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Items: 1 to 50 of 120

1.

The health effects of fine particulate air pollution.

Loxham M, Davies DE, Holgate ST.

BMJ. 2019 Nov 27;367:l6609. doi: 10.1136/bmj.l6609. No abstract available.

PMID:
31776108
2.

A method for the generation of large numbers of dendritic cells from CD34+ hematopoietic stem cells from cord blood.

Bedke N, Swindle EJ, Molnar C, Holt PG, Strickland DH, Roberts GC, Morris R, Holgate ST, Davies DE, Blume C.

J Immunol Methods. 2019 Nov 9:112703. doi: 10.1016/j.jim.2019.112703. [Epub ahead of print]

3.

Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux.

Perotin JM, Djukanovic R, Davies DE.

Eur Respir J. 2019 Oct 10;54(4). pii: 1901805. doi: 10.1183/13993003.01805-2019. Print 2019 Oct. No abstract available.

PMID:
31601724
4.

Pollen exposure weakens innate defense against respiratory viruses.

Gilles S, Blume C, Wimmer M, Damialis A, Meulenbroek L, Gökkaya M, Bergougnan C, Eisenbart S, Sundell N, Lindh M, Andersson LM, Dahl Å, Chaker A, Kolek F, Wagner S, Neumann AU, Akdis CA, Garssen J, Westin J, Van't Land B, Davies DE, Traidl-Hoffmann C.

Allergy. 2019 Sep 11. doi: 10.1111/all.14047. [Epub ahead of print]

PMID:
31512243
5.

Autophagy inhibition-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis.

Hill C, Li J, Liu D, Conforti F, Brereton CJ, Yao L, Zhou Y, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Ottensmeier CH, Steele AJ, Downward J, Richeldi L, Lu X, Davies DE, Jones MG, Wang Y.

Cell Death Dis. 2019 Aug 7;10(8):591. doi: 10.1038/s41419-019-1820-x.

6.

Engineering multi-layered tissue constructs using acoustic levitation.

Tait A, Glynne-Jones P, Hill AR, Smart DE, Blume C, Hammarstrom B, Fisher AL, Grossel MC, Swindle EJ, Hill M, Davies DE.

Sci Rep. 2019 Jul 5;9(1):9789. doi: 10.1038/s41598-019-46201-z.

7.

Hydration and nanomechanical changes in collagen fibrils bearing advanced glycation end-products.

Andriotis OG, Elsayad K, Smart DE, Nalbach M, Davies DE, Thurner PJ.

Biomed Opt Express. 2019 Mar 14;10(4):1841-1855. doi: 10.1364/BOE.10.001841. eCollection 2019 Apr 1.

8.
9.

Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux.

Perotin JM, Schofield JPR, Wilson SJ, Ward J, Brandsma J, Strazzeri F, Bansal A, Yang X, Rowe A, Corfield J, Lutter R, Shaw DE, Bakke PS, Caruso M, Dahlén B, Fowler SJ, Horváth I, Howarth P, Krug N, Montuschi P, Sanak M, Sandström T, Sun K, Pandis I, Auffray C, De Meulder B, Lefaudeux D, Riley JH, Sousa AR, Dahlen SE, Adcock IM, Chung KF, Sterk PJ, Skipp PJ, Collins JE, Davies DE, Djukanović R; U-BIOPRED Study Group; U-BIOPRED:.

Eur Respir J. 2019 Jun 27;53(6). pii: 1900453. doi: 10.1183/13993003.00453-2019. Print 2019 Jun. No abstract available.

PMID:
31023846
10.

Regulation of ectodomain shedding of ADAM33 in vitro and in vivo.

Davies ER, Denney L, Wandel M, Lloyd CM, Davies DE, Haitchi HM.

J Allergy Clin Immunol. 2019 Jun;143(6):2281-2284.e3. doi: 10.1016/j.jaci.2019.01.026. Epub 2019 Feb 2. No abstract available.

11.

Establishment of a pulmonary epithelial barrier on biodegradable poly-L-lactic-acid membranes.

Montesanto S, Smithers NP, Bucchieri F, Brucato V, La Carrubba V, Davies DE, Conforti F.

PLoS One. 2019 Jan 17;14(1):e0210830. doi: 10.1371/journal.pone.0210830. eCollection 2019.

12.

The Severe Heterogeneous Asthma Research collaboration, Patient-centred (SHARP) ERS Clinical Research Collaboration: a new dawn in asthma research.

Djukanovic R, Adcock IM, Anderson G, Bel EH, Canonica GW, Cao H, Chung KF, Davies DE, Genton C, Gibson-Latimer T, Hamerlijnck D, Heuvelin E, Louis R, Korn S, Kots M, Kwon N, Naddaf R, Wagers SS; SHARP Clinical Research Collaboration; Members of the CRC-SHARP.

Eur Respir J. 2018 Nov 29;52(5). pii: 1801671. doi: 10.1183/13993003.01671-2018. Print 2018 Nov. No abstract available.

PMID:
30498052
13.

Paracrine signalling during ZEB1-mediated epithelial-mesenchymal transition augments local myofibroblast differentiation in lung fibrosis.

Yao L, Conforti F, Hill C, Bell J, Drawater L, Li J, Liu D, Xiong H, Alzetani A, Chee SJ, Marshall BG, Fletcher SV, Hancock D, Coldwell M, Yuan X, Ottensmeier CH, Downward J, Collins JE, Ewing RM, Richeldi L, Skipp P, Jones MG, Davies DE, Wang Y.

Cell Death Differ. 2019 May;26(5):943-957. doi: 10.1038/s41418-018-0175-7. Epub 2018 Jul 26.

14.

Nanoscale dysregulation of collagen structure-function disrupts mechano-homeostasis and mediates pulmonary fibrosis.

Jones MG, Andriotis OG, Roberts JJ, Lunn K, Tear VJ, Cao L, Ask K, Smart DE, Bonfanti A, Johnson P, Alzetani A, Conforti F, Doherty R, Lai CY, Johnson B, Bourdakos KN, Fletcher SV, Marshall BG, Jogai S, Brereton CJ, Chee SJ, Ottensmeier CH, Sime P, Gauldie J, Kolb M, Mahajan S, Fabre A, Bhaskar A, Jarolimek W, Richeldi L, O'Reilly KM, Monk PD, Thurner PJ, Davies DE.

Elife. 2018 Jul 3;7. pii: e36354. doi: 10.7554/eLife.36354.

15.

A Disintegrin and A Metalloproteinase-9 (ADAM9): A Novel Proteinase Culprit with Multifarious Contributions to COPD.

Wang X, Polverino F, Rojas-Quintero J, Zhang D, Sánchez J, Yambayev I, Lindqvist E, Virtala R, Djukanovic R, Davies DE, Wilson S, O'Donnell R, Cunoosamy D, Hazon P, Higham A, Singh D, Olsson H, Owen CA.

Am J Respir Crit Care Med. 2018 Jun 4. doi: 10.1164/rccm.201711-2300OC. [Epub ahead of print]

PMID:
29864380
16.

Phenotypic and genetic aspects of epithelial barrier function in asthmatic patients.

Loxham M, Davies DE.

J Allergy Clin Immunol. 2017 Jun;139(6):1736-1751. doi: 10.1016/j.jaci.2017.04.005. Review.

17.

The histone deacetylase inhibitor, romidepsin, as a potential treatment for pulmonary fibrosis.

Conforti F, Davies ER, Calderwood CJ, Thatcher TH, Jones MG, Smart DE, Mahajan S, Alzetani A, Havelock T, Maher TM, Molyneaux PL, Thorley AJ, Tetley TD, Warner JA, Packham G, Ganesan A, Skipp PJ, Marshall BJ, Richeldi L, Sime PJ, O'Reilly KMA, Davies DE.

Oncotarget. 2017 Jul 25;8(30):48737-48754. doi: 10.18632/oncotarget.17114.

18.

Functional characterization of a novel 3D model of the epithelial-mesenchymal trophic unit.

Bucchieri F, Pitruzzella A, Fucarino A, Gammazza AM, Bavisotto CC, Marcianò V, Cajozzo M, Lo Iacono G, Marchese R, Zummo G, Holgate ST, Davies DE.

Exp Lung Res. 2017 Mar;43(2):82-92. doi: 10.1080/01902148.2017.1303098. Epub 2017 Apr 3.

PMID:
28368678
19.

Cellular crosstalk between airway epithelial and endothelial cells regulates barrier functions during exposure to double-stranded RNA.

Blume C, Reale R, Held M, Loxham M, Millar TM, Collins JE, Swindle EJ, Morgan H, Davies DE.

Immun Inflamm Dis. 2017 Jan 18;5(1):45-56. doi: 10.1002/iid3.139. eCollection 2017 Mar.

20.

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma.

Singhania A, Rupani H, Jayasekera N, Lumb S, Hales P, Gozzard N, Davies DE, Woelk CH, Howarth PH.

PLoS One. 2017 Jan 3;12(1):e0168680. doi: 10.1371/journal.pone.0168680. eCollection 2017.

21.

Long Term Culture of the A549 Cancer Cell Line Promotes Multilamellar Body Formation and Differentiation towards an Alveolar Type II Pneumocyte Phenotype.

Cooper JR, Abdullatif MB, Burnett EC, Kempsell KE, Conforti F, Tolley H, Collins JE, Davies DE.

PLoS One. 2016 Oct 28;11(10):e0164438. doi: 10.1371/journal.pone.0164438. eCollection 2016.

22.

IL-1α mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit.

Hill AR, Donaldson JE, Blume C, Smithers N, Tezera L, Tariq K, Dennison P, Rupani H, Edwards MJ, Howarth PH, Grainge C, Davies DE, Swindle EJ.

Tissue Barriers. 2016 Jun 28;4(3):e1206378. doi: 10.1080/21688370.2016.1206378. eCollection 2016 Jul-Sep.

23.

Modulation of Human Airway Barrier Functions during Burkholderia thailandensis and Francisella tularensis Infection Running Title: Airway Barrier Functions during Bacterial Infections.

Blume C, David J, Bell RE, Laver JR, Read RC, Clark GC, Davies DE, Swindle EJ.

Pathogens. 2016 Aug 3;5(3). pii: E53. doi: 10.3390/pathogens5030053.

24.

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life.

Davies ER, Kelly JF, Howarth PH, Wilson DI, Holgate ST, Davies DE, Whitsett JA, Haitchi HM.

JCI Insight. 2016 Jul 21;1(11). pii: e87632.

25.

Three-dimensional characterization of fibroblast foci in idiopathic pulmonary fibrosis.

Jones MG, Fabre A, Schneider P, Cinetto F, Sgalla G, Mavrogordato M, Jogai S, Alzetani A, Marshall BG, O'Reilly KM, Warner JA, Lackie PM, Davies DE, Hansell DM, Nicholson AG, Sinclair I, Brown KK, Richeldi L.

JCI Insight. 2016 Apr 21;1(5). pii: e86375.

26.

Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease.

Rigden HM, Alias A, Havelock T, O'Donnell R, Djukanovic R, Davies DE, Wilson SJ.

PLoS One. 2016 May 26;11(5):e0156009. doi: 10.1371/journal.pone.0156009. eCollection 2016.

27.

Mechanical Strain Causes Adaptive Change in Bronchial Fibroblasts Enhancing Profibrotic and Inflammatory Responses.

Manuyakorn W, Smart DE, Noto A, Bucchieri F, Haitchi HM, Holgate ST, Howarth PH, Davies DE.

PLoS One. 2016 Apr 21;11(4):e0153926. doi: 10.1371/journal.pone.0153926. eCollection 2016.

28.

Inhibition of Pim1 kinase, new therapeutic approach in virus-induced asthma exacerbations.

Vries Md, Bedke N, Smithers NP, Loxham M, Howarth PH, Nawijn MC, Davies DE.

Eur Respir J. 2016 Mar;47(3):783-91. doi: 10.1183/13993003.00171-2015. Epub 2016 Feb 11.

29.

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology.

Gordon S, Daneshian M, Bouwstra J, Caloni F, Constant S, Davies DE, Dandekar G, Guzman CA, Fabian E, Haltner E, Hartung T, Hasiwa N, Hayden P, Kandarova H, Khare S, Krug HF, Kneuer C, Leist M, Lian G, Marx U, Metzger M, Ott K, Prieto P, Roberts MS, Roggen EL, Tralau T, van den Braak C, Walles H, Lehr CM.

ALTEX. 2015;32(4):327-78. doi: 10.14573/altex.1510051.

30.

Low molecular weight components of pollen alter bronchial epithelial barrier functions.

Blume C, Swindle EJ, Gilles S, Traidl-Hoffmann C, Davies DE.

Tissue Barriers. 2015 Jul 15;3(3):e1062316. doi: 10.1080/15476286.2015.1062316. eCollection 2015 Jul-Sep.

31.

Temporal Monitoring of Differentiated Human Airway Epithelial Cells Using Microfluidics.

Blume C, Reale R, Held M, Millar TM, Collins JE, Davies DE, Morgan H, Swindle EJ.

PLoS One. 2015 Oct 5;10(10):e0139872. doi: 10.1371/journal.pone.0139872. eCollection 2015.

32.

Biocompatibility of poly(2-alkyl-2-oxazoline) brush surfaces for adherent lung cell lines.

Tait A, Fisher AL, Hartland T, Smart D, Glynne-Jones P, Hill M, Swindle EJ, Grossel M, Davies DE.

Biomaterials. 2015 Aug;61:26-32. doi: 10.1016/j.biomaterials.2015.04.059. Epub 2015 May 14.

PMID:
25993014
33.

Cigarette smoke causes caspase-independent apoptosis of bronchial epithelial cells from asthmatic donors.

Bucchieri F, Marino Gammazza A, Pitruzzella A, Fucarino A, Farina F, Howarth P, Holgate ST, Zummo G, Davies DE.

PLoS One. 2015 Mar 20;10(3):e0120510. doi: 10.1371/journal.pone.0120510. eCollection 2015.

34.

Inhibition of Pim1 kinase reduces viral replication in primary bronchial epithelial cells.

de Vries M, Smithers NP, Howarth PH, Nawijn MC, Davies DE.

Eur Respir J. 2015 Jun;45(6):1745-8. doi: 10.1183/09031936.00206514. Epub 2015 Mar 5. No abstract available.

35.

The effects on bronchial epithelial mucociliary cultures of coarse, fine, and ultrafine particulate matter from an underground railway station.

Loxham M, Morgan-Walsh RJ, Cooper MJ, Blume C, Swindle EJ, Dennison PW, Howarth PH, Cassee FR, Teagle DA, Palmer MR, Davies DE.

Toxicol Sci. 2015 May;145(1):98-107. doi: 10.1093/toxsci/kfv034. Epub 2015 Feb 10.

36.

Epithelial barrier function and immunity in asthma.

Davies DE.

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S244-51. doi: 10.1513/AnnalsATS.201407-304AW. Review.

PMID:
25525727
37.

Identification of host miRNAs that may limit human rhinovirus replication.

Bondanese VP, Francisco-Garcia A, Bedke N, Davies DE, Sanchez-Elsner T.

World J Biol Chem. 2014 Nov 26;5(4):437-56. doi: 10.4331/wjbc.v5.i4.437.

38.

A microRNA network dysregulated in asthma controls IL-6 production in bronchial epithelial cells.

Martinez-Nunez RT, Bondanese VP, Louafi F, Francisco-Garcia AS, Rupani H, Bedke N, Holgate S, Howarth PH, Davies DE, Sanchez-Elsner T.

PLoS One. 2014 Oct 31;9(10):e111659. doi: 10.1371/journal.pone.0111659. eCollection 2014.

39.

Nanomechanical assessment of human and murine collagen fibrils via atomic force microscopy cantilever-based nanoindentation.

Andriotis OG, Manuyakorn W, Zekonyte J, Katsamenis OL, Fabri S, Howarth PH, Davies DE, Thurner PJ.

J Mech Behav Biomed Mater. 2014 Nov;39:9-26. doi: 10.1016/j.jmbbm.2014.06.015. Epub 2014 Jul 15. Erratum in: J Mech Behav Biomed Mater. 2015 May;45:193.

PMID:
25081997
40.

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Djukanović R, Harrison T, Johnston SL, Gabbay F, Wark P, Thomson NC, Niven R, Singh D, Reddel HK, Davies DE, Marsden R, Boxall C, Dudley S, Plagnol V, Holgate ST, Monk P; INTERCIA Study Group.

Am J Respir Crit Care Med. 2014 Jul 15;190(2):145-54. doi: 10.1164/rccm.201312-2235OC.

41.

Rhinovirus-16 induced release of IP-10 and IL-8 is augmented by Th2 cytokines in a pediatric bronchial epithelial cell model.

Cakebread JA, Haitchi HM, Xu Y, Holgate ST, Roberts G, Davies DE.

PLoS One. 2014 Apr 4;9(4):e94010. doi: 10.1371/journal.pone.0094010. eCollection 2014.

42.

Autocrine ligands of the epithelial growth factor receptor mediate inflammatory responses to diesel exhaust particles.

Parnia S, Hamilton LM, Puddicombe SM, Holgate ST, Frew AJ, Davies DE.

Respir Res. 2014 Feb 20;15:22. doi: 10.1186/1465-9921-15-22.

43.

Epithelial injury and repair in airways diseases.

Grainge CL, Davies DE.

Chest. 2013 Dec;144(6):1906-1912. doi: 10.1378/chest.12-1944. Review.

PMID:
24297122
44.

A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.

Bønnelykke K, Sleiman P, Nielsen K, Kreiner-Møller E, Mercader JM, Belgrave D, den Dekker HT, Husby A, Sevelsted A, Faura-Tellez G, Mortensen LJ, Paternoster L, Flaaten R, Mølgaard A, Smart DE, Thomsen PF, Rasmussen MA, Bonàs-Guarch S, Holst C, Nohr EA, Yadav R, March ME, Blicher T, Lackie PM, Jaddoe VW, Simpson A, Holloway JW, Duijts L, Custovic A, Davies DE, Torrents D, Gupta R, Hollegaard MV, Hougaard DM, Hakonarson H, Bisgaard H.

Nat Genet. 2014 Jan;46(1):51-5. doi: 10.1038/ng.2830. Epub 2013 Nov 17.

PMID:
24241537
45.

The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling.

Andrews AL, Nordgren IK, Campbell-Harding G, Holloway JW, Holgate ST, Davies DE, Tavassoli A.

Mol Biosyst. 2013 Dec;9(12):3009-14. doi: 10.1039/c3mb70298g. Epub 2013 Sep 20.

PMID:
24056919
46.

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma.

Uddin M, Lau LC, Seumois G, Vijayanand P, Staples KJ, Bagmane D, Cornelius V, Dorinsky P, Davies DE, Djukanović R.

PLoS One. 2013 Sep 11;8(9):e72502. doi: 10.1371/journal.pone.0072502. eCollection 2013.

47.

Barrier disrupting effects of alternaria alternata extract on bronchial epithelium from asthmatic donors.

Leino MS, Loxham M, Blume C, Swindle EJ, Jayasekera NP, Dennison PW, Shamji BW, Edwards MJ, Holgate ST, Howarth PH, Davies DE.

PLoS One. 2013 Aug 23;8(8):e71278. doi: 10.1371/journal.pone.0071278. eCollection 2013.

48.

TNF-α-mediated bronchial barrier disruption and regulation by src-family kinase activation.

Hardyman MA, Wilkinson E, Martin E, Jayasekera NP, Blume C, Swindle EJ, Gozzard N, Holgate ST, Howarth PH, Davies DE, Collins JE.

J Allergy Clin Immunol. 2013 Sep;132(3):665-675.e8. doi: 10.1016/j.jaci.2013.03.005. Epub 2013 Apr 28.

49.

Physicochemical characterization of airborne particulate matter at a mainline underground railway station.

Loxham M, Cooper MJ, Gerlofs-Nijland ME, Cassee FR, Davies DE, Palmer MR, Teagle DA.

Environ Sci Technol. 2013 Apr 16;47(8):3614-22. doi: 10.1021/es304481m. Epub 2013 Apr 2.

50.

In vitro and ex vivo models of human asthma.

Blume C, Davies DE.

Eur J Pharm Biopharm. 2013 Jun;84(2):394-400. doi: 10.1016/j.ejpb.2012.12.014. Epub 2013 Jan 9. Review.

PMID:
23313714

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