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Items: 13


Functional deficit associated with a missense Werner syndrome mutation.

Tadokoro T, Rybanska-Spaeder I, Kulikowicz T, Dawut L, Oshima J, Croteau DL, Bohr VA.

DNA Repair (Amst). 2013 Jun 1;12(6):414-21. doi: 10.1016/j.dnarep.2013.03.004. Epub 2013 Apr 11.


RAPADILINO RECQL4 mutant protein lacks helicase and ATPase activity.

Croteau DL, Rossi ML, Ross J, Dawut L, Dunn C, Kulikowicz T, Bohr VA.

Biochim Biophys Acta. 2012 Nov;1822(11):1727-34. doi: 10.1016/j.bbadis.2012.07.014. Epub 2012 Jul 31.


DNA binding residues in the RQC domain of Werner protein are critical for its catalytic activities.

Tadokoro T, Kulikowicz T, Dawut L, Croteau DL, Bohr VA.

Aging (Albany NY). 2012 Jun;4(6):417-29.


Human RECQL5beta stimulates flap endonuclease 1.

Speina E, Dawut L, Hedayati M, Wang Z, May A, Schwendener S, Janscak P, Croteau DL, Bohr VA.

Nucleic Acids Res. 2010 May;38(9):2904-16. doi: 10.1093/nar/gkp1217. Epub 2010 Jan 16.


WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks.

Cheng WH, Muftic D, Muftuoglu M, Dawut L, Morris C, Helleday T, Shiloh Y, Bohr VA.

Mol Biol Cell. 2008 Sep;19(9):3923-33. doi: 10.1091/mbc.E07-07-0698. Epub 2008 Jul 2.


Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing.

Kusumoto R, Dawut L, Marchetti C, Wan Lee J, Vindigni A, Ramsden D, Bohr VA.

Biochemistry. 2008 Jul 15;47(28):7548-56. doi: 10.1021/bi702325t. Epub 2008 Jun 18.


Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.

von Kobbe C, Harrigan JA, Schreiber V, Stiegler P, Piotrowski J, Dawut L, Bohr VA.

Nucleic Acids Res. 2004 Aug 3;32(13):4003-14. Print 2004.


The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2.

Opresko PL, Otterlei M, Graakjaer J, Bruheim P, Dawut L, Kølvraa S, May A, Seidman MM, Bohr VA.

Mol Cell. 2004 Jun 18;14(6):763-74.


Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.

von Kobbe C, Harrigan JA, May A, Opresko PL, Dawut L, Cheng WH, Bohr VA.

Mol Cell Biol. 2003 Dec;23(23):8601-13.


Photolyase/cryptochrome family blue-light photoreceptors use light energy to repair DNA or set the circadian clock.

Sancar A, Thompson C, Thresher RJ, Araujo F, Mo J, Ozgur S, Vagas E, Dawut L, Selby CP.

Cold Spring Harb Symp Quant Biol. 2000;65:157-71. Review. No abstract available.


Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins.

von Kobbe C, Karmakar P, Dawut L, Opresko P, Zeng X, Brosh RM Jr, Hickson ID, Bohr VA.

J Biol Chem. 2002 Jun 14;277(24):22035-44. Epub 2002 Mar 27.


Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses.

Thresher RJ, Vitaterna MH, Miyamoto Y, Kazantsev A, Hsu DS, Petit C, Selby CP, Dawut L, Smithies O, Takahashi JS, Sancar A.

Science. 1998 Nov 20;282(5393):1490-4.

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