doi: 10.1136/bmjopen-2017-019970.


Combined immunosuppression and radiotherapy in thyroid eye disease (CIRTED): a multicentre, 2 × 2 factorial, double-blind, randomised controlled trial.

Rajendram R, Taylor PN, Wilson VJ, Harris N, Morris OC, Tomlinson M, Yarrow S, Garrott H, Herbert HM, Dick AD, Cook A, Gattamaneni R, Jain R, Olver J, Hurel SJ, Bremner F, Drummond SR, Kemp E, Ritchie DM, Rumsey N, Morris D, Lane C, Palaniappan N, Li C, Pell J, Hills R, Ezra DG, Potts MJ, Jackson S, Rose GE, Plowman N, Bunce C, Uddin JM, Lee RWJ, Dayan CM.

Lancet Diabetes Endocrinol. 2018 Apr;6(4):299-309. doi: 10.1016/S2213-8587(18)30021-4. Epub 2018 Jan 31.


TPOAb and Thyroid Function Are Not Associated with Breast Cancer Outcome: Evidence from a Large-Scale Study Using Data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001).

Muller I, Kilburn LS, Taylor PN, Barrett-Lee PJ, Bliss JM, Ellis P, Ludgate ME, Dayan CM.

Eur Thyroid J. 2017 Jul;6(4):197-207. doi: 10.1159/000460246. Epub 2017 Apr 4.


Metabolic and immune effects of immunotherapy with proinsulin peptide in human new-onset type 1 diabetes.

Alhadj Ali M, Liu YF, Arif S, Tatovic D, Shariff H, Gibson VB, Yusuf N, Baptista R, Eichmann M, Petrov N, Heck S, Yang JHM, Tree TIM, Pujol-Autonell I, Yeo L, Baumard LR, Stenson R, Howell A, Clark A, Boult Z, Powrie J, Adams L, Wong FS, Luzio S, Dunseath G, Green K, O'Keefe A, Bayly G, Thorogood N, Andrews R, Leech N, Joseph F, Nair S, Seal S, Cheung H, Beam C, Hills R, Peakman M, Dayan CM.

Sci Transl Med. 2017 Aug 9;9(402). pii: eaaf7779. doi: 10.1126/scitranslmed.aaf7779.


Maturation in Serum Thyroid Function Parameters Over Childhood and Puberty: Results of a Longitudinal Study.

Taylor PN, Sayers A, Okosieme O, Das G, Draman MS, Tabasum A, Abusahmin H, Rahman M, Stevenson K, Groom A, Northstone K, Woltersdorf W, Taylor A, Ring S, Lazarus JH, Gregory JW, Rees A, Timpson N, Dayan CM.

J Clin Endocrinol Metab. 2017 Jul 1;102(7):2508-2515. doi: 10.1210/jc.2016-3605.


The Role of Thyrotropin Receptor Activation in Adipogenesis and Modulation of Fat Phenotype.

Draman MS, Stechman M, Scott-Coombes D, Dayan CM, Rees DA, Ludgate M, Zhang L.

Front Endocrinol (Lausanne). 2017 Apr 19;8:83. doi: 10.3389/fendo.2017.00083. eCollection 2017.


Management of thyroid eye disease in the United Kingdom: A multi-centre thyroid eye disease audit.

Mellington FE, Dayan CM, Dickinson AJ, Hickey JL, MacEwen CJ, McLaren J, Perros P, Rose GE, Uddin J, Vaidya B, Foley P, Lazarus JH, Mitchell A, Ezra DG; Thyroid Eye Disease Amsterdam Declaration Implementation Group (TEAMeD).

Orbit. 2017 Jun;36(3):159-169. doi: 10.1080/01676830.2017.1280057. Epub 2017 Mar 15.


Formulation of hydrophobic peptides for skin delivery via coated microneedles.

Zhao X, Coulman SA, Hanna SJ, Wong FS, Dayan CM, Birchall JC.

J Control Release. 2017 Nov 10;265:2-13. doi: 10.1016/j.jconrel.2017.03.015. Epub 2017 Mar 9.


An Invitation to Join the Consortium on Thyroid and Pregnancy.

Korevaar TI, Taylor PN, Dayan CM, Peeters RP.

Eur Thyroid J. 2016 Dec;5(4):277. doi: 10.1159/000452331. Epub 2016 Nov 17. No abstract available.


Stimulated urine C-peptide creatinine ratio vs serum C-peptide level for monitoring of β-cell function in the first year after diagnosis of Type 1 diabetes.

Tatovic D, Luzio S, Dunseath G, Liu Y, Alhadj Ali M, Peakman M, Dayan CM; MonoPepT1De Study Group.

Diabet Med. 2016 Nov;33(11):1564-1568. doi: 10.1111/dme.13186. Epub 2016 Aug 8.


An Invitation to Join the Consortium on Thyroid and Pregnancy.

Korevaar TI, Taylor PN, Dayan CM, Peeters RP.

Obstet Gynecol. 2016 Oct;128(4):913. doi: 10.1097/AOG.0000000000001670. No abstract available.


β-cell specific T-lymphocyte response has a distinct inflammatory phenotype in children with Type 1 diabetes compared with adults.

Arif S, Gibson VB, Nguyen V, Bingley PJ, Todd JA, Guy C, Dunger DB, Dayan CM, Powrie J, Lorenc A, Peakman M.

Diabet Med. 2017 Mar;34(3):419-425. doi: 10.1111/dme.13153. Epub 2016 May 30.


Thyroxine replacement: a clinical endocrinologist's viewpoint.

Eligar V, Taylor PN, Okosieme OE, Leese GP, Dayan CM.

Ann Clin Biochem. 2016 Jul;53(Pt 4):421-33. doi: 10.1177/0004563216642255. Epub 2016 Apr 28. Review.


Microneedle delivery of autoantigen for immunotherapy in type 1 diabetes.

Zhao X, Birchall JC, Coulman SA, Tatovic D, Singh RK, Wen L, Wong FS, Dayan CM, Hanna SJ.

J Control Release. 2016 Feb 10;223:178-187. doi: 10.1016/j.jconrel.2015.12.040. Epub 2015 Dec 29.


Paradoxical Relationship Between Body Mass Index and Thyroid Hormone Levels: A Study Using Mendelian Randomization.

Taylor PN, Richmond R, Davies N, Sayers A, Stevenson K, Woltersdorf W, Taylor A, Groom A, Northstone K, Ring S, Okosieme O, Rees A, Nitsch D, Williams GR, Smith GD, Gregory JW, Timpson NJ, Tobias JH, Dayan CM.

J Clin Endocrinol Metab. 2016 Feb;101(2):730-8. doi: 10.1210/jc.2015-3505. Epub 2015 Nov 23.


Reversal of Pathological Features of Graves' Orbitopathy by Activation of Forkhead Transcription Factors, FOXOs.

Zhang L, Ji QH, Ruge F, Lane C, Morris D, Tee AR, Dayan CM, Ludgate M.

J Clin Endocrinol Metab. 2016 Jan;101(1):114-22. doi: 10.1210/jc.2015-2932. Epub 2015 Oct 26.


Future Research in Graves' Orbitopathy: From Priority Setting to Trial Design Through Patient and Public Involvement.

Perros P, Dayan CM, Dickinson AJ, Ezra DG, Hickey JL, Hintschisch C, Kahaly G, Lazarus JH, Ludgate M, Bartès B, MacEwen CJ, Mitchell AL, Morris D, O'Connor N, Pearce SH, Rose GE, Salvi M, Wiersinga WM, Williamson A; Thyroid Eye Disease Amsterdam Declaration Implementation Group UK; European Group on Graves’ Orbitopathy.

Thyroid. 2015 Nov;25(11):1181-4. doi: 10.1089/thy.2015.0222. Epub 2015 Oct 14. No abstract available.


Topical steroid therapy induces pro-tolerogenic changes in Langerhans cells in human skin.

Ali MA, Thrower SL, Hanna SJ, Coulman SA, Birchall JC, Wong FS, Dayan CM, Tatovic D.

Immunology. 2015 Nov;146(3):411-22. doi: 10.1111/imm.12518. Epub 2015 Sep 13.


The sodium iodide symporter is unlikely to be a thyroid/breast shared antigen.

Muller I, Zhang L, Giani C, Dayan CM, Ludgate ME, Grennan-Jones F.

J Endocrinol Invest. 2016 Mar;39(3):323-31. doi: 10.1007/s40618-015-0368-6. Epub 2015 Aug 8.


Genetic abnormalities in thyroid hormone deiodinases.

Taylor PN, Peeters R, Dayan CM.

Curr Opin Endocrinol Diabetes Obes. 2015 Oct;22(5):402-6. doi: 10.1097/MED.0000000000000180. Review.


Fine-Needle Aspiration Biopsy of the Lymph Node: A Novel Tool for the Monitoring of Immune Responses after Skin Antigen Delivery.

Tatovic D, Young P, Kochba E, Levin Y, Wong FS, Dayan CM.

J Immunol. 2015 Jul 1;195(1):386-92. doi: 10.4049/jimmunol.1500364. Epub 2015 May 29.


Erratum: Whole-genome sequence-based analysis of thyroid function.

Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA, Min J, Walter K, Memari Y, Huang J, Barnes MR, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta V, Greenwood C, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman D, Panicker V, Perry JR, Bell JT, Yuan W, Relton C, Gaunt T, Schlessinger D, Abecasis G, Cucca F, Surdulescu GL, Woltersdorf W, Zeggini E, Zheng HF, Toniolo D, Dayan CM, Naitza S, Walsh JP, Spector T, Smith GD, Durbin R, Richards JB, Sanna S, Soranzo N, Timpson NJ, Wilson SG; UK10K Consortium.

Nat Commun. 2015 May 20;6:7172. doi: 10.1038/ncomms8172. No abstract available.


Bariatric surgery in morbidly obese insulin resistant humans normalises insulin signalling but not insulin-stimulated glucose disposal.

Chen MZ, Hudson CA, Vincent EE, de Berker DA, May MT, Hers I, Dayan CM, Andrews RC, Tavaré JM.

PLoS One. 2015 Apr 13;10(4):e0120084. doi: 10.1371/journal.pone.0120084. eCollection 2015.


Evidence for a persistent, major excess in all cause admissions to hospital in children with type-1 diabetes: results from a large Welsh national matched community cohort study.

Sayers A, Thayer D, Harvey JN, Luzio S, Atkinson MD, French R, Warner JT, Dayan CM, Wong SF, Gregory JW.

BMJ Open. 2015 Apr 13;5(4):e005644. doi: 10.1136/bmjopen-2014-005644.


Management of patients with Graves' orbitopathy: initial assessment, management outside specialised centres and referral pathways.

Perros P, Dayan CM, Dickinson AJ, Ezra D, Estcourt S, Foley P, Hickey J, Lazarus JH, MacEwen CJ, McLaren J, Rose GE, Uddin J, Vaidya B.

Clin Med (Lond). 2015 Apr;15(2):173-8. doi: 10.7861/clinmedicine.15-2-173.


Whole-genome sequence-based analysis of thyroid function.

Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M, Brown SJ, Mullin BH, Shihab HA, Min J, Walter K, Memari Y, Huang J, Barnes MR, Beilby JP, Charoen P, Danecek P, Dudbridge F, Forgetta V, Greenwood C, Grundberg E, Johnson AD, Hui J, Lim EM, McCarthy S, Muddyman D, Panicker V, Perry JR, Bell JT, Yuan W, Relton C, Gaunt T, Schlessinger D, Abecasis G, Cucca F, Surdulescu GL, Woltersdorf W, Zeggini E, Zheng HF, Toniolo D, Dayan CM, Naitza S, Walsh JP, Spector T, Davey Smith G, Durbin R, Richards JB, Sanna S, Soranzo N, Timpson NJ, Wilson SG; UK0K Consortium.

Nat Commun. 2015 Mar 6;6:5681. doi: 10.1038/ncomms6681. Erratum in: Nat Commun. 2015;6:7172. Lotchkova, Valentina [corrected to Iotchkova, Valentina]; Quai, Michael A [corrected to Quail, Michael].


Treatment of borderline elevated thyrotropin levels--reply.

Taylor PN, Okosieme OE, Dayan CM.

JAMA Intern Med. 2015 Mar;175(3):466-7. doi: 10.1001/jamainternmed.2014.7862. No abstract available.


The second wave of the Controlled Antenatal Thyroid Screening (CATS II) study: the cognitive assessment protocol.

Hales C, Channon S, Taylor PN, Draman MS, Muller I, Lazarus J, Paradice R, Rees A, Shillabeer D, Gregory JW, Dayan CM, Ludgate M.

BMC Endocr Disord. 2014 Dec 12;14:95. doi: 10.1186/1472-6823-14-95.


β-cell-specific CD8 T cell phenotype in type 1 diabetes reflects chronic autoantigen exposure.

Skowera A, Ladell K, McLaren JE, Dolton G, Matthews KK, Gostick E, Kronenberg-Versteeg D, Eichmann M, Knight RR, Heck S, Powrie J, Bingley PJ, Dayan CM, Miles JJ, Sewell AK, Price DA, Peakman M.

Diabetes. 2015 Mar;64(3):916-925. doi: 10.2337/db14-0332. Epub 2014 Sep 23.


TSH levels and risk of miscarriage in women on long-term levothyroxine: a community-based study.

Taylor PN, Minassian C, Rehman A, Iqbal A, Draman MS, Hamilton W, Dunlop D, Robinson A, Vaidya B, Lazarus JH, Thomas S, Dayan CM, Okosieme OE.

J Clin Endocrinol Metab. 2014 Oct;99(10):3895-902. doi: 10.1210/jc.2014-1954. Epub 2014 Jul 24.


Maternal perchlorate levels in women with borderline thyroid function during pregnancy and the cognitive development of their offspring: data from the Controlled Antenatal Thyroid Study.

Taylor PN, Okosieme OE, Murphy R, Hales C, Chiusano E, Maina A, Joomun M, Bestwick JP, Smyth P, Paradice R, Channon S, Braverman LE, Dayan CM, Lazarus JH, Pearce EN.

J Clin Endocrinol Metab. 2014 Nov;99(11):4291-8. doi: 10.1210/jc.2014-1901. Epub 2014 Jul 24.


Description and evaluation of the first national patient and public involvement day for thyroid eye disease in the United Kingdom.

Smith HB, Porteous C, Bunce C, Bonstein K, Hickey J, Dayan CM, Adams G, Rose GE, Ezra DG.

Thyroid. 2014 Sep;24(9):1400-6. doi: 10.1089/thy.2014.0200. Epub 2014 Jul 21.


Sedentary time and markers of inflammation in people with newly diagnosed type 2 diabetes.

Falconer CL, Cooper AR, Walhin JP, Thompson D, Page AS, Peters TJ, Montgomery AA, Sharp DJ, Dayan CM, Andrews RC.

Nutr Metab Cardiovasc Dis. 2014 Sep;24(9):956-62. doi: 10.1016/j.numecd.2014.03.009. Epub 2014 Apr 26.


Hypothyroidism and depression.

Dayan CM, Panicker V.

Eur Thyroid J. 2013 Sep;2(3):168-79. doi: 10.1159/000353777. Epub 2013 Aug 27. Review.


Long-term outcome in patients with severe alcoholic hepatitis can be reliably determined using an in vitro measure of steroid sensitivity.

Dhanda AD, di Mambro AJ, Hunt VL, McCune CA, Dayan CM, Dick AD, Lee RW, Collins PL.

Hepatology. 2015 Mar;61(3):1099. doi: 10.1002/hep.27211. Epub 2014 Jul 31. No abstract available.


Possible targets for nonimmunosuppressive therapy of Graves' orbitopathy.

Zhang L, Grennan-Jones F, Draman MS, Lane C, Morris D, Dayan CM, Tee AR, Ludgate M.

J Clin Endocrinol Metab. 2014 Jul;99(7):E1183-90. doi: 10.1210/jc.2013-4182. Epub 2014 Apr 23.


Efficacy and safety of low-dose otelixizumab anti-CD3 monoclonal antibody in preserving C-peptide secretion in adolescent type 1 diabetes: DEFEND-2, a randomized, placebo-controlled, double-blind, multi-centre study.

Ambery P, Donner TW, Biswas N, Donaldson J, Parkin J, Dayan CM.

Diabet Med. 2014 Apr;31(4):399-402. doi: 10.1111/dme.12361. Epub 2013 Dec 6.


Does thyroid peroxidase provide an antigenic link between thyroid autoimmunity and breast cancer?

Muller I, Giani C, Zhang L, Grennan-Jones FA, Fiore E, Belardi V, Rosellini V, Funel N, Campani D, Giustarini E, Lewis MD, Bakhsh AD, Roncella M, Ghilli M, Vitti P, Dayan CM, Ludgate ME.

Int J Cancer. 2014 Apr 1;134(7):1706-14. doi: 10.1002/ijc.28493. Epub 2013 Oct 15.


Therapy of endocrine disease: Impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis.

Taylor PN, Okosieme OE, Dayan CM, Lazarus JH.

Eur J Endocrinol. 2013 Oct 2;170(1):R1-R15. doi: 10.1530/EJE-13-0651. Print 2014 Jan. Review.


Clinical review: A review of the clinical consequences of variation in thyroid function within the reference range.

Taylor PN, Razvi S, Pearce SH, Dayan CM.

J Clin Endocrinol Metab. 2013 Sep;98(9):3562-71. doi: 10.1210/jc.2013-1315. Epub 2013 Jul 3. Review.


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