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Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases.

Omar F, Findlay JE, Carfray G, Allcock RW, Jiang Z, Moore C, Muir AL, Lannoy M, Fertig BA, Mai D, Day JP, Bolger G, Baillie GS, Schwiebert E, Klussmann E, Pyne NJ, Ong ACM, Bowers K, Adam JM, Adams DR, Houslay MD, Henderson DJP.

Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13320-13329. doi: 10.1073/pnas.1822113116. Epub 2019 Jun 17.


A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signaling.

Vagena E, Ryu JK, Baeza-Raja B, Walsh NM, Syme C, Day JP, Houslay MD, Baillie GS.

Transl Psychiatry. 2019 May 10;9(1):141. doi: 10.1038/s41398-019-0470-1.


Host-pathogen coevolution increases genetic variation in susceptibility to infection.

Duxbury EM, Day JP, Maria Vespasiani D, Thüringer Y, Tolosana I, Smith SC, Tagliaferri L, Kamacioglu A, Lindsley I, Love L, Unckless RL, Jiggins FM, Longdon B.

Elife. 2019 Apr 30;8. pii: e46440. doi: 10.7554/eLife.46440.


Parallel adaptation of rabbit populations to myxoma virus.

Alves JM, Carneiro M, Cheng JY, Lemos de Matos A, Rahman MM, Loog L, Campos PF, Wales N, Eriksson A, Manica A, Strive T, Graham SC, Afonso S, Bell DJ, Belmont L, Day JP, Fuller SJ, Marchandeau S, Palmer WJ, Queney G, Surridge AK, Vieira FG, McFadden G, Nielsen R, Gilbert MTP, Esteves PJ, Ferrand N, Jiggins FM.

Science. 2019 Mar 22;363(6433):1319-1326. doi: 10.1126/science.aau7285. Epub 2019 Feb 14.


RAB40C regulates RACK1 stability via the ubiquitin-proteasome system.

Day JP, Whiteley E, Freeley M, Long A, Malacrida B, Kiely P, Baillie GS.

Future Sci OA. 2018 Jul 2;4(7):FSO317. doi: 10.4155/fsoa-2018-0022. eCollection 2018 Jul.


Host shifts result in parallel genetic changes when viruses evolve in closely related species.

Longdon B, Day JP, Alves JM, Smith SCL, Houslay TM, McGonigle JE, Tagliaferri L, Jiggins FM.

PLoS Pathog. 2018 Apr 12;14(4):e1006951. doi: 10.1371/journal.ppat.1006951. eCollection 2018 Apr.


Parallel and costly changes to cellular immunity underlie the evolution of parasitoid resistance in three Drosophila species.

McGonigle JE, Leitão AB, Ommeslag S, Smith S, Day JP, Jiggins FM.

PLoS Pathog. 2017 Oct 19;13(10):e1006683. doi: 10.1371/journal.ppat.1006683. eCollection 2017 Oct.


FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.

Yalla K, Elliott C, Day JP, Findlay J, Barratt S, Hughes ZA, Wilson L, Whiteley E, Popiolek M, Li Y, Dunlop J, Killick R, Adams DR, Brandon NJ, Houslay MD, Hao B, Baillie GS.

Mol Psychiatry. 2018 May;23(5):1278-1286. doi: 10.1038/mp.2017.138. Epub 2017 Jul 20.


Symbiont strain is the main determinant of variation in Wolbachia-mediated protection against viruses across Drosophila species.

Martinez J, Tolosana I, Ok S, Smith S, Snoeck K, Day JP, Jiggins FM.

Mol Ecol. 2017 Aug;26(15):4072-4084. doi: 10.1111/mec.14164. Epub 2017 May 30.


Population genomics reveals that an anthropophilic population of Aedes aegypti mosquitoes in West Africa recently gave rise to American and Asian populations of this major disease vector.

Crawford JE, Alves JM, Palmer WJ, Day JP, Sylla M, Ramasamy R, Surendran SN, Black WC 4th, Pain A, Jiggins FM.

BMC Biol. 2017 Feb 28;15(1):16. doi: 10.1186/s12915-017-0351-0.


Vertically transmitted rhabdoviruses are found across three insect families and have dynamic interactions with their hosts.

Longdon B, Day JP, Schulz N, Leftwich PT, de Jong MA, Breuker CJ, Gibbs M, Obbard DJ, Wilfert L, Smith SC, McGonigle JE, Houslay TM, Wright LI, Livraghi L, Evans LC, Friend LA, Chapman T, Vontas J, Kambouraki N, Jiggins FM.

Proc Biol Sci. 2017 Jan 25;284(1847). pii: 20162381. doi: 10.1098/rspb.2016.2381.


Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42-mediated cytotoxicity.

Cameron RT, Whiteley E, Day JP, Parachikova AI, Baillie GS.

FEBS Open Bio. 2016 Dec 5;7(1):64-73. doi: 10.1002/2211-5463.12156. eCollection 2017 Jan.


The evolution, diversity, and host associations of rhabdoviruses.

Longdon B, Murray GG, Palmer WJ, Day JP, Parker DJ, Welch JJ, Obbard DJ, Jiggins FM.

Virus Evol. 2015 Nov 13;1(1):vev014. eCollection 2015.


Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1.

Havekes R, Park AJ, Tudor JC, Luczak VG, Hansen RT, Ferri SL, Bruinenberg VM, Poplawski SG, Day JP, Aton SJ, Radwańska K, Meerlo P, Houslay MD, Baillie GS, Abel T.

Elife. 2016 Aug 23;5. pii: e13424. doi: 10.7554/eLife.13424.


SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex.

Tankou S, Ishii K, Elliott C, Yalla KC, Day JP, Furukori K, Kubo KI, Brandon NJ, Tang Q, Hayward G, Nakajima K, Houslay MD, Kamiya A, Baillie G, Ishizuka K, Sawa A.

Mol Neuropsychiatry. 2016 May;2(1):20-27. Epub 2016 Mar 15.


The genetic architecture of resistance to virus infection in Drosophila.

Cogni R, Cao C, Day JP, Bridson C, Jiggins FM.

Mol Ecol. 2016 Oct;25(20):5228-5241. doi: 10.1111/mec.13769. Epub 2016 Aug 26.


Deletion of the hemopexin or heme oxygenase-2 gene aggravates brain injury following stroma-free hemoglobin-induced intracerebral hemorrhage.

Ma B, Day JP, Phillips H, Slootsky B, Tolosano E, Doré S.

J Neuroinflammation. 2016 Feb 1;13:26. doi: 10.1186/s12974-016-0490-1.


A gene associated with social immunity in the burying beetle Nicrophorus vespilloides.

Palmer WJ, Duarte A, Schrader M, Day JP, Kilner R, Jiggins FM.

Proc Biol Sci. 2016 Jan 27;283(1823). pii: 20152733. doi: 10.1098/rspb.2015.2733. Epub 2016 Jan 27.


Should Symbionts Be Nice or Selfish? Antiviral Effects of Wolbachia Are Costly but Reproductive Parasitism Is Not.

Martinez J, Ok S, Smith S, Snoeck K, Day JP, Jiggins FM.

PLoS Pathog. 2015 Jul 1;11(7):e1005021. doi: 10.1371/journal.ppat.1005021. eCollection 2015 Jul.


The causes and consequences of changes in virulence following pathogen host shifts.

Longdon B, Hadfield JD, Day JP, Smith SC, McGonigle JE, Cogni R, Cao C, Jiggins FM.

PLoS Pathog. 2015 Mar 16;11(3):e1004728. doi: 10.1371/journal.ppat.1004728. eCollection 2015 Mar.


Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains.

Bolger GB, Dunlop AJ, Meng D, Day JP, Klussmann E, Baillie GS, Adams DR, Houslay MD.

Cell Signal. 2015 Apr;27(4):756-69. doi: 10.1016/j.cellsig.2014.12.009. Epub 2014 Dec 27.


Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis.

Kaname T, Ki CS, Niikawa N, Baillie GS, Day JP, Yamamura K, Ohta T, Nishimura G, Mastuura N, Kim OH, Sohn YB, Kim HW, Cho SY, Ko AR, Lee JY, Kim HW, Ryu SH, Rhee H, Yang KS, Joo K, Lee J, Kim CH, Cho KH, Kim D, Yanagi K, Naritomi K, Yoshiura K, Kondoh T, Nii E, Tonoki H, Houslay MD, Jin DK.

Cell Signal. 2014 Nov;26(11):2446-59. doi: 10.1016/j.cellsig.2014.07.025. Epub 2014 Jul 24.


Coherent anti-Stokes Raman scattering microspectroscopic kinetic study of fast hydrogen bond formation in microfluidic devices.

Oshovsky GV, Rago G, Day JP, Soudijn ML, Rock W, Parekh SH, Ciancaleoni G, Reek JN, Bonn M.

Anal Chem. 2013 Oct 1;85(19):8923-7. doi: 10.1021/ac402233n. Epub 2013 Sep 16.


Phosphodiesterase-8A binds to and regulates Raf-1 kinase.

Brown KM, Day JP, Huston E, Zimmermann B, Hampel K, Christian F, Romano D, Terhzaz S, Lee LC, Willis MJ, Morton DB, Beavo JA, Shimizu-Albergine M, Davies SA, Kolch W, Houslay MD, Baillie GS.

Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):E1533-42. doi: 10.1073/pnas.1303004110. Epub 2013 Mar 18.


Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4).

Cameron RT, Coleman RG, Day JP, Yalla KC, Houslay MD, Adams DR, Shoichet BK, Baillie GS.

Biochem Pharmacol. 2013 May 1;85(9):1297-305. doi: 10.1016/j.bcp.2013.02.026. Epub 2013 Mar 5.


Gravin orchestrates protein kinase A and β2-adrenergic receptor signaling critical for synaptic plasticity and memory.

Havekes R, Canton DA, Park AJ, Huang T, Nie T, Day JP, Guercio LA, Grimes Q, Luczak V, Gelman IH, Baillie GS, Scott JD, Abel T.

J Neurosci. 2012 Dec 12;32(50):18137-49. doi: 10.1523/JNEUROSCI.3612-12.2012.


Consolidated and labile odor memory are separately encoded within the Drosophila brain.

Scheunemann L, Jost E, Richlitzki A, Day JP, Sebastian S, Thum AS, Efetova M, Davies SA, Schwärzel M.

J Neurosci. 2012 Nov 28;32(48):17163-71. doi: 10.1523/JNEUROSCI.3286-12.2012.


Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation.

Brown KM, Lee LC, Findlay JE, Day JP, Baillie GS.

FEBS Lett. 2012 Jun 4;586(11):1631-7. doi: 10.1016/j.febslet.2012.04.033. Epub 2012 May 3.


Host-guest geometry in pores of zeolite ZSM-5 spatially resolved with multiplex CARS spectromicroscopy.

Domke KF, Day JP, Rago G, Riemer TA, Kox MH, Weckhuysen BM, Bonn M.

Angew Chem Int Ed Engl. 2012 Feb 6;51(6):1343-7. doi: 10.1002/anie.201106447. Epub 2011 Nov 11. No abstract available.


CARS microscopy for the visualization of micrometer-sized iron oxide MRI contrast agents in living cells.

Rago G, Langer CM, Brackman C, Day JP, Domke KF, Raschzok N, Schmidt C, Sauer IM, Enejder A, Mogl MT, Bonn M.

Biomed Opt Express. 2011 Sep 1;2(9):2470-83. doi: 10.1364/BOE.2.002470. Epub 2011 Jul 29.


Quantitative coherent anti-Stokes Raman scattering (CARS) microscopy.

Day JP, Domke KF, Rago G, Kano H, Hamaguchi HO, Vartiainen EM, Bonn M.

J Phys Chem B. 2011 Jun 23;115(24):7713-25. doi: 10.1021/jp200606e. Epub 2011 Apr 28.


Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4).

Day JP, Lindsay B, Riddell T, Jiang Z, Allcock RW, Abraham A, Sookup S, Christian F, Bogum J, Martin EK, Rae RL, Anthony D, Rosair GM, Houslay DM, Huston E, Baillie GS, Klussmann E, Houslay MD, Adams DR.

J Med Chem. 2011 May 12;54(9):3331-47. doi: 10.1021/jm200070e. Epub 2011 Apr 13.


Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)-HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes.

Sin YY, Edwards HV, Li X, Day JP, Christian F, Dunlop AJ, Adams DR, Zaccolo M, Houslay MD, Baillie GS.

J Mol Cell Cardiol. 2011 May;50(5):872-83. doi: 10.1016/j.yjmcc.2011.02.006. Epub 2011 Feb 18.


β-Arrestin 1 inhibits the GTPase-activating protein function of ARHGAP21, promoting activation of RhoA following angiotensin II type 1A receptor stimulation.

Anthony DF, Sin YY, Vadrevu S, Advant N, Day JP, Byrne AM, Lynch MJ, Milligan G, Houslay MD, Baillie GS.

Mol Cell Biol. 2011 Mar;31(5):1066-75. doi: 10.1128/MCB.00883-10. Epub 2010 Dec 20.


Quantitative CARS molecular fingerprinting of single living cells with the use of the maximum entropy method.

Okuno M, Kano H, Leproux P, Couderc V, Day JP, Bonn M, Hamaguchi HO.

Angew Chem Int Ed Engl. 2010 Sep 10;49(38):6773-7. doi: 10.1002/anie.201001560. No abstract available.


p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways.

Christian F, Anthony DF, Vadrevu S, Riddell T, Day JP, McLeod R, Adams DR, Baillie GS, Houslay MD.

Cell Signal. 2010 Oct;22(10):1576-96. doi: 10.1016/j.cellsig.2010.06.003. Epub 2010 Jun 19.


Label-free imaging of lipophilic bioactive molecules during lipid digestion by multiplex coherent anti-Stokes Raman scattering microspectroscopy.

Day JP, Rago G, Domke KF, Velikov KP, Bonn M.

J Am Chem Soc. 2010 Jun 23;132(24):8433-9. doi: 10.1021/ja102069d.


Ellipsometric study of the displacement of milk proteins from the oil-water interface by the non-ionic surfactant C(10)E(8).

Day JP, Pudney PD, Bain CD.

Phys Chem Chem Phys. 2010 May 14;12(18):4590-9. doi: 10.1039/b921887d. Epub 2010 Mar 16.


Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes.

Kelly MP, Logue SF, Brennan J, Day JP, Lakkaraju S, Jiang L, Zhong X, Tam M, Sukoff Rizzo SJ, Platt BJ, Dwyer JM, Neal S, Pulito VL, Agostino MJ, Grauer SM, Navarra RL, Kelley C, Comery TA, Murrills RJ, Houslay MD, Brandon NJ.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8457-62. doi: 10.1073/pnas.1000730107. Epub 2010 Apr 19.


Label-free chemical imaging of catalytic solids by coherent anti-Stokes Raman scattering and synchrotron-based infrared microscopy.

Kox MH, Domke KF, Day JP, Rago G, Stavitski E, Bonn M, Weckhuysen BM.

Angew Chem Int Ed Engl. 2009;48(47):8990-4. doi: 10.1002/anie.200904282. No abstract available.


Identification of two partners from the bacterial Kef exchanger family for the apical plasma membrane V-ATPase of Metazoa.

Day JP, Wan S, Allan AK, Kean L, Davies SA, Gray JV, Dow JA.

J Cell Sci. 2008 Aug 1;121(Pt 15):2612-9. doi: 10.1242/jcs.033084. Epub 2008 Jul 15.


Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by prenylation and interaction with a prenyl-binding protein.

Day JP, Cleghon V, Houslay MD, Davies SA.

Biochem J. 2008 Sep 15;414(3):363-74. doi: 10.1042/BJ20080560.


Near-contact interactions between a sphere and a plane.

Heath CE, Feng S, Day JP, Graham AL, Ingber MS.

Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Feb;77(2 Pt 2):026307. Epub 2008 Feb 26.


A new role for a classical gene: white transports cyclic GMP.

Evans JM, Day JP, Cabrero P, Dow JA, Davies SA.

J Exp Biol. 2008 Mar;211(Pt 6):890-9. doi: 10.1242/jeb.014837.


Ellipsometric study of depletion at oil-water interfaces.

Day JP, Bain CD.

Phys Rev E Stat Nonlin Soft Matter Phys. 2007 Oct;76(4 Pt 1):041601. Epub 2007 Oct 5.


Determination of technetium-99 using electrothermal vaporization inductively coupled plasma-mass spectrometry (ETV-ICP-MS) and NH4OH as chemical modifier.

Skipperud L, Oughton DH, Rosten LS, Wharton MJ, Day JP.

J Environ Radioact. 2007;98(3):251-63. Epub 2007 Jul 2.


cGMP signalling in a transporting epithelium.

Davies SA, Day JP.

Biochem Soc Trans. 2006 Aug;34(Pt 4):512-4. Review.


Lead concentrations and isotope ratios in street dust in major cities in Greece in relation to the use of lead in petrol.

Anagnostopoulou MA, Day JP.

Sci Total Environ. 2006 Aug 31;367(2-3):791-9. Epub 2006 Mar 6.


The SNPlex genotyping system: a flexible and scalable platform for SNP genotyping.

Tobler AR, Short S, Andersen MR, Paner TM, Briggs JC, Lambert SM, Wu PP, Wang Y, Spoonde AY, Koehler RT, Peyret N, Chen C, Broomer AJ, Ridzon DA, Zhou H, Hoo BS, Hayashibara KC, Leong LN, Ma CN, Rosenblum BB, Day JP, Ziegle JS, De La Vega FM, Rhodes MD, Hennessy KM, Wenz HM.

J Biomol Tech. 2005 Dec;16(4):398-406.


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