Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 56


Heritability of skewed X-inactivation in female twins is tissue-specific and associated with age.

Zito A, Davies MN, Tsai PC, Roberts S, Andres-Ejarque R, Nardone S, Bell JT, Wong CCY, Small KS.

Nat Commun. 2019 Nov 25;10(1):5339. doi: 10.1038/s41467-019-13340-w.


Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer.

Woolston A, Khan K, Spain G, Barber LJ, Griffiths B, Gonzalez-Exposito R, Hornsteiner L, Punta M, Patil Y, Newey A, Mansukhani S, Davies MN, Furness A, Sclafani F, Peckitt C, Jiménez M, Kouvelakis K, Ranftl R, Begum R, Rana I, Thomas J, Bryant A, Quezada S, Wotherspoon A, Khan N, Fotiadis N, Marafioti T, Powles T, Lise S, Calvo F, Guettler S, von Loga K, Rao S, Watkins D, Starling N, Chau I, Sadanandam A, Cunningham D, Gerlinger M.

Cancer Cell. 2019 Jul 8;36(1):35-50.e9. doi: 10.1016/j.ccell.2019.05.013.


Ultra-Sensitive Mutation Detection and Genome-Wide DNA Copy Number Reconstruction by Error-Corrected Circulating Tumor DNA Sequencing.

Mansukhani S, Barber LJ, Kleftogiannis D, Moorcraft SY, Davidson M, Woolston A, Proszek PZ, Griffiths B, Fenwick K, Herman B, Matthews N, O'Leary B, Hulkki S, Gonzalez De Castro D, Patel A, Wotherspoon A, Okachi A, Rana I, Begum R, Davies MN, Powles T, von Loga K, Hubank M, Turner N, Watkins D, Chau I, Cunningham D, Lise S, Starling N, Gerlinger M.

Clin Chem. 2018 Nov;64(11):1626-1635. doi: 10.1373/clinchem.2018.289629. Epub 2018 Aug 27.


Age-dependent changes in mean and variance of gene expression across tissues in a twin cohort.

Viñuela A, Brown AA, Buil A, Tsai PC, Davies MN, Bell JT, Dermitzakis ET, Spector TD, Small KS.

Hum Mol Genet. 2018 Feb 15;27(4):732-741. doi: 10.1093/hmg/ddx424.


Regional differences in mitochondrial DNA methylation in human post-mortem brain tissue.

Devall M, Smith RG, Jeffries A, Hannon E, Davies MN, Schalkwyk L, Mill J, Weedon M, Lunnon K.

Clin Epigenetics. 2017 May 3;9:47. doi: 10.1186/s13148-017-0337-3. eCollection 2017.


In Silico Adjuvant Design and Validation.

Davies MN, Pere H, Bosschem I, Haesebrouck F, Flahou B, Tartour E, Flower DR, Tough DF, Bayry J.

Methods Mol Biol. 2017;1494:107-125.


Cancer Evolution and the Limits of Predictability in Precision Cancer Medicine.

Lipinski KA, Barber LJ, Davies MN, Ashenden M, Sottoriva A, Gerlinger M.

Trends Cancer. 2016 Jan;2(1):49-63. doi: 10.1016/j.trecan.2015.11.003. Epub 2016 Jan 29. Review.


The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins.

Davies MN, Kjalarsdottir L, Thompson JW, Dubois LG, Stevens RD, Ilkayeva OR, Brosnan MJ, Rolph TP, Grimsrud PA, Muoio DM.

Cell Rep. 2016 Jan 12;14(2):243-54. doi: 10.1016/j.celrep.2015.12.030. Epub 2015 Dec 31.


Generalised Anxiety Disorder--A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression.

Davies MN, Verdi S, Burri A, Trzaskowski M, Lee M, Hettema JM, Jansen R, Boomsma DI, Spector TD.

PLoS One. 2015 Aug 14;10(8):e0134865. doi: 10.1371/journal.pone.0134865. eCollection 2015.


Carnitine Acetyltransferase Mitigates Metabolic Inertia and Muscle Fatigue during Exercise.

Seiler SE, Koves TR, Gooding JR, Wong KE, Stevens RD, Ilkayeva OR, Wittmann AH, DeBalsi KL, Davies MN, Lindeboom L, Schrauwen P, Schrauwen-Hinderling VB, Muoio DM.

Cell Metab. 2015 Jul 7;22(1):65-76. doi: 10.1016/j.cmet.2015.06.003.


Dissecting cancer evolution at the macro-heterogeneity and micro-heterogeneity scale.

Barber LJ, Davies MN, Gerlinger M.

Curr Opin Genet Dev. 2015 Feb;30:1-6. doi: 10.1016/j.gde.2014.12.001. Epub 2014 Dec 31. Review.


Gene-gene and gene-environment interactions detected by transcriptome sequence analysis in twins.

Buil A, Brown AA, Lappalainen T, Viñuela A, Davies MN, Zheng HF, Richards JB, Glass D, Small KS, Durbin R, Spector TD, Dermitzakis ET.

Nat Genet. 2015 Jan;47(1):88-91. doi: 10.1038/ng.3162. Epub 2014 Dec 1.


Hypermethylation in the ZBTB20 gene is associated with major depressive disorder.

Davies MN, Krause L, Bell JT, Gao F, Ward KJ, Wu H, Lu H, Liu Y, Tsai PC, Collier DA, Murphy T, Dempster E, Mill J; UK Brain Expression Consortium, Battle A, Mostafavi S, Zhu X, Henders A, Byrne E, Wray NR, Martin NG, Spector TD, Wang J.

Genome Biol. 2014 Apr 2;15(4):R56. doi: 10.1186/gb-2014-15-4-r56.


Differential methylation of the TRPA1 promoter in pain sensitivity.

Bell JT, Loomis AK, Butcher LM, Gao F, Zhang B, Hyde CL, Sun J, Wu H, Ward K, Harris J, Scollen S, Davies MN, Schalkwyk LC, Mill J; MuTHER Consortium, Williams FM, Li N, Deloukas P, Beck S, McMahon SB, Wang J, John SL, Spector TD.

Nat Commun. 2014;5:2978. doi: 10.1038/ncomms3978.


Gene expression changes with age in skin, adipose tissue, blood and brain.

Glass D, Viñuela A, Davies MN, Ramasamy A, Parts L, Knowles D, Brown AA, Hedman AK, Small KS, Buil A, Grundberg E, Nica AC, Di Meglio P, Nestle FO, Ryten M; UK Brain Expression consortium; MuTHER consortium, Durbin R, McCarthy MI, Deloukas P, Dermitzakis ET, Weale ME, Bataille V, Spector TD.

Genome Biol. 2013 Jul 26;14(7):R75. doi: 10.1186/gb-2013-14-7-r75.


How are drug regimen changes during hospitalisation handled after discharge: a cohort study.

Viktil KK, Blix HS, Eek AK, Davies MN, Moger TA, Reikvam A.

BMJ Open. 2012 Nov 19;2(6). pii: e001461. doi: 10.1136/bmjopen-2012-001461. Print 2012.


Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood.

Davies MN, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, Coarfa C, Harris RA, Milosavljevic A, Troakes C, Al-Sarraj S, Dobson R, Schalkwyk LC, Mill J.

Genome Biol. 2012 Jun 15;13(6):R43. doi: 10.1186/gb-2012-13-6-r43.


Muscle-specific deletion of carnitine acetyltransferase compromises glucose tolerance and metabolic flexibility.

Muoio DM, Noland RC, Kovalik JP, Seiler SE, Davies MN, DeBalsi KL, Ilkayeva OR, Stevens RD, Kheterpal I, Zhang J, Covington JD, Bajpeyi S, Ravussin E, Kraus W, Koves TR, Mynatt RL.

Cell Metab. 2012 May 2;15(5):764-77. doi: 10.1016/j.cmet.2012.04.005.


Present perspectives on the automated classification of the G-protein coupled receptors (GPCRs) at the protein sequence level.

Davies MN, Gloriam DE, Secker A, Freitas AA, Timmis J, Flower DR.

Curr Top Med Chem. 2011;11(15):1994-2009. Review.


T-cell epitope prediction and immune complex simulation using molecular dynamics: state of the art and persisting challenges.

Flower DR, Phadwal K, Macdonald IK, Coveney PV, Davies MN, Wan S.

Immunome Res. 2010 Nov 3;6 Suppl 2:S4. doi: 10.1186/1745-7580-6-S2-S4.


Computer aided selection of candidate vaccine antigens.

Flower DR, Macdonald IK, Ramakrishnan K, Davies MN, Doytchinova IA.

Immunome Res. 2010 Nov 3;6 Suppl 2:S1. doi: 10.1186/1745-7580-6-S2-S1.


Gene set enrichment; a problem of pathways.

Davies MN, Meaburn EL, Schalkwyk LC.

Brief Funct Genomics. 2010 Dec;9(5-6):385-90. doi: 10.1093/bfgp/elq021. Epub 2010 Sep 22.


Activation and repression of glucose-stimulated ChREBP requires the concerted action of multiple domains within the MondoA conserved region.

Davies MN, O'Callaghan BL, Towle HC.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E665-74. doi: 10.1152/ajpendo.00349.2010. Epub 2010 Aug 3.


Hierarchical classification of G-protein-coupled receptors with data-driven selection of attributes and classifiers.

Secker A, Davies MN, Freitas AA, Clark EB, Timmis J, Flower DR.

Int J Data Min Bioinform. 2010;4(2):191-210.


Allelic skewing of DNA methylation is widespread across the genome.

Schalkwyk LC, Meaburn EL, Smith R, Dempster EL, Jeffries AR, Davies MN, Plomin R, Mill J.

Am J Hum Genet. 2010 Feb 12;86(2):196-212. doi: 10.1016/j.ajhg.2010.01.014.


Toward the discovery of vaccine adjuvants: coupling in silico screening and in vitro analysis of antagonist binding to human and mouse CCR4 receptors.

Davies MN, Bayry J, Tchilian EZ, Vani J, Shaila MS, Forbes EK, Draper SJ, Beverley PC, Tough DF, Flower DR.

PLoS One. 2009 Nov 30;4(11):e8084. doi: 10.1371/journal.pone.0008084.


Whole-body sleeping beauty mutagenesis can cause penetrant leukemia/lymphoma and rare high-grade glioma without associated embryonic lethality.

Collier LS, Adams DJ, Hackett CS, Bendzick LE, Akagi K, Davies MN, Diers MD, Rodriguez FJ, Bender AM, Tieu C, Matise I, Dupuy AJ, Copeland NG, Jenkins NA, Hodgson JG, Weiss WA, Jenkins RB, Largaespada DA.

Cancer Res. 2009 Nov 1;69(21):8429-37. doi: 10.1158/0008-5472.CAN-09-1760. Epub 2009 Oct 20.


In silico identification of novel G protein coupled receptors.

Davies MN, Flower DR.

Methods Mol Biol. 2009;528:25-36. doi: 10.1007/978-1-60327-310-7_2.


To What Extent is Blood a Reasonable Surrogate for Brain in Gene Expression Studies: Estimation from Mouse Hippocampus and Spleen.

Davies MN, Lawn S, Whatley S, Fernandes C, Williams RW, Schalkwyk LC.

Front Neurosci. 2009 Oct 9;3:54. doi: 10.3389/neuro.15.002.2009. eCollection 2009.


GPCRTree: online hierarchical classification of GPCR function.

Davies MN, Secker A, Halling-Brown M, Moss DS, Freitas AA, Timmis J, Clark E, Flower DR.

BMC Res Notes. 2008 Aug 21;1:67. doi: 10.1186/1756-0500-1-67.


Optimizing amino acid groupings for GPCR classification.

Davies MN, Secker A, Freitas AA, Clark E, Timmis J, Flower DR.

Bioinformatics. 2008 Sep 15;24(18):1980-6. doi: 10.1093/bioinformatics/btn382. Epub 2008 Aug 1.


In silico identified CCR4 antagonists target regulatory T cells and exert adjuvant activity in vaccination.

Bayry J, Tchilian EZ, Davies MN, Forbes EK, Draper SJ, Kaveri SV, Hill AV, Kazatchkine MD, Beverley PC, Flower DR, Tough DF.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):10221-6. doi: 10.1073/pnas.0803453105. Epub 2008 Jul 11.


Glucose activates ChREBP by increasing its rate of nuclear entry and relieving repression of its transcriptional activity.

Davies MN, O'Callaghan BL, Towle HC.

J Biol Chem. 2008 Aug 29;283(35):24029-38. doi: 10.1074/jbc.M801539200. Epub 2008 Jun 30.


Static energy analysis of MHC class I and class II peptide-binding affinity.

Davies MN, Flower DR.

Methods Mol Biol. 2007;409:309-20. doi: 10.1007/978-1-60327-118-9_23.


Identification and function of phosphorylation in the glucose-regulated transcription factor ChREBP.

Tsatsos NG, Davies MN, O'Callaghan BL, Towle HC.

Biochem J. 2008 Apr 15;411(2):261-70. doi: 10.1042/BJ20071156.


On the hierarchical classification of G protein-coupled receptors.

Davies MN, Secker A, Freitas AA, Mendao M, Timmis J, Flower DR.

Bioinformatics. 2007 Dec 1;23(23):3113-8. Epub 2007 Oct 22.


Identification of the HLA-DM/HLA-DR interface.

Davies MN, Lamikanra A, Sansom CE, Flower DR, Moss DS, Travers PJ.

Mol Immunol. 2008 Feb;45(4):1063-70. Epub 2007 Sep 17.


Toward the atomistic simulation of T cell epitopes automated construction of MHC: peptide structures for free energy calculations.

Todman SJ, Halling-Brown MD, Davies MN, Flower DR, Kayikci M, Moss DS.

J Mol Graph Model. 2008 Feb;26(6):957-61. Epub 2007 Jul 28.


Proteomic applications of automated GPCR classification.

Davies MN, Gloriam DE, Secker A, Freitas AA, Mendao M, Timmis J, Flower DR.

Proteomics. 2007 Aug;7(16):2800-14. Review.


Harnessing bioinformatics to discover new vaccines.

Davies MN, Flower DR.

Drug Discov Today. 2007 May;12(9-10):389-95. Epub 2007 Apr 6. Review.


Using databases and data mining in vaccinology.

Davies MN, Guan P, Blythe MJ, Salomon J, Toseland CP, Hattotuwagama C, Walshe V, Doytchinova IA, Flower DR.

Expert Opin Drug Discov. 2007 Jan;2(1):19-35. doi: 10.1517/17460441.2.1.19.


Women's hedonic ratings of body odor of heterosexual and homosexual men.

Sergeant MJ, Dickins TE, Davies MN, Griffiths MD.

Arch Sex Behav. 2007 Jun;36(3):395-401.


Benchmarking pK(a) prediction.

Davies MN, Toseland CP, Moss DS, Flower DR.

BMC Biochem. 2006 Jun 2;7:18.


Receptor-ligand binding sites and virtual screening.

Hattotuwagama CK, Davies MN, Flower DR.

Curr Med Chem. 2006;13(11):1283-304. Review.


Statistical deconvolution of enthalpic energetic contributions to MHC-peptide binding affinity.

Davies MN, Hattotuwagama CK, Moss DS, Drew MG, Flower DR.

BMC Struct Biol. 2006 Mar 20;6:5.


PPD v1.0--an integrated, web-accessible database of experimentally determined protein pKa values.

Toseland CP, McSparron H, Davies MN, Flower DR.

Nucleic Acids Res. 2006 Jan 1;34(Database issue):D199-203.


Demographic factors and playing variables in online computer gaming.

Griffiths MD, Davies MN, Chappell D.

Cyberpsychol Behav. 2004 Aug;7(4):479-87.


A novel predictive technique for the MHC class II peptide-binding interaction.

Davies MN, Sansom CE, Beazley C, Moss DS.

Mol Med. 2003 Sep-Dec;9(9-12):220-5.


Online computer gaming: a comparison of adolescent and adult gamers.

Griffiths MD, Davies MN, Chappell D.

J Adolesc. 2004 Feb;27(1):87-96.


The structural characteristics of video games: a psycho-structural analysis.

Wood RT, Griffiths MD, Chappell D, Davies MN.

Cyberpsychol Behav. 2004 Feb;7(1):1-10.


Supplemental Content

Loading ...
Support Center