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Items: 1 to 50 of 91

1.

Sphingosine 1-phosphate receptor 2/adenylyl cyclase/protein kinase A pathway is involved in taurolithocholate-induced internalization of Abcc2 in rats.

Andermatten RB, Ciriaci N, Schuck VS, Di Siervi N, Razori MV, Miszczuk GS, Medeot AC, Davio CA, Crocenzi FA, Roma MG, Barosso IR, Sánchez Pozzi EJ.

Arch Toxicol. 2019 Jul 12. doi: 10.1007/s00204-019-02514-6. [Epub ahead of print]

PMID:
31300867
2.

Involvement of cAMP efflux, through MRP4 transporter, in the acquisition of fertilization ability of mouse spermatozoa.

Alonso CAI, Lottero Leconte R, Luque GM, Vernaz Z, Di Siervi N, Gervasi MG, Buffone MG, Davio C, Perez Martinez S.

J Cell Sci. 2019 Jun 28. pii: jcs.230565. doi: 10.1242/jcs.230565. [Epub ahead of print]

PMID:
31253671
3.

Metformin inhibits β-catenin phosphorylation on Ser-552 through an AMPK/PI3K/Akt pathway in colorectal cancer cells.

Amable G, Martínez-León E, Picco ME, Di Siervi N, Davio C, Rozengurt E, Rey O.

Int J Biochem Cell Biol. 2019 Jul;112:88-94. doi: 10.1016/j.biocel.2019.05.004. Epub 2019 May 10.

PMID:
31082618
4.

Identification of MRP4/ABCC4 as a Target for Reducing the Proliferation of Pancreatic Ductal Adenocarcinoma Cells by Modulating the cAMP Efflux.

Carozzo A, Yaneff A, Gómez N, Di Siervi N, Sahores A, Diez F, Attorresi AI, Rodríguez-González Á, Monczor F, Fernández N, Abba M, Shayo C, Davio C.

Mol Pharmacol. 2019 Jul;96(1):13-25. doi: 10.1124/mol.118.115444. Epub 2019 May 1.

PMID:
31043460
5.

Participation of Gαi-Adenylate Cyclase and ERK1/2 in Mas Receptor Signaling Pathways.

Burghi V, Echeverría EB, Sosa MH, Quiroga DT, Muñoz MC, Davio C, Monczor F, Fernández NC, Dominici FP.

Front Pharmacol. 2019 Feb 22;10:146. doi: 10.3389/fphar.2019.00146. eCollection 2019.

6.

Involvement of histamine H1 and H2 receptor inverse agonists in receptor's crossregulation.

Díaz Nebreda A, Zappia CD, Rodríguez González A, Sahores A, Sosa M, Burghi V, Monczor F, Davio C, Fernández N, Shayo C.

Eur J Pharmacol. 2019 Mar 15;847:42-52. doi: 10.1016/j.ejphar.2019.01.026. Epub 2019 Jan 24.

PMID:
30685431
7.

Altered expression of Aquaporin-2 in one-kidney, one-clip hypertension.

Albertoni Borghese MF, Hope S, Ortiz MDC, Barchuk M, Kessler C, Davio C, Vatta M, Majowicz M.

Life Sci. 2018 Sep 1;208:72-78. doi: 10.1016/j.lfs.2018.07.020. Epub 2018 Jul 17.

PMID:
30009821
8.

Unique pharmacological properties of serotoninergic G-protein coupled receptors from cestodes.

Camicia F, Celentano AM, Johns ME, Chan JD, Maldonado L, Vaca H, Di Siervi N, Kamentezky L, Gamo AM, Ortega-Gutierrez S, Martin-Fontecha M, Davio C, Marchant JS, Rosenzvit MC.

PLoS Negl Trop Dis. 2018 Feb 9;12(2):e0006267. doi: 10.1371/journal.pntd.0006267. eCollection 2018 Feb.

9.

MRP4/ABCC4 As a New Therapeutic Target: Meta-Analysis to Determine cAMP Binding Sites as a Tool for Drug Design.

Yaneff A, Sahores A, Gómez N, Carozzo A, Shayo C, Davio C.

Curr Med Chem. 2019;26(7):1270-1307. doi: 10.2174/0929867325666171229133259. Review.

PMID:
29284392
10.

Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.

Cabrera M, Echeverria E, Lenicov FR, Cardama G, Gonzalez N, Davio C, Fernández N, Menna PL.

Oncotarget. 2017 Oct 4;8(58):98509-98523. doi: 10.18632/oncotarget.21533. eCollection 2017 Nov 17.

11.

Synthesis and degradation of cAMP in Giardia lamblia: possible role and characterization of a nucleotidyl cyclase with a single cyclase homology domain.

Saraullo V, Di Siervi N, Jerez B, Davio C, Zurita A.

Biochem J. 2017 Nov 21;474(23):4001-4017. doi: 10.1042/BCJ20170590.

PMID:
29054977
12.

Effect of mutation of Phe 2436.44 of the histamine H2 receptor on cimetidine and ranitidine mechanism of action.

Granja-Galeano G, Zappia CD, Fabián L, Davio C, Shayo C, Fernández N, Monczor F.

Biochem Pharmacol. 2017 Dec 15;146:117-126. doi: 10.1016/j.bcp.2017.09.014. Epub 2017 Sep 28.

PMID:
28962836
13.

Extracellular cAMP activates molecular signalling pathways associated with sperm capacitation in bovines.

Alonso CAI, Osycka-Salut CE, Castellano L, Cesari A, Di Siervi N, Mutto A, Johannisson A, Morrell JM, Davio C, Perez-Martinez S.

Mol Hum Reprod. 2017 Aug 1;23(8):521-534. doi: 10.1093/molehr/gax030.

PMID:
28521061
14.

Evidence for CB2 receptor involvement in LPS-induced reduction of cAMP intracellular levels in uterine explants from pregnant mice: pathophysiological implications.

Salazar AI, Carozzo A, Correa F, Davio C, Franchi AM.

Mol Hum Reprod. 2017 Jul 1;23(7):500-508. doi: 10.1093/molehr/gax026.

PMID:
28460003
15.

Endogenous lysophosphatidic acid participates in vascularisation and decidualisation at the maternal-fetal interface in the rat.

Sordelli MS, Beltrame JS, Zotta E, Gomez N, Dmytrenko G, Sales ME, Blois SM, Davio C, Martinez SP, Franchi AM, Ribeiro ML.

Reprod Fertil Dev. 2017 Oct;29(11):2112-2126. doi: 10.1071/RD16235.

PMID:
28376314
16.

Melanocortin 4 receptor constitutive activity inhibits L-type voltage-gated calcium channels in neurons.

Agosti F, Cordisco Gonzalez S, Martinez Damonte V, Tolosa MJ, Di Siervi N, Schioth HB, Davio C, Perello M, Raingo J.

Neuroscience. 2017 Mar 27;346:102-112. doi: 10.1016/j.neuroscience.2017.01.007. Epub 2017 Jan 16.

PMID:
28093215
17.

A Novel Effect of β-Adrenergic Receptor on Mammary Branching Morphogenesis and its Possible Implications in Breast Cancer.

Gargiulo L, May M, Rivero EM, Copsel S, Lamb C, Lydon J, Davio C, Lanari C, Lüthy IA, Bruzzone A.

J Mammary Gland Biol Neoplasia. 2017 Mar;22(1):43-57. doi: 10.1007/s10911-017-9371-1. Epub 2017 Jan 11.

PMID:
28074314
18.

Heparin exerts anti-apoptotic effects on uterine explants by targeting the endocannabinoid system.

Salazar AI, Vercelli C, Schiariti V, Davio C, Correa F, Franchi AM.

Apoptosis. 2016 Sep;21(9):965-76. doi: 10.1007/s10495-016-1269-7.

PMID:
27364950
19.

Histamine H2 Receptor in Blood Cells: A Suitable Target for the Treatment of Acute Myeloid Leukemia.

Monczor F, Copsel S, Fernandez N, Davio C, Shayo C.

Handb Exp Pharmacol. 2017;241:141-160. doi: 10.1007/164_2016_8. Review.

PMID:
27316911
20.

PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells.

Alonso N, Diaz Nebreda A, Monczor F, Gutkind JS, Davio C, Fernandez N, Shayo C.

Biochim Biophys Acta. 2016 Sep;1860(9):1998-2007. doi: 10.1016/j.bbagen.2016.06.016. Epub 2016 Jun 15.

PMID:
27316323
21.

Effects of histamine H1 receptor signaling on glucocorticoid receptor activity. Role of canonical and non-canonical pathways.

Zappia CD, Granja-Galeano G, Fernández N, Shayo C, Davio C, Fitzsimons CP, Monczor F.

Sci Rep. 2015 Dec 4;5:17476. doi: 10.1038/srep17476.

22.

Role of 3'-5'-cyclic adenosine monophosphate on the epidermal growth factor dependent survival in mammary epithelial cells.

Grinman DY, Romorini L, Presman DM, Rocha-Viegas L, Coso OA, Davio C, Pecci A.

Mol Cell Endocrinol. 2016 Jan 5;419:259-67. doi: 10.1016/j.mce.2015.10.026. Epub 2015 Oct 30.

PMID:
26522133
23.

G2/M Cell Cycle Arrest and Tumor Selective Apoptosis of Acute Leukemia Cells by a Promising Benzophenone Thiosemicarbazone Compound.

Cabrera M, Gomez N, Remes Lenicov F, Echeverría E, Shayo C, Moglioni A, Fernández N, Davio C.

PLoS One. 2015 Sep 11;10(9):e0136878. doi: 10.1371/journal.pone.0136878. eCollection 2015.

24.

Physiological implications of biased signaling at histamine H2 receptors.

Alonso N, Zappia CD, Cabrera M, Davio CA, Shayo C, Monczor F, Fernández NC.

Front Pharmacol. 2015 Mar 10;6:45. doi: 10.3389/fphar.2015.00045. eCollection 2015.

25.

Dual role of cAMP in the transcriptional regulation of multidrug resistance-associated protein 4 (MRP4) in pancreatic adenocarcinoma cell lines.

Carozzo A, Diez F, Gomez N, Cabrera M, Shayo C, Davio C, Fernández N.

PLoS One. 2015 Mar 19;10(3):e0120651. doi: 10.1371/journal.pone.0120651. eCollection 2015.

26.

Blockade of Multidrug Resistance-Associated Proteins Aggravates Acute Pancreatitis and Blunts Atrial Natriuretic Factor's Beneficial Effect in Rats: Role of MRP4 (ABCC4).

Ventimiglia MS, Najenson AC, Perazzo JC, Carozzo A, Vatta MS, Davio CA, Bianciotti LG.

Mol Med. 2015 Jan 6;21:58-67. doi: 10.2119/molmed.2014.00166.

27.

Differential β₂-adrenergic receptor expression defines the phenotype of non-tumorigenic and malignant human breast cell lines.

Gargiulo L, Copsel S, Rivero EM, Galés C, Sénard JM, Lüthy IA, Davio C, Bruzzone A.

Oncotarget. 2014 Oct 30;5(20):10058-69.

28.

Multidrug resistance protein 4/ ATP binding cassette transporter 4: a new potential therapeutic target for acute myeloid leukemia.

Copsel S, Bruzzone A, May M, Beyrath J, Wargon V, Cany J, Russel FG, Shayo C, Davio C.

Oncotarget. 2014 Oct 15;5(19):9308-21.

29.

Signal transduction mechanism of biased ligands at histamine H2 receptors.

Alonso N, Monczor F, Echeverría E, Davio C, Shayo C, Fernández N.

Biochem J. 2014 Apr 1;459(1):117-26. doi: 10.1042/BJ20131226.

PMID:
24417223
30.

G-protein-coupled receptor 30/adenylyl cyclase/protein kinase A pathway is involved in estradiol 17ß-D-glucuronide-induced cholestasis.

Zucchetti AE, Barosso IR, Boaglio AC, Basiglio CL, Miszczuk G, Larocca MC, Ruiz ML, Davio CA, Roma MG, Crocenzi FA, Pozzi EJ.

Hepatology. 2014 Mar;59(3):1016-29. doi: 10.1002/hep.26752. Epub 2014 Jan 21.

PMID:
24115158
31.

Cyclic AMP efflux, via MRPs and A1 adenosine receptors, is critical for bovine sperm capacitation.

Osycka-Salut C, Diez F, Burdet J, Gervasi MG, Franchi A, Bianciotti LG, Davio C, Perez-Martinez S.

Mol Hum Reprod. 2014 Jan;20(1):89-99. doi: 10.1093/molehr/gat053. Epub 2013 Aug 1.

PMID:
23907162
32.

Antihistaminergics and inverse agonism: potential therapeutic applications.

Monczor F, Fernandez N, Fitzsimons CP, Shayo C, Davio C.

Eur J Pharmacol. 2013 Sep 5;715(1-3):26-32. doi: 10.1016/j.ejphar.2013.06.027. Epub 2013 Jul 4. Review.

PMID:
23831018
33.

Pharmacodynamic study of the 7,8-dihydroxy-4-methylcoumarin-induced selective cytotoxicity toward U-937 leukemic cells versus mature monocytes: cytoplasmic p21(Cip1/WAF1) as resistance factor.

Vázquez R, Riveiro ME, Mondillo C, Perazzo JC, Vermeulen M, Baldi A, Davio C, Shayo C.

Biochem Pharmacol. 2013 Jul 15;86(2):210-21. doi: 10.1016/j.bcp.2013.04.021. Epub 2013 May 9.

PMID:
23665351
34.

On the role of ATP release, ectoATPase activity, and extracellular ADP in the regulatory volume decrease of Huh-7 human hepatoma cells.

Espelt MV, de Tezanos Pinto F, Alvarez CL, Alberti GS, Incicco J, Leal Denis MF, Davio C, Schwarzbaum PJ.

Am J Physiol Cell Physiol. 2013 May 15;304(10):C1013-26. doi: 10.1152/ajpcell.00254.2012. Epub 2013 Mar 13.

35.

Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.

Alonso N, Fernandez N, Notcovich C, Monczor F, Simaan M, Baldi A, Gutkind JS, Davio C, Shayo C.

Mol Pharmacol. 2013 May;83(5):1087-98. doi: 10.1124/mol.112.083394. Epub 2013 Mar 5.

36.

Semen promotes the differentiation of tolerogenic dendritic cells.

Remes Lenicov F, Rodriguez Rodrigues C, Sabatté J, Cabrini M, Jancic C, Ostrowski M, Merlotti A, Gonzalez H, Alonso A, Pasqualini RA, Davio C, Geffner J, Ceballos A.

J Immunol. 2012 Nov 15;189(10):4777-86. doi: 10.4049/jimmunol.1202089. Epub 2012 Oct 12.

37.

Structure-anti-leukemic activity relationship study of ortho-dihydroxycoumarins in U-937 cells: key role of the δ-lactone ring in determining differentiation-inducing potency and selective pro-apoptotic action.

Vázquez R, Riveiro ME, Vermeulen M, Alonso E, Mondillo C, Facorro G, Piehl L, Gómez N, Moglioni A, Fernández N, Baldi A, Shayo C, Davio C.

Bioorg Med Chem. 2012 Sep 15;20(18):5537-49. doi: 10.1016/j.bmc.2012.07.043. Epub 2012 Aug 2.

PMID:
22925447
38.

Iron and holotransferrin induce cAMP-dependent differentiation of Schwann cells.

Salis C, Davio C, Usach V, Urtasun N, Goitia B, Martinez-Vivot R, Pasquini JM, Setton-Avruj CP.

Neurochem Int. 2012 Oct;61(5):798-806. doi: 10.1016/j.neuint.2012.06.023. Epub 2012 Jul 7.

PMID:
22776360
39.

Toddaculin, a natural coumarin from Toddalia asiatica, induces differentiation and apoptosis in U-937 leukemic cells.

Vázquez R, Riveiro ME, Vermeulen M, Mondillo C, Coombes PH, Crouch NR, Ismail F, Mulholland DA, Baldi A, Shayo C, Davio C.

Phytomedicine. 2012 Jun 15;19(8-9):737-46. doi: 10.1016/j.phymed.2012.03.008. Epub 2012 Apr 25.

PMID:
22537907
40.

ALAS1 gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FOXO1 by vanadate in diabetic mice.

Oliveri LM, Davio C, Batlle AM, Gerez EN.

Biochem J. 2012 Mar 1;442(2):303-10. doi: 10.1042/BJ20111005.

PMID:
22070747
41.

Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2.

Fernandez N, Gottardo FL, Alonso MN, Monczor F, Shayo C, Davio C.

J Biol Chem. 2011 Aug 19;286(33):28697-706. doi: 10.1074/jbc.M111.269613. Epub 2011 Jun 24.

42.

Synthesis, structural characterization, and pro-apoptotic activity of 1-indanone thiosemicarbazone platinum(II) and palladium(II) complexes: potential as antileukemic agents.

Gómez N, Santos D, Vázquez R, Suescun L, Mombrú A, Vermeulen M, Finkielsztein L, Shayo C, Moglioni A, Gambino D, Davio C.

ChemMedChem. 2011 Aug 1;6(8):1485-94. doi: 10.1002/cmdc.201100060. Epub 2011 May 23.

PMID:
21608131
43.

Atrial natriuretic factor stimulates efflux of cAMP in rat exocrine pancreas via multidrug resistance-associated proteins.

Rodríguez MR, Diez F, Ventimiglia MS, Morales V, Copsel S, Vatta MS, Davio CA, Bianciotti LG.

Gastroenterology. 2011 Apr;140(4):1292-302. doi: 10.1053/j.gastro.2010.12.053. Epub 2011 Jan 13.

PMID:
21237168
44.

Multidrug resistance protein 4 (MRP4/ABCC4) regulates cAMP cellular levels and controls human leukemia cell proliferation and differentiation.

Copsel S, Garcia C, Diez F, Vermeulem M, Baldi A, Bianciotti LG, Russel FG, Shayo C, Davio C.

J Biol Chem. 2011 Mar 4;286(9):6979-88. doi: 10.1074/jbc.M110.166868. Epub 2011 Jan 4.

45.

Endothelins participate in the central and peripheral regulation of submandibular gland secretion in the rat.

Ventimiglia MS, Rodriguez MR, Morales VP, Elverdin JC, Perazzo JC, Castañeda MM, Davio CA, Vatta MS, Bianciotti LG.

Am J Physiol Regul Integr Comp Physiol. 2011 Jan;300(1):R109-20. doi: 10.1152/ajpregu.00041.2010. Epub 2010 Oct 13.

46.

Expression of a G protein-coupled receptor (GPCR) leads to attenuation of signaling by other GPCRs: experimental evidence for a spontaneous GPCR constitutive inactive form.

Tubio MR, Fernandez N, Fitzsimons CP, Copsel S, Santiago S, Shayo C, Davio C, Monczor F.

J Biol Chem. 2010 May 14;285(20):14990-8. doi: 10.1074/jbc.M109.099689. Epub 2010 Mar 18.

47.

Coumarins: old compounds with novel promising therapeutic perspectives.

Riveiro ME, De Kimpe N, Moglioni A, Vázquez R, Monczor F, Shayo C, Davio C.

Curr Med Chem. 2010;17(13):1325-38. Review.

PMID:
20166938
48.

Histamine acting on H1 receptor promotes inhibition of proliferation via PLC, RAC, and JNK-dependent pathways.

Notcovich C, Diez F, Tubio MR, Baldi A, Kazanietz MG, Davio C, Shayo C.

Exp Cell Res. 2010 Feb 1;316(3):401-11. doi: 10.1016/j.yexcr.2009.11.002. Epub 2009 Nov 11.

PMID:
19913013
49.

Toward establishing structure-activity relationships for oxygenated coumarins as differentiation inducers of promonocytic leukemic cells.

Riveiro ME, Maes D, Vázquez R, Vermeulen M, Mangelinckx S, Jacobs J, Debenedetti S, Shayo C, De Kimpe N, Davio C.

Bioorg Med Chem. 2009 Sep 15;17(18):6547-59. doi: 10.1016/j.bmc.2009.08.002. Epub 2009 Aug 8.

PMID:
19716307
50.

Histamine H2 receptor trafficking: role of arrestin, dynamin, and clathrin in histamine H2 receptor internalization.

Fernandez N, Monczor F, Baldi A, Davio C, Shayo C.

Mol Pharmacol. 2008 Oct;74(4):1109-18. doi: 10.1124/mol.108.045336. Epub 2008 Jul 10.

PMID:
18617631

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