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Modification by isolevuglandins, highly reactive γ-ketoaldehydes, deleteriously alters high-density lipoprotein structure and function.

May-Zhang LS, Yermalitsky V, Huang J, Pleasent T, Borja MS, Oda MN, Jerome WG, Yancey PG, Linton MF, Davies SS.

J Biol Chem. 2018 Jun 15;293(24):9176-9187. doi: 10.1074/jbc.RA117.001099. Epub 2018 Apr 30.


Dietary Fatty Acids Control the Species of N-Acyl-Phosphatidylethanolamines Synthesized by Therapeutically Modified Bacteria in the Intestinal Tract.

Dosoky NS, Guo L, Chen Z, Feigley AV, Davies SS.

ACS Infect Dis. 2018 Jan 12;4(1):3-13. doi: 10.1021/acsinfecdis.7b00127. Epub 2017 Oct 17.


Reactive Carbonyl Species Scavengers-Novel Therapeutic Approaches for Chronic Diseases.

Davies SS, Zhang LS.

Curr Pharmacol Rep. 2017 Apr;3(2):51-67. doi: 10.1007/s40495-017-0081-6. Epub 2017 Feb 14.


Leptogenic effects of NAPE require activity of NAPE-hydrolyzing phospholipase D.

Chen Z, Zhang Y, Guo L, Dosoky N, de Ferra L, Peters S, Niswender KD, Davies SS.

J Lipid Res. 2017 Aug;58(8):1624-1635. doi: 10.1194/jlr.M076513. Epub 2017 Jun 8.


Net cholesterol efflux capacity of HDL enriched serum and coronary atherosclerosis in rheumatoid arthritis.

Ormseth MJ, Yancey PG, Yamamoto S, Oeser AM, Gebretsadik T, Shintani A, Linton MF, Fazio S, Davies SS, Roberts LJ 2nd, Vickers KC, Raggi P, Kon V, Stein CM.

IJC Metab Endocr. 2016 Dec;13:6-11. doi: 10.1016/j.ijcme.2016.08.002. Epub 2016 Aug 28.


Isolevuglandins as a gauge of lipid peroxidation in human tumors.

Yan HP, Roberts LJ, Davies SS, Pohlmann P, Parl FF, Estes S, Maeng J, Parker B, Mernaugh R.

Free Radic Biol Med. 2017 May;106:62-68. doi: 10.1016/j.freeradbiomed.2017.02.020. Epub 2017 Feb 9.


Dendritic cells and isolevuglandins in immunity, inflammation, and hypertension.

Dixon KB, Davies SS, Kirabo A.

Am J Physiol Heart Circ Physiol. 2017 Mar 1;312(3):H368-H374. doi: 10.1152/ajpheart.00603.2016. Epub 2016 Dec 16. Review.


Reactive gamma-ketoaldehydes as novel activators of hepatic stellate cells in vitro.

Longato L, Andreola F, Davies SS, Roberts JL, Fusai G, Pinzani M, Moore K, Rombouts K.

Free Radic Biol Med. 2017 Jan;102:162-173. doi: 10.1016/j.freeradbiomed.2016.11.036. Epub 2016 Nov 24.


Accumulation of isolevuglandin-modified protein in normal and fibrotic lung.

Mont S, Davies SS, Roberts Second LJ, Mernaugh RL, McDonald WH, Segal BH, Zackert W, Kropski JA, Blackwell TS, Sekhar KR, Galligan JJ, Massion PP, Marnett LJ, Travis EL, Freeman ML.

Sci Rep. 2016 Apr 27;6:24919. doi: 10.1038/srep24919.


Microbial metabolism of dietary components to bioactive metabolites: opportunities for new therapeutic interventions.

Zhang LS, Davies SS.

Genome Med. 2016 Apr 21;8(1):46. doi: 10.1186/s13073-016-0296-x. Review.


Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.

J Clin Invest. 2016 Apr 1;126(4):1607. doi: 10.1172/JCI87425. Epub 2016 Apr 1. No abstract available.


Effect of Drug Therapy on Net Cholesterol Efflux Capacity of High-Density Lipoprotein-Enriched Serum in Rheumatoid Arthritis.

Ormseth MJ, Yancey PG, Solus JF, Bridges SL Jr, Curtis JR, Linton MF, Fazio S, Davies SS, Roberts LJ 2nd, Vickers KC, Kon V, Michael Stein C; TETRAD Investigators.

Arthritis Rheumatol. 2016 Sep;68(9):2099-105. doi: 10.1002/art.39675.


The Role of Lipids and Lipoproteins in Atherosclerosis.

Linton MF, Yancey PG, Davies SS, Jerome WGJ, Linton EF, Vickers KC.

In: De Groot LJ, Chrousos G, Dungan K, Feingold KR, Grossman A, Hershman JM, Koch C, Korbonits M, McLachlan R, New M, Purnell J, Rebar R, Singer F, Vinik A, editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-.
2015 Dec 24.


Corynebacterium accolens Releases Antipneumococcal Free Fatty Acids from Human Nostril and Skin Surface Triacylglycerols.

Bomar L, Brugger SD, Yost BH, Davies SS, Lemon KP.

MBio. 2016 Jan 5;7(1):e01725-15. doi: 10.1128/mBio.01725-15.


Immune activation caused by vascular oxidation promotes fibrosis and hypertension.

Wu J, Saleh MA, Kirabo A, Itani HA, Montaniel KR, Xiao L, Chen W, Mernaugh RL, Cai H, Bernstein KE, Goronzy JJ, Weyand CM, Curci JA, Barbaro NR, Moreno H, Davies SS, Roberts LJ 2nd, Madhur MS, Harrison DG.

J Clin Invest. 2016 Jan;126(1):50-67. doi: 10.1172/JCI80761. Epub 2015 Nov 23. Erratum in: J Clin Invest. 2016 Apr 1;126(4):1607.


Clinical Relevance of Biomarkers of Oxidative Stress.

Frijhoff J, Winyard PG, Zarkovic N, Davies SS, Stocker R, Cheng D, Knight AR, Taylor EL, Oettrich J, Ruskovska T, Gasparovic AC, Cuadrado A, Weber D, Poulsen HE, Grune T, Schmidt HH, Ghezzi P.

Antioxid Redox Signal. 2015 Nov 10;23(14):1144-70. doi: 10.1089/ars.2015.6317. Epub 2015 Oct 26. Review.


Isolevuglandin-type lipid aldehydes induce the inflammatory response of macrophages by modifying phosphatidylethanolamines and activating the receptor for advanced glycation endproducts.

Guo L, Chen Z, Amarnath V, Yancey PG, Van Lenten BJ, Savage JR, Fazio S, Linton MF, Davies SS.

Antioxid Redox Signal. 2015 Jun 20;22(18):1633-45. doi: 10.1089/ars.2014.6078. Epub 2015 Mar 18.


Reactive γ-ketoaldehydes promote protein misfolding and preamyloid oligomer formation in rapidly-activated atrial cells.

Sidorova TN, Yermalitskaya LV, Mace LC, Wells KS, Boutaud O, Prinsen JK, Davies SS, Roberts LJ 2nd, Dikalov SI, Glabe CG, Amarnath V, Barnett JV, Murray KT.

J Mol Cell Cardiol. 2015 Feb;79:295-302. doi: 10.1016/j.yjmcc.2014.11.013. Epub 2014 Nov 18.


DC isoketal-modified proteins activate T cells and promote hypertension.

Kirabo A, Fontana V, de Faria AP, Loperena R, Galindo CL, Wu J, Bikineyeva AT, Dikalov S, Xiao L, Chen W, Saleh MA, Trott DW, Itani HA, Vinh A, Amarnath V, Amarnath K, Guzik TJ, Bernstein KE, Shen XZ, Shyr Y, Chen SC, Mernaugh RL, Laffer CL, Elijovich F, Davies SS, Moreno H, Madhur MS, Roberts J 2nd, Harrison DG.

J Clin Invest. 2014 Oct;124(10):4642-56. doi: 10.1172/JCI74084. Epub 2014 Sep 17.


Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity.

Chen Z, Guo L, Zhang Y, Walzem RL, Pendergast JS, Printz RL, Morris LC, Matafonova E, Stien X, Kang L, Coulon D, McGuinness OP, Niswender KD, Davies SS.

J Clin Invest. 2014 Aug;124(8):3391-406. doi: 10.1172/JCI72517. Epub 2014 Jun 24.


Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids.

Davies SS, Guo L.

Chem Phys Lipids. 2014 Jul;181:1-33. doi: 10.1016/j.chemphyslip.2014.03.002. Epub 2014 Apr 2. Review.


Isolevuglandin-modified phosphatidylethanolamine is metabolized by NAPE-hydrolyzing phospholipase D.

Guo L, Gragg SD, Chen Z, Zhang Y, Amarnath V, Davies SS.

J Lipid Res. 2013 Nov;54(11):3151-7. doi: 10.1194/jlr.M042556. Epub 2013 Sep 9.


Dietary selenium deficiency exacerbates DSS-induced epithelial injury and AOM/DSS-induced tumorigenesis.

Barrett CW, Singh K, Motley AK, Lintel MK, Matafonova E, Bradley AM, Ning W, Poindexter SV, Parang B, Reddy VK, Chaturvedi R, Fingleton BM, Washington MK, Wilson KT, Davies SS, Hill KE, Burk RF, Williams CS.

PLoS One. 2013 Jul 4;8(7):e67845. doi: 10.1371/journal.pone.0067845. Print 2013.


Neuron-specific deletion of peroxisome proliferator-activated receptor delta (PPARδ) in mice leads to increased susceptibility to diet-induced obesity.

Kocalis HE, Turney MK, Printz RL, Laryea GN, Muglia LJ, Davies SS, Stanwood GD, McGuinness OP, Niswender KD.

PLoS One. 2012;7(8):e42981. doi: 10.1371/journal.pone.0042981. Epub 2012 Aug 20.


Identification of novel bioactive aldehyde-modified phosphatidylethanolamines formed by lipid peroxidation.

Guo L, Chen Z, Amarnath V, Davies SS.

Free Radic Biol Med. 2012 Sep 15;53(6):1226-38. doi: 10.1016/j.freeradbiomed.2012.07.077. Epub 2012 Aug 4.


Bioactive aldehyde-modified phosphatidylethanolamines.

Guo L, Davies SS.

Biochimie. 2013 Jan;95(1):74-8. doi: 10.1016/j.biochi.2012.07.010. Epub 2012 Jul 20. Review.


Isoprostane generation and function.

Milne GL, Yin H, Hardy KD, Davies SS, Roberts LJ 2nd.

Chem Rev. 2011 Oct 12;111(10):5973-96. doi: 10.1021/cr200160h. Epub 2011 Aug 18. Review. No abstract available.


Treatment with a γ-ketoaldehyde scavenger prevents working memory deficits in hApoE4 mice.

Davies SS, Bodine C, Matafonova E, Pantazides BG, Bernoud-Hubac N, Harrison FE, Olson SJ, Montine TJ, Amarnath V, Roberts LJ 2nd.

J Alzheimers Dis. 2011;27(1):49-59. doi: 10.3233/JAD-2011-102118.


Oxidative stress in older adults: effects of physical fitness.

Traustadóttir T, Davies SS, Su Y, Choi L, Brown-Borg HM, Roberts LJ 2nd, Harman SM.

Age (Dordr). 2012 Aug;34(4):969-82. doi: 10.1007/s11357-011-9277-6. Epub 2011 Jun 14.


Phosphatidylethanolamines modified by γ-ketoaldehyde (γKA) induce endoplasmic reticulum stress and endothelial activation.

Guo L, Chen Z, Cox BE, Amarnath V, Epand RF, Epand RM, Davies SS.

J Biol Chem. 2011 May 20;286(20):18170-80. doi: 10.1074/jbc.M110.213470. Epub 2011 Mar 25.


F2-isoprostanes as an indicator and risk factor for coronary heart disease.

Davies SS, Roberts LJ 2nd.

Free Radic Biol Med. 2011 Mar 1;50(5):559-66. doi: 10.1016/j.freeradbiomed.2010.11.023. Epub 2010 Nov 30. Review.


Evidence of oxidative stress in relation to feeding type during early life in premature infants.

Friel JK, Diehl-Jones B, Cockell KA, Chiu A, Rabanni R, Davies SS, Roberts LJ 2nd.

Pediatr Res. 2011 Feb;69(2):160-4. doi: 10.1203/PDR.0b013e3182042a07.


A liquid chromatography-tandem mass spectrometry method for measurement of N-modified phosphatidylethanolamines.

Guo L, Amarnath V, Davies SS.

Anal Biochem. 2010 Oct 15;405(2):236-45. doi: 10.1016/j.ab.2010.06.027. Epub 2010 Jun 19.


Reactive gamma-ketoaldehydes formed via the isoprostane pathway disrupt mitochondrial respiration and calcium homeostasis.

Stavrovskaya IG, Baranov SV, Guo X, Davies SS, Roberts LJ 2nd, Kristal BS.

Free Radic Biol Med. 2010 Aug 15;49(4):567-79. doi: 10.1016/j.freeradbiomed.2010.04.037. Epub 2010 Jun 2.


Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Zagol-Ikapitte IA, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts LJ 2nd, Davies SS.

Pharmaceutics. 2010 Mar;2(1):18-29.


Determination of the Pharmacokinetics and Oral Bioavailability of Salicylamine, a Potent γ-Ketoaldehyde Scavenger, by LC/MS/MS.

Zagol-Ikapitte I, Matafonova E, Amarnath V, Bodine CL, Boutaud O, Tirona RG, Oates JA, Roberts Ii LJ, Davies SS.

Pharmaceutics. 2010 Feb 1;2(1):18-29.


Isoketals form cytotoxic phosphatidylethanolamine adducts in cells.

Sullivan CB, Matafonova E, Roberts LJ 2nd, Amarnath V, Davies SS.

J Lipid Res. 2010 May;51(5):999-1009. doi: 10.1194/jlr.M001040. Epub 2009 Nov 25.


Selective gamma-ketoaldehyde scavengers protect Nav1.5 from oxidant-induced inactivation.

Nakajima T, Davies SS, Matafonova E, Potet F, Amarnath V, Tallman KA, Serwa RA, Porter NA, Balser JR, Kupershmidt S, Roberts LJ 3rd.

J Mol Cell Cardiol. 2010 Feb;48(2):352-9. doi: 10.1016/j.yjmcc.2009.11.016. Epub 2009 Dec 3.


Tart cherry juice decreases oxidative stress in healthy older men and women.

Traustadóttir T, Davies SS, Stock AA, Su Y, Heward CB, Roberts LJ 2nd, Harman SM.

J Nutr. 2009 Oct;139(10):1896-900. doi: 10.3945/jn.109.111716. Epub 2009 Aug 19.


Ischemia/reperfusion unveils impaired capacity of older adults to restrain oxidative insult.

Davies SS, Traustadóttir T, Stock AA, Ye F, Shyr Y, Harman SM, Roberts LJ 2nd.

Free Radic Biol Med. 2009 Oct 1;47(7):1014-8. doi: 10.1016/j.freeradbiomed.2009.07.005. Epub 2009 Jul 21.


Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans.

Watanabe H, Chopra N, Laver D, Hwang HS, Davies SS, Roach DE, Duff HJ, Roden DM, Wilde AA, Knollmann BC.

Nat Med. 2009 Apr;15(4):380-3. doi: 10.1038/nm.1942. Epub 2009 Mar 29.


Low concentrations of reactive gamma-ketoaldehydes prime thromboxane-dependent human platelet aggregation via p38-MAPK activation.

Bernoud-Hubac N, Alam DA, Lefils J, Davies SS, Amarnath V, Guichardant M, Roberts LJ 2nd, Lagarde M.

Biochim Biophys Acta. 2009 Apr;1791(4):307-13. doi: 10.1016/j.bbalip.2009.02.003. Epub 2009 Feb 21.


Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release.

Chopra N, Laver D, Davies SS, Knollmann BC.

Mol Pharmacol. 2009 Jan;75(1):183-95. doi: 10.1124/mol.108.051490. Epub 2008 Oct 9.


Modulation of protein function by isoketals and levuglandins.

Davies SS.

Subcell Biochem. 2008;49:49-70. doi: 10.1007/978-1-4020-8831-5_2. Review.


Elimination of GD3 synthase improves memory and reduces amyloid-beta plaque load in transgenic mice.

Bernardo A, Harrison FE, McCord M, Zhao J, Bruchey A, Davies SS, Jackson Roberts L 2nd, Mathews PM, Matsuoka Y, Ariga T, Yu RK, Thompson R, McDonald MP.

Neurobiol Aging. 2009 Nov;30(11):1777-91. doi: 10.1016/j.neurobiolaging.2007.12.022. Epub 2008 Feb 6.


Potential role of isoketals formed via the isoprostane pathway of lipid peroxidation in ischemic arrhythmias.

Boyden PA, Davies SS, Viswanathan PC, Amarnath V, Balser JR, Roberts LJ 2nd.

J Cardiovasc Pharmacol. 2007 Nov;50(5):480-6. Review.


Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study.

Frisard MI, Broussard A, Davies SS, Roberts LJ 2nd, Rood J, de Jonge L, Fang X, Jazwinski SM, Deutsch WA, Ravussin E; Louisiana Healthy Aging Study.

J Gerontol A Biol Sci Med Sci. 2007 Jul;62(7):752-9.


Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.

Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ 2nd.

Biochemistry. 2006 Dec 26;45(51):15756-67. Epub 2006 Dec 6.


Oxidant stress modulates murine allergic airway responses.

Talati M, Meyrick B, Peebles RS Jr, Davies SS, Dworski R, Mernaugh R, Mitchell D, Boothby M, Roberts LJ 2nd, Sheller JR.

Free Radic Biol Med. 2006 Apr 1;40(7):1210-9. Epub 2005 Dec 9.


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