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Functional Brush Poly(2-ethyl-2-oxazine)s: Synthesis by CROP and RAFT, Thermoresponsiveness and Grafting onto Iron Oxide Nanoparticles.

Klein T, Parkin J, de Jongh PAJM, Esser L, Sepehrizadeh T, Zheng G, De Veer M, Alt K, Hagemeyer CE, Haddleton DM, Davis TP, Thelakkat M, Kempe K.

Macromol Rapid Commun. 2019 Feb 12:e1800911. doi: 10.1002/marc.201800911. [Epub ahead of print]


A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction.

Somers K, Wen VW, Middlemiss SMC, Osborne B, Forgham H, Jung M, Karsa M, Clifton M, Bongers A, Gao J, Mayoh C, Raoufi-Rad N, Kusnadi EP, Hannan KM, Scott DA, Kwek A, Liu B, Flemming C, Chudakova DA, Pandher R, Failes TW, Lim J, Angeli A, Osterman AL, Imamura T, Kees UR, Supuran CT, Pearson RB, Hannan RD, Davis TP, McCarroll J, Kavallaris M, Turner N, Gudkov AV, Haber M, Norris MD, Henderson MJ.

Oncogene. 2019 Jan 22. doi: 10.1038/s41388-018-0666-5. [Epub ahead of print]


Probing the Aggregation and Immune Response of Human Islet Amyloid Polypeptides with Ligand-Stabilized Gold Nanoparticles.

Javed I, He J, Kakinen A, Faridi A, Yang W, Davis TP, Ke PC, Chen P.

ACS Appl Mater Interfaces. 2019 Feb 1. doi: 10.1021/acsami.8b19506. [Epub ahead of print]


Physical and Toxicological Profiles of Human IAPP Amyloids and Plaques.

Kakinen A, Sun Y, Javed I, Faridi A, Pilkington EH, Faridi P, Purcell AW, Zhou R, Ding F, Lin S, Chun Ke P, Davis TP.

Sci Bull (Beijing). 2019 Jan 15;64(1):26-35. doi: 10.1016/j.scib.2018.11.012. Epub 2018 Nov 22.


Vascular dysfunction-The disregarded partner of Alzheimer's disease.

Sweeney MD, Montagne A, Sagare AP, Nation DA, Schneider LS, Chui HC, Harrington MG, Pa J, Law M, Wang DJJ, Jacobs RE, Doubal FN, Ramirez J, Black SE, Nedergaard M, Benveniste H, Dichgans M, Iadecola C, Love S, Bath PM, Markus HS, Salman RA, Allan SM, Quinn TJ, Kalaria RN, Werring DJ, Carare RO, Touyz RM, Williams SCR, Moskowitz MA, Katusic ZS, Lutz SE, Lazarov O, Minshall RD, Rehman J, Davis TP, Wellington CL, González HM, Yuan C, Lockhart SN, Hughes TM, Chen CLH, Sachdev P, O'Brien JT, Skoog I, Pantoni L, Gustafson DR, Biessels GJ, Wallin A, Smith EE, Mok V, Wong A, Passmore P, Barkof F, Muller M, Breteler MMB, Román GC, Hamel E, Seshadri S, Gottesman RF, van Buchem MA, Arvanitakis Z, Schneider JA, Drewes LR, Hachinski V, Finch CE, Toga AW, Wardlaw JM, Zlokovic BV.

Alzheimers Dement. 2019 Jan;15(1):158-167. doi: 10.1016/j.jalz.2018.07.222.


Frequency of 30-Day Readmission and Its Causes After Endovascular Aneurysm Intervention of Abdominal Aortic Aneurysm (from the Nationwide Readmission Database).

Atti V, Nalluri N, Kumar V, Tabet R, Yandrapalli S, Edla S, Tripathi A, Patel NJ, Dave M, Aronow WS, Basir MB, Davis TP, Drachman DE, Bhatt DL.

Am J Cardiol. 2018 Dec 19. pii: S0002-9149(18)32195-7. doi: 10.1016/j.amjcard.2018.12.006. [Epub ahead of print]


Synthesis and identification of novel pyridazinylpyrazolone based diazo compounds as inhibitors of human islet amyloid polypeptide aggregation.

Farrukh SUB, Javed I, Ather AQ, Emwas AH, Alazmi M, Gao X, Chotana GA, Davis TP, Ke PC, Saleem RSZ.

Bioorg Chem. 2019 Mar;84:339-346. doi: 10.1016/j.bioorg.2018.11.039. Epub 2018 Nov 28.


Nucleation of β-rich oligomers and β-barrels in the early aggregation of human islet amyloid polypeptide.

Sun Y, Kakinen A, Xing Y, Pilkington EH, Davis TP, Ke PC, Ding F.

Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):434-444. doi: 10.1016/j.bbadis.2018.11.021. Epub 2018 Nov 28.


Arginine-Rich Manganese Silicate Nanobubbles as a Ferroptosis-Inducing Agent for Tumor-Targeted Theranostics.

Wang S, Li F, Qiao R, Hu X, Liao H, Chen L, Wu J, Haibin W, Zhao M, Liu J, Chen R, Ma X, Kim D, Sun J, Davis TP, Chen C, Tian J, Hyeon T, Ling D.

ACS Nano. 2018 Nov 29. doi: 10.1021/acsnano.8b06399. [Epub ahead of print]


Final Results of the RHAPSODY Trial: A Multi-Center, Phase 2 Trial Using a Continual Reassessment Method to Determine the Safety and Tolerability of 3K3A-APC, A Recombinant Variant of Human Activated Protein C, in Combination with Tissue Plasminogen Activator, Mechanical Thrombectomy or both in Moderate to Severe Acute Ischemic Stroke.

Lyden P, Pryor KE, Coffey CS, Cudkowicz M, Conwit R, Jadhav A, Sawyer RN Jr, Claassen J, Adeoye O, Song S, Hannon P, Rost NS, Hinduja A, Torbey M, Lee JM, Benesch C, Rippee M, Rymer M, Froehler MT, Clarke Haley E, Johnson M, Yankey J, Magee K, Qidwai J, Levy H, Mark Haacke E, Fawaz M, Davis TP, Toga AW, Griffin JH, Zlokovic BV; NeuroNEXT Clinical Trials Network NN104 Investigators.

Ann Neurol. 2019 Jan;85(1):125-136. doi: 10.1002/ana.25383. Epub 2019 Jan 7.


Mitigating Human IAPP Amyloidogenesis In Vivo with Chiral Silica Nanoribbons.

Faridi A, Sun Y, Okazaki Y, Peng G, Gao J, Kakinen A, Faridi P, Zhao M, Javed I, Purcell AW, Davis TP, Lin S, Oda R, Ding F, Ke PC.

Small. 2018 Nov;14(47):e1802825. doi: 10.1002/smll.201802825. Epub 2018 Oct 7.


Exploiting Macromolecular Design To Optimize the Antibacterial Activity of Alkylated Cationic Oligomers.

Grace JL, Schneider-Futschik EK, Elliott AG, Amado M, Truong NP, Cooper MA, Li J, Davis TP, Quinn JF, Velkov T, Whittaker MR.

Biomacromolecules. 2018 Nov 6. doi: 10.1021/acs.biomac.8b01317. [Epub ahead of print]


Bioconjugation and Fluorescence Labeling of Iron Oxide Nanoparticles Grafted with Bromomaleimide-Terminal Polymers.

Qiao R, Esser L, Fu C, Zhang C, Hu J, Ramírez-Arcía P, Li Y, Quinn JF, Whittaker MR, Whittaker AK, Davis TP.

Biomacromolecules. 2018 Nov 12;19(11):4423-4429. doi: 10.1021/acs.biomac.8b01282. Epub 2018 Oct 23.


Graphene quantum dots against human IAPP aggregation and toxicity in vivo.

Wang M, Sun Y, Cao X, Peng G, Javed I, Kakinen A, Davis TP, Lin S, Liu J, Ding F, Ke PC.

Nanoscale. 2018 Nov 1;10(42):19995-20006. doi: 10.1039/c8nr07180b.


Acute pain alters P-glycoprotein-containing protein complexes in rat cerebral microvessels: Implications for P-glycoprotein trafficking.

Tome ME, Jarvis CK, Schaefer CP, Jacobs LM, Herndon JM, Hunn KC, Arkwright NB, Kellohen KL, Mierau PC, Davis TP.

J Cereb Blood Flow Metab. 2018 Dec;38(12):2209-2222. doi: 10.1177/0271678X18803623. Epub 2018 Oct 22.


Modulation of Opioid Transport at the Blood-Brain Barrier by Altered ATP-Binding Cassette (ABC) Transporter Expression and Activity.

Yang J, Reilly BG, Davis TP, Ronaldson PT.

Pharmaceutics. 2018 Oct 18;10(4). pii: E192. doi: 10.3390/pharmaceutics10040192. Review.


Nanoscale inhibition of polymorphic and ambidextrous IAPP amyloid aggregation with small molecules.

Kakinen A, Adamcik J, Wang B, Ge X, Mezzenga R, Davis TP, Ding F, Ke PC.

Nano Res. 2018 Jul;11(7):3636-3647. doi: 10.1007/s12274-017-1930-7. Epub 2018 Aug 2.


Minimum information reporting in bio-nano experimental literature.

Faria M, Björnmalm M, Thurecht KJ, Kent SJ, Parton RG, Kavallaris M, Johnston APR, Gooding JJ, Corrie SR, Boyd BJ, Thordarson P, Whittaker AK, Stevens MM, Prestidge CA, Porter CJH, Parak WJ, Davis TP, Crampin EJ, Caruso F.

Nat Nanotechnol. 2018 Sep;13(9):777-785. doi: 10.1038/s41565-018-0246-4. Epub 2018 Sep 6. Review.


Biologically Targeted Magnetic Hyperthermia: Potential and Limitations.

Chang D, Lim M, Goos JACM, Qiao R, Ng YY, Mansfeld FM, Jackson M, Davis TP, Kavallaris M.

Front Pharmacol. 2018 Aug 2;9:831. doi: 10.3389/fphar.2018.00831. eCollection 2018. Review.


Controlling Nanomaterial Size and Shape for Biomedical Applications via Polymerization-Induced Self-Assembly.

Khor SY, Quinn JF, Whittaker MR, Truong NP, Davis TP.

Macromol Rapid Commun. 2019 Jan;40(2):e1800438. doi: 10.1002/marc.201800438. Epub 2018 Aug 9. Review.


In Vivo Mitigation of Amyloidogenesis through Functional-Pathogenic Double-Protein Coronae.

Javed I, Yu T, Peng G, Sánchez-Ferrer A, Faridi A, Kakinen A, Zhao M, Mezzenga R, Davis TP, Lin S, Ke PC.

Nano Lett. 2018 Aug 13. doi: 10.1021/acs.nanolett.8b02446. [Epub ahead of print]


Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery.

Cottier KE, Galloway EA, Calabrese EC, Tome ME, Liktor-Busa E, Kim J, Davis TP, Vanderah TW, Largent-Milnes TM.

eNeuro. 2018 Jul 16;5(4). pii: ENEURO.0116-18.2018. doi: 10.1523/ENEURO.0116-18.2018. eCollection 2018 Jul-Aug.


Elucidating the Influences of Size, Surface Chemistry, and Dynamic Flow on Cellular Association of Nanoparticles Made by Polymerization-Induced Self-Assembly.

Khor SY, Vu MN, Pilkington EH, Johnston APR, Whittaker MR, Quinn JF, Truong NP, Davis TP.

Small. 2018 Aug;14(34):e1801702. doi: 10.1002/smll.201801702. Epub 2018 Jul 25.


Organic Arsenicals as Functional Motifs in Polymer and Biomaterials Science.

Tanaka J, Davis TP, Wilson P.

Macromol Rapid Commun. 2018 Oct;39(19):e1800205. doi: 10.1002/marc.201800205. Epub 2018 May 28. Review.


Recent Advances in Magnetic Nanoparticle-based Molecular Probes for Hepatocellular Carcinoma Diagnosis and Therapy.

Zhang Q, Wang S, Qiao R, Whittaker MR, Quinn JF, Davis TP, Li H.

Curr Pharm Des. 2018;24(21):2432-2437. doi: 10.2174/1381612824666180516111939.


Profiling the Serum Protein Corona of Fibrillar Human Islet Amyloid Polypeptide.

Pilkington EH, Gustafsson OJR, Xing Y, Hernandez-Fernaud J, Zampronio C, Kakinen A, Faridi A, Ding F, Wilson P, Ke PC, Davis TP.

ACS Nano. 2018 May 16. doi: 10.1021/acsnano.8b02346. [Epub ahead of print]


Microfluidic Mass Production of Stabilized and Stealthy Liquid Metal Nanoparticles.

Tang SY, Qiao R, Yan S, Yuan D, Zhao Q, Yun G, Davis TP, Li W.

Small. 2018 May;14(21):e1800118. doi: 10.1002/smll.201800118. Epub 2018 Apr 22.


Human plasma proteome association and cytotoxicity of nano-graphene oxide grafted with stealth polyethylene glycol and poly(2-ethyl-2-oxazoline).

Wang M, Gustafsson OJR, Siddiqui G, Javed I, Kelly HG, Blin T, Yin H, Kent SJ, Creek DJ, Kempe K, Ke PC, Davis TP.

Nanoscale. 2018 Jun 14;10(23):10863-10875. doi: 10.1039/c8nr00835c.


Nano-assemblies of cationic mPEG brush block copolymers with gadolinium polyoxotungstate [Gd(W5O18)2]9- form stable, high relaxivity MRI contrast agents.

Ly J, Li Y, Vu MN, Moffat BA, Jack KS, Quinn JF, Whittaker MR, Davis TP.

Nanoscale. 2018 Apr 19;10(15):7270-7280. doi: 10.1039/c8nr01544a.


Chronic morphine exposure potentiates p-glycoprotein trafficking from nuclear reservoirs in cortical rat brain microvessels.

Schaefer CP, Arkwright NB, Jacobs LM, Jarvis CK, Hunn KC, Largent-Milnes TM, Tome ME, Davis TP.

PLoS One. 2018 Feb 7;13(2):e0192340. doi: 10.1371/journal.pone.0192340. eCollection 2018.


17-β-Estradiol induces spreading depression and pain behavior in alert female rats.

Sandweiss AJ, Cottier KE, McIntosh MI, Dussor G, Davis TP, Vanderah TW, Largent-Milnes TM.

Oncotarget. 2017 Dec 9;8(69):114109-114122. doi: 10.18632/oncotarget.23141. eCollection 2017 Dec 26.


Serum albumin impedes the amyloid aggregation and hemolysis of human islet amyloid polypeptide and alpha synuclein.

Kakinen A, Javed I, Faridi A, Davis TP, Ke PC.

Biochim Biophys Acta Biomembr. 2018 Jan 27. pii: S0005-2736(18)30021-X. doi: 10.1016/j.bbamem.2018.01.015. [Epub ahead of print]


Association of Anemia With Outcomes in Patients Undergoing Percutaneous Peripheral Vascular Intervention: Insights From the Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2 VIC).

Ambulgekar NV, Grey SF, Rosman HS, Othman H, Davis TP, Nypaver TJ, Schreiber T, Yamasaki H, Lalonde TA, Henke PK, Gurm HS, Mehta RH, Grossman PM; Blue Cross Blue Shield of Michigan Cardiovascular Consortium (BMC2) Investigators.

J Invasive Cardiol. 2018 Jan;30(1):35-42.


Uptake and transcytosis of functionalized superparamagnetic iron oxide nanoparticles in an in vitro blood brain barrier model.

Ivask A, Pilkington EH, Blin T, Käkinen A, Vija H, Visnapuu M, Quinn JF, Whittaker MR, Qiao R, Davis TP, Ke PC, Voelcker NH.

Biomater Sci. 2018 Jan 30;6(2):314-323. doi: 10.1039/c7bm01012e.


Modulating protein amyloid aggregation with nanomaterials.

Wang B, Pilkington EH, Sun Y, Davis TP, Ke PC, Ding F.

Environ Sci Nano. 2017 Sep 1;4(9):1772-1783. doi: 10.1039/C7EN00436B. Epub 2017 Jul 28.


A Decade of the Protein Corona.

Ke PC, Lin S, Parak WJ, Davis TP, Caruso F.

ACS Nano. 2017 Dec 26;11(12):11773-11776. doi: 10.1021/acsnano.7b08008. Epub 2017 Dec 5.


The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse.

Schaefer CP, Tome ME, Davis TP.

Fluids Barriers CNS. 2017 Nov 29;14(1):32. doi: 10.1186/s12987-017-0080-3. Review.


Journey to the centre of the cell: Virtual reality immersion into scientific data.

Johnston APR, Rae J, Ariotti N, Bailey B, Lilja A, Webb R, Ferguson C, Maher S, Davis TP, Webb RI, McGhee J, Parton RG.

Traffic. 2018 Feb;19(2):105-110. doi: 10.1111/tra.12538. Epub 2017 Nov 21.


NanoEHS beyond Toxicity - Focusing on Biocorona.

Lin S, Mortimer M, Chen R, Kakinen A, Riviere JE, Davis TP, Ding F, Ke PC.

Environ Sci Nano. 2017 Jul 1;7(4):1433-1454. doi: 10.1039/C6EN00579A. Epub 2017 Jun 1.


Lysophosphatidylcholine modulates the aggregation of human islet amyloid polypeptide.

Xing Y, Pilkington EH, Wang M, Nowell CJ, Kakinen A, Sun Y, Wang B, Davis TP, Ding F, Ke PC.

Phys Chem Chem Phys. 2017 Nov 22;19(45):30627-30635. doi: 10.1039/c7cp06670h.


Cofibrillization of Pathogenic and Functional Amyloid Proteins with Gold Nanoparticles against Amyloidogenesis.

Javed I, Sun Y, Adamcik J, Wang B, Kakinen A, Pilkington EH, Ding F, Mezzenga R, Davis TP, Ke PC.

Biomacromolecules. 2017 Dec 11;18(12):4316-4322. doi: 10.1021/acs.biomac.7b01359. Epub 2017 Nov 14.


Star Polymers Reduce Islet Amyloid Polypeptide Toxicity via Accelerated Amyloid Aggregation.

Pilkington EH, Lai M, Ge X, Stanley WJ, Wang B, Wang M, Kakinen A, Sani MA, Whittaker MR, Gurzov EN, Ding F, Quinn JF, Davis TP, Ke PC.

Biomacromolecules. 2017 Dec 11;18(12):4249-4260. doi: 10.1021/acs.biomac.7b01301. Epub 2017 Oct 31.


One-Pot Synthesis of ABCDE Multiblock Copolymers with Hydrophobic, Hydrophilic, and Semi-Fluorinated Segments.

Anastasaki A, Oschmann B, Willenbacher J, Melker A, Van Son MHC, Truong NP, Schulze MW, Discekici EH, McGrath AJ, Davis TP, Bates CM, Hawker CJ.

Angew Chem Int Ed Engl. 2017 Nov 13;56(46):14483-14487. doi: 10.1002/anie.201707646. Epub 2017 Oct 24.


Cationic Acrylate Oligomers Comprising Amino Acid Mimic Moieties Demonstrate Improved Antibacterial Killing Efficiency.

Grace JL, Elliott AG, Huang JX, Schneider EK, Truong NP, Cooper MA, Li J, Davis TP, Quinn JF, Velkov T, Whittaker MR.

J Mater Chem B. 2017 Jan 21;5(3):531-536. doi: 10.1039/C6TB02787C. Epub 2016 Dec 13.


Lipidated polymers for the stabilization of cubosomes: nanostructured drug delivery vehicles.

Grace JL, Alcaraz N, Truong NP, Davis TP, Boyd BJ, Quinn JF, Whittaker MR.

Chem Commun (Camb). 2017 Sep 21;53(76):10552-10555. doi: 10.1039/c7cc05842j.


Influence of Size and Shape on the Biodistribution of Nanoparticles Prepared by Polymerization-Induced Self-Assembly.

Kaga S, Truong NP, Esser L, Senyschyn D, Sanyal A, Sanyal R, Quinn JF, Davis TP, Kaminskas LM, Whittaker MR.

Biomacromolecules. 2017 Dec 11;18(12):3963-3970. doi: 10.1021/acs.biomac.7b00995. Epub 2017 Sep 29.


Distal Cuff Occlusion: A Novel, Simple Approach for Distal Embolic Protection in Peripheral Vascular Intervention.

Jalal S, Mustapha JA, Rosman HS, Mehta RH, Davis TP.

J Invasive Cardiol. 2017 Sep;29(9):297-300.


Nitric oxide-sensing actuators for modulating structure in lipid-based liquid crystalline drug delivery systems.

Liu Q, Hu J, Whittaker MR, Davis TP, Boyd BJ.

J Colloid Interface Sci. 2017 Dec 15;508:517-524. doi: 10.1016/j.jcis.2017.08.079. Epub 2017 Aug 24.


Plasma Proteome Association and Catalytic Activity of Stealth Polymer-Grafted Iron Oxide Nanoparticles.

Wang M, Siddiqui G, Gustafsson OJR, Käkinen A, Javed I, Voelcker NH, Creek DJ, Ke PC, Davis TP.

Small. 2017 Sep;13(36). doi: 10.1002/smll.201701528. Epub 2017 Aug 7.


Zinc-coordination and C-peptide complexation: a potential mechanism for the endogenous inhibition of IAPP aggregation.

Ge X, Kakinen A, Gurzov EN, Yang W, Pang L, Pilkington EH, Govindan-Nedumpully P, Chen P, Separovic F, Davis TP, Ke PC, Ding F.

Chem Commun (Camb). 2017 Aug 22;53(68):9394-9397. doi: 10.1039/c7cc04291d.

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