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Items: 1 to 50 of 130

1.

Very rapid flow cytometric assessment of antimicrobial susceptibility during the apparent lag phase of microbial (re)growth.

Jindal S, Thampy H, Day PJR, Kell DB.

Microbiology. 2019 Apr;165(4):439-454. doi: 10.1099/mic.0.000777. Epub 2019 Feb 11.

PMID:
30741628
2.

Peripheral blood RNA gene expression in children with pneumococcal meningitis: a prospective case-control study.

Kulohoma BW, Marriage F, Vasieva O, Mankhambo L, Nguyen K, Molyneux ME, Molyneux EM, Day PJR, Carrol ED.

BMJ Paediatr Open. 2017 Aug 31;1(1):e000092. doi: 10.1136/bmjpo-2017-000092. eCollection 2017.

3.

GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles.

O'Hagan S, Wright Muelas M, Day PJ, Lundberg E, Kell DB.

Cell Syst. 2018 Feb 28;6(2):230-244.e1. doi: 10.1016/j.cels.2018.01.003. Epub 2018 Feb 7.

4.

Integrative analysis of rewired central metabolism in temozolomide resistant cells.

Immanuel SRC, Ghanate AD, Parmar DS, Marriage F, Panchagnula V, Day PJ, Raghunathan A.

Biochem Biophys Res Commun. 2018 Jan 8;495(2):2010-2016. doi: 10.1016/j.bbrc.2017.12.073. Epub 2017 Dec 14.

PMID:
29248726
5.

Endoplasmic reticulum chaperone prolyl 4-hydroxylase, beta polypeptide (P4HB) promotes malignant phenotypes in glioma via MAPK signaling.

Sun S, Kiang KMY, Ho ASW, Lee D, Poon MW, Xu FF, Pu JKS, Kan ANC, Lee NPY, Liu XB, Man K, Day PJR, Lui WM, Fung CF, Leung GKK.

Oncotarget. 2017 May 19;8(42):71911-71923. doi: 10.18632/oncotarget.18026. eCollection 2017 Sep 22.

6.
7.

Computing exponentially faster: implementing a non-deterministic universal Turing machine using DNA.

Currin A, Korovin K, Ababi M, Roper K, Kell DB, Day PJ, King RD.

J R Soc Interface. 2017 Mar;14(128). pii: 20160990. doi: 10.1098/rsif.2016.0990.

8.

L-β-N-methylamino-l-alanine (BMAA) nitrosation generates a cytotoxic DNA damaging alkylating agent: An unexplored mechanism for neurodegenerative disease.

Potjewyd G, Day PJ, Shangula S, Margison GP, Povey AC.

Neurotoxicology. 2017 Mar;59:105-109. doi: 10.1016/j.neuro.2017.01.007. Epub 2017 Feb 3.

PMID:
28163087
9.

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2).

Woolford AJ, Day PJ, Bénéton V, Berdini V, Coyle JE, Dudit Y, Grondin P, Huet P, Lee LY, Manas ES, McMenamin RL, Murray CW, Page LW, Patel VK, Potvain F, Rich SJ, Sang Y, Somers DO, Trottet L, Wan Z, Zhang X.

J Med Chem. 2016 Dec 8;59(23):10738-10749. Epub 2016 Nov 18.

PMID:
27933945
10.

SpeedyGenes: Exploiting an Improved Gene Synthesis Method for the Efficient Production of Synthetic Protein Libraries for Directed Evolution.

Currin A, Swainston N, Day PJ, Kell DB.

Methods Mol Biol. 2017;1472:63-78. doi: 10.1007/978-1-4939-6343-0_5.

PMID:
27671932
11.

Systematic protein-protein interaction and pathway analyses in the idiopathic inflammatory myopathies.

Parkes JE, Rothwell S, Day PJ, McHugh NJ, Betteridge ZE, Cooper RG, Ollier WE, Chinoy H, Lamb JA; Myositis Genetics Consortium (MYOGEN).

Arthritis Res Ther. 2016 Jul 7;18(1):156. doi: 10.1186/s13075-016-1061-7.

12.

Integrated Electrowetting Nanoinjector for Single Cell Transfection.

Shekaramiz E, Varadarajalu G, Day PJ, Wickramasinghe HK.

Sci Rep. 2016 Jul 4;6:29051. doi: 10.1038/srep29051.

13.

Transcriptome analysis of human ageing in male skin shows mid-life period of variability and central role of NF-κB.

Haustead DJ, Stevenson A, Saxena V, Marriage F, Firth M, Silla R, Martin L, Adcroft KF, Rea S, Day PJ, Melton P, Wood FM, Fear MW.

Sci Rep. 2016 May 27;6:26846. doi: 10.1038/srep26846.

14.

Exploitation of a Novel Binding Pocket in Human Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Discovered through X-ray Fragment Screening.

Woolford AJ, Pero JE, Aravapalli S, Berdini V, Coyle JE, Day PJ, Dodson AM, Grondin P, Holding FP, Lee LY, Li P, Manas ES, Marino J Jr, Martin AC, McCleland BW, McMenamin RL, Murray CW, Neipp CE, Page LW, Patel VK, Potvain F, Rich S, Rivero RA, Smith K, Somers DO, Trottet L, Velagaleti R, Williams G, Xie R.

J Med Chem. 2016 Jun 9;59(11):5356-67. doi: 10.1021/acs.jmedchem.6b00212. Epub 2016 May 20.

PMID:
27167608
15.

The role of microRNAs in the idiopathic inflammatory myopathies.

Parkes JE, Day PJ, Chinoy H, Lamb JA.

Curr Opin Rheumatol. 2015 Nov;27(6):608-15. doi: 10.1097/BOR.0000000000000225. Review.

PMID:
26398013
16.

Systems Medicine: The Application of Systems Biology Approaches for Modern Medical Research and Drug Development.

Ayers D, Day PJ.

Mol Biol Int. 2015;2015:698169. doi: 10.1155/2015/698169. Epub 2015 Aug 18. Review.

17.

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP.

Chessari G, Buck IM, Day JE, Day PJ, Iqbal A, Johnson CN, Lewis EJ, Martins V, Miller D, Reader M, Rees DC, Rich SJ, Tamanini E, Vitorino M, Ward GA, Williams PA, Williams G, Wilsher NE, Woolford AJ.

J Med Chem. 2015 Aug 27;58(16):6574-88. doi: 10.1021/acs.jmedchem.5b00706. Epub 2015 Aug 7.

PMID:
26218264
18.

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors.

Murray CW, Berdini V, Buck IM, Carr ME, Cleasby A, Coyle JE, Curry JE, Day JE, Day PJ, Hearn K, Iqbal A, Lee LY, Martins V, Mortenson PN, Munck JM, Page LW, Patel S, Roomans S, Smith K, Tamanini E, Saxty G.

ACS Med Chem Lett. 2015 Jun 4;6(7):798-803. doi: 10.1021/acsmedchemlett.5b00143. eCollection 2015 Jul 9.

19.

Structure-Based Design of Type II Inhibitors Applied to Maternal Embryonic Leucine Zipper Kinase.

Johnson CN, Adelinet C, Berdini V, Beke L, Bonnet P, Brehmer D, Calo F, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA, Hamlett CC, Howard S, Meerpoel L, Mevellec L, McMenamin R, Pasquier E, Patel S, Rees DC, Linders JT.

ACS Med Chem Lett. 2014 May 23;6(1):31-6. doi: 10.1021/ml5001273. eCollection 2015 Jan 8.

20.

Fragment-based discovery of type I inhibitors of maternal embryonic leucine zipper kinase.

Johnson CN, Berdini V, Beke L, Bonnet P, Brehmer D, Coyle JE, Day PJ, Frederickson M, Freyne EJ, Gilissen RA, Hamlett CC, Howard S, Meerpoel L, McMenamin R, Patel S, Rees DC, Sharff A, Sommen F, Wu T, Linders JT.

ACS Med Chem Lett. 2014 May 23;6(1):25-30. doi: 10.1021/ml5001245. eCollection 2015 Jan 8.

21.

Synthetic biology for the directed evolution of protein biocatalysts: navigating sequence space intelligently.

Currin A, Swainston N, Day PJ, Kell DB.

Chem Soc Rev. 2015 Mar 7;44(5):1172-239. doi: 10.1039/c4cs00351a. Review.

22.

SpeedyGenes: an improved gene synthesis method for the efficient production of error-corrected, synthetic protein libraries for directed evolution.

Currin A, Swainston N, Day PJ, Kell DB.

Protein Eng Des Sel. 2014 Sep;27(9):273-80. doi: 10.1093/protein/gzu029. Epub 2014 Aug 9.

23.

Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO.

Cleasby A, Yon J, Day PJ, Richardson C, Tickle IJ, Williams PA, Callahan JF, Carr R, Concha N, Kerns JK, Qi H, Sweitzer T, Ward P, Davies TG.

PLoS One. 2014 Jun 4;9(6):e98896. doi: 10.1371/journal.pone.0098896. eCollection 2014.

24.

GeneGenie: optimized oligomer design for directed evolution.

Swainston N, Currin A, Day PJ, Kell DB.

Nucleic Acids Res. 2014 Jul;42(Web Server issue):W395-400. doi: 10.1093/nar/gku336. Epub 2014 Apr 29.

25.

The IFN-λ Genetic Polymorphism Association With the Viral Clearance Induced by Hepatitis C Virus Treatment in Pakistani Patients.

Tipu I, Marriage F, Farooqi ZU, Platt H, Athar MA, Day PJ, Short A.

Hepat Mon. 2014 Mar 9;14(3):e15076. doi: 10.5812/hepatmon.15076. eCollection 2014 Mar.

26.

Microfluidic channel-assisted screening of hematopoietic malignancies.

Mughal F, Baldock SJ, Karimiani EG, Telford N, Goddard NJ, Day PJ.

Genes Chromosomes Cancer. 2014 Mar;53(3):255-63. doi: 10.1002/gcc.22137. Epub 2013 Dec 16.

PMID:
24339206
27.

Single-cell analysis of K562 cells: an imatinib-resistant subpopulation is adherent and has upregulated expression of BCR-ABL mRNA and protein.

Karimiani EG, Marriage F, Merritt AJ, Burthem J, Byers RJ, Day PJ.

Exp Hematol. 2014 Mar;42(3):183-191.e5. doi: 10.1016/j.exphem.2013.11.006. Epub 2013 Nov 20.

PMID:
24269846
28.

Cytokeratin 15 marks basal epithelia in developing ureters and is upregulated in a subset of urothelial cell carcinomas.

Tai G, Ranjzad P, Marriage F, Rehman S, Denley H, Dixon J, Mitchell K, Day PJ, Woolf AS.

PLoS One. 2013 Nov 18;8(11):e81167. doi: 10.1371/journal.pone.0081167. eCollection 2013.

29.

The need for transparency and good practices in the qPCR literature.

Bustin SA, Benes V, Garson J, Hellemans J, Huggett J, Kubista M, Mueller R, Nolan T, Pfaffl MW, Shipley G, Wittwer CT, Schjerling P, Day PJ, Abreu M, Aguado B, Beaulieu JF, Beckers A, Bogaert S, Browne JA, Carrasco-Ramiro F, Ceelen L, Ciborowski K, Cornillie P, Coulon S, Cuypers A, De Brouwer S, De Ceuninck L, De Craene J, De Naeyer H, De Spiegelaere W, Deckers K, Dheedene A, Durinck K, Ferreira-Teixeira M, Fieuw A, Gallup JM, Gonzalo-Flores S, Goossens K, Heindryckx F, Herring E, Hoenicka H, Icardi L, Jaggi R, Javad F, Karampelias M, Kibenge F, Kibenge M, Kumps C, Lambertz I, Lammens T, Markey A, Messiaen P, Mets E, Morais S, Mudarra-Rubio A, Nakiwala J, Nelis H, Olsvik PA, Pérez-Novo C, Plusquin M, Remans T, Rihani A, Rodrigues-Santos P, Rondou P, Sanders R, Schmidt-Bleek K, Skovgaard K, Smeets K, Tabera L, Toegel S, Van Acker T, Van den Broeck W, Van der Meulen J, Van Gele M, Van Peer G, Van Poucke M, Van Roy N, Vergult S, Wauman J, Tshuikina-Wiklander M, Willems E, Zaccara S, Zeka F, Vandesompele J.

Nat Methods. 2013 Nov;10(11):1063-7. doi: 10.1038/nmeth.2697.

PMID:
24173381
30.

HA-coated chitosan nanoparticles for CD44-mediated nucleic acid delivery.

Almalik A, Day PJ, Tirelli N.

Macromol Biosci. 2013 Dec;13(12):1671-80. doi: 10.1002/mabi.201300302. Epub 2013 Sep 17.

PMID:
24106105
31.

Hyaluronic acid-coated chitosan nanoparticles: molecular weight-dependent effects on morphology and hyaluronic acid presentation.

Almalik A, Donno R, Cadman CJ, Cellesi F, Day PJ, Tirelli N.

J Control Release. 2013 Dec 28;172(3):1142-50. doi: 10.1016/j.jconrel.2013.09.032. Epub 2013 Oct 6.

PMID:
24103813
32.

Hyaluronic acid (HA) presentation as a tool to modulate and control the receptor-mediated uptake of HA-coated nanoparticles.

Almalik A, Karimi S, Ouasti S, Donno R, Wandrey C, Day PJ, Tirelli N.

Biomaterials. 2013 Jul;34(21):5369-80. doi: 10.1016/j.biomaterials.2013.03.065. Epub 2013 Apr 21.

PMID:
23615561
33.

Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways.

Sun S, Lee D, Ho AS, Pu JK, Zhang XQ, Lee NP, Day PJ, Lui WM, Fung CF, Leung GK.

Neuro Oncol. 2013 May;15(5):562-77. doi: 10.1093/neuonc/not005. Epub 2013 Feb 26.

34.

Shortened telomere length in patients with systemic lupus erythematosus.

Haque S, Rakieh C, Marriage F, Ho P, Gorodkin R, Teh LS, Snowden N, Day PJ, Bruce IN.

Arthritis Rheum. 2013 May;65(5):1319-23. doi: 10.1002/art.37895.

35.

Mathematical modelling of miRNA mediated BCR.ABL protein regulation in chronic myeloid leukaemia vis-a-vis therapeutic strategies.

Verma M, Karimiani EG, Byers RJ, Rehman S, Westerhoff HV, Day PJ.

Integr Biol (Camb). 2013 Mar;5(3):543-54. doi: 10.1039/c3ib20230e.

PMID:
23340812
36.

Understanding Dupuytren's Disease Using Systems Biology: A Move Away from Reductionism.

Rehman S, Day PJ, Bayat A, Westerhoff HV.

Front Physiol. 2012 Aug 9;3:316. doi: 10.3389/fphys.2012.00316. eCollection 2012. No abstract available.

37.

Perturbation of cell cycle expression in keloid fibroblast.

Javad F, Marriage F, Bayat A, Day PJ.

Skinmed. 2012 May-Jun;10(3):152-9.

PMID:
22779097
38.

Dupuytren's disease metabolite analyses reveals alterations following initial short-term fibroblast culturing.

Rehman S, Xu Y, Dunn WB, Day PJ, Westerhoff HV, Goodacre R, Bayat A.

Mol Biosyst. 2012 Sep;8(9):2274-88. Epub 2012 Jul 6.

PMID:
22772395
39.

Novel biomarker combination improves the diagnosis of serious bacterial infections in Malawian children.

Irwin AD, Marriage F, Mankhambo LA; IPD Group Study, Jeffers G, Kolamunnage-Dona R, Guiver M, Denis B, Molyneux EM, Molyneux ME, Day PJ, Carrol ED.

BMC Med Genomics. 2012 May 4;5:13. doi: 10.1186/1755-8794-5-13.

40.

Protein profiling of keloidal scar tissue.

Javad F, Day PJ.

Arch Dermatol Res. 2012 Sep;304(7):533-40. doi: 10.1007/s00403-012-1224-6. Epub 2012 Mar 11.

PMID:
22407076
41.

Protein alterations associated with temozolomide resistance in subclones of human glioblastoma cell lines.

Sun S, Wong TS, Zhang XQ, Pu JK, Lee NP, Day PJ, Ng GK, Lui WM, Leung GK.

J Neurooncol. 2012 Mar;107(1):89-100. doi: 10.1007/s11060-011-0729-8. Epub 2011 Oct 7.

42.

Dupuytren's: a systems biology disease.

Rehman S, Goodacre R, Day PJ, Bayat A, Westerhoff HV.

Arthritis Res Ther. 2011;13(5):238. doi: 10.1186/ar3438. Epub 2011 Sep 12. Review.

43.
44.

Human papilloma virus strain detection utilising custom-designed oligonucleotide microarrays.

Ayers D, Platt M, Javad F, Day PJ.

Methods Mol Biol. 2011;688:75-95. doi: 10.1007/978-1-60761-947-5_7.

PMID:
20938834
45.

Convergent evolution to an aptamer observed in small populations on DNA microarrays.

Rowe W, Platt M, Wedge DC, Day PJ, Kell DB, Knowles JD.

Phys Biol. 2010 Sep 1;7(3):036007. doi: 10.1088/1478-3975/7/3/036007.

PMID:
20811084
46.

Discovery of (2,4-dihydroxy-5-isopropylphenyl)-[5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl]methanone (AT13387), a novel inhibitor of the molecular chaperone Hsp90 by fragment based drug design.

Woodhead AJ, Angove H, Carr MG, Chessari G, Congreve M, Coyle JE, Cosme J, Graham B, Day PJ, Downham R, Fazal L, Feltell R, Figueroa E, Frederickson M, Lewis J, McMenamin R, Murray CW, O'Brien MA, Parra L, Patel S, Phillips T, Rees DC, Rich S, Smith DM, Trewartha G, Vinkovic M, Williams B, Woolford AJ.

J Med Chem. 2010 Aug 26;53(16):5956-69. doi: 10.1021/jm100060b.

PMID:
20662534
47.

Applications of modern micro-Raman spectroscopy for cell analyses.

Mariani MM, Day PJ, Deckert V.

Integr Biol (Camb). 2010 Mar;2(2-3):94-101. doi: 10.1039/b920572a. Epub 2010 Feb 9.

PMID:
20473387
48.

Systems biology and modeling in neuroblastoma: practicalities and perspectives.

Logan JA, Kelly ME, Ayers D, Shipillis N, Baier G, Day PJ.

Expert Rev Mol Diagn. 2010 Mar;10(2):131-45. doi: 10.1586/erm.10.4. Review.

PMID:
20214533
49.

Spectrophotometric analysis of nucleic acids: oxygenation-dependent hyperchromism of DNA.

Doshi R, Day PJ, Carampin P, Blanch E, Stratford IJ, Tirelli N.

Anal Bioanal Chem. 2010 Mar;396(6):2331-9. doi: 10.1007/s00216-010-3461-x. Epub 2010 Feb 19.

PMID:
20169336
50.

Proteomics of hepatocellular carcinoma: serum vimentin as a surrogate marker for small tumors (<or=2 cm).

Sun S, Poon RT, Lee NP, Yeung C, Chan KL, Ng IO, Day PJ, Luk JM.

J Proteome Res. 2010 Apr 5;9(4):1923-30. doi: 10.1021/pr901085z.

PMID:
20121168

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