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Items: 1 to 50 of 65

1.

Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase.

Marozienė A, Lesanavičius M, Davioud-Charvet E, Aliverti A, Grellier P, Šarlauskas J, Čėnas N.

Molecules. 2019 Dec 10;24(24). pii: E4509. doi: 10.3390/molecules24244509.

2.

A Mild and Versatile Friedel-Crafts Methodology for the Diversity-Oriented Synthesis of Redox-Active 3-Benzoylmenadiones with Tunable Redox Potentials.

Cotos L, Donzel M, Elhabiri M, Davioud-Charvet E.

Chemistry. 2019 Nov 20. doi: 10.1002/chem.201904220. [Epub ahead of print]

PMID:
31746499
3.

Physicochemical Properties Govern the Activity of Potent Antiviral Flavones.

Martin-Benlloch X, Haid S, Novodomska A, Rominger F, Pietschmann T, Davioud-Charvet E, Elhabiri M.

ACS Omega. 2019 Mar 5;4(3):4871-4887. doi: 10.1021/acsomega.8b03332. eCollection 2019 Mar 31.

4.

Author Correction: Arylmethylamino steroids as antiparasitic agents.

Krieg R, Jortzik E, Goetz AA, Blandin S, Wittlin S, Elhabiri M, Rahbari M, Nuryyeva S, Voigt K, Dahse HM, Brakhage A, Beckmann S, Quack T, Grevelding CG, Pinkerton AB, Schönecker B, Burrows J, Davioud-Charvet E, Rahlfs S, Becker K.

Nat Commun. 2019 Jul 8;10(1):2997. doi: 10.1038/s41467-019-11018-x.

5.

Selenium Status in Elderly People: Longevity and Age-Related Diseases.

Robberecht H, De Bruyne T, Davioud-Charvet E, Mackrill J, Hermans N.

Curr Pharm Des. 2019;25(15):1694-1706. doi: 10.2174/1381612825666190701144709.

PMID:
31267854
6.

Investigating the mode of action of the redox-active antimalarial drug plasmodione using the yeast model.

Mounkoro P, Michel T, Blandin S, Golinelli-Cohen MP, Davioud-Charvet E, Meunier B.

Free Radic Biol Med. 2019 Sep;141:269-278. doi: 10.1016/j.freeradbiomed.2019.06.026. Epub 2019 Jun 22.

PMID:
31238126
7.

AntiMalarial Mode of Action (AMMA) Database: Data Selection, Verification and Chemical Space Analysis.

Sidorov P, Davioud-Charvet E, Marcou G, Horvath D, Varnek A.

Mol Inform. 2018 Sep;37(9-10):e1800021. doi: 10.1002/minf.201800021. Epub 2018 May 11.

PMID:
29749713
8.

Synthesis of plasmodione metabolites and 13C-enriched plasmodione as chemical tools for drug metabolism investigation.

Feng L, Lanfranchi DA, Cotos L, Cesar-Rodo E, Ehrhardt K, Goetz AA, Zimmermann H, Fenaille F, Blandin SA, Davioud-Charvet E.

Org Biomol Chem. 2018 Apr 18;16(15):2647-2665. doi: 10.1039/c8ob00227d.

PMID:
29542786
9.

QSAR modeling and chemical space analysis of antimalarial compounds.

Sidorov P, Viira B, Davioud-Charvet E, Maran U, Marcou G, Horvath D, Varnek A.

J Comput Aided Mol Des. 2017 May;31(5):441-451. doi: 10.1007/s10822-017-0019-4. Epub 2017 Apr 3.

PMID:
28374255
10.

Arylmethylamino steroids as antiparasitic agents.

Krieg R, Jortzik E, Goetz AA, Blandin S, Wittlin S, Elhabiri M, Rahbari M, Nuryyeva S, Voigt K, Dahse HM, Brakhage A, Beckmann S, Quack T, Grevelding CG, Pinkerton AB, Schönecker B, Burrows J, Davioud-Charvet E, Rahlfs S, Becker K.

Nat Commun. 2017 Feb 17;8:14478. doi: 10.1038/ncomms14478. Erratum in: Nat Commun. 2019 Jul 8;10(1):2997.

11.

A Redox-Active Fluorescent pH Indicator for Detecting Plasmodium falciparum Strains with Reduced Responsiveness to Quinoline Antimalarial Drugs.

Jida M, Sanchez CP, Urgin K, Ehrhardt K, Mounien S, Geyer A, Elhabiri M, Lanzer M, Davioud-Charvet E.

ACS Infect Dis. 2017 Feb 10;3(2):119-131. doi: 10.1021/acsinfecdis.5b00141. Epub 2016 Dec 7.

PMID:
28183182
12.

A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay.

Siciliano G, Santha Kumar TR, Bona R, Camarda G, Calabretta MM, Cevenini L, Davioud-Charvet E, Becker K, Cara A, Fidock DA, Alano P.

Mol Microbiol. 2017 Apr;104(2):306-318. doi: 10.1111/mmi.13626. Epub 2017 Feb 21.

13.

Pharmacomodulation of the Antimalarial Plasmodione: Synthesis of Biaryl- and N-Arylalkylamine Analogues, Antimalarial Activities and Physicochemical Properties.

Urgin K, Jida M, Ehrhardt K, Müller T, Lanzer M, Maes L, Elhabiri M, Davioud-Charvet E.

Molecules. 2017 Jan 19;22(1). pii: E161. doi: 10.3390/molecules22010161.

14.

In Silico Mining for Antimalarial Structure-Activity Knowledge and Discovery of Novel Antimalarial Curcuminoids.

Viira B, Gendron T, Lanfranchi DA, Cojean S, Horvath D, Marcou G, Varnek A, Maes L, Maran U, Loiseau PM, Davioud-Charvet E.

Molecules. 2016 Jun 29;21(7). pii: E853. doi: 10.3390/molecules21070853.

15.

The Redox Cycler Plasmodione Is a Fast-Acting Antimalarial Lead Compound with Pronounced Activity against Sexual and Early Asexual Blood-Stage Parasites.

Ehrhardt K, Deregnaucourt C, Goetz AA, Tzanova T, Gallo V, Arese P, Pradines B, Adjalley SH, Bagrel D, Blandin S, Lanzer M, Davioud-Charvet E.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5146-58. doi: 10.1128/AAC.02975-15. Print 2016 Sep.

16.

Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites.

Sidorov P, Desta I, Chessé M, Horvath D, Marcou G, Varnek A, Davioud-Charvet E, Elhabiri M.

ChemMedChem. 2016 Jun 20;11(12):1339-51. doi: 10.1002/cmdc.201600009. Epub 2016 Mar 7.

PMID:
26947575
17.

Synthesis and evaluation of 1,4-naphthoquinone ether derivatives as SmTGR inhibitors and new anti-schistosomal drugs.

Johann L, Belorgey D, Huang HH, Day L, Chessé M, Becker K, Williams DL, Davioud-Charvet E.

FEBS J. 2015 Aug;282(16):3199-217. doi: 10.1111/febs.13359. Epub 2015 Aug 3.

18.

Antimalarial NADPH-Consuming Redox-Cyclers As Superior Glucose-6-Phosphate Dehydrogenase Deficiency Copycats.

Bielitza M, Belorgey D, Ehrhardt K, Johann L, Lanfranchi DA, Gallo V, Schwarzer E, Mohring F, Jortzik E, Williams DL, Becker K, Arese P, Elhabiri M, Davioud-Charvet E.

Antioxid Redox Signal. 2015 May 20;22(15):1337-51. doi: 10.1089/ars.2014.6047. Epub 2015 Apr 14.

19.

Electrochemical properties of substituted 2-methyl-1,4-naphthoquinones: redox behavior predictions.

Elhabiri M, Sidorov P, Cesar-Rodo E, Marcou G, Lanfranchi DA, Davioud-Charvet E, Horvath D, Varnek A.

Chemistry. 2015 Feb 16;21(8):3415-24. doi: 10.1002/chem.201403703. Epub 2014 Dec 30.

PMID:
25556761
20.

Antiglioma activity of GoPI-sugar, a novel gold(I)-phosphole inhibitor: chemical synthesis, mechanistic studies, and effectiveness in vivo.

Jortzik E, Farhadi M, Ahmadi R, Tóth K, Lohr J, Helmke BM, Kehr S, Unterberg A, Ott I, Gust R, Deborde V, Davioud-Charvet E, Réau R, Becker K, Herold-Mende C.

Biochim Biophys Acta. 2014 Aug;1844(8):1415-26. doi: 10.1016/j.bbapap.2014.01.006. Epub 2014 Jan 16.

PMID:
24440405
21.

The antimalarial activities of methylene blue and the 1,4-naphthoquinone 3-[4-(trifluoromethyl)benzyl]-menadione are not due to inhibition of the mitochondrial electron transport chain.

Ehrhardt K, Davioud-Charvet E, Ke H, Vaidya AB, Lanzer M, Deponte M.

Antimicrob Agents Chemother. 2013 May;57(5):2114-20. doi: 10.1128/AAC.02248-12. Epub 2013 Feb 25.

22.

1,4-naphthoquinones and other NADPH-dependent glutathione reductase-catalyzed redox cyclers as antimalarial agents.

Belorgey D, Lanfranchi DA, Davioud-Charvet E.

Curr Pharm Des. 2013;19(14):2512-28. Review.

23.

Synthesis and biological evaluation of 1,4-naphthoquinones and quinoline-5,8-diones as antimalarial and schistosomicidal agents.

Lanfranchi DA, Cesar-Rodo E, Bertrand B, Huang HH, Day L, Johann L, Elhabiri M, Becker K, Williams DL, Davioud-Charvet E.

Org Biomol Chem. 2012 Aug 21;10(31):6375-87. doi: 10.1039/c2ob25812a. Epub 2012 Jul 10.

24.

Exploring the trifluoromenadione core as a template to design antimalarial redox-active agents interacting with glutathione reductase.

Lanfranchi DA, Belorgey D, Müller T, Vezin H, Lanzer M, Davioud-Charvet E.

Org Biomol Chem. 2012 Jun 28;10(24):4795-806. doi: 10.1039/c2ob25229e. Epub 2012 May 23.

PMID:
22618151
25.

A physico-biochemical study on potential redox-cyclers as antimalarial and anti-schistosomal drugs.

Johann L, Lanfranchi DA, Davioud-Charvet E, Elhabiri M.

Curr Pharm Des. 2012;18(24):3539-66. Review.

26.

A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes.

Haid S, Novodomská A, Gentzsch J, Grethe C, Geuenich S, Bankwitz D, Chhatwal P, Jannack B, Hennebelle T, Bailleul F, Keppler OT, Poenisch M, Bartenschlager R, Hernandez C, Lemasson M, Rosenberg AR, Wong-Staal F, Davioud-Charvet E, Pietschmann T.

Gastroenterology. 2012 Jul;143(1):213-22.e5. doi: 10.1053/j.gastro.2012.03.036. Epub 2012 Mar 27.

PMID:
22465429
27.

Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study.

Blank O, Davioud-Charvet E, Elhabiri M.

Antioxid Redox Signal. 2012 Aug 15;17(4):544-54. doi: 10.1089/ars.2011.4239. Epub 2012 Jan 18.

PMID:
22256987
28.

Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones--a new strategy to combat malarial parasites.

Müller T, Johann L, Jannack B, Brückner M, Lanfranchi DA, Bauer H, Sanchez C, Yardley V, Deregnaucourt C, Schrével J, Lanzer M, Schirmer RH, Davioud-Charvet E.

J Am Chem Soc. 2011 Aug 3;133(30):11557-71. doi: 10.1021/ja201729z. Epub 2011 Jul 12.

PMID:
21682307
29.

Antimalarial versus cytotoxic properties of dual drugs derived from 4-aminoquinolines and Mannich bases: interaction with DNA.

Wenzel NI, Chavain N, Wang Y, Friebolin W, Maes L, Pradines B, Lanzer M, Yardley V, Brun R, Herold-Mende C, Biot C, Tóth K, Davioud-Charvet E.

J Med Chem. 2010 Apr 22;53(8):3214-26. doi: 10.1021/jm9018383.

PMID:
20329733
30.

Antimalarial activities of ferroquine conjugates with either glutathione reductase inhibitors or glutathione depletors via a hydrolyzable amide linker.

Chavain N, Davioud-Charvet E, Trivelli X, Mbeki L, Rottmann M, Brun R, Biot C.

Bioorg Med Chem. 2009 Dec 1;17(23):8048-59. doi: 10.1016/j.bmc.2009.10.008. Epub 2009 Oct 12.

PMID:
19864147
31.

Unsaturated Mannich bases active against multidrug-resistant Trypanosoma brucei brucei strains.

Wenzel IN, Wong PE, Maes L, Müller TJ, Krauth-Siegel RL, Barrett MP, Davioud-Charvet E.

ChemMedChem. 2009 Mar;4(3):339-51. doi: 10.1002/cmdc.200800360.

PMID:
19219843
32.

A sugar-modified phosphole gold complex with antiproliferative properties acting as a thioredoxin reductase inhibitor in MCF-7 cells.

Viry E, Battaglia E, Deborde V, Müller T, Réau R, Davioud-Charvet E, Bagrel D.

ChemMedChem. 2008 Nov;3(11):1667-70. doi: 10.1002/cmdc.200800210. No abstract available.

PMID:
18759235
33.

The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase.

Morin C, Besset T, Moutet JC, Fayolle M, Brückner M, Limosin D, Becker K, Davioud-Charvet E.

Org Biomol Chem. 2008 Aug 7;6(15):2731-42. doi: 10.1039/b802649c. Epub 2008 May 30.

PMID:
18633531
34.

Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.

Friebolin W, Jannack B, Wenzel N, Furrer J, Oeser T, Sanchez CP, Lanzer M, Yardley V, Becker K, Davioud-Charvet E.

J Med Chem. 2008 Mar 13;51(5):1260-77. doi: 10.1021/jm7009292. Epub 2008 Feb 9.

PMID:
18260613
35.

Thioredoxin glutathione reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target.

Kuntz AN, Davioud-Charvet E, Sayed AA, Califf LL, Dessolin J, Arnér ES, Williams DL.

PLoS Med. 2007 Jun;4(6):e206. Erratum in: PLoS Med. 2007 Aug;4(8):e264.

36.

A fluoro analogue of the menadione derivative 6-[2'-(3'-methyl)-1',4'-naphthoquinolyl]hexanoic acid is a suicide substrate of glutathione reductase. Crystal structure of the alkylated human enzyme.

Bauer H, Fritz-Wolf K, Winzer A, Kühner S, Little S, Yardley V, Vezin H, Palfey B, Schirmer RH, Davioud-Charvet E.

J Am Chem Soc. 2006 Aug 23;128(33):10784-94.

PMID:
16910673
37.

Undressing of phosphine gold(I) complexes as irreversible inhibitors of human disulfide reductases.

Urig S, Fritz-Wolf K, Réau R, Herold-Mende C, Tóth K, Davioud-Charvet E, Becker K.

Angew Chem Int Ed Engl. 2006 Mar 13;45(12):1881-6. No abstract available.

PMID:
16493712
38.

Specific inhibitors of Plasmodium falciparum thioredoxin reductase as potential antimalarial agents.

Andricopulo AD, Akoachere MB, Krogh R, Nickel C, McLeish MJ, Kenyon GL, Arscott LD, Williams CH Jr, Davioud-Charvet E, Becker K.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2283-92. Epub 2006 Feb 3.

PMID:
16458512
39.

Irreversible inactivation of trypanothione reductase by unsaturated Mannich bases: a divinyl ketone as key intermediate.

Lee B, Bauer H, Melchers J, Ruppert T, Rattray L, Yardley V, Davioud-Charvet E, Krauth-Siegel RL.

J Med Chem. 2005 Nov 17;48(23):7400-10.

PMID:
16279799
40.

Synthesis of 5-nitro-2-furancarbohydrazides and their cis-diamminedichloroplatinum complexes as bitopic and irreversible human thioredoxin reductase inhibitors.

Millet R, Urig S, Jacob J, Amtmann E, Moulinoux JP, Gromer S, Becker K, Davioud-Charvet E.

J Med Chem. 2005 Nov 3;48(22):7024-39.

PMID:
16250662
41.

Mechanistic studies on a novel, highly potent gold-phosphole inhibitor of human glutathione reductase.

Deponte M, Urig S, Arscott LD, Fritz-Wolf K, Réau R, Herold-Mende C, Koncarevic S, Meyer M, Davioud-Charvet E, Ballou DP, Williams CH Jr, Becker K.

J Biol Chem. 2005 May 27;280(21):20628-37. Epub 2005 Mar 24.

42.
43.

Double-drug development against antioxidant enzymes from Plasmodium falciparum.

Biot C, Dessolin J, Grellier P, Davioud-Charvet E.

Redox Rep. 2003;8(5):280-3.

PMID:
14962365
44.

Mechanism-based inactivation of thioredoxin reductase from Plasmodium falciparum by Mannich bases. Implication for cytotoxicity.

Davioud-Charvet E, McLeish MJ, Veine DM, Giegel D, Arscott LD, Andricopulo AD, Becker K, Müller S, Schirmer RH, Williams CH Jr, Kenyon GL.

Biochemistry. 2003 Nov 18;42(45):13319-30.

PMID:
14609342
45.

Screening of Plasmodium falciparum iron superoxide dismutase inhibitors and accuracy of the SOD-assays.

Soulère L, Delplace P, Davioud-Charvet E, Py S, Sergheraert C, Périé J, Ricard I, Hoffmann P, Dive D.

Bioorg Med Chem. 2003 Nov 17;11(23):4941-4.

PMID:
14604655
46.

A novel mechanism for inhibition of HIV-1 reverse transcriptase.

Skillman AG, Maurer KW, Roe DC, Stauber MJ, Eargle D, Ewing TJ, Muscate A, Davioud-Charvet E, Medaglia MV, Fisher RJ, Arnold E, Gao HQ, Buckheit R, Boyer PL, Hughes SH, Kuntz ID, Kenyon GL.

Bioorg Chem. 2002 Dec;30(6):443-58.

PMID:
12642128
47.

Antitrypanosomal activities and cytotoxicity of 5-nitro-2-furancarbohydrazides.

Millet R, Maes L, Landry V, Sergheraert C, Davioud-Charvet E.

Bioorg Med Chem Lett. 2002 Dec 16;12(24):3601-4.

PMID:
12443785
48.

Comparison of the inhibition of human and Trypanosoma cruzi prolyl endopeptidases.

Vendeville S, Goossens F, Debreu-Fontaine MA, Landry V, Davioud-Charvet E, Grellier P, Scharpe S, Sergheraert C.

Bioorg Med Chem. 2002 Jun;10(6):1719-29.

PMID:
11937331
49.

A prodrug form of a Plasmodium falciparum glutathione reductase inhibitor conjugated with a 4-anilinoquinoline.

Davioud-Charvet E, Delarue S, Biot C, Schwöbel B, Boehme CC, Müssigbrodt A, Maes L, Sergheraert C, Grellier P, Schirmer RH, Becker K.

J Med Chem. 2001 Nov 22;44(24):4268-76.

PMID:
11708927
50.

Trypanosoma cruzi prolyl oligopeptidase Tc80 is involved in nonphagocytic mammalian cell invasion by trypomastigotes.

Grellier P, Vendeville S, Joyeau R, Bastos IM, Drobecq H, Frappier F, Teixeira AR, Schrével J, Davioud-Charvet E, Sergheraert C, Santana JM.

J Biol Chem. 2001 Dec 14;276(50):47078-86. Epub 2001 Oct 11.

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