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Do we have to reconsider the guidelines for exercise intensity determination in cardiovascular rehabilitation?

Davos CH.

Eur J Prev Cardiol. 2019 Aug 25:2047487319871870. doi: 10.1177/2047487319871870. [Epub ahead of print] No abstract available.


Regional differences in exercise training implementation in heart failure: findings from the Exercise Training in Heart Failure (ExTraHF) survey.

Piepoli MF, Binno S, Coats AJS, Cohen-Solal A, Corrà U, Davos CH, Jaarsma T, Lund L, Niederseer D, Orso F, Villani GQ, Agostoni P, Volterrani M, Seferovic P; Committee on Exercise Physiology & Training of the Heart Failure Association of the European Society of Cardiology.

Eur J Heart Fail. 2019 Sep;21(9):1142-1148. doi: 10.1002/ejhf.1538. Epub 2019 Jul 25.


Levosimendan prevents doxorubicin-induced cardiotoxicity in time- and dose dependent manner: Implications for inotropy.

Efentakis P, Varela A, Chavdoula E, Sigala F, Sanoudou D, Tenta R, Gioti K, Kostomitsopoulos N, Papapetropoulos A, Tasouli A, Farmakis D, Davos CH, Klinakis A, Suter T, Cokkinos DV, Iliodromitis EK, Wenzel P, Andreadou I.

Cardiovasc Res. 2019 Jun 22. pii: cvz163. doi: 10.1093/cvr/cvz163. [Epub ahead of print]


Exercise-based cardiac rehabilitation for chronic heart failure: the EXTRAMATCH II individual participant data meta-analysis.

Taylor RS, Walker S, Ciani O, Warren F, Smart NA, Piepoli M, Davos CH.

Health Technol Assess. 2019 May;23(25):1-98. doi: 10.3310/hta23250.


Impact of Exercise Rehabilitation on Exercise Capacity and Quality-of-Life in Heart Failure: Individual Participant Meta-Analysis.

Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, Whellan D, O'Connor C, Keteyian SJ, Coats A, Davos CH, Dalal HM, Dracup K, Evangelista LS, Jolly K, Myers J, Nilsson BB, Passino C, Witham MD, Yeh GY; ExTraMATCH II Collaboration.

J Am Coll Cardiol. 2019 Apr 2;73(12):1430-1443. doi: 10.1016/j.jacc.2018.12.072.


Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin.

Efentakis P, Kremastiotis G, Varela A, Nikolaou PE, Papanagnou ED, Davos CH, Tsoumani M, Agrogiannis G, Konstantinidou A, Kastritis E, Kanaki Z, Iliodromitis EK, Klinakis A, Dimopoulos MA, Trougakos IP, Andreadou I, Terpos E.

Blood. 2019 Feb 14;133(7):710-723. doi: 10.1182/blood-2018-06-858415. Epub 2018 Nov 27.


Exercise training in patients with ventricular assist devices: a review of the evidence and practical advice. A position paper from the Committee on Exercise Physiology and Training and the Committee of Advanced Heart Failure of the Heart Failure Association of the European Society of Cardiology.

Adamopoulos S, Corrà U, Laoutaris ID, Pistono M, Agostoni PG, Coats AJS, Crespo Leiro MG, Cornelis J, Davos CH, Filippatos G, Lund LH, Jaarsma T, Ruschitzka F, Seferovic PM, Schmid JP, Volterrani M, Piepoli MF.

Eur J Heart Fail. 2019 Jan;21(1):3-13. doi: 10.1002/ejhf.1352. Epub 2018 Nov 26. Review.


Exercise training for chronic heart failure (ExTraMATCH II): Why all data are not equal.

Smart NA, Taylor R, Walker S, Warren F, Ciani O, Davos CH, Piepoli M.

Eur J Prev Cardiol. 2019 Jul;26(11):1229-1231. doi: 10.1177/2047487318815314. Epub 2018 Nov 22. No abstract available.


Amelioration of desmin network defects by αB-crystallin overexpression confers cardioprotection in a mouse model of dilated cardiomyopathy caused by LMNA gene mutation.

Galata Z, Kloukina I, Kostavasili I, Varela A, Davos CH, Makridakis M, Bonne G, Capetanaki Y.

J Mol Cell Cardiol. 2018 Dec;125:73-86. doi: 10.1016/j.yjmcc.2018.10.017. Epub 2018 Oct 18.


Impact of exercise-based cardiac rehabilitation in patients with heart failure (ExTraMATCH II) on mortality and hospitalisation: an individual patient data meta-analysis of randomised trials.

Taylor RS, Walker S, Smart NA, Piepoli MF, Warren FC, Ciani O, O'Connor C, Whellan D, Keteyian SJ, Coats A, Davos CH, Dalal HM, Dracup K, Evangelista L, Jolly K, Myers J, McKelvie RS, Nilsson BB, Passino C, Witham MD, Yeh GY, Zwisler AO; ExTraMATCH II Collaboration.

Eur J Heart Fail. 2018 Dec;20(12):1735-1743. doi: 10.1002/ejhf.1311. Epub 2018 Sep 26. Review.


Combined Type III and Type II Endoleaks after Endovascular Aneurysm Repair: Presentation of 2 Cases and a Literature Review.

Theodoridis PG, Staramos DN, Ptochis N, Davos CH, Dodos I, Iatrou N, Potouridis AG, Argitis V, Antoniadis P, Dervisis K.

Ann Vasc Surg. 2019 Feb;55:308.e5-308.e10. doi: 10.1016/j.avsg.2018.06.028. Epub 2018 Sep 12. Review.


Validation of Exercise Capacity as a Surrogate Endpoint in Exercise-Based Rehabilitation for Heart Failure: A Meta-Analysis of Randomized Controlled Trials.

Ciani O, Piepoli M, Smart N, Uddin J, Walker S, Warren FC, Zwisler AD, Davos CH, Taylor RS.

JACC Heart Fail. 2018 Jul;6(7):596-604. doi: 10.1016/j.jchf.2018.03.017.


Thrombolysis in Acute Lower Limb Ischemia: Review of the Current Literature.

Theodoridis PG, Davos CH, Dodos I, Iatrou N, Potouridis A, Pappas GM, Staramos D, Antoniadis P, Argitis V, Dervisis K.

Ann Vasc Surg. 2018 Oct;52:255-262. doi: 10.1016/j.avsg.2018.02.030. Epub 2018 Jun 6. Review.


Exercise Prescription in Patients with Different Combinations of Cardiovascular Disease Risk Factors: A Consensus Statement from the EXPERT Working Group.

Hansen D, Niebauer J, Cornelissen V, Barna O, Neunhäuserer D, Stettler C, Tonoli C, Greco E, Fagard R, Coninx K, Vanhees L, Piepoli MF, Pedretti R, Ruiz GR, Corrà U, Schmid JP, Davos CH, Edelmann F, Abreu A, Rauch B, Ambrosetti M, Braga SS, Beckers P, Bussotti M, Faggiano P, Garcia-Porrero E, Kouidi E, Lamotte M, Reibis R, Spruit MA, Takken T, Vigorito C, Völler H, Doherty P, Dendale P.

Sports Med. 2018 Aug;48(8):1781-1797. doi: 10.1007/s40279-018-0930-4. Review.


Empagliflozin Limits Myocardial Infarction in Vivo and Cell Death in Vitro: Role of STAT3, Mitochondria, and Redox Aspects.

Andreadou I, Efentakis P, Balafas E, Togliatto G, Davos CH, Varela A, Dimitriou CA, Nikolaou PE, Maratou E, Lambadiari V, Ikonomidis I, Kostomitsopoulos N, Brizzi MF, Dimitriadis G, Iliodromitis EK.

Front Physiol. 2017 Dec 19;8:1077. doi: 10.3389/fphys.2017.01077. eCollection 2017.


Seeking best practices for cardiac rehabilitation registries in Europe.

Davos CH.

Eur J Prev Cardiol. 2017 Dec;24(18):1925-1926. doi: 10.1177/2047487317739385. Epub 2017 Oct 25. No abstract available.


Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.

Tzimas C, Johnson DM, Santiago DJ, Vafiadaki E, Arvanitis DA, Davos CH, Varela A, Athanasiadis NC, Dimitriou C, Katsimpoulas M, Sonntag S, Kryzhanovska M, Shmerling D, Lehnart SE, Sipido KR, Kranias EG, Sanoudou D.

Cardiovasc Res. 2017 Sep 1;113(11):1403-1417. doi: 10.1093/cvr/cvx113.


Opposite effects of catalase and MnSOD ectopic expression on stress induced defects and mortality in the desmin deficient cardiomyopathy model.

Rapti K, Diokmetzidou A, Kloukina I, Milner DJ, Varela A, Davos CH, Capetanaki Y.

Free Radic Biol Med. 2017 Sep;110:206-218. doi: 10.1016/j.freeradbiomed.2017.06.010. Epub 2017 Jun 16.


Corrigendum to "Exercise-based cardiac rehabilitation in twelve European countries: Results of the European Cardiac Rehabilitation Registry" [Int. J. Cardiol. 228 (2017) 58-67].

Benzer W, Rauch B, Schmid JP, Zwisler AD, Dendale P, Davos CH, Kouidi E, Simon A, Abreu A, Pogosova N, Gaita D, Miletic B, Bönner G, Ouarrak T, McGee H; EuroCaReD study group.

Int J Cardiol. 2017 Sep 1;242:50. doi: 10.1016/j.ijcard.2017.04.017. Epub 2017 May 27. No abstract available.


Targeting of the breast cancer microenvironment with a potent and linkable oxindole based antiangiogenic small molecule.

Argyros O, Karampelas T, Varela A, Asvos X, Papakyriakou A, Agalou A, Beis D, Davos CH, Fokas D, Tamvakopoulos C.

Oncotarget. 2017 Jun 6;8(23):37250-37262. doi: 10.18632/oncotarget.16763.


The European Association of Preventive Cardiology Exercise Prescription in Everyday Practice and Rehabilitative Training (EXPERT) tool: A digital training and decision support system for optimized exercise prescription in cardiovascular disease. Concept, definitions and construction methodology.

Hansen D, Dendale P, Coninx K, Vanhees L, Piepoli MF, Niebauer J, Cornelissen V, Pedretti R, Geurts E, Ruiz GR, Corrà U, Schmid JP, Greco E, Davos CH, Edelmann F, Abreu A, Rauch B, Ambrosetti M, Braga SS, Barna O, Beckers P, Bussotti M, Fagard R, Faggiano P, Garcia-Porrero E, Kouidi E, Lamotte M, Neunhäuserer D, Reibis R, Spruit MA, Stettler C, Takken T, Tonoli C, Vigorito C, Völler H, Doherty P.

Eur J Prev Cardiol. 2017 Jul;24(10):1017-1031. doi: 10.1177/2047487317702042. Epub 2017 Apr 18. Review.


Determining exercise training responders through inflammatory status in heart failure.

Adamopoulos S, Davos CH.

Eur J Prev Cardiol. 2017 Jul;24(10):1015-1016. doi: 10.1177/2047487317703823. Epub 2017 Apr 7. No abstract available.


Frailty and cardiac rehabilitation: A call to action from the EAPC Cardiac Rehabilitation Section.

Vigorito C, Abreu A, Ambrosetti M, Belardinelli R, Corrà U, Cupples M, Davos CH, Hoefer S, Iliou MC, Schmid JP, Voeller H, Doherty P.

Eur J Prev Cardiol. 2017 Apr;24(6):577-590. doi: 10.1177/2047487316682579. Epub 2016 Dec 11.


Exercise-based cardiac rehabilitation in twelve European countries results of the European cardiac rehabilitation registry.

Benzer W, Rauch B, Schmid JP, Zwisler AD, Dendale P, Davos CH, Kouidi E, Simon A, Abreu A, Pogosova N, Gaita D, Miletic B, Bönner G, Ouarrak T, McGee H; EuroCaReD study group.

Int J Cardiol. 2017 Feb 1;228:58-67. doi: 10.1016/j.ijcard.2016.11.059. Epub 2016 Nov 11. Erratum in: Int J Cardiol. 2017 Sep 1;242:50. Koudi, Evangelia [corrected to Kouidi, Evangelia].


The prognostic effect of cardiac rehabilitation in the era of acute revascularisation and statin therapy: A systematic review and meta-analysis of randomized and non-randomized studies - The Cardiac Rehabilitation Outcome Study (CROS).

Rauch B, Davos CH, Doherty P, Saure D, Metzendorf MI, Salzwedel A, Völler H, Jensen K, Schmid JP; ‘Cardiac Rehabilitation Section’, European Association of Preventive Cardiology (EAPC), in cooperation with the Institute of Medical Biometry and Informatics (IMBI), Department of Medical Biometry, University of Heidelberg, and the Cochrane Metabolic and Endocrine Disorders Group, Institute of General Practice, Heinrich-Heine University, Düsseldorf, Germany.

Eur J Prev Cardiol. 2016 Dec;23(18):1914-1939. doi: 10.1177/2047487316671181. Epub 2016 Oct 25. Review.


Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival.

Diokmetzidou A, Soumaka E, Kloukina I, Tsikitis M, Makridakis M, Varela A, Davos CH, Georgopoulos S, Anesti V, Vlahou A, Capetanaki Y.

J Cell Sci. 2016 Oct 15;129(20):3705-3720. Epub 2016 Aug 26.


A contemporary cross-sectional study on dyslipidemia management, cardiovascular risk status, and patients' quality of life in Greece: The CHALLENGE study.

Alexopoulos D, Anastasiou-Nana M, Elisaf MS, Liberopoulos E, Rallidis LS, Davos CH, Moulis A, Nikas N, Zacharis E, Vardas P; CHALLENGE Investigators.

Int J Cardiol. 2016 Aug 15;217:183-9. doi: 10.1016/j.ijcard.2016.05.003. Epub 2016 May 3.


Peptide-Drug Conjugate GnRH-Sunitinib Targets Angiogenesis Selectively at the Site of Action to Inhibit Tumor Growth.

Argyros O, Karampelas T, Asvos X, Varela A, Sayyad N, Papakyriakou A, Davos CH, Tzakos AG, Fokas D, Tamvakopoulos C.

Cancer Res. 2016 Mar 1;76(5):1181-92. doi: 10.1158/0008-5472.CAN-15-2138. Epub 2015 Dec 8.


Elevated expression of mechanosensory polycystins in human carotid atherosclerotic plaques: association with p53 activation and disease severity.

Varela A, Piperi C, Sigala F, Agrogiannis G, Davos CH, Andri MA, Manopoulos C, Tsangaris S, Basdra EK, Papavassiliou AG.

Sci Rep. 2015 Aug 19;5:13461. doi: 10.1038/srep13461.


Tumor necrosis factor-α confers cardioprotection through ectopic expression of keratins K8 and K18.

Papathanasiou S, Rickelt S, Soriano ME, Schips TG, Maier HJ, Davos CH, Varela A, Kaklamanis L, Mann DL, Capetanaki Y.

Nat Med. 2015 Sep;21(9):1076-84. doi: 10.1038/nm.3925. Epub 2015 Aug 17.


Hemodynamic effects of high intensity interval training in COPD patients exhibiting exercise-induced dynamic hyperinflation.

Nasis I, Kortianou E, Vasilopoulou Μ, Spetsioti S, Louvaris Z, Kaltsakas G, Davos CH, Zakynthinos S, Koulouris NG, Vogiatzis I.

Respir Physiol Neurobiol. 2015 Oct;217:8-16. doi: 10.1016/j.resp.2015.06.006. Epub 2015 Jun 23.


Complement system modulation as a target for treatment of arrhythmogenic cardiomyopathy.

Mavroidis M, Davos CH, Psarras S, Varela A, C Athanasiadis N, Katsimpoulas M, Kostavasili I, Maasch C, Vater A, van Tintelen JP, Capetanaki Y.

Basic Res Cardiol. 2015 May;110(3):27. doi: 10.1007/s00395-015-0485-6. Epub 2015 Apr 8.


Diverse radiofrequency sensitivity and radiofrequency effects of mobile or cordless phone near fields exposure in Drosophila melanogaster.

Geronikolou S, Zimeras S, Davos CH, Michalopoulos I, Tsitomeneas S.

PLoS One. 2014 Nov 17;9(11):e112139. doi: 10.1371/journal.pone.0112139. eCollection 2014.


Cardiac autonomic nervous activity in adults with coarctation of the aorta late after repair.

Moutafi AC, Manis G, Dellos C, Tousoulis D, Davos CH.

Int J Cardiol. 2014 May 15;173(3):566-8. doi: 10.1016/j.ijcard.2014.03.120. Epub 2014 Mar 21. No abstract available.


Neurohormones, cytokines, and aortic function in children with repaired coarctation of the aorta.

Moutafi AC, Alissafi T, Chryssanthopoulos S, Thanopoulos V, Tousoulis D, Stefanadis C, Davos CH.

Int J Cardiol. 2014 Mar 1;172(1):e26-7. doi: 10.1016/j.ijcard.2013.12.091. Epub 2014 Jan 4. No abstract available.


Toll-like receptor 7 protects from atherosclerosis by constraining "inflammatory" macrophage activation.

Salagianni M, Galani IE, Lundberg AM, Davos CH, Varela A, Gavriil A, Lyytikäinen LP, Lehtimäki T, Sigala F, Folkersen L, Gorgoulis V, Lenglet S, Montecucco F, Mach F, Hedin U, Hansson GK, Monaco C, Andreakos E.

Circulation. 2012 Aug 21;126(8):952-62. doi: 10.1161/CIRCULATIONAHA.111.067678. Epub 2012 Jul 11.


Neurohormonal and cytokine fluctuations following transcatheter closure for an atrial septal defect.

Chamakou AC, Dede E, Moutafi A, Thanopoulos V, Chryssanthopoulos S, Loukopoulou S, Pitsavos C, Stefanadis C, Davos CH.

Cytokine. 2012 Jan;57(1):130-5. doi: 10.1016/j.cyto.2011.10.002. Epub 2011 Nov 9.


Early shear stress signaling on vascular endothelium by a modified partial carotid ligation model.

Varela A, Katsiboulas M, Tousoulis D, Politi K, Papaioannou TG, Vaina S, Davos CH, Piperi C, Stefanadis C, Basdra EK, Papavassiliou AG.

Int J Cardiol. 2011 Nov 3;152(3):413-6. doi: 10.1016/j.ijcard.2011.08.051. Epub 2011 Sep 13. No abstract available.


Regulation of adverse remodelling by osteopontin in a genetic heart failure model.

Psarras S, Mavroidis M, Sanoudou D, Davos CH, Xanthou G, Varela AE, Panoutsakopoulou V, Capetanaki Y.

Eur Heart J. 2012 Aug;33(15):1954-63. doi: 10.1093/eurheartj/ehr119. Epub 2011 Apr 26.


Neurohormonal activity and vascular properties late after aortic coarctation repair.

Moutafi AC, Alissafi T, Chamakou A, Chryssanthopoulos S, Thanopoulos V, Dellos C, Xanthou G, Tousoulis D, Stefanadis C, Gatzoulis MA, Davos CH.

Int J Cardiol. 2012 Sep 6;159(3):211-6. doi: 10.1016/j.ijcard.2011.02.071. Epub 2011 Mar 22.


Local hemodynamics and intimal hyperplasia at the venous side of a porcine arteriovenous shunt.

Manos TA, Sokolis DP, Giagini AT, Davos CH, Kakisis JD, Kritharis EP, Stergiopulos N, Karayannacos PE, Tsangaris S.

IEEE Trans Inf Technol Biomed. 2010 May;14(3):681-90. doi: 10.1109/TITB.2010.2040288. Epub 2010 Mar 25.


Heart rate turbulence in adults with repaired tetralogy of Fallot.

Davos CH, Moutafi AC, Alexandridi A, Petropoulou E, Varela E, Chamakou AC, Francis DP, Kilner PJ, Piepoli MF, Gatzoulis MA.

Int J Cardiol. 2009 Jul 10;135(3):308-14. doi: 10.1016/j.ijcard.2008.03.096. Epub 2008 Jul 7.


Desmin mediates TNF-alpha-induced aggregate formation and intercalated disk reorganization in heart failure.

Panagopoulou P, Davos CH, Milner DJ, Varela E, Cameron J, Mann DL, Capetanaki Y.

J Cell Biol. 2008 Jun 2;181(5):761-75. doi: 10.1083/jcb.200710049.


Psychological consequences among adults following the 1999 earthquake in Athens, Greece.

Varela E, Koustouki V, Davos CH, Eleni K.

Disasters. 2008 Jun;32(2):280-91. doi: 10.1111/j.1467-7717.2008.01039.x.


Heart transplantation in heart failure: the prognostic importance of body mass index at time of surgery and subsequent weight changes.

Clark AL, Knosalla C, Birks E, Loebe M, Davos CH, Tsang S, Negassa A, Yacoub M, Hetzer R, Coats AJ, Anker SD.

Eur J Heart Fail. 2007 Aug;9(8):839-44. Epub 2007 May 29.


Statin use and survival in patients with chronic heart failure--results from two observational studies with 5200 patients.

Anker SD, Clark AL, Winkler R, Zugck C, Cicoira M, Ponikowski P, Davos CH, Banasiak W, Zardini P, Haass M, Senges J, Coats AJ, Poole-Wilson PA, Pitt B.

Int J Cardiol. 2006 Sep 20;112(2):234-42. Epub 2006 Jul 17.


Putative contribution of prostaglandin and bradykinin to muscle reflex hyperactivity in patients on Ace-inhibitor therapy for chronic heart failure.

Scott AC, Wensel R, Davos CH, Georgiadou P, Ceri Davies L, Coats AJ, Francis DP, Piepoli MF.

Eur Heart J. 2004 Oct;25(20):1806-13.


Prediction of mortality in chronic heart failure from peak oxygen consumption adjusted for either body weight or lean tissue.

Cicoira M, Davos CH, Francis DP, Doehner W, Zanolla L, Franceschini L, Piepoli MF, Coats AJ, Zardini P, Poole-Wilson PA, Anker SD.

J Card Fail. 2004 Oct;10(5):421-6.


Global impairment of cardiac autonomic nervous activity late after the Fontan operation.

Davos CH, Francis DP, Leenarts MF, Yap SC, Li W, Davlouros PA, Wensel R, Coats AJ, Piepoli M, Sreeram N, Gatzoulis MA.

Circulation. 2003 Sep 9;108 Suppl 1:II180-5.


Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging.

Anker SD, Doehner W, Rauchhaus M, Sharma R, Francis D, Knosalla C, Davos CH, Cicoira M, Shamim W, Kemp M, Segal R, Osterziel KJ, Leyva F, Hetzer R, Ponikowski P, Coats AJ.

Circulation. 2003 Apr 22;107(15):1991-7. Epub 2003 Apr 21.


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