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UV oxidation of cyclic AMP receptor protein, a global bacterial gene regulator, decreases DNA binding and cleaves DNA at specific sites.

Leinisch F, Mariotti M, Andersen SH, Lindemose S, Hägglund P, Møllegaard NE, Davies MJ.

Sci Rep. 2020 Feb 20;10(1):3106. doi: 10.1038/s41598-020-59855-x.


Efficacy and tolerability of sodium-glucose co-transporter-2 inhibitors and glucagon-like peptide-1 receptor agonists: A systematic review and network meta-analysis.

Hussein H, Zaccardi F, Khunti K, Davies MJ, Patsko E, Dhalwani NN, Kloecker DE, Ioannidou E, Gray LJ.

Diabetes Obes Metab. 2020 Feb 19. doi: 10.1111/dom.14008. [Epub ahead of print] Review.


A Cost and Cost-Benefit Analysis of the Stand More AT Work (SMArT Work) Intervention.

Munir F, Miller P, Biddle SJH, Davies MJ, Dunstan DW, Esliger DW, Gray LJ, O'Connell SE, Waheed G, Yates T, Edwardson CL.

Int J Environ Res Public Health. 2020 Feb 13;17(4). pii: E1214. doi: 10.3390/ijerph17041214.


Cost-effectiveness of intensive interventions compared to standard care in individuals with type 2 diabetes: A systematic review and critical appraisal of decision-analytic models.

Usman M, Khunti K, Davies MJ, Gillies CL.

Diabetes Res Clin Pract. 2020 Feb 12;161:108073. doi: 10.1016/j.diabres.2020.108073. [Epub ahead of print]


Effectiveness and cost of integrating a pragmatic pathway for prescribing liraglutide 3.0 mg in obesity services (STRIVE study): study protocol of an open-label, real-world, randomised, controlled trial.

Papamargaritis D, Al-Najim W, Lim J, Crane J, Lean M, le Roux C, McGowan B, O'Shea D, Webb D, Wilding J, Davies MJ.

BMJ Open. 2020 Feb 13;10(2):e034137. doi: 10.1136/bmjopen-2019-034137.


Priorities of patients with multimorbidity and of clinicians regarding treatment and health outcomes: a systematic mixed studies review.

Sathanapally H, Sidhu M, Fahami R, Gillies C, Kadam U, Davies MJ, Khunti K, Seidu S.

BMJ Open. 2020 Feb 12;10(2):e033445. doi: 10.1136/bmjopen-2019-033445.


Management of Pneumonitis and Neuropathy in Patients Receiving PD-1-Based Therapy for Non-Small-Cell Lung Cancer.

Davies MJ, Chiang AC.

JCO Oncol Pract. 2020 Feb;16(2_suppl):4s-9s. doi: 10.1200/JOP.19.00676.


Pragmatic management of low-energy diets in people with type 2 diabetes in primary care: a decision aid for clinicians.

Baldry EL, Davies MJ, Khunti K, Webb DR.

Diabet Med. 2020 Feb 5. doi: 10.1111/dme.14265. [Epub ahead of print] No abstract available.


Epidural Blood Patch as a diagnostic and therapeutic intervention in Spontaneous Intracranial Hypotension - a novel approach to management.

Davies MJ, Davies MA, Sharpe R, Cordato D, Schwartz R.

World Neurosurg. 2020 Jan 28. pii: S1878-8750(20)30181-9. doi: 10.1016/j.wneu.2020.01.163. [Epub ahead of print]


Burden of Cardiovascular Disease in Adult Patients with Type 1 Diabetes in the US.

Edelman S, Zhou FL, Preblick R, Verma S, Paranjape S, Davies MJ, Joish VN.

Pharmacoecon Open. 2020 Jan 29. doi: 10.1007/s41669-019-00192-9. [Epub ahead of print]


Binding of myeloperoxidase to the extracellular matrix of smooth muscle cells and subsequent matrix modification.

Cai H, Chuang CY, Hawkins CL, Davies MJ.

Sci Rep. 2020 Jan 20;10(1):666. doi: 10.1038/s41598-019-57299-6.


Therapeutic efficacy and safety of initial triple combination of metformin, sitagliptin, and lobeglitazone in drug-naïve patients with type 2 diabetes: initial triple study.

Lim S, Ku EJ, Lee SY, Lee JH, Lee JE, Kim KM, Davies MJ.

BMJ Open Diabetes Res Care. 2020 Jan;8(1). pii: e000807. doi: 10.1136/bmjdrc-2019-000807.


Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway.

Shu N, Hägglund P, Cai H, Hawkins CL, Davies MJ.

Redox Biol. 2020 Jan;29:101400. doi: 10.1016/j.redox.2019.101400. Epub 2019 Dec 6.


Predictors of the Acute Postprandial Response to Breaking Up Prolonged Sitting.

Henson J, Edwardson CL, Celis-Morales CA, Davies MJ, Dunstan DW, Esliger DW, Gill JMR, Kazi A, Khunti K, King J, McCarthy M, Sattar N, Stensel DJ, Velayudhan L, Zaccardi F, Yates T.

Med Sci Sports Exerc. 2020 Feb 5. doi: 10.1249/MSS.0000000000002249. [Epub ahead of print]


2019 Update to: Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Buse JB, Wexler DJ, Tsapas A, Rossing P, Mingrone G, Mathieu C, D'Alessio DA, Davies MJ.

Diabetes Care. 2020 Feb;43(2):487-493. doi: 10.2337/dci19-0066. Epub 2019 Dec 19.


2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD).

Buse JB, Wexler DJ, Tsapas A, Rossing P, Mingrone G, Mathieu C, D'Alessio DA, Davies MJ.

Diabetologia. 2020 Feb;63(2):221-228. doi: 10.1007/s00125-019-05039-w.


Enhancing the value of accelerometer-assessed physical activity: meaningful visual comparisons of data-driven translational accelerometer metrics.

Rowlands AV, Dawkins NP, Maylor B, Edwardson CL, Fairclough SJ, Davies MJ, Harrington DM, Khunti K, Yates T.

Sports Med Open. 2019 Dec 5;5(1):47. doi: 10.1186/s40798-019-0225-9.


Trends in Cause-Specific Outcomes Among Individuals With Type 2 Diabetes and Heart Failure in the United Kingdom, 1998-2017.

Lawson CA, Zaccardi F, McCann GP, Davies MJ, Kadam UT, Khunti K.

JAMA Netw Open. 2019 Dec 2;2(12):e1916447. doi: 10.1001/jamanetworkopen.2019.16447.


Long-term effects of intensive multifactorial therapy in individuals with screen-detected type 2 diabetes in primary care: 10-year follow-up of the ADDITION-Europe cluster-randomised trial.

Griffin SJ, Rutten GEHM, Khunti K, Witte DR, Lauritzen T, Sharp SJ, Dalsgaard EM, Davies MJ, Irving GJ, Vos RC, Webb DR, Wareham NJ, Sandbæk A.

Lancet Diabetes Endocrinol. 2019 Dec;7(12):925-937. doi: 10.1016/S2213-8587(19)30349-3.


Rationale and design of a cross-sectional study to investigate and describe the chronotype of patients with type 2 diabetes and the effect on glycaemic control: the CODEC study.

Brady EM, Hall AP, Baldry E, Chatterjee S, Daniels LJ, Edwardson C, Khunti K, Patel MI, Henson JJ, Rowlands A, Smith AC, Yates T, Davies MJ.

BMJ Open. 2019 Nov 11;9(11):e027773. doi: 10.1136/bmjopen-2018-027773.


Mortality risk comparing walking pace to handgrip strength and a healthy lifestyle: A UK Biobank study.

Zaccardi F, Franks PW, Dudbridge F, Davies MJ, Khunti K, Yates T.

Eur J Prev Cardiol. 2019 Nov 12:2047487319885041. doi: 10.1177/2047487319885041. [Epub ahead of print]


The impact of an intervention to increase uptake to structured self-management education for people with type 2 diabetes mellitus in primary care (the embedding package), compared to usual care, on glycaemic control: study protocol for a mixed methods study incorporating a wait-list cluster randomised controlled trial.

Davies MJ, Kristunas CA, Alshreef A, Dixon S, Eborall H, Glab A, Huddlestone L, Hudson N, Khunti K, Martin G, Northern A, Patterson M, Pritchard R, Schreder S, Stribling B, Turner J, Gray LJ.

BMC Fam Pract. 2019 Nov 7;20(1):152. doi: 10.1186/s12875-019-1038-0.


Walking pace improves all-cause and cardiovascular mortality risk prediction: A UK Biobank prognostic study.

Argyridou S, Zaccardi F, Davies MJ, Khunti K, Yates T.

Eur J Prev Cardiol. 2019 Nov 7:2047487319887281. doi: 10.1177/2047487319887281. [Epub ahead of print]


Prospectively Reallocating Sedentary Time: Associations with Cardiometabolic Health.

Yates T, Edwardson CL, Henson J, Zaccardi F, Khunti K, Davies MJ.

Med Sci Sports Exerc. 2019 Nov 1. doi: 10.1249/MSS.0000000000002204. [Epub ahead of print]


Increasing patient activation through diabetes self-management education: Outcomes of DESMOND in regional Western Australia.

Miller VM, Davies MJ, Etherton-Beer C, McGough S, Schofield D, Jensen JF, Watson N.

Patient Educ Couns. 2019 Oct 22. pii: S0738-3991(19)30449-5. doi: 10.1016/j.pec.2019.10.013. [Epub ahead of print]


Detection, identification, and quantification of oxidative protein modifications.

Hawkins CL, Davies MJ.

J Biol Chem. 2019 Dec 20;294(51):19683-19708. doi: 10.1074/jbc.REV119.006217. Epub 2019 Oct 31. Review.


Towards a Portable Model to Discriminate Activity Clusters from Accelerometer Data.

Jones P, Mirkes EM, Yates T, Edwardson CL, Catt M, Davies MJ, Khunti K, Rowlands AV.

Sensors (Basel). 2019 Oct 17;19(20). pii: E4504. doi: 10.3390/s19204504.


Diabetic peripheral neuropathy: advances in diagnosis and strategies for screening and early intervention.

Selvarajah D, Kar D, Khunti K, Davies MJ, Scott AR, Walker J, Tesfaye S.

Lancet Diabetes Endocrinol. 2019 Dec;7(12):938-948. doi: 10.1016/S2213-8587(19)30081-6. Epub 2019 Oct 14. Review.


Mechanisms of improved exercise capacity following respiratory muscle training in athletes with cervical spinal cord injury.

Hardy TA, Chadwick MR, Davies MJ.

J Physiol. 2019 Dec;597(23):5531-5532. doi: 10.1113/JP278733. Epub 2019 Nov 11. No abstract available.


Leisure-time physical activity and life expectancy in people with cardiometabolic multimorbidity and depression.

Chudasama YV, Zaccardi F, Gillies CL, Dhalwani NN, Yates T, Rowlands AV, Davies MJ, Khunti K.

J Intern Med. 2020 Jan;287(1):87-99. doi: 10.1111/joim.12987. Epub 2019 Nov 6.


In-exercise vascular shear rate during acute continuous and interval exercise: impact on endothelial function and miR-21.

Lyall GK, Davies MJ, Ferguson C, Porter KE, Birch KM.

J Appl Physiol (1985). 2019 Dec 1;127(6):1754-1762. doi: 10.1152/japplphysiol.00156.2019. Epub 2019 Oct 10.


Inhibition and crosslinking of the selenoprotein thioredoxin reductase-1 by p-benzoquinone.

Shu N, Cheng Q, Arnér ESJ, Davies MJ.

Redox Biol. 2020 Jan;28:101335. doi: 10.1016/j.redox.2019.101335. Epub 2019 Sep 27.


Iodide modulates protein damage induced by the inflammation-associated heme enzyme myeloperoxidase.

Gamon LF, Dieterich S, Ignasiak MT, Schrameyer V, Davies MJ.

Redox Biol. 2020 Jan;28:101331. doi: 10.1016/j.redox.2019.101331. Epub 2019 Sep 20.


A Review of the Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter 2 Inhibitors on Lean Body Mass in Humans.

Sargeant JA, Henson J, King JA, Yates T, Khunti K, Davies MJ.

Endocrinol Metab (Seoul). 2019 Sep;34(3):247-262. doi: 10.3803/EnM.2019.34.3.247. Review.


Emerging glucose-lowering therapies: a guide for cardiologists.

Gulsin GS, Graham-Brown MPM, Davies MJ, McCann GP.

Heart. 2020 Jan;106(1):18-23. doi: 10.1136/heartjnl-2019-315758. Epub 2019 Sep 24. Review.


Whey proteins: targets of oxidation, or mediators of redox protection.

Giblin L, Yalçın AS, Biçim G, Krämer AC, Chen Z, Callanan MJ, Arranz E, Davies MJ.

Free Radic Res. 2019;53(sup1):1136-1152. doi: 10.1080/10715762.2019.1632445. Epub 2019 Sep 12.


The Microalbuminuria Education Medication and Optimisation (MEMO) study: 4 years follow-up of multifactorial intervention in high-risk individuals with type 2 diabetes.

Crasto W, Morrison AE, Gray LJ, John E, Jarvis J, Brela J, Khunti K, Troughton J, Lawrence IG, McNally PG, Davies MJ.

Diabet Med. 2020 Feb;37(2):286-297. doi: 10.1111/dme.14134. Epub 2019 Sep 23.


Effects of a novel selenium substituted-sugar (1,4-anhydro-4-seleno-d-talitol, SeTal) on human coronary artery cell lines and mouse aortic rings.

Zacharias T, Flouda K, Jepps TA, Gammelgaard B, Schiesser CH, Davies MJ.

Biochem Pharmacol. 2019 Sep 5:113631. doi: 10.1016/j.bcp.2019.113631. [Epub ahead of print]


The right place for Sulphonylureas today.

Webb DR, Davies MJ, Jarvis J, Seidu S, Khunti K.

Diabetes Res Clin Pract. 2019 Nov;157:107836. doi: 10.1016/j.diabres.2019.107836. Epub 2019 Aug 31. Review.


activPAL and ActiGraph Assessed Sedentary Behavior and Cardiometabolic Health Markers.

Edwardson CL, Henson J, Biddle SJH, Davies MJ, Khunti K, Maylor B, Yates T.

Med Sci Sports Exerc. 2020 Feb;52(2):391-397. doi: 10.1249/MSS.0000000000002138.


Process evaluation of the school-based Girls Active programme.

Gorely T, Harrington DM, Bodicoat DH, Davies MJ, Khunti K, Sherar LB, Tudor-Edwards R, Yates T, Edwardson CL.

BMC Public Health. 2019 Aug 29;19(1):1187. doi: 10.1186/s12889-019-7493-7.


Binding of rose bengal to lysozyme modulates photooxidation and cross-linking reactions involving tyrosine and tryptophan.

Fuentes-Lemus E, Mariotti M, Hägglund P, Leinisch F, Fierro A, Silva E, López-Alarcón C, Davies MJ.

Free Radic Biol Med. 2019 Nov 1;143:375-386. doi: 10.1016/j.freeradbiomed.2019.08.023. Epub 2019 Aug 22.


Micro-costing and a cost-consequence analysis of the 'Girls Active' programme: A cluster randomised controlled trial.

Charles JM, Harrington DM, Davies MJ, Edwardson CL, Gorely T, Bodicoat DH, Khunti K, Sherar LB, Yates T, Edwards RT.

PLoS One. 2019 Aug 16;14(8):e0221276. doi: 10.1371/journal.pone.0221276. eCollection 2019.


Impact of Depression and Anxiety on Change to Physical Activity Following a Pragmatic Diabetes Prevention Program Within Primary Care: Pooled Analysis From Two Randomized Controlled Trials.

Yates T, Gray LJ, Henson J, Edwardson CL, Khunti K, Davies MJ.

Diabetes Care. 2019 Oct;42(10):1847-1853. doi: 10.2337/dc19-0400. Epub 2019 Aug 9.


Statins and risk of thromboembolism: A meta-regression to disentangle the efficacy-to-effectiveness gap using observational and trial evidence.

Miksza JK, Zaccardi F, Kunutsor SK, Seidu S, Davies MJ, Khunti K.

Nutr Metab Cardiovasc Dis. 2019 Oct;29(10):1023-1029. doi: 10.1016/j.numecd.2019.06.022. Epub 2019 Jul 6.


Relevance of physical function in the association of red and processed meat intake with all-cause, cardiovascular, and cancer mortality.

Argyridou S, Zaccardi F, Davies MJ, Khunti K, Yates T.

Nutr Metab Cardiovasc Dis. 2019 Dec;29(12):1308-1315. doi: 10.1016/j.numecd.2019.06.019. Epub 2019 Jun 27.


20-year trends in cause-specific heart failure outcomes by sex, socioeconomic status, and place of diagnosis: a population-based study.

Lawson CA, Zaccardi F, Squire I, Ling S, Davies MJ, Lam CSP, Mamas MA, Khunti K, Kadam UT.

Lancet Public Health. 2019 Aug;4(8):e406-e420. doi: 10.1016/S2468-2667(19)30108-2.


Evaluation and refinement of the PRESTARt tool for identifying 12-14 year olds at high lifetime risk of developing type 2 diabetes compared to a clinicians assessment of risk: a cross-sectional study.

Gray LJ, Brady EM, Albaina O, Edwardson CL, Harrington D, Khunti K, Miksza J, Raposo JF, Smith E, Vazeou A, Vergara I, Weihrauch-Blüher S, Davies MJ; PRE-STARt Collaborative.

BMC Endocr Disord. 2019 Jul 25;19(1):79. doi: 10.1186/s12902-019-0410-3.


Differential left ventricular and left atrial remodelling in heart failure with preserved ejection fraction patients with and without diabetes.

Gulsin GS, Kanagala P, Chan DCS, Cheng ASH, Athithan L, Graham-Brown MPM, Singh A, Yang J, Li Z, Khunti K, Davies MJ, Arnold JR, Squire IB, Ng LL, McCann GP.

Ther Adv Endocrinol Metab. 2019 Jul 5;10:2042018819861593. doi: 10.1177/2042018819861593. eCollection 2019.


A data-driven, meaningful, easy to interpret, standardised accelerometer outcome variable for global surveillance.

Rowlands AV, Sherar LB, Fairclough SJ, Yates T, Edwardson CL, Harrington DM, Davies MJ, Munir F, Khunti K, Stiles VH.

J Sci Med Sport. 2019 Oct;22(10):1132-1138. doi: 10.1016/j.jsams.2019.06.016. Epub 2019 Jul 1.


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