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Items: 1 to 50 of 263


Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells.

Zhang H, Zhou L, Davies KJA, Forman HJ.

Arch Biochem Biophys. 2019 Sep 15;672:108074. doi: 10.1016/ Epub 2019 Aug 15. Review.


Measuring redox effects on the activities of intracellular proteases such as the 20S Proteasome and the Immuno-Proteasome with fluorogenic peptides.

Bonet-Costa V, Sun PY, Davies KJA.

Free Radic Biol Med. 2019 Jul 25;143:16-24. doi: 10.1016/j.freeradbiomed.2019.07.020. [Epub ahead of print]


Pediatric CNS-isolated hemophagocytic lymphohistiocytosis.

Benson LA, Li H, Henderson LA, Solomon IH, Soldatos A, Murphy J, Bielekova B, Kennedy AL, Rivkin MJ, Davies KJ, Hsu AP, Holland SM, Gahl WA, Sundel RP, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Duncan CN, Gorman MP.

Neurol Neuroimmunol Neuroinflamm. 2019 Apr 8;6(3):e560. doi: 10.1212/NXI.0000000000000560. eCollection 2019 May.


Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing.

Pomatto LCD, Sun PY, Yu K, Gullapalli S, Bwiza CP, Sisliyan C, Wong S, Zhang H, Forman HJ, Oliver PL, Davies KE, Davies KJA.

Redox Biol. 2019 Jun;24:101194. doi: 10.1016/j.redox.2019.101194. Epub 2019 Apr 14.


Central nervous system-restricted familial hemophagocytic lymphohistiocytosis responds to hematopoietic cell transplantation.

Li H, Benson LA, Henderson LA, Solomon IH, Kennedy AL, Soldatos A, Bielekova B, Murphy J, Davies KJ, Lehmann LE, Lee MA, Alexandrescu S, Degar BA, Gorman MP, Duncan CN.

Blood Adv. 2019 Feb 26;3(4):503-507. doi: 10.1182/bloodadvances.2018027417. No abstract available.


Sex-specific stress tolerance, proteolysis, and lifespan in the invertebrate Tigriopus californicus.

Foley HB, Sun PY, Ramirez R, So BK, Venkataraman YR, Nixon EN, Davies KJA, Edmands S.

Exp Gerontol. 2019 May;119:146-156. doi: 10.1016/j.exger.2019.02.006. Epub 2019 Feb 7.


Free radicals and redox regulation in ageing.

Davies KJA.

Free Radic Biol Med. 2019 Apr;134:688-689. doi: 10.1016/j.freeradbiomed.2019.01.041. Epub 2019 Jan 30. No abstract available.


Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing?

Davies KJA, Forman HJ.

Free Radic Biol Med. 2019 Apr;134:708-714. doi: 10.1016/j.freeradbiomed.2019.01.028. Epub 2019 Jan 26. Review.


Disruption of CTCF-YY1-dependent looping of the human papillomavirus genome activates differentiation-induced viral oncogene transcription.

Pentland I, Campos-León K, Cotic M, Davies KJ, Wood CD, Groves IJ, Burley M, Coleman N, Stockton JD, Noyvert B, Beggs AD, West MJ, Roberts S, Parish JL.

PLoS Biol. 2018 Oct 25;16(10):e2005752. doi: 10.1371/journal.pbio.2005752. eCollection 2018 Oct.


Partnering to Analyze Selection of Resources by Medical Students for Case-Based Small Group Learning: A Collaboration between Librarians and Medical Educators.

Gaines JK, Blake L, Kouame G, Davies KJ, Ballance D, Thomas Gaddy V, Gallman E, Russell M, Wood E.

Med Ref Serv Q. 2018 Jul-Sep;37(3):249-265. doi: 10.1080/02763869.2018.1477709.


A Quality Improvement Initiative to Increase and Sustain Influenza Vaccination Rates in Pediatric Oncology and Stem Cell Transplant Patients.

Wong CI, Billett AL, Weng S, Eng K, Thakrar U, Davies KJ.

Pediatr Qual Saf. 2018 Jan 5;3(1):e052. doi: 10.1097/pq9.0000000000000052. eCollection 2018 Jan-Feb.


Adaptive homeostasis and the free radical theory of ageing.

Pomatto LCD, Davies KJA.

Free Radic Biol Med. 2018 Aug 20;124:420-430. doi: 10.1016/j.freeradbiomed.2018.06.016. Epub 2018 Jun 28. Review.


Rust never sleeps: The continuing story of the Iron Bolt.

van der Vliet A, Dick TP, Aust SD, Koppenol WH, Ursini F, Kettle AJ, Beckman JS, O'Donnell V, Darley-Usmar V, Lancaster J Jr, Hogg N, Davies KJA, Forman HJ, Janssen-Heininger YMW.

Free Radic Biol Med. 2018 Aug 20;124:353-357. doi: 10.1016/j.freeradbiomed.2018.06.017. Epub 2018 Jun 18. Review.


To adapt or not to adapt: Consequences of declining Adaptive Homeostasis and Proteostasis with age.

Pomatto LCD, Sun PY, Davies KJA.

Mech Ageing Dev. 2019 Jan;177:80-87. doi: 10.1016/j.mad.2018.05.006. Epub 2018 May 17. Review.


Cardiovascular Adaptive Homeostasis in Exercise.

Davies KJA.

Front Physiol. 2018 May 1;9:369. doi: 10.3389/fphys.2018.00369. eCollection 2018.


The role of oxidative stress in anxiety disorder: cause or consequence?

Fedoce ADG, Ferreira F, Bota RG, Bonet-Costa V, Sun PY, Davies KJA.

Free Radic Res. 2018 Jul;52(7):737-750. doi: 10.1080/10715762.2018.1475733. Epub 2018 Jun 4. Review.


Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog').

Pomatto LCD, Cline M, Woodward N, Pakbin P, Sioutas C, Morgan TE, Finch CE, Forman HJ, Davies KJA.

Free Radic Biol Med. 2018 Jun;121:86-97. doi: 10.1016/j.freeradbiomed.2018.04.574. Epub 2018 Apr 27.


Sex-specific adaptive homeostasis in D. melanogaster depends on increased proteolysis by the 20S Proteasome: Data-in-Brief.

Pomatto LCD, Wong S, Tower J, Davies KJA.

Data Brief. 2018 Jan 31;17:653-661. doi: 10.1016/j.dib.2018.01.044. eCollection 2018 Apr.


The Oxygen Paradox, the French Paradox, and age-related diseases.

Davies JMS, Cillard J, Friguet B, Cadenas E, Cadet J, Cayce R, Fishmann A, Liao D, Bulteau AL, Derbré F, Rébillard A, Burstein S, Hirsch E, Kloner RA, Jakowec M, Petzinger G, Sauce D, Sennlaub F, Limon I, Ursini F, Maiorino M, Economides C, Pike CJ, Cohen P, Salvayre AN, Halliday MR, Lundquist AJ, Jakowec NA, Mechta-Grigoriou F, Mericskay M, Mariani J, Li Z, Huang D, Grant E, Forman HJ, Finch CE, Sun PY, Pomatto LCD, Agbulut O, Warburton D, Neri C, Rouis M, Cillard P, Capeau J, Rosenbaum J, Davies KJA.

Geroscience. 2017 Dec;39(5-6):499-550. doi: 10.1007/s11357-017-0002-y. Epub 2017 Dec 21. Review.


Redox Regulation of Homeostasis and Proteostasis in Peroxisomes.

Walker CL, Pomatto LCD, Tripathi DN, Davies KJA.

Physiol Rev. 2018 Jan 1;98(1):89-115. doi: 10.1152/physrev.00033.2016. Review.


Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains.

Pomatto LCD, Wong S, Tower J, Davies KJA.

Arch Biochem Biophys. 2017 Dec 15;636:57-70. doi: 10.1016/ Epub 2017 Oct 31.


Diminished stress resistance and defective adaptive homeostasis in age-related diseases.

Lomeli N, Bota DA, Davies KJA.

Clin Sci (Lond). 2017 Oct 25;131(21):2573-2599. doi: 10.1042/CS20160982. Print 2017 Nov 1. Review.


The role of declining adaptive homeostasis in ageing.

Pomatto LCD, Davies KJA.

J Physiol. 2017 Dec 15;595(24):7275-7309. doi: 10.1113/JP275072. Epub 2017 Nov 21. Review.


Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells.

Zhou L, Zhang H, Davies KJA, Forman HJ.

Redox Biol. 2018 Apr;14:35-40. doi: 10.1016/j.redox.2017.08.014. Epub 2017 Aug 24.


HPV8 Field Cancerization in a Transgenic Mouse Model Is due to Lrig1+ Keratinocyte Stem Cell Expansion.

Lanfredini S, Olivero C, Borgogna C, Calati F, Powell K, Davies KJ, De Andrea M, Harries S, Tang HKC, Pfister H, Gariglio M, Patel GK.

J Invest Dermatol. 2017 Oct;137(10):2208-2216. doi: 10.1016/j.jid.2017.04.039. Epub 2017 Jun 6.


Sexual Dimorphism and Aging Differentially Regulate Adaptive Homeostasis.

Pomatto LCD, Tower J, Davies KJA.

J Gerontol A Biol Sci Med Sci. 2018 Jan 16;73(2):141-149. doi: 10.1093/gerona/glx083.


The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster.

Pomatto LCD, Wong S, Carney C, Shen B, Tower J, Davies KJA.

Aging (Albany NY). 2017 Apr;9(4):1153-1185. doi: 10.18632/aging.101218.


Oxidative DNA damage & repair: An introduction.

Cadet J, Davies KJA.

Free Radic Biol Med. 2017 Jun;107:2-12. doi: 10.1016/j.freeradbiomed.2017.03.030. Epub 2017 Mar 28.


SIRT1 may play a crucial role in overload-induced hypertrophy of skeletal muscle.

Koltai E, Bori Z, Chabert C, Dubouchaud H, Naito H, Machida S, Davies KJ, Murlasits Z, Fry AC, Boldogh I, Radak Z.

J Physiol. 2017 Jun 1;595(11):3361-3376. doi: 10.1113/JP273774. Epub 2017 Apr 28.


Formation and repair of oxidatively generated damage in cellular DNA.

Cadet J, Davies KJA, Medeiros MH, Di Mascio P, Wagner JR.

Free Radic Biol Med. 2017 Jun;107:13-34. doi: 10.1016/j.freeradbiomed.2016.12.049. Epub 2017 Jan 2. Review.


The Mitochondrial Lon Protease Is Required for Age-Specific and Sex-Specific Adaptation to Oxidative Stress.

Pomatto LCD, Carney C, Shen B, Wong S, Halaszynski K, Salomon MP, Davies KJA, Tower J.

Curr Biol. 2017 Jan 9;27(1):1-15. doi: 10.1016/j.cub.2016.10.044. Epub 2016 Dec 1.


The molecular chaperone Hsp70 promotes the proteolytic removal of oxidatively damaged proteins by the proteasome.

Reeg S, Jung T, Castro JP, Davies KJA, Henze A, Grune T.

Free Radic Biol Med. 2016 Oct;99:153-166. doi: 10.1016/j.freeradbiomed.2016.08.002. Epub 2016 Aug 3.


Corrigendum to "What is the concentration of hydrogen peroxide in blood and plasma?" [Arch. Biochem. Biophys. 603 (2016) 48-53].

Forman HJ, Bernardo A, Davies KJ.

Arch Biochem Biophys. 2016 Oct 1;607:7. doi: 10.1016/ Epub 2016 Aug 20. No abstract available.


The Proteasome and Oxidative Stress in Alzheimer's Disease.

Bonet-Costa V, Pomatto LC, Davies KJ.

Antioxid Redox Signal. 2016 Dec 1;25(16):886-901. Epub 2016 Aug 25. Review.


Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders.

Bota DA, Davies KJ.

Free Radic Biol Med. 2016 Nov;100:188-198. doi: 10.1016/j.freeradbiomed.2016.06.031. Epub 2016 Jul 5. Review.


Aging and SKN-1-dependent Loss of 20S Proteasome Adaptation to Oxidative Stress in C. elegans.

Raynes R, Juarez C, Pomatto LC, Sieburth D, Davies KJ.

J Gerontol A Biol Sci Med Sci. 2017 Feb;72(2):143-151. doi: 10.1093/gerona/glw093. Epub 2016 Jun 23.


What is the concentration of hydrogen peroxide in blood and plasma?

Forman HJ, Bernardo A, Davies KJ.

Arch Biochem Biophys. 2016 Aug 1;603:48-53. doi: 10.1016/ Epub 2016 May 9. Review.


Degradation of oxidized proteins by the proteasome: Distinguishing between the 20S, 26S, and immunoproteasome proteolytic pathways.

Raynes R, Pomatto LC, Davies KJ.

Mol Aspects Med. 2016 Aug;50:41-55. doi: 10.1016/j.mam.2016.05.001. Epub 2016 May 4. Review.


Adaptive homeostasis.

Davies KJ.

Mol Aspects Med. 2016 Jun;49:1-7. doi: 10.1016/j.mam.2016.04.007. Epub 2016 Apr 22. Review.


The Immunoproteasome in oxidative stress, aging, and disease.

Johnston-Carey HK, Pomatto LC, Davies KJ.

Crit Rev Biochem Mol Biol. 2015 Jul-Aug;51(4):268-81. doi: 10.3109/10409238.2016.1172554. Epub 2016 Apr 20. Review.


The Oxygen Paradox, oxidative stress, and ageing.

Davies KJ.

Arch Biochem Biophys. 2016 Apr 1;595:28-32. doi: 10.1016/


Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish.

Appenzeller-Herzog C, Bánhegyi G, Bogeski I, Davies KJ, Delaunay-Moisan A, Forman HJ, Görlach A, Kietzmann T, Laurindo F, Margittai E, Meyer AJ, Riemer J, Rützler M, Simmen T, Sitia R, Toledano MB, Touw IP.

Free Radic Biol Med. 2016 May;94:157-60. doi: 10.1016/j.freeradbiomed.2016.02.030. Epub 2016 Feb 27.


The peroxisomal Lon protease LonP2 in aging and disease: functions and comparisons with mitochondrial Lon protease LonP1.

Pomatto LC, Raynes R, Davies KJ.

Biol Rev Camb Philos Soc. 2017 May;92(2):739-753. doi: 10.1111/brv.12253. Epub 2016 Feb 8. Review.


Commentary on "Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels" by Chapple et al.

Forman HJ, Davies KJA.

Free Radic Biol Med. 2016 Mar;92:163-164. doi: 10.1016/j.freeradbiomed.2016.01.013. Epub 2016 Jan 21. No abstract available.


What Goes Wrong with Lon in Ageing?

Davies KJ.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S6. doi: 10.1016/j.freeradbiomed.2014.10.840. Epub 2014 Dec 10.


Acute Electrical Pulse Stimulation and Hyperglycemia Regulates RCAN1-4 in C2C12 myotubes through Oxidative Stress.

Emrani Bidi R, Rebillard A, Saligaut D, Delamarche A, Davies KJ, Cillard J.

Free Radic Biol Med. 2014 Oct;75 Suppl 1:S29. doi: 10.1016/j.freeradbiomed.2014.10.757. Epub 2014 Dec 10.


The calcineurin antagonist RCAN1-4 is induced by exhaustive exercise in rat skeletal muscle.

Emrani R, Rébillard A, Lefeuvre L, Gratas-Delamarche A, Davies KJ, Cillard J.

Free Radic Biol Med. 2015 Oct;87:290-9. doi: 10.1016/j.freeradbiomed.2015.06.023. Epub 2015 Jun 26.


Oxidative stress response and Nrf2 signaling in aging.

Zhang H, Davies KJA, Forman HJ.

Free Radic Biol Med. 2015 Nov;88(Pt B):314-336. doi: 10.1016/j.freeradbiomed.2015.05.036. Epub 2015 Jun 9. Review.


TGFβ1 rapidly activates Src through a non-canonical redox signaling mechanism.

Zhang H, Davies KJ, Forman HJ.

Arch Biochem Biophys. 2015 Feb 15;568:1-7. doi: 10.1016/ Epub 2015 Jan 10.


Even free radicals should follow some rules: a guide to free radical research terminology and methodology.

Forman HJ, Augusto O, Brigelius-Flohe R, Dennery PA, Kalyanaraman B, Ischiropoulos H, Mann GE, Radi R, Roberts LJ 2nd, Vina J, Davies KJ.

Free Radic Biol Med. 2015 Jan;78:233-5. doi: 10.1016/j.freeradbiomed.2014.10.504. Epub 2014 Oct 23.


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