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Items: 1 to 50 of 90

1.

Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q58⁻K59 Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities.

Sikorra S, Skiba M, Dorner MB, Weisemann J, Weil M, Valdezate S, Davletov B, Rummel A, Dorner BG, Binz T.

Toxins (Basel). 2018 Aug 1;10(8). pii: E311. doi: 10.3390/toxins10080311.

2.

Selective neuronal silencing using synthetic botulinum molecules alleviates chronic pain in mice.

Maiarù M, Leese C, Certo M, Echeverria-Altuna I, Mangione AS, Arsenault J, Davletov B, Hunt SP.

Sci Transl Med. 2018 Jul 18;10(450). pii: eaar7384. doi: 10.1126/scitranslmed.aar7384.

PMID:
30021888
3.

Emerging evidence for the modulation of exocytosis by signalling lipids.

Garcia-Martinez V, Gimenez-Molina Y, Villanueva J, Darios FD, Davletov B, Gutiérrez LM.

FEBS Lett. 2018 Nov;592(21):3493-3503. doi: 10.1002/1873-3468.13178. Epub 2018 Jul 10. Review.

4.

Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells.

Rust A, Shah S, Hautbergue GM, Davletov B.

Toxins (Basel). 2018 Jun 27;10(7). pii: E261. doi: 10.3390/toxins10070261.

5.

Structural and Aggregation Properties of Alpha-Synuclein Linked to Phospholipase A2 Action.

Broersen K, Ruiperez V, Davletov B.

Protein Pept Lett. 2018;25(4):368-378. doi: 10.2174/0929866525666180326120052.

PMID:
29577851
6.

A Cell Line for Detection of Botulinum Neurotoxin Type B.

Rust A, Doran C, Hart R, Binz T, Stickings P, Sesardic D, Peden AA, Davletov B.

Front Pharmacol. 2017 Nov 9;8:796. doi: 10.3389/fphar.2017.00796. eCollection 2017.

7.

The Use of Plant-Derived Ribosome Inactivating Proteins in Immunotoxin Development: Past, Present and Future Generations.

Rust A, Partridge LJ, Davletov B, Hautbergue GM.

Toxins (Basel). 2017 Oct 27;9(11). pii: E344. doi: 10.3390/toxins9110344. Review.

8.

Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion.

Darios FD, Jorgacevski J, Flašker A, Zorec R, García-Martinez V, Villanueva J, Gutiérrez LM, Leese C, Bal M, Nosyreva E, Kavalali ET, Davletov B.

Sci Rep. 2017 Jul 20;7(1):5958. doi: 10.1038/s41598-017-05948-z.

9.

Sigma-1 receptor expression in the dorsal root ganglion: Reexamination using a highly specific antibody.

Mavlyutov TA, Duellman T, Kim HT, Epstein ML, Leese C, Davletov BA, Yang J.

Neuroscience. 2016 Sep 7;331:148-57. doi: 10.1016/j.neuroscience.2016.06.030. Epub 2016 Jun 23.

10.

Botulinum neurotoxin type C protease induces apoptosis in differentiated human neuroblastoma cells.

Rust A, Leese C, Binz T, Davletov B.

Oncotarget. 2016 May 31;7(22):33220-8. doi: 10.18632/oncotarget.8903.

11.

Angiotensin II activates different calcium signaling pathways in adipocytes.

Dolgacheva LP, Turovskaya MV, Dynnik VV, Zinchenko VP, Goncharov NV, Davletov B, Turovsky EA.

Arch Biochem Biophys. 2016 Mar 1;593:38-49. doi: 10.1016/j.abb.2016.02.001. Epub 2016 Feb 3.

PMID:
26850364
12.

Nonparalytic botulinum molecules for the control of pain.

Mangione AS, Obara I, Maiarú M, Geranton SM, Tassorelli C, Ferrari E, Leese C, Davletov B, Hunt SP.

Pain. 2016 May;157(5):1045-55. doi: 10.1097/j.pain.0000000000000478.

13.

Two complementary approaches for intracellular delivery of exogenous enzymes.

Rust A, Hassan HH, Sedelnikova S, Niranjan D, Hautbergue G, Abbas SA, Partridge L, Rice D, Binz T, Davletov B.

Sci Rep. 2015 Jul 24;5:12444. doi: 10.1038/srep12444.

14.

Control of autophagosome axonal retrograde flux by presynaptic activity unveiled using botulinum neurotoxin type a.

Wang T, Martin S, Papadopulos A, Harper CB, Mavlyutov TA, Niranjan D, Glass NR, Cooper-White JJ, Sibarita JB, Choquet D, Davletov B, Meunier FA.

J Neurosci. 2015 Apr 15;35(15):6179-94. doi: 10.1523/JNEUROSCI.3757-14.2015.

15.

Unexpected transcellular protein crossover occurs during canonical DNA transfection.

Arsenault J, Cuijpers SA, Niranjan D, Davletov B.

J Cell Biochem. 2014 Dec;115(12):2047-54. doi: 10.1002/jcb.24884.

16.

A multiple sclerosis drug sheds light on astrocyte biology.

Davletov B.

Acta Physiol (Oxf). 2014 Sep;212(1):8-10. doi: 10.1111/apha.12330. Epub 2014 Jul 1. No abstract available.

PMID:
24947320
17.

Botulinum protease-cleaved SNARE fragments induce cytotoxicity in neuroblastoma cells.

Arsenault J, Cuijpers SA, Ferrari E, Niranjan D, Rust A, Leese C, O'Brien JA, Binz T, Davletov B.

J Neurochem. 2014 Jun;129(5):781-91. doi: 10.1111/jnc.12645. Epub 2014 Jan 23.

18.

Lipid metabolites enhance secretion acting on SNARE microdomains and altering the extent and kinetics of single release events in bovine adrenal chromaffin cells.

García-Martínez V, Villanueva J, Torregrosa-Hetland CJ, Bittman R, Higdon A, Darley-Usmar VM, Davletov B, Gutiérrez LM.

PLoS One. 2013 Sep 20;8(9):e75845. doi: 10.1371/journal.pone.0075845. eCollection 2013.

19.

Cortical spreading depression induces oxidative stress in the trigeminal nociceptive system.

Shatillo A, Koroleva K, Giniatullina R, Naumenko N, Slastnikova AA, Aliev RR, Bart G, Atalay M, Gu C, Khazipov R, Davletov B, Grohn O, Giniatullin R.

Neuroscience. 2013 Dec 3;253:341-9. doi: 10.1016/j.neuroscience.2013.09.002. Epub 2013 Sep 11.

PMID:
24036374
20.

Synthetic self-assembling clostridial chimera for modulation of sensory functions.

Ferrari E, Gu C, Niranjan D, Restani L, Rasetti-Escargueil C, Obara I, Geranton SM, Arsenault J, Goetze TA, Harper CB, Nguyen TH, Maywood E, O'Brien J, Schiavo G, Wheeler DW, Meunier FA, Hastings M, Edwardson JM, Sesardic D, Caleo M, Hunt SP, Davletov B.

Bioconjug Chem. 2013 Oct 16;24(10):1750-9. doi: 10.1021/bc4003103. Epub 2013 Sep 20.

21.

Synaptotagmin interaction with SNAP-25 governs vesicle docking, priming, and fusion triggering.

Mohrmann R, de Wit H, Connell E, Pinheiro PS, Leese C, Bruns D, Davletov B, Verhage M, Sørensen JB.

J Neurosci. 2013 Sep 4;33(36):14417-30. doi: 10.1523/JNEUROSCI.1236-13.2013.

22.

Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells.

Arsenault J, Ferrari E, Niranjan D, Cuijpers SA, Gu C, Vallis Y, O'Brien J, Davletov B.

J Neurochem. 2013 Jul;126(2):223-33. doi: 10.1111/jnc.12284. Epub 2013 May 20.

23.

Presynaptic neurotoxins: an expanding array of natural and modified molecules.

Davletov B, Ferrari E, Ushkaryov Y.

Cell Calcium. 2012 Sep-Oct;52(3-4):234-40. doi: 10.1016/j.ceca.2012.05.006. Epub 2012 Jun 1. Review.

PMID:
22658826
24.

Fingolimod--a sphingosine-like molecule inhibits vesicle mobility and secretion in astrocytes.

Trkov S, Stenovec M, Kreft M, Potokar M, Parpura V, Davletov B, Zorec R.

Glia. 2012 Sep;60(9):1406-16. doi: 10.1002/glia.22361. Epub 2012 May 25.

25.

VAMP4 directs synaptic vesicles to a pool that selectively maintains asynchronous neurotransmission.

Raingo J, Khvotchev M, Liu P, Darios F, Li YC, Ramirez DM, Adachi M, Lemieux P, Toth K, Davletov B, Kavalali ET.

Nat Neurosci. 2012 Mar 11;15(5):738-45. doi: 10.1038/nn.3067.

26.

Assembly of protein building blocks using a short synthetic peptide.

Ferrari E, Soloviev M, Niranjan D, Arsenault J, Gu C, Vallis Y, O'Brien J, Davletov B.

Bioconjug Chem. 2012 Mar 21;23(3):479-84. doi: 10.1021/bc2005208. Epub 2012 Feb 10.

27.

Re-assembled botulinum neurotoxin inhibits CNS functions without systemic toxicity.

Ferrari E, Maywood ES, Restani L, Caleo M, Pirazzini M, Rossetto O, Hastings MH, Niranjan D, Schiavo G, Davletov B.

Toxins (Basel). 2011 Apr;3(4):345-55. doi: 10.3390/toxins3040345. Epub 2011 Mar 24.

28.

SNARE tagging allows stepwise assembly of a multimodular medicinal toxin.

Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y, Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18197-201. doi: 10.1073/pnas.1007125107. Epub 2010 Oct 4.

29.

Lipid function at synapses.

Davletov B, Montecucco C.

Curr Opin Neurobiol. 2010 Oct;20(5):543-9. doi: 10.1016/j.conb.2010.06.008. Epub 2010 Jul 23. Review.

PMID:
20655194
30.

Alpha-synuclein, lipids and Parkinson's disease.

Ruipérez V, Darios F, Davletov B.

Prog Lipid Res. 2010 Oct;49(4):420-8. doi: 10.1016/j.plipres.2010.05.004. Epub 2010 May 23. Review.

PMID:
20580911
31.

Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis.

Darios F, Ruipérez V, López I, Villanueva J, Gutierrez LM, Davletov B.

EMBO Rep. 2010 Jul;11(7):528-33. doi: 10.1038/embor.2010.66. Epub 2010 May 21.

32.

Binary polypeptide system for permanent and oriented protein immobilization.

Ferrari E, Darios F, Zhang F, Niranjan D, Bailes J, Soloviev M, Davletov B.

J Nanobiotechnology. 2010 May 12;8:9. doi: 10.1186/1477-3155-8-9.

33.

N-terminal acetylation of the neuronal protein SNAP-25 is revealed by the SMI81 monoclonal antibody.

Connell E, Darios F, Peak-Chew S, Soloviev M, Davletov B.

Biochemistry. 2009 Oct 13;48(40):9582-9. doi: 10.1021/bi9012403.

PMID:
19747004
34.

Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis.

Darios F, Wasser C, Shakirzyanova A, Giniatullin A, Goodman K, Munoz-Bravo JL, Raingo J, Jorgacevski J, Kreft M, Zorec R, Rosa JM, Gandia L, Gutiérrez LM, Binz T, Giniatullin R, Kavalali ET, Davletov B.

Neuron. 2009 Jun 11;62(5):683-94. doi: 10.1016/j.neuron.2009.04.024.

35.

DOC2B acts as a calcium switch and enhances vesicle fusion.

Friedrich R, Groffen AJ, Connell E, van Weering JR, Gutman O, Henis YI, Davletov B, Ashery U.

J Neurosci. 2008 Jul 2;28(27):6794-806. doi: 10.1523/JNEUROSCI.0538-08.2008.

36.

Cross-linking of phospholipid membranes is a conserved property of calcium-sensitive synaptotagmins.

Connell E, Giniatullina A, Lai-Kee-Him J, Tavare R, Ferrari E, Roseman A, Cojoc D, Brisson AR, Davletov B.

J Mol Biol. 2008 Jun 27;380(1):42-50. doi: 10.1016/j.jmb.2008.01.084. Epub 2008 Feb 5.

37.

Real-time assay for monitoring membrane association of lipid-binding domains.

Connell E, Scott P, Davletov B.

Anal Biochem. 2008 Jun 1;377(1):83-8. doi: 10.1016/j.ab.2008.02.016. Epub 2008 Feb 23.

38.

Detection of cell death in tumors by using MR imaging and a gadolinium-based targeted contrast agent.

Krishnan AS, Neves AA, de Backer MM, Hu DE, Davletov B, Kettunen MI, Brindle KM.

Radiology. 2008 Mar;246(3):854-62. doi: 10.1148/radiol.2463070471. Epub 2008 Jan 9.

PMID:
18187402
39.

Munc18-1 is critical for plasma membrane localization of syntaxin1 but not of SNAP-25 in PC12 cells.

Arunachalam L, Han L, Tassew NG, He Y, Wang L, Xie L, Fujita Y, Kwan E, Davletov B, Monnier PP, Gaisano HY, Sugita S.

Mol Biol Cell. 2008 Feb;19(2):722-34. Epub 2007 Dec 12.

40.

SPECT imaging of myocardial infarction using 99mTc-labeled C2A domain of synaptotagmin I in a porcine ischemia-reperfusion model.

Fang W, Wang F, Ji S, Zhu X, Meier HT, Hellman RS, Brindle KM, Davletov B, Zhao M.

Nucl Med Biol. 2007 Nov;34(8):917-23. Epub 2007 Sep 4.

PMID:
17998093
41.

Neurexin Ibeta and neuroligin are localized on opposite membranes in mature central synapses.

Berninghausen O, Rahman MA, Silva JP, Davletov B, Hopkins C, Ushkaryov YA.

J Neurochem. 2007 Dec;103(5):1855-63. Epub 2007 Sep 13.

42.

Phospholipases and fatty acid signalling in exocytosis.

Darios F, Connell E, Davletov B.

J Physiol. 2007 Dec 15;585(Pt 3):699-704. Epub 2007 Jun 21. Review.

43.
44.

Regulation of SNARE fusion machinery by fatty acids.

Davletov B, Connell E, Darios F.

Cell Mol Life Sci. 2007 Jul;64(13):1597-608. Review.

PMID:
17458500
45.

A paramagnetic nanoprobe to detect tumor cell death using magnetic resonance imaging.

Neves AA, Krishnan AS, Kettunen MI, Hu DE, Backer MM, Davletov B, Brindle KM.

Nano Lett. 2007 May;7(5):1419-23. Epub 2007 Apr 6.

PMID:
17411099
46.

Mechanism of arachidonic acid action on syntaxin-Munc18.

Connell E, Darios F, Broersen K, Gatsby N, Peak-Chew SY, Rickman C, Davletov B.

EMBO Rep. 2007 Apr;8(4):414-9. Epub 2007 Mar 16.

47.

Alpha-synuclein adopts an alpha-helical conformation in the presence of polyunsaturated fatty acids to hinder micelle formation.

Broersen K, van den Brink D, Fraser G, Goedert M, Davletov B.

Biochemistry. 2006 Dec 26;45(51):15610-6. Epub 2006 Dec 7.

PMID:
17176082
48.

Tight coupling of the t-SNARE and calcium channel microdomains in adrenomedullary slices and not in cultured chromaffin cells.

Lopez I, Giner D, Ruiz-Nuño A, Fuentealba J, Viniegra S, Garcia AG, Davletov B, Gutiérrez LM.

Cell Calcium. 2007 Jun;41(6):547-58. Epub 2006 Nov 16.

PMID:
17112584
49.

SNAP25 is a pre-synaptic target for the depressant action of reactive oxygen species on transmitter release.

Giniatullin AR, Darios F, Shakirzyanova A, Davletov B, Giniatullin R.

J Neurochem. 2006 Sep;98(6):1789-97.

50.

Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3.

Darios F, Davletov B.

Nature. 2006 Apr 6;440(7085):813-7.

PMID:
16598260

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