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Items: 13


Profound Tissue Specificity in Proliferation Control Underlies Cancer Drivers and Aneuploidy Patterns.

Sack LM, Davoli T, Li MZ, Li Y, Xu Q, Naxerova K, Wooten EC, Bernardi RJ, Martin TD, Chen T, Leng Y, Liang AC, Scorsone KA, Westbrook TF, Wong KK, Elledge SJ.

Cell. 2018 Apr 5;173(2):499-514.e23. doi: 10.1016/j.cell.2018.02.037. Epub 2018 Mar 22.


A genetic interaction analysis identifies cancer drivers that modify EGFR dependency.

Liao S, Davoli T, Leng Y, Li MZ, Xu Q, Elledge SJ.

Genes Dev. 2017 Jan 15;31(2):184-196. doi: 10.1101/gad.291948.116. Epub 2017 Feb 6.


Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy.

Davoli T, Uno H, Wooten EC, Elledge SJ.

Science. 2017 Jan 20;355(6322). pii: eaaf8399. doi: 10.1126/science.aaf8399.


Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover.

Davoli T, Mengwasser KE, Duan J, Chen T, Christensen C, Wooten EC, Anselmo AN, Li MZ, Wong KK, Kahle KT, Elledge SJ.

Genes Dev. 2016 Dec 15;30(24):2684-2695. doi: 10.1101/gad.290122.116.


Sources of Error in Mammalian Genetic Screens.

Sack LM, Davoli T, Xu Q, Li MZ, Elledge SJ.

G3 (Bethesda). 2016 Sep 8;6(9):2781-90. doi: 10.1534/g3.116.030973.


A primary melanoma and its asynchronous metastasis highlight the role of BRAF, CDKN2A, and TERT.

Hosler GA, Davoli T, Mender I, Litzner B, Choi J, Kapur P, Shay JW, Wang RC.

J Cutan Pathol. 2015 Feb;42(2):108-17. doi: 10.1111/cup.12444. Epub 2014 Dec 11.


Comprehensive identification of host modulators of HIV-1 replication using multiple orthologous RNAi reagents.

Zhu J, Davoli T, Perriera JM, Chin CR, Gaiha GD, John SP, Sigiollot FD, Gao G, Xu Q, Qu H, Pertel T, Sims JS, Smith JA, Baker RE, Maranda L, Ng A, Elledge SJ, Brass AL.

Cell Rep. 2014 Oct 23;9(2):752-66. doi: 10.1016/j.celrep.2014.09.031. Epub 2014 Oct 16.


Cumulative haploinsufficiency and triplosensitivity drive aneuploidy patterns and shape the cancer genome.

Davoli T, Xu AW, Mengwasser KE, Sack LM, Yoon JC, Park PJ, Elledge SJ.

Cell. 2013 Nov 7;155(4):948-62. doi: 10.1016/j.cell.2013.10.011. Epub 2013 Oct 31.


STOP gene Phactr4 is a tumor suppressor.

Solimini NL, Liang AC, Xu C, Pavlova NN, Xu Q, Davoli T, Li MZ, Wong KK, Elledge SJ.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):E407-14. doi: 10.1073/pnas.1221385110. Epub 2013 Jan 14.


Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells.

Davoli T, de Lange T.

Cancer Cell. 2012 Jun 12;21(6):765-76. doi: 10.1016/j.ccr.2012.03.044.


The causes and consequences of polyploidy in normal development and cancer.

Davoli T, de Lange T.

Annu Rev Cell Dev Biol. 2011;27:585-610. doi: 10.1146/annurev-cellbio-092910-154234. Epub 2011 Jul 21. Review.


Persistent telomere damage induces bypass of mitosis and tetraploidy.

Davoli T, Denchi EL, de Lange T.

Cell. 2010 Apr 2;141(1):81-93. doi: 10.1016/j.cell.2010.01.031.


Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7 gamma.

Bonetti P, Davoli T, Sironi C, Amati B, Pelicci PG, Colombo E.

J Cell Biol. 2008 Jul 14;182(1):19-26. doi: 10.1083/jcb.200711040.

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