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Stress and ageing in yeast.

Dawes IW, Perrone GG.

FEMS Yeast Res. 2020 Feb 1;20(1). pii: foz085. doi: 10.1093/femsyr/foz085.


Ian Dawes-the third Pope-lucky to be a researcher.

Dawes IW.

FEMS Yeast Res. 2016 Jun;16(4). pii: fow040. doi: 10.1093/femsyr/fow040. Epub 2016 Apr 23.


CDP-diacylglycerol synthases regulate the growth of lipid droplets and adipocyte development.

Qi Y, Kapterian TS, Du X, Ma Q, Fei W, Zhang Y, Huang X, Dawes IW, Yang H.

J Lipid Res. 2016 May;57(5):767-80. doi: 10.1194/jlr.M060574. Epub 2016 Mar 5.


Transcriptional and antioxidative responses to endogenous polyunsaturated fatty acid accumulation in yeast.

Andrisic L, Collinson EJ, Tehlivets O, Perak E, Zarkovic T, Dawes IW, Zarkovic N, Cipak Gasparovic A.

Mol Cell Biochem. 2015 Jan;399(1-2):27-37. doi: 10.1007/s11010-014-2229-6. Epub 2014 Oct 4.


Genome-wide analysis of Saccharomyces cerevisiae identifies cellular processes affecting intracellular aggregation of Alzheimer's amyloid-β42: importance of lipid homeostasis.

Nair S, Traini M, Dawes IW, Perrone GG.

Mol Biol Cell. 2014 Aug 1;25(15):2235-49. doi: 10.1091/mbc.E13-04-0216. Epub 2014 May 28.


Cellular redox homeostasis, reactive oxygen species and replicative ageing in Saccharomyces cerevisiae.

Ayer A, Gourlay CW, Dawes IW.

FEMS Yeast Res. 2014 Feb;14(1):60-72. doi: 10.1111/1567-1364.12114. Epub 2013 Nov 8. Review.


Actin - a biosensor that determines cell fate in yeasts.

Smethurst DG, Dawes IW, Gourlay CW.

FEMS Yeast Res. 2014 Feb;14(1):89-95. doi: 10.1111/1567-1364.12119. Epub 2013 Nov 26. Review.


Saccharomyces cerevisiae genes involved in survival of heat shock.

Jarolim S, Ayer A, Pillay B, Gee AC, Phrakaysone A, Perrone GG, Breitenbach M, Dawes IW.

G3 (Bethesda). 2013 Dec 9;3(12):2321-33. doi: 10.1534/g3.113.007971.


Maintenance of mitochondrial morphology by autophagy and its role in high glucose effects on chronological lifespan of Saccharomyces cerevisiae.

Aung-Htut MT, Lam YT, Lim YL, Rinnerthaler M, Gelling CL, Yang H, Breitenbach M, Dawes IW.

Oxid Med Cell Longev. 2013;2013:636287. doi: 10.1155/2013/636287. Epub 2013 Jul 11.


Superoxide radicals have a protective role during H2O2 stress.

Thorpe GW, Reodica M, Davies MJ, Heeren G, Jarolim S, Pillay B, Breitenbach M, Higgins VJ, Dawes IW.

Mol Biol Cell. 2013 Sep;24(18):2876-84. doi: 10.1091/mbc.E13-01-0052. Epub 2013 Jul 17.


Cellular responses to L-serine in Saccharomyces cerevisiae: roles of general amino acid control, compartmentalization, and aspartate synthesis.

Lee JC, Tsoi A, Kornfeld GD, Dawes IW.

FEMS Yeast Res. 2013 Nov;13(7):618-34. doi: 10.1111/1567-1364.12063. Epub 2013 Jul 29.


Distinct redox regulation in sub-cellular compartments in response to various stress conditions in Saccharomyces cerevisiae.

Ayer A, Sanwald J, Pillay BA, Meyer AJ, Perrone GG, Dawes IW.

PLoS One. 2013 Jun 7;8(6):e65240. doi: 10.1371/journal.pone.0065240. Print 2013.


Oxidative stress and neurodegeneration: the yeast model system.

Breitenbach M, Ralser M, Perrone GG, Iglseder B, Rinnerthaler M, Dawes IW.

Front Biosci (Landmark Ed). 2013 Jun 1;18:1174-93. Review.


Accumulation of squalene is associated with the clustering of lipid droplets.

Ta MT, Kapterian TS, Fei W, Du X, Brown AJ, Dawes IW, Yang H.

FEBS J. 2012 Nov;279(22):4231-44. doi: 10.1111/febs.12015. Epub 2012 Oct 22.


The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III.

Du X, Kazim AS, Dawes IW, Brown AJ, Yang H.

Traffic. 2013 Jan;14(1):107-19. doi: 10.1111/tra.12015. Epub 2012 Oct 14.


A genome-wide screen in yeast identifies specific oxidative stress genes required for the maintenance of sub-cellular redox homeostasis.

Ayer A, Fellermeier S, Fife C, Li SS, Smits G, Meyer AJ, Dawes IW, Perrone GG.

PLoS One. 2012;7(9):e44278. doi: 10.1371/journal.pone.0044278. Epub 2012 Sep 6.


Redox control of cell proliferation.

Chiu J, Dawes IW.

Trends Cell Biol. 2012 Nov;22(11):592-601. doi: 10.1016/j.tcb.2012.08.002. Epub 2012 Aug 30. Review.


The endosomal protein-sorting receptor sortilin has a role in trafficking α-1 antitrypsin.

Gelling CL, Dawes IW, Perlmutter DH, Fisher EA, Brodsky JL.

Genetics. 2012 Nov;192(3):889-903. doi: 10.1534/genetics.112.143487. Epub 2012 Aug 24.


The role of mitochondria in the aging processes of yeast.

Breitenbach M, Laun P, Dickinson JR, Klocker A, Rinnerthaler M, Dawes IW, Aung-Htut MT, Breitenbach-Koller L, Caballero A, Nyström T, Büttner S, Eisenberg T, Madeo F, Ralser M.

Subcell Biochem. 2012;57:55-78. doi: 10.1007/978-94-007-2561-4_3. Review.


Oxidative stresses and ageing.

Aung-Htut MT, Ayer A, Breitenbach M, Dawes IW.

Subcell Biochem. 2012;57:13-54. doi: 10.1007/978-94-007-2561-4_2. Review.


A role for phosphatidic acid in the formation of "supersized" lipid droplets.

Fei W, Shui G, Zhang Y, Krahmer N, Ferguson C, Kapterian TS, Lin RC, Dawes IW, Brown AJ, Li P, Huang X, Parton RG, Wenk MR, Walther TC, Yang H.

PLoS Genet. 2011 Jul;7(7):e1002201. doi: 10.1371/journal.pgen.1002201. Epub 2011 Jul 28.


An antioxidant screening assay based on oxidant-induced growth arrest in Saccharomyces cerevisiae.

Wu MJ, O'Doherty PJ, Fernandez HR, Lyons V, Rogers PJ, Dawes IW, Higgins VJ.

FEMS Yeast Res. 2011 Jun;11(4):379-87. doi: 10.1111/j.1567-1364.2011.00726.x. Epub 2011 Mar 24.


Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells.

Lam YT, Aung-Htut MT, Lim YL, Yang H, Dawes IW.

Free Radic Biol Med. 2011 Apr 15;50(8):963-70. doi: 10.1016/j.freeradbiomed.2011.01.013. Epub 2011 Jan 19.


Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p.

Chiu J, Tactacan CM, Tan SX, Lin RC, Wouters MA, Dawes IW.

J Biol Chem. 2011 Feb 18;286(7):5204-14. doi: 10.1074/jbc.M110.172973. Epub 2010 Dec 8.


The yeast homolog of heme oxygenase-1 affords cellular antioxidant protection via the transcriptional regulation of known antioxidant genes.

Collinson EJ, Wimmer-Kleikamp S, Gerega SK, Yang YH, Parish CR, Dawes IW, Stocker R.

J Biol Chem. 2011 Jan 21;286(3):2205-14. doi: 10.1074/jbc.M110.187062. Epub 2010 Nov 16.


The critical role of glutathione in maintenance of the mitochondrial genome.

Ayer A, Tan SX, Grant CM, Meyer AJ, Dawes IW, Perrone GG.

Free Radic Biol Med. 2010 Dec 15;49(12):1956-68. doi: 10.1016/j.freeradbiomed.2010.09.023. Epub 2010 Sep 29.


The lipophilic antioxidants alpha-tocopherol and coenzyme Q10 reduce the replicative lifespan of Saccharomyces cerevisiae.

Lam YT, Stocker R, Dawes IW.

Free Radic Biol Med. 2010 Jul 15;49(2):237-44. doi: 10.1016/j.freeradbiomed.2010.04.008. Epub 2010 Apr 18.


Quantitation of (a)symmetric inheritance of functional and of oxidatively damaged mitochondrial aconitase in the cell division of old yeast mother cells.

Klinger H, Rinnerthaler M, Lam YT, Laun P, Heeren G, Klocker A, Simon-Nobbe B, Dickinson JR, Dawes IW, Breitenbach M.

Exp Gerontol. 2010 Aug;45(7-8):533-42. doi: 10.1016/j.exger.2010.03.016. Epub 2010 Apr 8.


PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.

Lin RC, Weeks KL, Gao XM, Williams RB, Bernardo BC, Kiriazis H, Matthews VB, Woodcock EA, Bouwman RD, Mollica JP, Speirs HJ, Dawes IW, Daly RJ, Shioi T, Izumo S, Febbraio MA, Du XJ, McMullen JR.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):724-32. doi: 10.1161/ATVBAHA.109.201988.


Thioredoxins function as deglutathionylase enzymes in the yeast Saccharomyces cerevisiae.

Greetham D, Vickerstaff J, Shenton D, Perrone GG, Dawes IW, Grant CM.

BMC Biochem. 2010 Jan 14;11:3. doi: 10.1186/1471-2091-11-3.


The thioredoxin-thioredoxin reductase system can function in vivo as an alternative system to reduce oxidized glutathione in Saccharomyces cerevisiae.

Tan SX, Greetham D, Raeth S, Grant CM, Dawes IW, Perrone GG.

J Biol Chem. 2010 Feb 26;285(9):6118-26. doi: 10.1074/jbc.M109.062844. Epub 2009 Dec 1.


Zinc starvation induces a stress response in Saccharomyces cerevisiae that is mediated by the Msn2p and Msn4p transcriptional activators.

Gauci VJ, Beckhouse AG, Lyons V, Beh EJ, Rogers PJ, Dawes IW, Higgins VJ.

FEMS Yeast Res. 2009 Dec;9(8):1187-95. doi: 10.1111/j.1567-1364.2009.00557.x. Epub 2009 Jul 31.


Avoiding unscheduled transcription in shared promoters: Saccharomyces cerevisiae Sum1p represses the divergent gene pair SPS18-SPS19 through a midsporulation element (MSE).

Gurvitz A, Suomi F, Rottensteiner H, Hiltunen JK, Dawes IW.

FEMS Yeast Res. 2009 Sep;9(6):821-31. doi: 10.1111/j.1567-1364.2009.00527.x. Epub 2009 May 6.


Population structure of Helicobacter pylori among ethnic groups in Malaysia: recent acquisition of the bacterium by the Malay population.

Tay CY, Mitchell H, Dong Q, Goh KL, Dawes IW, Lan R.

BMC Microbiol. 2009 Jun 19;9:126. doi: 10.1186/1471-2180-9-126.


Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae.

Thorsen M, Perrone GG, Kristiansson E, Traini M, Ye T, Dawes IW, Nerman O, Tamás MJ.

BMC Genomics. 2009 Mar 12;10:105. doi: 10.1186/1471-2164-10-105.


Gene-expression profiling of peripheral blood mononuclear cells in sepsis.

Tang BM, McLean AS, Dawes IW, Huang SJ, Lin RC.

Crit Care Med. 2009 Mar;37(3):882-8. doi: 10.1097/CCM.0b013e31819b52fd.


Response of Saccharomyces cerevisiae to stress-free acidification.

Chen AK, Gelling C, Rogers PL, Dawes IW, Rosche B.

J Microbiol. 2009 Feb;47(1):1-8. doi: 10.1007/s12275-008-0167-2. Epub 2009 Feb 20.


Essential role of one-carbon metabolism and Gcn4p and Bas1p transcriptional regulators during adaptation to anaerobic growth of Saccharomyces cerevisiae.

Tsoi BM, Beckhouse AG, Gelling CL, Raftery MJ, Chiu J, Tsoi AM, Lauterbach L, Rogers PJ, Higgins VJ, Dawes IW.

J Biol Chem. 2009 Apr 24;284(17):11205-15. doi: 10.1074/jbc.M809225200. Epub 2009 Feb 18.


Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae.

Tan SX, Teo M, Lam YT, Dawes IW, Perrone GG.

Mol Biol Cell. 2009 Mar;20(5):1493-508. doi: 10.1091/mbc.E08-07-0697. Epub 2009 Jan 7.


The adaptive response of anaerobically grown Saccharomyces cerevisiae to hydrogen peroxide is mediated by the Yap1 and Skn7 transcription factors.

Beckhouse AG, Grant CM, Rogers PJ, Dawes IW, Higgins VJ.

FEMS Yeast Res. 2008 Dec;8(8):1214-22. doi: 10.1111/j.1567-1364.2008.00439.x. Epub 2008 Sep 15.


Plasma membrane electron transport in Saccharomyces cerevisiae depends on the presence of mitochondrial respiratory subunits.

Herst PM, Perrone GG, Dawes IW, Bircham PW, Berridge MV.

FEMS Yeast Res. 2008 Sep;8(6):897-905. doi: 10.1111/j.1567-1364.2008.00418.x. Epub 2008 Jul 23.


Caspase-dependent and -independent lipotoxic cell-death pathways in fission yeast.

Low CP, Shui G, Liew LP, Buttner S, Madeo F, Dawes IW, Wenk MR, Yang H.

J Cell Sci. 2008 Aug 15;121(Pt 16):2671-84. doi: 10.1242/jcs.028977. Epub 2008 Jul 24.


Site-directed, Ligase-Independent Mutagenesis (SLIM) for highly efficient mutagenesis of plasmids greater than 8kb.

Chiu J, Tillett D, Dawes IW, March PE.

J Microbiol Methods. 2008 May;73(2):195-8. doi: 10.1016/j.mimet.2008.02.013. Epub 2008 Feb 26.


Gene-expression profiling of gram-positive and gram-negative sepsis in critically ill patients.

Tang BM, McLean AS, Dawes IW, Huang SJ, Cowley MJ, Lin RC.

Crit Care Med. 2008 Apr;36(4):1125-8. doi: 10.1097/CCM.0b013e3181692c0b.


Reactive oxygen species and yeast apoptosis.

Perrone GG, Tan SX, Dawes IW.

Biochim Biophys Acta. 2008 Jul;1783(7):1354-68. doi: 10.1016/j.bbamcr.2008.01.023. Epub 2008 Feb 11. Review.


Adaptation to hydrogen peroxide in Saccharomyces cerevisiae: the role of NADPH-generating systems and the SKN7 transcription factor.

Ng CH, Tan SX, Perrone GG, Thorpe GW, Higgins VJ, Dawes IW.

Free Radic Biol Med. 2008 Mar 15;44(6):1131-45. doi: 10.1016/j.freeradbiomed.2007.12.008. Epub 2007 Dec 23.


Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the involvement of the SWI6 transcription factor.

Fong CS, Temple MD, Alic N, Chiu J, Durchdewald M, Thorpe GW, Higgins VJ, Dawes IW.

FEMS Yeast Res. 2008 May;8(3):386-99. doi: 10.1111/j.1567-1364.2007.00349.x. Epub 2008 Jan 14.


Mitochondrial Iba57p is required for Fe/S cluster formation on aconitase and activation of radical SAM enzymes.

Gelling C, Dawes IW, Richhardt N, Lill R, Mühlenhoff U.

Mol Cell Biol. 2008 Mar;28(5):1851-61. Epub 2007 Dec 17.


The effect of resveratrol on a cell model of human aging.

Stefani M, Markus MA, Lin RC, Pinese M, Dawes IW, Morris BJ.

Ann N Y Acad Sci. 2007 Oct;1114:407-18. Epub 2007 Sep 5.


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