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Items: 1 to 50 of 309


Varenicline versus nicotine replacement therapy for long-term smoking cessation: an observational study using the Clinical Practice Research Datalink.

Davies NM, Taylor AE, Taylor GM, Itani T, Jones T, Martin RM, Munafò MR, Windmeijer F, Thomas KH.

Health Technol Assess. 2020 Feb;24(9):1-46. doi: 10.3310/hta24090.


Development and validation of a compact on-person storage device (SMHeartCard) for emergency access to acetylsalicylic acid and nitroglycerin.

Le T, Paterson DI, Davies NM, Mackey JR.

CMAJ Open. 2020 Feb 11;8(1):E75-E82. doi: 10.9778/cmajo.20190147. Print 2020 Jan-Mar.


Mendelian Randomization analysis of the causal effect of adiposity on hospital costs.

Dixon P, Hollingworth W, Harrison S, Davies NM, Davey Smith G.

J Health Econ. 2020 Jan 25;70:102300. doi: 10.1016/j.jhealeco.2020.102300. [Epub ahead of print]


Education, intelligence and Alzheimer's disease: evidence from a multivariable two-sample Mendelian randomization study.

Anderson EL, Howe LD, Wade KH, Ben-Shlomo Y, Hill WD, Deary IJ, Sanderson EC, Zheng J, Korologou-Linden R, Stergiakouli E, Davey Smith G, Davies NM, Hemani G.

Int J Epidemiol. 2020 Jan 31. pii: dyz280. doi: 10.1093/ije/dyz280. [Epub ahead of print]


Long-term effectiveness and safety of varenicline and nicotine replacement therapy in people with neurodevelopmental disorders: A prospective cohort study.

Itani T, Rai D, Jones T, Taylor GMJ, Thomas KH, Martin RM, Munafò MR, Davies NM, Taylor AE.

Sci Rep. 2019 Dec 20;9(1):19488. doi: 10.1038/s41598-019-54727-5.


Genome-wide analysis identifies molecular systems and 149 genetic loci associated with income.

Hill WD, Davies NM, Ritchie SJ, Skene NG, Bryois J, Bell S, Di Angelantonio E, Roberts DJ, Xueyi S, Davies G, Liewald DCM, Porteous DJ, Hayward C, Butterworth AS, McIntosh AM, Gale CR, Deary IJ.

Nat Commun. 2019 Dec 16;10(1):5741. doi: 10.1038/s41467-019-13585-5.


Effects of body mass index on relationship status, social contact and socio-economic position: Mendelian randomization and within-sibling study in UK Biobank.

Howe LD, Kanayalal R, Harrison S, Beaumont RN, Davies AR, Frayling TM, Davies NM, Hughes A, Jones SE, Sassi F, Wood AR, Tyrrell J.

Int J Epidemiol. 2019 Dec 4. pii: dyz240. doi: 10.1093/ije/dyz240. [Epub ahead of print]


Comparison with randomized controlled trials as a strategy for evaluating instruments in Mendelian randomization.

Gill D, Walker VM, Martin RM, Davies NM, Tzoulaki I.

Int J Epidemiol. 2019 Nov 25. pii: dyz236. doi: 10.1093/ije/dyz236. [Epub ahead of print] No abstract available.


Genetic evidence for assortative mating on alcohol consumption in the UK Biobank.

Howe LJ, Lawson DJ, Davies NM, St Pourcain B, Lewis SJ, Davey Smith G, Hemani G.

Nat Commun. 2019 Nov 19;10(1):5039. doi: 10.1038/s41467-019-12424-x.


Using the MR-Base platform to investigate risk factors and drug targets for thousands of phenotypes.

Walker VM, Davies NM, Hemani G, Zheng J, Haycock PC, Gaunt TR, Davey Smith G, Martin RM.

Version 2. Wellcome Open Res. 2019 Nov 7 [revised 2019 Jan 1];4:113. doi: 10.12688/wellcomeopenres.15334.2. eCollection 2019.


Within family Mendelian randomization studies.

Davies NM, Howe LJ, Brumpton B, Havdahl A, Evans DM, Davey Smith G.

Hum Mol Genet. 2019 Nov 21;28(R2):R170-R179. doi: 10.1093/hmg/ddz204.


Elucidation of Hosts, Native Distribution, and Habitat of the Coffee Berry Borer (Hypothenemus hampei) Using Herbaria and Other Museum Collections.

Vega FE, Smith LT, Davies NMJ, Moat J, Góral T, O'Sullivan R, Davis AP.

Front Plant Sci. 2019 Oct 1;10:1188. doi: 10.3389/fpls.2019.01188. eCollection 2019.


Factors Affecting Targeted Sequencing of 353 Nuclear Genes From Herbarium Specimens Spanning the Diversity of Angiosperms.

Brewer GE, Clarkson JJ, Maurin O, Zuntini AR, Barber V, Bellot S, Biggs N, Cowan RS, Davies NMJ, Dodsworth S, Edwards SL, Eiserhardt WL, Epitawalage N, Frisby S, Grall A, Kersey PJ, Pokorny L, Leitch IJ, Forest F, Baker WJ.

Front Plant Sci. 2019 Sep 18;10:1102. doi: 10.3389/fpls.2019.01102. eCollection 2019.


Pharmacy's Trojan horse.

Davies NM.

Can Pharm J (Ott). 2019 Aug 5;152(5):284. doi: 10.1177/1715163519865738. eCollection 2019 Sep-Oct. No abstract available.


Validation of Cadherin HAV6 Peptide in the Transient Modulation of the Blood-Brain Barrier for the Treatment of Brain Tumors.

Sajesh BV, On NH, Omar R, Alrushaid S, Kopec BM, Wang WG, Sun HD, Lillico R, Lakowski TM, Siahaan TJ, Davies NM, Puno PT, Vanan MI, Miller DW.

Pharmaceutics. 2019 Sep 17;11(9). pii: E481. doi: 10.3390/pharmaceutics11090481.


Multivariable two-sample Mendelian randomization estimates of the effects of intelligence and education on health.

Davies NM, Hill WD, Anderson EL, Sanderson E, Deary IJ, Davey Smith G.

Elife. 2019 Sep 17;8. pii: e43990. doi: 10.7554/eLife.43990.


Using Genetic Instruments to Estimate Interactions in Mendelian Randomization Studies.

North TL, Davies NM, Harrison S, Carter AR, Hemani G, Sanderson E, Tilling K, Howe LD.

Epidemiology. 2019 Nov;30(6):e33-e35. doi: 10.1097/EDE.0000000000001096. No abstract available.


Correction to: Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Lawson DJ, Davies NM, Haworth S, Ashraf B, Howe L, Crawford A, Hemani G, Davey Smith G, Timpson NJ.

Hum Genet. 2020 Jan;139(1):43-44. doi: 10.1007/s00439-019-02051-3.


Repurposing antihypertensive drugs for the prevention of Alzheimer's disease: a Mendelian randomization study.

Walker VM, Kehoe PG, Martin RM, Davies NM.

Int J Epidemiol. 2019 Jul 23. pii: dyz155. doi: 10.1093/ije/dyz155. [Epub ahead of print]


Prescribing Prevalence, Effectiveness, and Mental Health Safety of Smoking Cessation Medicines in Patients With Mental Disorders.

Taylor GMJ, Itani T, Thomas KH, Rai D, Jones T, Windmeijer F, Martin RM, Munafò MR, Davies NM, Taylor AE.

Nicotine Tob Res. 2020 Jan 27;22(1):48-57. doi: 10.1093/ntr/ntz072.


Comment on the Relationship Between Common Variant Schizophrenia Liability and Number of Offspring in the UK Biobank.

Lawn RB, Sallis HM, Taylor AE, Wootton RE, Davey Smith G, Davies NM, Hemani G, Fraser A, Penton-Voak IS, Munafò MR.

Am J Psychiatry. 2019 Jul 1;176(7):573-574. doi: 10.1176/appi.ajp.2019.19010071. No abstract available.


Simulated, biorelevant, clinically relevant or physiologically relevant dissolution media: The hidden role of bicarbonate buffer.

Amaral Silva D, Al-Gousous J, Davies NM, Bou Chacra N, Webster GK, Lipka E, Amidon G, Löbenberg R.

Eur J Pharm Biopharm. 2019 Sep;142:8-19. doi: 10.1016/j.ejpb.2019.06.006. Epub 2019 Jun 10. Review.


Understanding the consequences of education inequality on cardiovascular disease: mendelian randomisation study.

Carter AR, Gill D, Davies NM, Taylor AE, Tillmann T, Vaucher J, Wootton RE, Munafò MR, Hemani G, Malik R, Seshadri S, Woo D, Burgess S, Davey Smith G, Holmes MV, Tzoulaki I, Howe LD, Dehghan A.

BMJ. 2019 May 22;365:l1855. doi: 10.1136/bmj.l1855.


Schizophrenia risk and reproductive success: a Mendelian randomization study.

Lawn RB, Sallis HM, Taylor AE, Wootton RE, Smith GD, Davies NM, Hemani G, Fraser A, Penton-Voak IS, Munafò MR.

R Soc Open Sci. 2019 Mar 6;6(3):181049. doi: 10.1098/rsos.181049. eCollection 2019 Mar.


Is population structure in the genetic biobank era irrelevant, a challenge, or an opportunity?

Lawson DJ, Davies NM, Haworth S, Ashraf B, Howe L, Crawford A, Hemani G, Davey Smith G, Timpson NJ.

Hum Genet. 2020 Jan;139(1):23-41. doi: 10.1007/s00439-019-02014-8. Epub 2019 Apr 27. Review. Erratum in: Hum Genet. 2019 Jul 30;:.


Testing the validity of value-added measures of educational progress with genetic data.

Morris TT, Davies NM, Dorling D, Richmond RC, Smith GD.

Br Educ Res J. 2018 Oct;44(5):725-747. doi: 10.1002/berj.3466. Epub 2018 Sep 9.


Selection Bias When Estimating Average Treatment Effects Using One-sample Instrumental Variable Analysis.

Hughes RA, Davies NM, Davey Smith G, Tilling K.

Epidemiology. 2019 May;30(3):350-357. doi: 10.1097/EDE.0000000000000972.


Searching for the causal effects of body mass index in over 300 000 participants in UK Biobank, using Mendelian randomization.

Millard LAC, Davies NM, Tilling K, Gaunt TR, Davey Smith G.

PLoS Genet. 2019 Feb 1;15(2):e1007951. doi: 10.1371/journal.pgen.1007951. eCollection 2019 Feb.


A genome-wide association study identifies new loci for factor VII and implicates factor VII in ischemic stroke etiology.

de Vries PS, Sabater-Lleal M, Huffman JE, Marten J, Song C, Pankratz N, Bartz TM, de Haan HG, Delgado GE, Eicher JD, Martinez-Perez A, Ward-Caviness CK, Brody JA, Chen MH, de Maat MPM, Frånberg M, Gill D, Kleber ME, Rivadeneira F, Soria JM, Tang W, Tofler GH, Uitterlinden AG, van Hylckama Vlieg A, Seshadri S, Boerwinkle E, Davies NM, Giese AK, Ikram MK, Kittner SJ, McKnight B, Psaty BM, Reiner AP, Sargurupremraj M, Taylor KD; INVENT Consortium; MEGASTROKE Consortium of the International Stroke Genetics Consortium, Fornage M, Hamsten A, März W, Rosendaal FR, Souto JC, Dehghan A, Johnson AD, Morrison AC, O'Donnell CJ, Smith NL.

Blood. 2019 Feb 28;133(9):967-977. doi: 10.1182/blood-2018-05-849240. Epub 2019 Jan 14.


Genome-Wide Association Transethnic Meta-Analyses Identifies Novel Associations Regulating Coagulation Factor VIII and von Willebrand Factor Plasma Levels.

Sabater-Lleal M, Huffman JE, de Vries PS, Marten J, Mastrangelo MA, Song C, Pankratz N, Ward-Caviness CK, Yanek LR, Trompet S, Delgado GE, Guo X, Bartz TM, Martinez-Perez A, Germain M, de Haan HG, Ozel AB, Polasek O, Smith AV, Eicher JD, Reiner AP, Tang W, Davies NM, Stott DJ, Rotter JI, Tofler GH, Boerwinkle E, de Maat MPM, Kleber ME, Welsh P, Brody JA, Chen MH, Vaidya D, Soria JM, Suchon P, van Hylckama Vlieg A, Desch KC, Kolcic I, Joshi PK, Launer LJ, Harris TB, Campbell H, Rudan I, Becker DM, Li JZ, Rivadeneira F, Uitterlinden AG, Hofman A, Franco OH, Cushman M, Psaty BM, Morange PE, McKnight B, Chong MR, Fernandez-Cadenas I, Rosand J, Lindgren A; INVENT Consortium; MEGASTROKE Consortium of the International Stroke Genetics Consortium (ISGC), Gudnason V, Wilson JF, Hayward C, Ginsburg D, Fornage M, Rosendaal FR, Souto JC, Becker LC, Jenny NS, März W, Jukema JW, Dehghan A, Trégouët DA, Morrison AC, Johnson AD, O'Donnell CJ, Strachan DP, Lowenstein CJ, Smith NL.

Circulation. 2019 Jan 29;139(5):620-635. doi: 10.1161/CIRCULATIONAHA.118.034532.


A systematic review and meta-analysis of effects of early life non-cognitive skills on academic, psychosocial, cognitive and health outcomes.

Smithers LG, Sawyer ACP, Chittleborough CR, Davies NM, Davey Smith G, Lynch JW.

Nat Hum Behav. 2018 Nov;2(11):867-880. doi: 10.1038/s41562-018-0461-x. Epub 2018 Nov 5.


Effect modification of FADS2 polymorphisms on the association between breastfeeding and intelligence: results from a collaborative meta-analysis.

Hartwig FP, Davies NM, Horta BL, Ahluwalia TS, Bisgaard H, Bønnelykke K, Caspi A, Moffitt TE, Poulton R, Sajjad A, Tiemeier HW, Dalmau-Bueno A, Guxens M, Bustamante M, Santa-Marina L, Parker N, Paus T, Pausova Z, Lauritzen L, Schnurr TM, Michaelsen KF, Hansen T, Oddy W, Pennell CE, Warrington NM, Davey Smith G, Victora CG.

Int J Epidemiol. 2019 Feb 1;48(1):45-57. doi: 10.1093/ije/dyy273.


The Antioxidant Activity of Recombinant Rat Hepatic Fatty Acid Binding Protein T94A Variant.

Le T, Gong Y, Davies NM, Lillico R, Lakowski T, Roberts MS, Burczynski FJ.

J Pharm Pharm Sci. 2018;21(1s):309s-324s. doi: 10.18433/jpps30246.


The Causal Effects of Education on Health Outcomes in the UK Biobank.

Davies NM, Dickson M, Davey Smith G, van den Berg GJ, Windmeijer F.

Nat Hum Behav. 2018 Feb;2(2):117-125. doi: 10.1038/s41562-017-0279-y. Epub 2018 Jan 29. No abstract available.


Application of in Silico Tools in Clinical Practice using Ketoconazole as a Model Drug.

Silva DA, Duque MD, Davies NM, Löbenberg R, Ferraz HG.

J Pharm Pharm Sci. 2018;21(1s):242s-253s. doi: 10.18433/jpps30227.


Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study.

Wootton RE, Lawn RB, Millard LAC, Davies NM, Taylor AE, Munafò MR, Timpson NJ, Davis OSP, Davey Smith G, Haworth CMA.

BMJ. 2018 Sep 25;362:k3788. doi: 10.1136/bmj.k3788.


DOX-Vit D, a Novel Doxorubicin Delivery Approach, Inhibits Human Osteosarcoma Cell Proliferation by Inducing Apoptosis While Inhibiting Akt and mTOR Signaling Pathways.

Maayah ZH, Zhang T, Forrest ML, Alrushaid S, Doschak MR, Davies NM, El-Kadi AOS.

Pharmaceutics. 2018 Sep 4;10(3). pii: E144. doi: 10.3390/pharmaceutics10030144.


Correction to: Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative.

Alrushaid S, Zhao Y, Sayre CL, Maayah ZH, Forrest ML, Senadheera SN, Chaboyer K, Anderson HD, El-Kadi AOS, Davies NM.

Drug Deliv Transl Res. 2018 Oct;8(5):1592. doi: 10.1007/s13346-018-0569-6.


Effects of low-level laser therapy on bone healing and signs of pain in dogs following tibial plateau leveling osteotomy.

Kennedy KC, Martinez SA, Martinez SE, Tucker RL, Davies NM.

Am J Vet Res. 2018 Aug;79(8):893-904. doi: 10.2460/ajvr.79.8.893.


Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians.

Davies NM, Holmes MV, Davey Smith G.

BMJ. 2018 Jul 12;362:k601. doi: 10.1136/bmj.k601. No abstract available.


Bias in Mendelian randomization due to assortative mating.

Hartwig FP, Davies NM, Davey Smith G.

Genet Epidemiol. 2018 Oct;42(7):608-620. doi: 10.1002/gepi.22138. Epub 2018 Jul 3.


Education and myopia: assessing the direction of causality by mendelian randomisation.

Mountjoy E, Davies NM, Plotnikov D, Smith GD, Rodriguez S, Williams CE, Guggenheim JA, Atan D.

BMJ. 2018 Jun 6;361:k2022. doi: 10.1136/bmj.k2022. Erratum in: BMJ. 2018 Jul 4;362:k2932.


Exploring the association of genetic factors with participation in the Avon Longitudinal Study of Parents and Children.

Taylor AE, Jones HJ, Sallis H, Euesden J, Stergiakouli E, Davies NM, Zammit S, Lawlor DA, Munafò MR, Davey Smith G, Tilling K.

Int J Epidemiol. 2018 Aug 1;47(4):1207-1216. doi: 10.1093/ije/dyy060.


Response to: Long-term smoking cessation: from general practice to public health.

Taylor GMJ, Davies NM.

Int J Epidemiol. 2018 Aug 1;47(4):1356. doi: 10.1093/ije/dyy084. No abstract available.


Pharmaceutical Characterization of MyoNovin, a Novel Skeletal Muscle Regenerator: in silico, in vitro and in vivo Studies.

Alrushaid S, Davies NM, Anderson JE, Le T, Yáñez JA, Maayah ZH, El-Kadi AOS, Rachid O, Sayre CL, Löbenberg R, Burczynski FJ.

J Pharm Pharm Sci. 2018;21(1s):29683. doi: 10.18433/J3MS8H.


Are Excipients Inert? Phenytoin Pharmaceutical Investigations with New Incompatibility Insights.

Amaral Silva D, Löbenberg R, Davies NM.

J Pharm Pharm Sci. 2018;21(1s):29745. doi: 10.18433/jpps29745.


The effects of prescribing varenicline on two-year health outcomes: an observational cohort study using electronic medical records.

Davies NM, Taylor GMJ, Taylor AE, Jones T, Martin RM, Munafò MR, Windmeijer F, Thomas KH.

Addiction. 2018 Jun;113(6):1105-1116. doi: 10.1111/add.14146. Epub 2018 Feb 20.


Pharmacokinetics and Drug Metabolism in Canada: The Current Landscape-A Summary of This Indispensable Special Issue.

Davies NM, Wasan KM.

Pharmaceutics. 2018 Jan 16;10(1). pii: E13. doi: 10.3390/pharmaceutics10010013.

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