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Autophagy Inhibition to Augment mTOR Inhibition: a Phase I/II Trial of Everolimus and Hydroxychloroquine in Patients with Previously Treated Renal Cell Carcinoma.

Haas NB, Appleman LJ, Stein M, Redlinger M, Wilks M, Xu X, Onorati A, Kalavacharla A, Kim T, Zhen CJ, Kadri S, Segal JP, Gimotty PA, Davis LE, Amaravadi RK.

Clin Cancer Res. 2019 Jan 11. doi: 10.1158/1078-0432.CCR-18-2204. [Epub ahead of print]


Safety and efficacy of high-dose methotrexate for osteosarcoma in adolescents compared with young adults.

Wippel B, Gundle KR, Dang T, Paxton J, Bubalo J, Stork L, Fu R, Ryan CW, Davis LE.

Cancer Med. 2019 Jan;8(1):111-116. doi: 10.1002/cam4.1898. Epub 2018 Dec 22.


Foramen ovale blood flow and cardiac function after main pulmonary artery occlusion in fetal sheep.

Lantto J, Erkinaro T, Haapsamo M, Huhta H, Voipio HM, Hohimer AR, Davis LE, Acharya G, Räsänen J.

Exp Physiol. 2019 Feb;104(2):189-198. doi: 10.1113/EP087423. Epub 2019 Jan 13.


Discovery and Characterization of Recurrent, Targetable ALK Fusions in Leiomyosarcoma.

Davis LE, Nusser KD, Przybyl J, Pittsenbarger J, Hofmann NE, Varma S, Vennam S, Debiec-Rychter M, van de Rijn M, Davare MA.

Mol Cancer Res. 2018 Dec 5. doi: 10.1158/1541-7786.MCR-18-1075. [Epub ahead of print]


Dynamin Is Required for Efficient Cytomegalovirus Maturation and Envelopment.

Hasan MH, Davis LE, Bollavarapu RK, Mitra D, Parmar R, Tandon R.

J Virol. 2018 Nov 27;92(24). pii: e01418-18. doi: 10.1128/JVI.01418-18. Print 2018 Dec 15.


Acute Bacterial Meningitis.

Davis LE.

Continuum (Minneap Minn). 2018 Oct;24(5, Neuroinfectious Disease):1264-1283. doi: 10.1212/CON.0000000000000660.


Using Teleneurology to Deliver Chronic Neurologic Care to Rural Veterans: Analysis of the First 1,100 Patient Visits.

Davis LE, Harnar J, LaChey-Barbee LA, Richardson SP, Fraser A, King MK.

Telemed J E Health. 2018 Jul 17. doi: 10.1089/tmj.2018.0067. [Epub ahead of print]


Patient-reported symptoms after breast cancer diagnosis and treatment: A retrospective cohort study.

Davis LE, Bubis LD, Mahar AL, Li Q, Sussman J, Moody L, Barbera L, Holloway CM, Coburn NG.

Eur J Cancer. 2018 Sep;101:1-11. doi: 10.1016/j.ejca.2018.06.006. Epub 2018 Jul 13.


Pseudoprogression of CNS metastatic disease of alveolar soft part sarcoma during anti-PDL1 treatment.

Vander Jagt TA, Davis LE, Thakur MD, Franz C, Pollock JM.

Radiol Case Rep. 2018 Jul 3;13(4):882-885. doi: 10.1016/j.radcr.2018.05.013. eCollection 2018 Aug.


Combined angiotensin receptor and neprilysin inhibition therapy for heart failure.

Lu BN, Davis LE.

JAAPA. 2018 Jul;31(7):35-37. doi: 10.1097/01.JAA.0000534982.53989.c2.


CDK4/6 Inhibitors: The Mechanism of Action May Not Be as Simple as Once Thought.

Klein ME, Kovatcheva M, Davis LE, Tap WD, Koff A.

Cancer Cell. 2018 Jul 9;34(1):9-20. doi: 10.1016/j.ccell.2018.03.023. Epub 2018 May 3. Review.


A Pilot Study on an Interprofessional Course Involving Pharmacy and Dental Students in a Dental Clinic.

Pogge EK, Hunt RJ, Patton LR, Reynolds SC, Davis LE, Storjohann TD, Tennant SE, Call SR.

Am J Pharm Educ. 2018 Apr;82(3):6361. doi: 10.5688/ajpe6361.


A Case of Self-Enucleation in an Incarcerated Patient: Case Report and Review of Literature.

Davis LE, Tripathi S.

J Forensic Sci. 2018 Nov;63(6):1908-1910. doi: 10.1111/1556-4029.13764. Epub 2018 Feb 21. Review.


Evaluating the Safety and Tolerability of Sacubitril/Valsartan for HFrEF Managed Within a Pharmacist Clinic.

Pogge EK, Davis LE.

Am J Cardiovasc Drugs. 2018 Apr;18(2):143-151. doi: 10.1007/s40256-018-0264-5.


Epirubicin and Ifosfamide with Preoperative Radiation for High-Risk Soft Tissue Sarcomas.

Lu E, Perlewitz KS, Hayden JB, Hung AY, Doung YC, Davis LE, Mansoor A, Vetto JT, Billingsley KG, Kaempf A, Park B, Ryan CW.

Ann Surg Oncol. 2018 Apr;25(4):920-927. doi: 10.1245/s10434-018-6346-4. Epub 2018 Jan 31.


Diagnoses of Cardiovascular Disease or Substance Addiction/Abuse in US Adults Treated for ADHD with Stimulants or Atomoxetine: Is Use Consistent with Product Labeling?

Fairman KA, Davis LE, Peckham AM, Sclar DA.

Drugs Real World Outcomes. 2018 Mar;5(1):69-79. doi: 10.1007/s40801-017-0129-2.


The Diuretic Potential of Sacubitril/Valsartan: A Tale of 2 Patients.

Hormann SM, Davis LE, Pogge EK.

J Cardiovasc Nurs. 2018 Mar/Apr;33(2):104-110. doi: 10.1097/JCN.0000000000000451.


Osteosarcoma, Chondrosarcoma, and Chordoma.

Whelan JS, Davis LE.

J Clin Oncol. 2018 Jan 10;36(2):188-193. doi: 10.1200/JCO.2017.75.1743. Epub 2017 Dec 8.


Integration of genomic, transcriptomic and functional profiles of aggressive osteosarcomas across multiple species.

Davis LE, Jeng S, Svalina MN, Huang E, Pittsenbarger J, Cantor EL, Berlow N, Seguin B, Mansoor A, McWeeney SK, Keller C.

Oncotarget. 2017 Jul 25;8(44):76241-76256. doi: 10.18632/oncotarget.19532. eCollection 2017 Sep 29.


Fetal sheep central haemodynamics and cardiac function during occlusion of the ascending aorta.

Huhta H, Junno J, Haapsamo M, Erkinaro T, Ohtonen P, Davis LE, Hohimer AR, Acharya G, Rasanen J.

Exp Physiol. 2018 Jan 1;103(1):58-67. doi: 10.1113/EP086500. Epub 2017 Dec 3.


Pembrolizumab in advanced soft-tissue sarcoma and bone sarcoma (SARC028): a multicentre, two-cohort, single-arm, open-label, phase 2 trial.

Tawbi HA, Burgess M, Bolejack V, Van Tine BA, Schuetze SM, Hu J, D'Angelo S, Attia S, Riedel RF, Priebat DA, Movva S, Davis LE, Okuno SH, Reed DR, Crowley J, Butterfield LH, Salazar R, Rodriguez-Canales J, Lazar AJ, Wistuba II, Baker LH, Maki RG, Reinke D, Patel S.

Lancet Oncol. 2017 Nov;18(11):1493-1501. doi: 10.1016/S1470-2045(17)30624-1. Epub 2017 Oct 4. Erratum in: Lancet Oncol. 2017 Dec;18(12 ):e711. Lancet Oncol. 2018 Jan;19(1):e8.


Real-world use of PCSK-9 inhibitors by early adopters: cardiovascular risk factors, statin co-treatment, and short-term adherence in routine clinical practice.

Fairman KA, Davis LE, Sclar DA.

Ther Clin Risk Manag. 2017 Aug 3;13:957-965. doi: 10.2147/TCRM.S143008. eCollection 2017.


Clinical trial enrollment of adolescents and young adults with sarcoma.

Davis LE, Janeway KA, Weiss AR, Chen YE, Scharschmidt TJ, Krailo M, Glade Bender JL, Kopp LM, Patel SR, Schwartz GK, Horvath LE, Hawkins DS, Chuk MK, Reinke DK, Gorlick RG, Randall RL.

Cancer. 2017 Sep 15;123(18):3434-3440. doi: 10.1002/cncr.30757. Epub 2017 May 11. Review.


Inhibition of endocytic pathways impacts cytomegalovirus maturation.

Archer MA, Brechtel TM, Davis LE, Parmar RC, Hasan MH, Tandon R.

Sci Rep. 2017 Apr 13;7:46069. doi: 10.1038/srep46069.


Authorities and Mechanisms for Purchased Care at the Department of Veterans Affairs.

Greenberg MD, Batka C, Buttorff C, Dunigan M, Lovejoy SL, McGovern G, Pace NM, Pillemer F, Williams KM, Apaydin E, Aranibar C, Buenaventura M, Carter P, Cherney S, Davis LE, Donohue AG, Geyer L, Hemler J, Roshan P, Skrabala L, Simmons S, Thompson J, Welch J, Hosek SD, Farmer CM.

Rand Health Q. 2016 May 9;5(4):15. eCollection 2016 May 9.


Financial Impact of Direct-Acting Oral Anticoagulants in Medicaid: Budgetary Assessment Based on Number Needed to Treat.

Fairman KA, Davis LE, Kruse CR, Sclar DA.

Appl Health Econ Health Policy. 2017 Apr;15(2):203-214. doi: 10.1007/s40258-016-0295-5.


Constructive ways to prevent, identify, and remediate deficiencies of "challenging trainees" in experiential education.

Davis LE, Miller ML, Raub JN, Gortney JS.

Am J Health Syst Pharm. 2016 Jul 1;73(13):996-1009. doi: 10.2146/ajhp150330. Review. No abstract available.


An Integrated Approach to Anti-Cancer Drug Sensitivity Prediction.

Berlow N, Haider S, Wan Q, Geltzeiler M, Davis LE, Keller C, Pal R.

IEEE/ACM Trans Comput Biol Bioinform. 2014 Nov-Dec;11(6):995-1008. doi: 10.1109/TCBB.2014.2321138.


An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101.

Doebele RC, Davis LE, Vaishnavi A, Le AT, Estrada-Bernal A, Keysar S, Jimeno A, Varella-Garcia M, Aisner DL, Li Y, Stephens PJ, Morosini D, Tuch BB, Fernandes M, Nanda N, Low JA.

Cancer Discov. 2015 Oct;5(10):1049-57. doi: 10.1158/2159-8290.CD-15-0443. Epub 2015 Jul 27.


Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.

Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA, Quist MJ, Davis LE, Huang EC, Woo PJ, Ponnuswami A, Chen S, Johung TB, Sun W, Kogiso M, Du Y, Qi L, Huang Y, Hütt-Cabezas M, Warren KE, Le Dret L, Meltzer PS, Mao H, Quezado M, van Vuurden DG, Abraham J, Fouladi M, Svalina MN, Wang N, Hawkins C, Nazarian J, Alonso MM, Raabe EH, Hulleman E, Spellman PT, Li XN, Keller C, Pal R, Grill J, Monje M.

Nat Med. 2015 Jul;21(7):827. doi: 10.1038/nm0715-827a. No abstract available.


Should patients with chronic liver disease receive venous thromboembolism prophylaxis?

Dang JD, Davis LE.

JAAPA. 2015 Jun;28(6):27-8, 30. doi: 10.1097/01.JAA.0000463876.73116.91.


Preoperative therapy for extremity soft tissue sarcomas.

Davis LE, Ryan CW.

Curr Treat Options Oncol. 2015 Jun;16(6):25. doi: 10.1007/s11864-015-0346-4. Review.


Functionally defined therapeutic targets in diffuse intrinsic pontine glioma.

Grasso CS, Tang Y, Truffaux N, Berlow NE, Liu L, Debily MA, Quist MJ, Davis LE, Huang EC, Woo PJ, Ponnuswami A, Chen S, Johung TB, Sun W, Kogiso M, Du Y, Qi L, Huang Y, Hütt-Cabezas M, Warren KE, Le Dret L, Meltzer PS, Mao H, Quezado M, van Vuurden DG, Abraham J, Fouladi M, Svalina MN, Wang N, Hawkins C, Nazarian J, Alonso MM, Raabe EH, Hulleman E, Spellman PT, Li XN, Keller C, Pal R, Grill J, Monje M.

Nat Med. 2015 Jun;21(6):555-9. doi: 10.1038/nm.3855. Epub 2015 May 4. Erratum in: Nat Med. 2015 Jul;21(7):827.


Fetal ventricular interactions and wall mechanics during ductus arteriosus occlusion in a sheep model.

Hashima JN, Rogers V, Langley SM, Ashraf M, Sahn DJ, Ohtonen P, Davis LE, Hohimer AR, Rasanen J.

Ultrasound Med Biol. 2015 Apr;41(4):1020-8. doi: 10.1016/j.ultrasmedbio.2014.11.002. Epub 2015 Feb 17.


Neurologic aspects of influenza viruses.

Davis LE, Koster F, Cawthon A.

Handb Clin Neurol. 2014;123:619-45. doi: 10.1016/B978-0-444-53488-0.00030-4. No abstract available.


A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme.

Rosenfeld MR, Ye X, Supko JG, Desideri S, Grossman SA, Brem S, Mikkelson T, Wang D, Chang YC, Hu J, McAfee Q, Fisher J, Troxel AB, Piao S, Heitjan DF, Tan KS, Pontiggia L, O'Dwyer PJ, Davis LE, Amaravadi RK.

Autophagy. 2014 Aug;10(8):1359-68. doi: 10.4161/auto.28984. Epub 2014 May 20.


Phase I trial of hydroxychloroquine with dose-intense temozolomide in patients with advanced solid tumors and melanoma.

Rangwala R, Leone R, Chang YC, Fecher LA, Schuchter LM, Kramer A, Tan KS, Heitjan DF, Rodgers G, Gallagher M, Piao S, Troxel AB, Evans TL, DeMichele AM, Nathanson KL, O'Dwyer PJ, Kaiser J, Pontiggia L, Davis LE, Amaravadi RK.

Autophagy. 2014 Aug;10(8):1369-79. doi: 10.4161/auto.29118. Epub 2014 May 20.


Combined MTOR and autophagy inhibition: phase I trial of hydroxychloroquine and temsirolimus in patients with advanced solid tumors and melanoma.

Rangwala R, Chang YC, Hu J, Algazy KM, Evans TL, Fecher LA, Schuchter LM, Torigian DA, Panosian JT, Troxel AB, Tan KS, Heitjan DF, DeMichele AM, Vaughn DJ, Redlinger M, Alavi A, Kaiser J, Pontiggia L, Davis LE, O'Dwyer PJ, Amaravadi RK.

Autophagy. 2014 Aug;10(8):1391-402. doi: 10.4161/auto.29119. Epub 2014 May 20.


Combined autophagy and HDAC inhibition: a phase I safety, tolerability, pharmacokinetic, and pharmacodynamic analysis of hydroxychloroquine in combination with the HDAC inhibitor vorinostat in patients with advanced solid tumors.

Mahalingam D, Mita M, Sarantopoulos J, Wood L, Amaravadi RK, Davis LE, Mita AC, Curiel TJ, Espitia CM, Nawrocki ST, Giles FJ, Carew JS.

Autophagy. 2014 Aug;10(8):1403-14. doi: 10.4161/auto.29231. Epub 2014 May 20.


Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma.

Vogl DT, Stadtmauer EA, Tan KS, Heitjan DF, Davis LE, Pontiggia L, Rangwala R, Piao S, Chang YC, Scott EC, Paul TM, Nichols CW, Porter DL, Kaplan J, Mallon G, Bradner JE, Amaravadi RK.

Autophagy. 2014 Aug;10(8):1380-90. doi: 10.4161/auto.29264. Epub 2014 May 20.


Teleneurology: successful delivery of chronic neurologic care to 354 patients living remotely in a rural state.

Davis LE, Coleman J, Harnar J, King MK.

Telemed J E Health. 2014 May;20(5):473-7. doi: 10.1089/tmj.2013.0217. Epub 2014 Mar 11.


Proton Pump Inhibitors and the Risk for Hospital-Acquired Clostridium difficile Infection.

Barletta JF, El-Ibiary SY, Davis LE, Nguyen B, Raney CR.

Mayo Clin Proc. 2013 Oct;88(10):1085-90. doi: 10.1016/j.mayocp.2013.07.004. Epub 2013 Sep 5.


A new approach for prediction of tumor sensitivity to targeted drugs based on functional data.

Berlow N, Davis LE, Cantor EL, Séguin B, Keller C, Pal R.

BMC Bioinformatics. 2013 Jul 29;14:239. doi: 10.1186/1471-2105-14-239.


Bacterial meningitis in older adults.

Hofinger D, Davis LE.

Curr Treat Options Neurol. 2013 Aug;15(4):477-91. doi: 10.1007/s11940-013-0244-7.


Elevated CSF cytokines in the Jarisch-Herxheimer reaction of general paresis.

Davis LE, Oyer R, Beckham JD, Tyler KL.

JAMA Neurol. 2013 Aug;70(8):1060-4. doi: 10.1001/jamaneurol.2013.2120.


Safety of zoster vaccine in elderly adults following documented herpes zoster.

Morrison VA, Oxman MN, Levin MJ, Schmader KE, Guatelli JC, Betts RF, Gelb LD, Pachucki CT, Keay SK, Menzies B, Griffin MR, Kauffman CA, Marques AR, Toney JF, Simberkoff MS, Serrao R, Arbeit RD, Gnann JW, Greenberg RN, Holodniy M, Keitel WA, Yeh SS, Davis LE, Crawford GE, Neuzil KM, Johnson GR, Zhang JH, Harbecke R, Chan IS, Keller PM, Williams HM, Boardman KD, Silber JL, Annunziato PW; Shingles Prevention Study Group.

J Infect Dis. 2013 Aug 15;208(4):559-63. doi: 10.1093/infdis/jit182. Epub 2013 Apr 30.


High-fidelity simulation for advanced cardiac life support training.

Davis LE, Storjohann TD, Spiegel JJ, Beiber KM, Barletta JF.

Am J Pharm Educ. 2013 Apr 12;77(3):59. doi: 10.5688/ajpe77359.


A case study of personalized therapy for osteosarcoma.

Davis LE, Hofmann NE, Li G, Huang ET, Loriaux MM, Bracha S, Helfand SC, Mata JE, Marley K, Mansoor A, Tyner JW, Abraham J, Séguin B, Keller C.

Pediatr Blood Cancer. 2013 Aug;60(8):1313-9. doi: 10.1002/pbc.24512. Epub 2013 Mar 22.


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