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Items: 1 to 50 of 512

1.

Dynamic and Functional Profiling of Xylan-Degrading Enzymes in Aspergillus Secretomes Using Activity-Based Probes.

Schröder SP, de Boer C, McGregor NGS, Rowland RJ, Moroz O, Blagova E, Reijngoud J, Arentshorst M, Osborn D, Morant MD, Abbate E, Stringer MA, Krogh KBRM, Raich L, Rovira C, Berrin JG, van Wezel GP, Ram AFJ, Florea BI, van der Marel GA, Codée JDC, Wilson KS, Wu L, Davies GJ, Overkleeft HS.

ACS Cent Sci. 2019 Jun 26;5(6):1067-1078. doi: 10.1021/acscentsci.9b00221. Epub 2019 May 24.

2.

Functionalized Cyclophellitols Are Selective Glucocerebrosidase Inhibitors and Induce a Bona Fide Neuropathic Gaucher Model in Zebrafish.

Artola M, Kuo CL, Lelieveld LT, Rowland RJ, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS.

J Am Chem Soc. 2019 Mar 13;141(10):4214-4218. doi: 10.1021/jacs.9b00056. Epub 2019 Mar 4.

3.

Crystal structure and substrate interactions of an unusual fungal non-CBM carrying GH26 endo-β-mannanase from Yunnania penicillata.

von Freiesleben P, Moroz OV, Blagova E, Wiemann M, Spodsberg N, Agger JW, Davies GJ, Wilson KS, Stålbrand H, Meyer AS, Krogh KBRM.

Sci Rep. 2019 Feb 19;9(1):2266. doi: 10.1038/s41598-019-38602-x.

4.

A Cell-Surface GH9 Endo-Glucanase Coordinates with Surface Glycan-Binding Proteins to Mediate Xyloglucan Uptake in the Gut Symbiont Bacteroides ovatus.

Foley MH, Déjean G, Hemsworth GR, Davies GJ, Brumer H, Koropatkin NM.

J Mol Biol. 2019 Mar 1;431(5):981-995. doi: 10.1016/j.jmb.2019.01.008. Epub 2019 Jan 19.

PMID:
30668971
5.

Synthetic and Crystallographic Insight into Exploiting sp2 Hybridization in the Development of α-l-Fucosidase Inhibitors.

Coyle T, Wu L, Debowski AW, Davies GJ, Stubbs KA.

Chembiochem. 2019 Jun 3;20(11):1365-1368. doi: 10.1002/cbic.201800710. Epub 2019 Mar 18.

6.

Structural studies of a surface-entropy reduction mutant of O-GlcNAcase.

Males A, Davies GJ.

Acta Crystallogr D Struct Biol. 2019 Jan 1;75(Pt 1):70-78. doi: 10.1107/S2059798318016595. Epub 2019 Jan 8.

7.

The structure of the AliC GH13 α-amylase from Alicyclobacillus sp. reveals the accommodation of starch branching points in the α-amylase family.

Agirre J, Moroz O, Meier S, Brask J, Munch A, Hoff T, Andersen C, Wilson KS, Davies GJ.

Acta Crystallogr D Struct Biol. 2019 Jan 1;75(Pt 1):1-7. doi: 10.1107/S2059798318014900. Epub 2019 Jan 4.

8.

Correction: Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases.

Jain N, Attia MA, Offen WA, Davies GJ, Brumer H.

Org Biomol Chem. 2019 Jan 2;17(2):398. doi: 10.1039/c8ob90185f.

PMID:
30520923
9.

Production and spectroscopic characterization of lytic polysaccharide monooxygenases.

Hemsworth GR, Ciano L, Davies GJ, Walton PH.

Methods Enzymol. 2018;613:63-90. doi: 10.1016/bs.mie.2018.10.014. Epub 2018 Nov 15.

PMID:
30509474
10.

From 1,4-Disaccharide to 1,3-Glycosyl Carbasugar: Synthesis of a Bespoke Inhibitor of Family GH99 Endo-α-mannosidase.

Lu D, Zhu S, Sobala LF, Bernardo-Seisdedos G, Millet O, Zhang Y, Jiménez-Barbero J, Davies GJ, Sollogoub M.

Org Lett. 2018 Dec 7;20(23):7488-7492. doi: 10.1021/acs.orglett.8b03260. Epub 2018 Nov 14.

PMID:
30427198
11.

Functional and informatics analysis enables glycosyltransferase activity prediction.

Yang M, Fehl C, Lees KV, Lim EK, Offen WA, Davies GJ, Bowles DJ, Davidson MG, Roberts SJ, Davis BG.

Nat Chem Biol. 2018 Dec;14(12):1109-1117. doi: 10.1038/s41589-018-0154-9. Epub 2018 Nov 12.

PMID:
30420693
12.

Synthesis and application of a highly branched, mechanism-based 2-deoxy-2-fluoro-oligosaccharide inhibitor of endo-xyloglucanases.

Jain N, Attia MA, Offen WA, Davies GJ, Brumer H.

Org Biomol Chem. 2018 Nov 21;16(45):8732-8741. doi: 10.1039/c8ob02250j. Erratum in: Org Biomol Chem. 2019 Jan 2;17(2):398.

PMID:
30387796
13.

A Pivotal Moment.

Davies GJ.

Sports Health. 2018 Nov/Dec;10(6):491-494. doi: 10.1177/1941738118804536. No abstract available.

14.

A Bilateral Comparison of the Underlying Mechanics Contributing to the Seated Single-Arm Shot-Put Functional Performance Test.

Riemann BL, Johnson W, Murphy T, Davies GJ.

J Athl Train. 2018 Oct;53(10):976-982. doi: 10.4085/1062-6050-388-17. Epub 2018 Oct 9.

PMID:
30299159
15.

Structure and function of a glycoside hydrolase family 8 endoxylanase from Teredinibacter turnerae.

Fowler CA, Hemsworth GR, Cuskin F, Hart S, Turkenburg J, Gilbert HJ, Walton PH, Davies GJ.

Acta Crystallogr D Struct Biol. 2018 Oct 1;74(Pt 10):946-955. doi: 10.1107/S2059798318009737. Epub 2018 Oct 2.

16.

Structural and Biochemical Insights into the Function and Evolution of Sulfoquinovosidases.

Abayakoon P, Jin Y, Lingford JP, Petricevic M, John A, Ryan E, Wai-Ying Mui J, Pires DEV, Ascher DB, Davies GJ, Goddard-Borger ED, Williams SJ.

ACS Cent Sci. 2018 Sep 26;4(9):1266-1273. doi: 10.1021/acscentsci.8b00453. Epub 2018 Sep 5.

17.

Structure of the GH9 glucosidase/glucosaminidase from Vibrio cholerae.

Wu L, Davies GJ.

Acta Crystallogr F Struct Biol Commun. 2018 Aug 1;74(Pt 8):512-523. doi: 10.1107/S2053230X18011019. Epub 2018 Aug 6.

18.

Structural studies of the unusual metal-ion site of the GH124 endoglucanase from Ruminiclostridium thermocellum.

Urresti S, Cartmell A, Liu F, Walton PH, Davies GJ.

Acta Crystallogr F Struct Biol Commun. 2018 Aug 1;74(Pt 8):496-505. doi: 10.1107/S2053230X18006842. Epub 2018 Aug 1.

19.

Structure of a Talaromyces pinophilus GH62 arabinofuranosidase in complex with AraDNJ at 1.25 Å resolution.

Moroz OV, Sobala LF, Blagova E, Coyle T, Peng W, Mørkeberg Krogh KBR, Stubbs KA, Wilson KS, Davies GJ.

Acta Crystallogr F Struct Biol Commun. 2018 Aug 1;74(Pt 8):490-495. doi: 10.1107/S2053230X18000250. Epub 2018 Jul 26.

20.

Spiro-epoxyglycosides as Activity-Based Probes for Glycoside Hydrolase Family 99 Endomannosidase/Endomannanase.

Schröder SP, Kallemeijn WW, Debets MF, Hansen T, Sobala LF, Hakki Z, Williams SJ, Beenakker TJM, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS.

Chemistry. 2018 Jul 11;24(39):9983-9992. doi: 10.1002/chem.201801902. Epub 2018 Jun 21.

21.

Structural insight into industrially relevant glucoamylases: flexible positions of starch-binding domains.

Roth C, Moroz OV, Ariza A, Skov LK, Ayabe K, Davies GJ, Wilson KS.

Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):463-470. doi: 10.1107/S2059798318004989. Epub 2018 Apr 26.

PMID:
29717717
22.

Bacteroides thetaiotaomicron generates diverse α-mannosidase activities through subtle evolution of a distal substrate-binding motif.

Thompson AJ, Spears RJ, Zhu Y, Suits MDL, Williams SJ, Gilbert HJ, Davies GJ.

Acta Crystallogr D Struct Biol. 2018 May 1;74(Pt 5):394-404. doi: 10.1107/S2059798318002942. Epub 2018 Apr 24.

23.

Gluco-1 H-imidazole: A New Class of Azole-Type β-Glucosidase Inhibitor.

Schröder SP, Wu L, Artola M, Hansen T, Offen WA, Ferraz MJ, Li KY, Aerts JMFG, van der Marel GA, Codée JDC, Davies GJ, Overkleeft HS.

J Am Chem Soc. 2018 Apr 18;140(15):5045-5048. doi: 10.1021/jacs.8b02399. Epub 2018 Apr 4.

24.

Discovery and characterization of a sulfoquinovose mutarotase using kinetic analysis at equilibrium by exchange spectroscopy.

Abayakoon P, Lingford JP, Jin Y, Bengt C, Davies GJ, Yao S, Goddard-Borger ED, Williams SJ.

Biochem J. 2018 Apr 16;475(7):1371-1383. doi: 10.1042/BCJ20170947.

25.

Exploration of Strategies for Mechanism-Based Inhibitor Design for Family GH99 endo-α-1,2-Mannanases.

Fernandes PZ, Petricevic M, Sobala L, Davies GJ, Williams SJ.

Chemistry. 2018 May 23;24(29):7464-7473. doi: 10.1002/chem.201800435. Epub 2018 Apr 30.

26.

An ancient family of lytic polysaccharide monooxygenases with roles in arthropod development and biomass digestion.

Sabbadin F, Hemsworth GR, Ciano L, Henrissat B, Dupree P, Tryfona T, Marques RDS, Sweeney ST, Besser K, Elias L, Pesante G, Li Y, Dowle AA, Bates R, Gomez LD, Simister R, Davies GJ, Walton PH, Bruce NC, McQueen-Mason SJ.

Nat Commun. 2018 Feb 22;9(1):756. doi: 10.1038/s41467-018-03142-x.

27.

In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone-cleaving functions.

Attia MA, Nelson CE, Offen WA, Jain N, Davies GJ, Gardner JG, Brumer H.

Biotechnol Biofuels. 2018 Feb 17;11:45. doi: 10.1186/s13068-018-1039-6. eCollection 2018.

28.

Corrigendum: Complex pectin metabolism by gut bacteria reveals novel catalytic functions.

Ndeh D, Rogowski A, Cartmell A, Luis AS, Baslé A, Gray J, Venditto I, Briggs J, Zhang X, Labourel A, Terrapon N, Buffetto F, Nepogodiev S, Xiao Y, Field RA, Zhu Y, O'Neill MA, Urbanowicz BR, York WS, Davies GJ, Abbott DW, Ralet MC, Martens EC, Henrissat B, Gilbert HJ.

Nature. 2017 Aug 31;548(7669):612. doi: 10.1038/nature23659. Epub 2017 Aug 23.

PMID:
29411780
29.

Lytic xylan oxidases from wood-decay fungi unlock biomass degradation.

Couturier M, Ladevèze S, Sulzenbacher G, Ciano L, Fanuel M, Moreau C, Villares A, Cathala B, Chaspoul F, Frandsen KE, Labourel A, Herpoël-Gimbert I, Grisel S, Haon M, Lenfant N, Rogniaux H, Ropartz D, Davies GJ, Rosso MN, Walton PH, Henrissat B, Berrin JG.

Nat Chem Biol. 2018 Mar;14(3):306-310. doi: 10.1038/nchembio.2558. Epub 2018 Jan 29.

PMID:
29377002
30.

Increase of enzyme activity through specific covalent modification with fragments.

Darby JF, Atobe M, Firth JD, Bond P, Davies GJ, O'Brien P, Hubbard RE.

Chem Sci. 2017 Nov 1;8(11):7772-7779. doi: 10.1039/c7sc01966a. Epub 2017 Sep 27.

31.

Molecular Mechanism by which Prominent Human Gut Bacteroidetes Utilize Mixed-Linkage Beta-Glucans, Major Health-Promoting Cereal Polysaccharides.

Tamura K, Hemsworth GR, Déjean G, Rogers TE, Pudlo NA, Urs K, Jain N, Davies GJ, Martens EC, Brumer H.

Cell Rep. 2017 Nov 14;21(7):2030. doi: 10.1016/j.celrep.2017.11.013. No abstract available.

32.

Towards broad spectrum activity-based glycosidase probes: synthesis and evaluation of deoxygenated cyclophellitol aziridines.

Schröder SP, van de Sande JW, Kallemeijn WW, Kuo CL, Artola M, van Rooden EJ, Jiang J, Beenakker TJM, Florea BI, Offen WA, Davies GJ, Minnaard AJ, Aerts JMFG, Codée JDC, van der Marel GA, Overkleeft HS.

Chem Commun (Camb). 2017 Nov 21;53(93):12528-12531. doi: 10.1039/c7cc07730k.

PMID:
29116266
33.

Molecular Mechanism by which Prominent Human Gut Bacteroidetes Utilize Mixed-Linkage Beta-Glucans, Major Health-Promoting Cereal Polysaccharides.

Tamura K, Hemsworth GR, Déjean G, Rogers TE, Pudlo NA, Urs K, Jain N, Davies GJ, Martens EC, Brumer H.

Cell Rep. 2017 Oct 10;21(2):417-430. doi: 10.1016/j.celrep.2017.09.049. Erratum in: Cell Rep. 2017 Nov 14;21(7):2030.

34.

High-fidelity replication of thermoplastic microneedles with open microfluidic channels.

Faraji Rad Z, Nordon RE, Anthony CJ, Bilston L, Prewett PD, Arns JY, Arns CH, Zhang L, Davies GJ.

Microsyst Nanoeng. 2017 Oct 9;3:17034. doi: 10.1038/micronano.2017.34. eCollection 2017.

35.

A Fluorescence Polarization Activity-Based Protein Profiling Assay in the Discovery of Potent, Selective Inhibitors for Human Nonlysosomal Glucosylceramidase.

Lahav D, Liu B, van den Berg RJBHN, van den Nieuwendijk AMCH, Wennekes T, Ghisaidoobe AT, Breen I, Ferraz MJ, Kuo CL, Wu L, Geurink PP, Ovaa H, van der Marel GA, van der Stelt M, Boot RG, Davies GJ, Aerts JMFG, Overkleeft HS.

J Am Chem Soc. 2017 Oct 11;139(40):14192-14197. doi: 10.1021/jacs.7b07352. Epub 2017 Sep 29.

36.

1,6-Cyclophellitol Cyclosulfates: A New Class of Irreversible Glycosidase Inhibitor.

Artola M, Wu L, Ferraz MJ, Kuo CL, Raich L, Breen IZ, Offen WA, Codée JDC, van der Marel GA, Rovira C, Aerts JMFG, Davies GJ, Overkleeft HS.

ACS Cent Sci. 2017 Jul 26;3(7):784-793. doi: 10.1021/acscentsci.7b00214. Epub 2017 Jul 13.

37.

An atypical interaction explains the high-affinity of a non-hydrolyzable S-linked 1,6-α-mannanase inhibitor.

Belz T, Jin Y, Coines J, Rovira C, Davies GJ, Williams SJ.

Chem Commun (Camb). 2017 Aug 25;53(66):9238-9241. doi: 10.1039/c7cc04977c. Epub 2017 Aug 2.

PMID:
28766587
38.

Effects of Trial Duration on Intrasession Reliability of Single Leg Balance Testing on Stable and Unstable Surfaces.

Riemann BI, Piersol K, Davies GJ.

J Sport Rehabil. 2017 Nov 1;26(6). doi: 10.1123/jsr.2016-0205. Epub 2017 Jul 17.

PMID:
28714763
39.

ACL Return to Sport Guidelines and Criteria.

Davies GJ, McCarty E, Provencher M, Manske RC.

Curr Rev Musculoskelet Med. 2017 Sep;10(3):307-314. doi: 10.1007/s12178-017-9420-9. Review.

40.

Correction to "Detection of Active Mammalian GH31 α-Glucosidases in Health and Disease Using In-Class, Broad-Spectrum Activity-Based Probes".

Jiang J, Kuo CL, Wu L, Franke C, Kallemeijn WW, Florea BI, van Meel E, van der Marel GA, Codée JDC, Boot RG, Davies GJ, Overkleeft HS, Aerts JMFG.

ACS Cent Sci. 2017 Jun 28;3(6):673. doi: 10.1021/acscentsci.7b00185. Epub 2017 May 18.

41.

Activity-based probes for functional interrogation of retaining β-glucuronidases.

Wu L, Jiang J, Jin Y, Kallemeijn WW, Kuo CL, Artola M, Dai W, van Elk C, van Eijk M, van der Marel GA, Codée JDC, Florea BI, Aerts JMFG, Overkleeft HS, Davies GJ.

Nat Chem Biol. 2017 Aug;13(8):867-873. doi: 10.1038/nchembio.2395. Epub 2017 Jun 5.

42.

Conformational Analysis of the Mannosidase Inhibitor Kifunensine: A Quantum Mechanical and Structural Approach.

Males A, Raich L, Williams SJ, Rovira C, Davies GJ.

Chembiochem. 2017 Aug 4;18(15):1496-1501. doi: 10.1002/cbic.201700166. Epub 2017 Jun 26.

PMID:
28493500
43.

Effects of neuropeptide Y on coronary artery vasomotion in patients with microvascular angina.

Rosano GMC, Tousoulis D, McFadden E, Clarke J, Davies GJ, Kaski JC.

Int J Cardiol. 2017 Jul 1;238:123-127. doi: 10.1016/j.ijcard.2017.03.024. Epub 2017 Mar 16.

PMID:
28476516
44.

Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors.

Beenakker TJM, Wander DPA, Offen WA, Artola M, Raich L, Ferraz MJ, Li KY, Houben JHPM, van Rijssel ER, Hansen T, van der Marel GA, Codée JDC, Aerts JMFG, Rovira C, Davies GJ, Overkleeft HS.

J Am Chem Soc. 2017 May 17;139(19):6534-6537. doi: 10.1021/jacs.7b01773. Epub 2017 May 5.

45.

Structural and functional insight into human O-GlcNAcase.

Roth C, Chan S, Offen WA, Hemsworth GR, Willems LI, King DT, Varghese V, Britton R, Vocadlo DJ, Davies GJ.

Nat Chem Biol. 2017 Jun;13(6):610-612. doi: 10.1038/nchembio.2358. Epub 2017 Mar 27.

46.

Complex pectin metabolism by gut bacteria reveals novel catalytic functions.

Ndeh D, Rogowski A, Cartmell A, Luis AS, Baslé A, Gray J, Venditto I, Briggs J, Zhang X, Labourel A, Terrapon N, Buffetto F, Nepogodiev S, Xiao Y, Field RA, Zhu Y, O'Neil MA, Urbanowicz BR, York WS, Davies GJ, Abbott DW, Ralet MC, Martens EC, Henrissat B, Gilbert HJ.

Nature. 2017 Apr 6;544(7648):65-70. doi: 10.1038/nature21725. Epub 2017 Mar 22. Erratum in: Nature. 2017 Aug 31;548(7669):612.

47.

Conformational Behaviour of Azasugars Based on Mannuronic Acid.

van Rijssel ER, Janssen APA, Males A, Davies GJ, van der Marel GA, Overkleeft HS, Codée JDC.

Chembiochem. 2017 Jul 4;18(13):1297-1304. doi: 10.1002/cbic.201700080. Epub 2017 Apr 18.

PMID:
28256791
48.

A β-Mannanase with a Lysozyme-like Fold and a Novel Molecular Catalytic Mechanism.

Jin Y, Petricevic M, John A, Raich L, Jenkins H, Portela De Souza L, Cuskin F, Gilbert HJ, Rovira C, Goddard-Borger ED, Williams SJ, Davies GJ.

ACS Cent Sci. 2016 Dec 28;2(12):896-903. doi: 10.1021/acscentsci.6b00232. Epub 2016 Nov 8.

49.

Computational Design of Experiment Unveils the Conformational Reaction Coordinate of GH125 α-Mannosidases.

Alonso-Gil S, Males A, Fernandes PZ, Williams SJ, Davies GJ, Rovira C.

J Am Chem Soc. 2017 Jan 25;139(3):1085-1088. doi: 10.1021/jacs.6b11247. Epub 2017 Jan 3.

50.

Contribution of Shape and Charge to the Inhibition of a Family GH99 endo-α-1,2-Mannanase.

Petricevic M, Sobala LF, Fernandes PZ, Raich L, Thompson AJ, Bernardo-Seisdedos G, Millet O, Zhu S, Sollogoub M, Jiménez-Barbero J, Rovira C, Davies GJ, Williams SJ.

J Am Chem Soc. 2017 Jan 25;139(3):1089-1097. doi: 10.1021/jacs.6b10075. Epub 2017 Jan 17.

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