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HIV Infection Is Associated With Downregulation of BTLA Expression on Mycobacterium tuberculosis-Specific CD4 T Cells in Active Tuberculosis Disease.

Barham MS, Abrahams DA, Khayumbi J, Ongalo J, Tonui J, Campbell A, de Kock M, Ouma SG, Odhiambo FH, Hanekom WA, Gandhi NR, Day CL.

Front Immunol. 2019 Aug 21;10:1983. doi: 10.3389/fimmu.2019.01983. eCollection 2019.


Ubiquitin Variant Inhibitors Meet the Deubiquitinase USP15.

Middleton AJ, Day CL.

Structure. 2019 Apr 2;27(4):564-565. doi: 10.1016/j.str.2019.03.011.


E2 enzymes: lessons in ubiquitin transfer from XLID patients.

Foglizzo M, Day CL.

Nat Chem Biol. 2019 Jan;15(1):6-7. doi: 10.1038/s41589-018-0191-4. No abstract available.


A bidentate Polycomb Repressive-Deubiquitinase complex is required for efficient activity on nucleosomes.

Foglizzo M, Middleton AJ, Burgess AE, Crowther JM, Dobson RCJ, Murphy JM, Day CL, Mace PD.

Nat Commun. 2018 Sep 26;9(1):3932. doi: 10.1038/s41467-018-06186-1.


PD-1 Expression on Mycobacterium tuberculosis-Specific CD4 T Cells Is Associated With Bacterial Load in Human Tuberculosis.

Day CL, Abrahams DA, Bunjun R, Stone L, de Kock M, Walzl G, Wilkinson RJ, Burgers WA, Hanekom WA.

Front Immunol. 2018 Aug 31;9:1995. doi: 10.3389/fimmu.2018.01995. eCollection 2018.


A Diverse Lipid Antigen-Specific TCR Repertoire Is Clonally Expanded during Active Tuberculosis.

DeWitt WS, Yu KKQ, Wilburn DB, Sherwood A, Vignali M, Day CL, Scriba TJ, Robins HS, Swanson WJ, Emerson RO, Bradley PH, Seshadri C.

J Immunol. 2018 Aug 1;201(3):888-896. doi: 10.4049/jimmunol.1800186. Epub 2018 Jun 18.


A High Throughput Whole Blood Assay for Analysis of Multiple Antigen-Specific T Cell Responses in Human Mycobacterium tuberculosis Infection.

Whatney WE, Gandhi NR, Lindestam Arlehamn CS, Nizam A, Wu H, Quezada MJ, Campbell A, Allana S, Kabongo MM, Khayumbi J, Muchiri B, Ongalo J, Tonui J, Sasser LE, Fergus TJ, Ouma GS, Ouma SG, Beck AA, Mulligan MJ, Oladele A, Kaushal D, Cain KP, Waller L, Blumberg HM, Altman JD, Ernst JD, Rengarajan J, Day CL; TBRU-ASTRa Study Group.

J Immunol. 2018 Apr 15;200(8):3008-3019. doi: 10.4049/jimmunol.1701737. Epub 2018 Mar 14.


The RING domain of RING Finger 11 (RNF11) protein binds Ubc13 and inhibits formation of polyubiquitin chains.

Budhidarmo R, Zhu J, Middleton AJ, Day CL.

FEBS Lett. 2018 Apr;592(8):1434-1444. doi: 10.1002/1873-3468.13029. Epub 2018 Apr 1.


The activity of TRAF RING homo- and heterodimers is regulated by zinc finger 1.

Middleton AJ, Budhidarmo R, Das A, Zhu J, Foglizzo M, Mace PD, Day CL.

Nat Commun. 2017 Nov 27;8(1):1788. doi: 10.1038/s41467-017-01665-3.


Tumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 binding.

Feltham RL, Moulin M, Vince JE, Mace PD, Wong WW, Anderton H, Day CL, Vaux DL, Silke J.

J Biol Chem. 2017 Aug 25;292(34):14310. doi: 10.1074/jbc.A109.087635. No abstract available.


HIV-1 Infection Is Associated with Depletion and Functional Impairment of Mycobacterium tuberculosis-Specific CD4 T Cells in Individuals with Latent Tuberculosis Infection.

Day CL, Abrahams DA, Harris LD, van Rooyen M, Stone L, de Kock M, Hanekom WA.

J Immunol. 2017 Sep 15;199(6):2069-2080. doi: 10.4049/jimmunol.1700558. Epub 2017 Jul 31.


Regulation of E2s: A Role for Additional Ubiquitin Binding Sites?

Middleton AJ, Wright JD, Day CL.

J Mol Biol. 2017 Nov 10;429(22):3430-3440. doi: 10.1016/j.jmb.2017.06.008. Epub 2017 Jun 15. Review.


Systemic Expression of Notch Ligand Delta-Like 4 during Mycobacterial Infection Alters the T Cell Immune Response.

Schaller MA, Allen RM, Kimura S, Day CL, Kunkel SL.

Front Immunol. 2016 Nov 24;7:527. eCollection 2016.


Noncovalent Ubiquitin Interactions Regulate the Catalytic Activity of Ubiquitin Writers.

Wright JD, Mace PD, Day CL.

Trends Biochem Sci. 2016 Nov;41(11):924-937. doi: 10.1016/j.tibs.2016.08.003. Epub 2016 Sep 7. Review.


Bronchopulmonary dysplasia: new becomes old again!

Day CL, Ryan RM.

Pediatr Res. 2017 Jan;81(1-2):210-213. doi: 10.1038/pr.2016.201. Epub 2016 Sep 28. Review.


IFN-γ Release Assay Result Is Associated with Disease Site and Death in Active Tuberculosis.

Auld SC, Lee SH, Click ES, Miramontes R, Day CL, Gandhi NR, Heilig CM.

Ann Am Thorac Soc. 2016 Dec;13(12):2151-2158.


Structure and Function of the RING Domains of RNF20 and RNF40, Dimeric E3 Ligases that Monoubiquitylate Histone H2B.

Foglizzo M, Middleton AJ, Day CL.

J Mol Biol. 2016 Oct 9;428(20):4073-4086. doi: 10.1016/j.jmb.2016.07.025. Epub 2016 Aug 25.


Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity.

Wright JD, Mace PD, Day CL.

Nat Struct Mol Biol. 2016 Jan;23(1):45-52. doi: 10.1038/nsmb.3142. Epub 2015 Dec 14.


The molecular basis of lysine 48 ubiquitin chain synthesis by Ube2K.

Middleton AJ, Day CL.

Sci Rep. 2015 Nov 23;5:16793. doi: 10.1038/srep16793.


Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response.

Adekambi T, Ibegbu CC, Cagle S, Kalokhe AS, Wang YF, Hu Y, Day CL, Ray SM, Rengarajan J.

J Clin Invest. 2015 Sep;125(9):3723. doi: 10.1172/JCI83279. Epub 2015 Sep 1. No abstract available.


First-in-human trial of the post-exposure tuberculosis vaccine H56:IC31 in Mycobacterium tuberculosis infected and non-infected healthy adults.

Luabeya AK, Kagina BM, Tameris MD, Geldenhuys H, Hoff ST, Shi Z, Kromann I, Hatherill M, Mahomed H, Hanekom WA, Andersen P, Scriba TJ; H56-032 Trial Study Group, Schoeman E, Krohn C, Day CL, Africa H, Makhethe L, Smit E, Brown Y, Suliman S, Hughes EJ, Bang P, Snowden MA, McClain B, Hussey GD.

Vaccine. 2015 Aug 7;33(33):4130-40. doi: 10.1016/j.vaccine.2015.06.051. Epub 2015 Jun 19.


Safety and immunogenicity of candidate vaccine M72/AS01E in adolescents in a TB endemic setting.

Penn-Nicholson A, Geldenhuys H, Burny W, van der Most R, Day CL, Jongert E, Moris P, Hatherill M, Ofori-Anyinam O, Hanekom W; Vaccine Study Team, Bollaerts A, Demoitie MA, Kany Luabeya AK, De Ruymaeker E, Tameris M, Lapierre D, Scriba TJ.

Vaccine. 2015 Jul 31;33(32):4025-34. doi: 10.1016/j.vaccine.2015.05.088. Epub 2015 Jun 10.


Biomarkers on patient T cells diagnose active tuberculosis and monitor treatment response.

Adekambi T, Ibegbu CC, Cagle S, Kalokhe AS, Wang YF, Hu Y, Day CL, Ray SM, Rengarajan J.

J Clin Invest. 2015 May;125(5):1827-38. doi: 10.1172/JCI77990. Epub 2015 Mar 30. Erratum in: J Clin Invest. 2015 Sep;125(9):3723.


IAPs: Modular regulators of cell signalling.

Budhidarmo R, Day CL.

Semin Cell Dev Biol. 2015 Mar;39:80-90. doi: 10.1016/j.semcdb.2014.12.002. Epub 2014 Dec 24. Review.


Combined use of Mycobacterium tuberculosis-specific CD4 and CD8 T-cell responses is a powerful diagnostic tool of active tuberculosis.

Rozot V, Patrizia A, Vigano S, Mazza-Stalder J, Idrizi E, Day CL, Perreau M, Lazor-Blanchet C, Ohmiti K, Goletti D, Bart PA, Hanekom W, Scriba TJ, Nicod L, Pantaleo G, Harari A.

Clin Infect Dis. 2015 Feb 1;60(3):432-7. doi: 10.1093/cid/ciu795. Epub 2014 Oct 31.


Impaired degranulation and proliferative capacity of Mycobacterium tuberculosis-specific CD8+ T cells in HIV-infected individuals with latent tuberculosis.

Kalokhe AS, Adekambi T, Ibegbu CC, Ray SM, Day CL, Rengarajan J.

J Infect Dis. 2015 Feb 15;211(4):635-40. doi: 10.1093/infdis/jiu505. Epub 2014 Sep 9.


Use of E2~ubiquitin conjugates for the characterization of ubiquitin transfer by RING E3 ligases such as the inhibitor of apoptosis proteins.

Middleton AJ, Budhidarmo R, Day CL.

Methods Enzymol. 2014;545:243-63. doi: 10.1016/B978-0-12-801430-1.00010-X. Review.


The ubiquitin-associated domain of cellular inhibitor of apoptosis proteins facilitates ubiquitylation.

Budhidarmo R, Day CL.

J Biol Chem. 2014 Sep 12;289(37):25721-36. doi: 10.1074/jbc.M113.545475. Epub 2014 Jul 26.


Patients with tuberculosis disease have Mycobacterium tuberculosis-specific CD8 T cells with a pro-apoptotic phenotype and impaired proliferative capacity, which is not restored following treatment.

Day CL, Moshi ND, Abrahams DA, van Rooyen M, O'rie T, de Kock M, Hanekom WA.

PLoS One. 2014 Apr 16;9(4):e94949. doi: 10.1371/journal.pone.0094949. eCollection 2014.


Birinapant, a smac-mimetic with improved tolerability for the treatment of solid tumors and hematological malignancies.

Condon SM, Mitsuuchi Y, Deng Y, LaPorte MG, Rippin SR, Haimowitz T, Alexander MD, Kumar PT, Hendi MS, Lee YH, Benetatos CA, Yu G, Kapoor GS, Neiman E, Seipel ME, Burns JM, Graham MA, McKinlay MA, Li X, Wang J, Shi Y, Feltham R, Bettjeman B, Cumming MH, Vince JE, Khan N, Silke J, Day CL, Chunduru SK.

J Med Chem. 2014 May 8;57(9):3666-77. doi: 10.1021/jm500176w. Epub 2014 Apr 15.


Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation.

Heikal A, Nakatani Y, Dunn E, Weimar MR, Day CL, Baker EN, Lott JS, Sazanov LA, Cook GM.

Mol Microbiol. 2014 Mar;91(5):950-64. doi: 10.1111/mmi.12507. Epub 2014 Jan 21.


Enhancing the peroxidase activity of cytochrome c by mutation of residue 41: implications for the peroxidase mechanism and cytochrome c release.

Josephs TM, Morison IM, Day CL, Wilbanks SM, Ledgerwood EC.

Biochem J. 2014 Mar 1;458(2):259-65. doi: 10.1042/BJ20131386.


Distinct T-cell responses when BCG vaccination is delayed from birth to 6 weeks of age in Ugandan infants.

Lutwama F, Kagina BM, Wajja A, Waiswa F, Mansoor N, Kirimunda S, Hughes EJ, Kiwanuka N, Joloba ML, Musoke P, Scriba TJ, Mayanja-Kizza H, Day CL, Hanekom WA.

J Infect Dis. 2014 Mar;209(6):887-97. doi: 10.1093/infdis/jit570. Epub 2013 Oct 31.


The N-terminal extension of UBE2E ubiquitin-conjugating enzymes limits chain assembly.

Schumacher FR, Wilson G, Day CL.

J Mol Biol. 2013 Nov 15;425(22):4099-111. doi: 10.1016/j.jmb.2013.06.039. Epub 2013 Jul 17.


Heterologous vaccination against human tuberculosis modulates antigen-specific CD4+ T-cell function.

Dintwe OB, Day CL, Smit E, Nemes E, Gray C, Tameris M, McShane H, Mahomed H, Hanekom WA, Scriba TJ.

Eur J Immunol. 2013 Sep;43(9):2409-20. doi: 10.1002/eji.201343454. Epub 2013 Jul 8.


Mycobacterium tuberculosis-specific CD8+ T cells are functionally and phenotypically different between latent infection and active disease.

Rozot V, Vigano S, Mazza-Stalder J, Idrizi E, Day CL, Perreau M, Lazor-Blanchet C, Petruccioli E, Hanekom W, Goletti D, Bart PA, Nicod L, Pantaleo G, Harari A.

Eur J Immunol. 2013 Jun;43(6):1568-77. doi: 10.1002/eji.201243262.


Induction and regulation of T-cell immunity by the novel tuberculosis vaccine M72/AS01 in South African adults.

Day CL, Tameris M, Mansoor N, van Rooyen M, de Kock M, Geldenhuys H, Erasmus M, Makhethe L, Hughes EJ, Gelderbloem S, Bollaerts A, Bourguignon P, Cohen J, Demoitié MA, Mettens P, Moris P, Sadoff JC, Hawkridge A, Hussey GD, Mahomed H, Ofori-Anyinam O, Hanekom WA.

Am J Respir Crit Care Med. 2013 Aug 15;188(4):492-502. doi: 10.1164/rccm.201208-1385OC.


Regulation of ubiquitin transfer by XIAP, a dimeric RING E3 ligase.

Nakatani Y, Kleffmann T, Linke K, Condon SM, Hinds MG, Day CL.

Biochem J. 2013 Mar 15;450(3):629-38. doi: 10.1042/BJ20121702.


SATVI - after 10 years closing in on a new and better vaccine to prevent tuberculosis.

Hanekom WA, Hawkridge A, Mahomed H, Scriba TJ, Tameris M, Hughes J, Hatherill M, Day CL, Hussey GD.

S Afr Med J. 2012 Mar 2;102(6):438-41.


RINGs hold the key to ubiquitin transfer.

Budhidarmo R, Nakatani Y, Day CL.

Trends Biochem Sci. 2012 Feb;37(2):58-65. doi: 10.1016/j.tibs.2011.11.001. Epub 2011 Dec 10. Review.


A molecular assay for sensitive detection of pathogen-specific T-cells.

Kasprowicz VO, Mitchell JE, Chetty S, Govender P, Huang KH, Fletcher HA, Webster DP, Brown S, Kasmar A, Millington K, Day CL, Mkhwanazi N, McClurg C, Chonco F, Lalvani A, Walker BD, Ndung'u T, Klenerman P.

PLoS One. 2011;6(8):e20606. doi: 10.1371/journal.pone.0020606. Epub 2011 Aug 11.


Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load.

Day CL, Abrahams DA, Lerumo L, Janse van Rensburg E, Stone L, O'rie T, Pienaar B, de Kock M, Kaplan G, Mahomed H, Dheda K, Hanekom WA.

J Immunol. 2011 Sep 1;187(5):2222-32. doi: 10.4049/jimmunol.1101122. Epub 2011 Jul 20.


CARD-mediated autoinhibition of cIAP1's E3 ligase activity suppresses cell proliferation and migration.

Lopez J, John SW, Tenev T, Rautureau GJ, Hinds MG, Francalanci F, Wilson R, Broemer M, Santoro MM, Day CL, Meier P.

Mol Cell. 2011 Jun 10;42(5):569-83. doi: 10.1016/j.molcel.2011.04.008. Epub 2011 May 5.


HIV-specific gag responses in early infancy correlate with clinical outcome and inversely with viral load.

Nqoko B, Day CL, Mansoor N, De Kock M, Hughes EJ, Hawkridge T, Kaplan G, Boom WH, Hussey GD, Hanekom WA.

AIDS Res Hum Retroviruses. 2011 Dec;27(12):1311-6. doi: 10.1089/aid.2011.0081. Epub 2011 May 12.


Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization.

Feltham R, Bettjeman B, Budhidarmo R, Mace PD, Shirley S, Condon SM, Chunduru SK, McKinlay MA, Vaux DL, Silke J, Day CL.

J Biol Chem. 2011 May 13;286(19):17015-28. doi: 10.1074/jbc.M111.222919. Epub 2011 Mar 10.


Dominant TNF-α+ Mycobacterium tuberculosis-specific CD4+ T cell responses discriminate between latent infection and active disease.

Harari A, Rozot V, Bellutti Enders F, Perreau M, Stalder JM, Nicod LP, Cavassini M, Calandra T, Blanchet CL, Jaton K, Faouzi M, Day CL, Hanekom WA, Bart PA, Pantaleo G.

Nat Med. 2011 Mar;17(3):372-6. doi: 10.1038/nm.2299. Epub 2011 Feb 20.


RING domain dimerization is essential for RNF4 function.

Liew CW, Sun H, Hunter T, Day CL.

Biochem J. 2010 Oct 1;431(1):23-9. doi: 10.1042/BJ20100957.


Intrinsically disordered proteins in bcl-2 regulated apoptosis.

Rautureau GJ, Day CL, Hinds MG.

Int J Mol Sci. 2010 Apr 16;11(4):1808-24. doi: 10.3390/ijms11041808. Review.


The structure of Boo/Diva reveals a divergent Bcl-2 protein.

Rautureau GJ, Day CL, Hinds MG.

Proteins. 2010 Jul;78(9):2181-6. doi: 10.1002/prot.22728. No abstract available.


Asymmetric recruitment of cIAPs by TRAF2.

Mace PD, Smits C, Vaux DL, Silke J, Day CL.

J Mol Biol. 2010 Jul 2;400(1):8-15. doi: 10.1016/j.jmb.2010.04.055. Epub 2010 May 4.


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