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The coronary circulation in acute myocardial ischaemia/reperfusion injury - a target for cardioprotection.

Hausenloy DJ, Chilian W, Crea F, Davidson SM, Ferdinandy P, Garcia-Dorado D, van Royen N, Schulz R, Heusch G.

Cardiovasc Res. 2018 Nov 14. doi: 10.1093/cvr/cvy286. [Epub ahead of print]


Endothelial cells release cardioprotective exosomes that may contribute to ischaemic preconditioning.

Davidson SM, Riquelme JA, Zheng Y, Vicencio JM, Lavandero S, Yellon DM.

Sci Rep. 2018 Oct 26;8(1):15885. doi: 10.1038/s41598-018-34357-z.


The 10th Biennial Hatter Cardiovascular Institute workshop: cellular protection-evaluating new directions in the setting of myocardial infarction, ischaemic stroke, and cardio-oncology.

Davidson SM, Arjun S, Basalay MV, Bell RM, Bromage DI, Bøtker HE, Carr RD, Cunningham J, Ghosh AK, Heusch G, Ibanez B, Kleinbongard P, Lecour S, Maddock H, Ovize M, Walker M, Wiart M, Yellon DM.

Basic Res Cardiol. 2018 Oct 11;113(6):43. doi: 10.1007/s00395-018-0704-z. Review.


Practical guidelines for rigor and reproducibility in preclinical and clinical studies on cardioprotection.

Bøtker HE, Hausenloy D, Andreadou I, Antonucci S, Boengler K, Davidson SM, Deshwal S, Devaux Y, Di Lisa F, Di Sante M, Efentakis P, Femminò S, García-Dorado D, Giricz Z, Ibanez B, Iliodromitis E, Kaludercic N, Kleinbongard P, Neuhäuser M, Ovize M, Pagliaro P, Rahbek-Schmidt M, Ruiz-Meana M, Schlüter KD, Schulz R, Skyschally A, Wilder C, Yellon DM, Ferdinandy P, Heusch G.

Basic Res Cardiol. 2018 Aug 17;113(5):39. doi: 10.1007/s00395-018-0696-8. Review. No abstract available.


ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation.

Monypenny J, Milewicz H, Flores-Borja F, Weitsman G, Cheung A, Chowdhury R, Burgoyne T, Arulappu A, Lawler K, Barber PR, Vicencio JM, Keppler M, Wulaningsih W, Davidson SM, Fraternali F, Woodman N, Turmaine M, Gillett C, Franz D, Quezada SA, Futter CE, Von Kriegsheim A, Kolch W, Vojnovic B, Carlton JG, Ng T.

Cell Rep. 2018 Jul 17;24(3):630-641. doi: 10.1016/j.celrep.2018.06.066.


How can we better help cancer patients quit smoking? The London Regional Cancer Program experience with smoking cessation.

Davidson SM, Boldt RG, Louie AV.

Curr Oncol. 2018 Jun;25(3):226-230. doi: 10.3747/co.25.3921. Epub 2018 Jun 28. Review.


Neural mechanisms in remote ischaemic conditioning in the heart and brain: mechanistic and translational aspects.

Basalay MV, Davidson SM, Gourine AV, Yellon DM.

Basic Res Cardiol. 2018 Jun 1;113(4):25. doi: 10.1007/s00395-018-0684-z. Review.


Imaging Mitochondrial Calcium Fluxes with Fluorescent Probes and Single- or Two-Photon Confocal Microscopy.

Davidson SM, Duchen MR.

Methods Mol Biol. 2018;1782:171-186. doi: 10.1007/978-1-4939-7831-1_10.


Ischaemic Preconditioning Protects Cardiomyocytes from Anthracycline-Induced Toxicity via the PI3K Pathway.

Maulik A, Davidson SM, Piotrowska I, Walker M, Yellon DM.

Cardiovasc Drugs Ther. 2018 May 15. doi: 10.1007/s10557-018-6793-y. [Epub ahead of print]


The GTN patch: a simple and effective new approach to cardioprotection?

Yellon DM, He Z, Khambata R, Ahluwalia A, Davidson SM.

Basic Res Cardiol. 2018 Apr 17;113(3):20. doi: 10.1007/s00395-018-0681-2.


Impact of HPV Status on the Prognostic Potential of the AJCC Staging System for Larynx Cancer.

Davidson SM, Ko HC, Harari PM, Wieland AM, Chen S, Baschnagel AM, Kimple RJ, Witek ME.

Otolaryngol Head Neck Surg. 2018 Sep;159(3):456-465. doi: 10.1177/0194599818766035. Epub 2018 Apr 3.


Cardioprotection - is no the answer? A renewed look at nitric oxide signalling in cardiomyocytes.

Davidson SM, Yellon DM.

Cardiovasc Res. 2018 May 1;114(6):773-775. doi: 10.1093/cvr/cvy073. No abstract available.


The Caspase 1 Inhibitor VX-765 Protects the Isolated Rat Heart via the RISK Pathway.

Do Carmo H, Arjun S, Petrucci O, Yellon DM, Davidson SM.

Cardiovasc Drugs Ther. 2018 Apr;32(2):165-168. doi: 10.1007/s10557-018-6781-2.


Biologically active constituents of the secretome of human W8B2+ cardiac stem cells.

Nie S, Wang X, Sivakumaran P, Chong MMW, Liu X, Karnezis T, Bandara N, Takov K, Nowell CJ, Wilcox S, Shambrook M, Hill AF, Harris NC, Newcomb AE, Strappe P, Shayan R, Hernández D, Clarke J, Hanssen E, Davidson SM, Dusting GJ, Pébay A, Ho JWK, Williamson N, Lim SY.

Sci Rep. 2018 Jan 25;8(1):1579. doi: 10.1038/s41598-018-19855-4.


Confounding factors in vesicle uptake studies using fluorescent lipophilic membrane dyes.

Takov K, Yellon DM, Davidson SM.

J Extracell Vesicles. 2017 Oct 12;6(1):1388731. doi: 10.1080/20013078.2017.1388731. eCollection 2017.


Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion.

Rossello X, Riquelme JA, Davidson SM, Yellon DM.

J Cell Mol Med. 2018 Feb;22(2):926-935. doi: 10.1111/jcmm.13394. Epub 2017 Nov 20.


Exosomes and cardioprotection - A critical analysis.

Davidson SM, Yellon DM.

Mol Aspects Med. 2018 Apr;60:104-114. doi: 10.1016/j.mam.2017.11.004. Epub 2017 Nov 15. Review.


Extracellular vesicles in diagnostics and therapy of the ischaemic heart: Position Paper from the Working Group on Cellular Biology of the Heart of the European Society of Cardiology.

Sluijter JPG, Davidson SM, Boulanger CM, Buzás EI, de Kleijn DPV, Engel FB, Giricz Z, Hausenloy DJ, Kishore R, Lecour S, Leor J, Madonna R, Perrino C, Prunier F, Sahoo S, Schiffelers RM, Schulz R, Van Laake LW, Ytrehus K, Ferdinandy P.

Cardiovasc Res. 2018 Jan 1;114(1):19-34. doi: 10.1093/cvr/cvx211.


New insights into cardiotoxicity caused by chemotherapeutic agents.

Grieve DJ, Davidson SM.

Br J Pharmacol. 2017 Nov;174(21):3675-3676. doi: 10.1111/bph.14025.


The role of PI3Kα isoform in cardioprotection.

Rossello X, Riquelme JA, He Z, Taferner S, Vanhaesebroeck B, Davidson SM, Yellon DM.

Basic Res Cardiol. 2017 Oct 17;112(6):66. doi: 10.1007/s00395-017-0657-7.


Therapeutic strategies utilizing SDF-1α in ischaemic cardiomyopathy.

Ziff OJ, Bromage DI, Yellon DM, Davidson SM.

Cardiovasc Res. 2018 Mar 1;114(3):358-367. doi: 10.1093/cvr/cvx203.


Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis.

Romero R, Sayin VI, Davidson SM, Bauer MR, Singh SX, LeBoeuf SE, Karakousi TR, Ellis DC, Bhutkar A, Sánchez-Rivera FJ, Subbaraj L, Martinez B, Bronson RT, Prigge JR, Schmidt EE, Thomas CJ, Goparaju C, Davies A, Dolgalev I, Heguy A, Allaj V, Poirier JT, Moreira AL, Rudin CM, Pass HI, Vander Heiden MG, Jacks T, Papagiannakopoulos T.

Nat Med. 2017 Nov;23(11):1362-1368. doi: 10.1038/nm.4407. Epub 2017 Oct 2.


Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.

Sayin VI, LeBoeuf SE, Singh SX, Davidson SM, Biancur D, Guzelhan BS, Alvarez SW, Wu WL, Karakousi TR, Zavitsanou AM, Ubriaco J, Muir A, Karagiannis D, Morris PJ, Thomas CJ, Possemato R, Vander Heiden MG, Papagiannakopoulos T.

Elife. 2017 Oct 2;6. pii: e28083. doi: 10.7554/eLife.28083.


Subinhibitory Dalbavancin Attenuates Exotoxin Production from Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus In Vitro.

Hobdey SE, Katahira EJ, Dockstader P, Davidson SM, Bond L, Bolz DD, Bryant AE, Stevens DL.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01090-17. doi: 10.1128/AAC.01090-17. Print 2017 Nov.


Melatonin as a cardioprotective therapy following ST-segment elevation myocardial infarction: is it really promising? Reply.

Hausenloy DJ, Garcia-Dorado D, Erik Bøtker H, Davidson SM, Downey J, Engel FB, Jennings R, Lecour S, Leor J, Madonna R, Ovize M, Perrino C, Prunier F, Schulz R, Sluijter JPG, Van Laake LW, Vinten-Johansen J, Yellon DM, Ytrehus K, Heusch G, Ferdinandy P.

Cardiovasc Res. 2017 Sep 1;113(11):1418-1419. doi: 10.1093/cvr/cvx137. No abstract available.


Cardioprotection mediated by exosomes is impaired in the setting of type II diabetes but can be rescued by the use of non-diabetic exosomes in vitro.

Davidson SM, Riquelme JA, Takov K, Vicencio JM, Boi-Doku C, Khoo V, Doreth C, Radenkovic D, Lavandero S, Yellon DM.

J Cell Mol Med. 2018 Jan;22(1):141-151. doi: 10.1111/jcmm.13302. Epub 2017 Aug 25.


Letter by Takov et al Regarding Article, "Fabrication of Synthetic Mesenchymal Stem Cells for the Treatment of Acute Myocardial Infarction in Mice".

Takov K, Yellon DM, Davidson SM.

Circ Res. 2017 May 26;120(11):e46-e47. doi: 10.1161/CIRCRESAHA.117.311127. No abstract available.


Epigenomic and transcriptomic approaches in the post-genomic era: path to novel targets for diagnosis and therapy of the ischaemic heart? Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.

Perrino C, Barabási AL, Condorelli G, Davidson SM, De Windt L, Dimmeler S, Engel FB, Hausenloy DJ, Hill JA, Van Laake LW, Lecour S, Leor J, Madonna R, Mayr M, Prunier F, Sluijter JPG, Schulz R, Thum T, Ytrehus K, Ferdinandy P.

Cardiovasc Res. 2017 Jun 1;113(7):725-736. doi: 10.1093/cvr/cvx070. Review.


Novel targets and future strategies for acute cardioprotection: Position Paper of the European Society of Cardiology Working Group on Cellular Biology of the Heart.

Hausenloy DJ, Garcia-Dorado D, Bøtker HE, Davidson SM, Downey J, Engel FB, Jennings R, Lecour S, Leor J, Madonna R, Ovize M, Perrino C, Prunier F, Schulz R, Sluijter JPG, Van Laake LW, Vinten-Johansen J, Yellon DM, Ytrehus K, Heusch G, Ferdinandy P.

Cardiovasc Res. 2017 May 1;113(6):564-585. doi: 10.1093/cvr/cvx049. Review.


A novel recombinant antibody specific to full-length stromal derived factor-1 for potential application in biomarker studies.

Bromage DI, Taferner S, Pillai M, Yellon DM, Davidson SM.

PLoS One. 2017 Apr 5;12(4):e0174447. doi: 10.1371/journal.pone.0174447. eCollection 2017.


Ventilation strategy has a major influence on remote ischaemic preconditioning in mice.

Davidson SM, He Z, Dyson A, Bromage DI, Yellon DM.

J Cell Mol Med. 2017 Oct;21(10):2426-2431. doi: 10.1111/jcmm.13164. Epub 2017 Apr 4.


Editorial to: "Building a Bridge to the Future of Cardiovascular Drugs and Therapy".

Davidson SM.

Cardiovasc Drugs Ther. 2017 Feb;31(1):51-52. doi: 10.1007/s10557-017-6715-4. No abstract available.


The dimensional reduction method for identification of parameters that trade-off due to similar model roles.

Davidson SM, Docherty PD, Murray R.

Math Biosci. 2017 Mar;285:119-127. doi: 10.1016/j.mbs.2017.01.003. Epub 2017 Jan 18.


Intrinsic cardiac ganglia and acetylcholine are important in the mechanism of ischaemic preconditioning.

Pickard JMJ, Burke N, Davidson SM, Yellon DM.

Basic Res Cardiol. 2017 Mar;112(2):11. doi: 10.1007/s00395-017-0601-x. Epub 2017 Jan 13.


Remote ischaemic conditioning reduces infarct size in animal in vivo models of ischaemia-reperfusion injury: a systematic review and meta-analysis.

Bromage DI, Pickard JM, Rossello X, Ziff OJ, Burke N, Yellon DM, Davidson SM.

Cardiovasc Res. 2017 Mar 1;113(3):288-297. doi: 10.1093/cvr/cvw219. Review.


Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors.

Davidson SM, Jonas O, Keibler MA, Hou HW, Luengo A, Mayers JR, Wyckoff J, Del Rosario AM, Whitman M, Chin CR, Condon KJ, Lammers A, Kellersberger KA, Stall BK, Stephanopoulos G, Bar-Sagi D, Han J, Rabinowitz JD, Cima MJ, Langer R, Vander Heiden MG.

Nat Med. 2017 Feb;23(2):235-241. doi: 10.1038/nm.4256. Epub 2016 Dec 26.


Exosomes and Cardiovascular Protection.

Davidson SM, Takov K, Yellon DM.

Cardiovasc Drugs Ther. 2017 Feb;31(1):77-86. doi: 10.1007/s10557-016-6698-6. Review.


Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery.

Hausenloy DJ, Barrabes JA, Bøtker HE, Davidson SM, Di Lisa F, Downey J, Engstrom T, Ferdinandy P, Carbrera-Fuentes HA, Heusch G, Ibanez B, Iliodromitis EK, Inserte J, Jennings R, Kalia N, Kharbanda R, Lecour S, Marber M, Miura T, Ovize M, Perez-Pinzon MA, Piper HM, Przyklenk K, Schmidt MR, Redington A, Ruiz-Meana M, Vilahur G, Vinten-Johansen J, Yellon DM, Garcia-Dorado D.

Basic Res Cardiol. 2016 Nov;111(6):70. Epub 2016 Oct 20. Review.


Environment Dictates Dependence on Mitochondrial Complex I for NAD+ and Aspartate Production and Determines Cancer Cell Sensitivity to Metformin.

Gui DY, Sullivan LB, Luengo A, Hosios AM, Bush LN, Gitego N, Davidson SM, Freinkman E, Thomas CJ, Vander Heiden MG.

Cell Metab. 2016 Nov 8;24(5):716-727. doi: 10.1016/j.cmet.2016.09.006. Epub 2016 Oct 13.


Breast Cancer-Derived Lung Metastases Show Increased Pyruvate Carboxylase-Dependent Anaplerosis.

Christen S, Lorendeau D, Schmieder R, Broekaert D, Metzger K, Veys K, Elia I, Buescher JM, Orth MF, Davidson SM, Grünewald TG, De Bock K, Fendt SM.

Cell Rep. 2016 Oct 11;17(3):837-848. doi: 10.1016/j.celrep.2016.09.042.


Critical Functions of the Lysosome in Cancer Biology.

Davidson SM, Vander Heiden MG.

Annu Rev Pharmacol Toxicol. 2017 Jan 6;57:481-507. doi: 10.1146/annurev-pharmtox-010715-103101. Epub 2016 Oct 12. Review.


Calcium handling precedes cardiac differentiation to initiate the first heartbeat.

Tyser RC, Miranda AM, Chen CM, Davidson SM, Srinivas S, Riley PR.

Elife. 2016 Oct 11;5. pii: e17113. doi: 10.7554/eLife.17113.


Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers.

Mayers JR, Torrence ME, Danai LV, Papagiannakopoulos T, Davidson SM, Bauer MR, Lau AN, Ji BW, Dixit PD, Hosios AM, Muir A, Chin CR, Freinkman E, Jacks T, Wolpin BM, Vitkup D, Vander Heiden MG.

Science. 2016 Sep 9;353(6304):1161-5. doi: 10.1126/science.aaf5171.


Mutations in mitochondrial enzyme GPT2 cause metabolic dysfunction and neurological disease with developmental and progressive features.

Ouyang Q, Nakayama T, Baytas O, Davidson SM, Yang C, Schmidt M, Lizarraga SB, Mishra S, Ei-Quessny M, Niaz S, Gul Butt M, Imran Murtaza S, Javed A, Chaudhry HR, Vaughan DJ, Hill RS, Partlow JN, Yoo SY, Lam AT, Nasir R, Al-Saffar M, Barkovich AJ, Schwede M, Nagpal S, Rajab A, DeBerardinis RJ, Housman DE, Mochida GH, Morrow EM.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5598-607. doi: 10.1073/pnas.1609221113. Epub 2016 Sep 6.


Circadian Rhythm Disruption Promotes Lung Tumorigenesis.

Papagiannakopoulos T, Bauer MR, Davidson SM, Heimann M, Subbaraj L, Bhutkar A, Bartlebaugh J, Vander Heiden MG, Jacks T.

Cell Metab. 2016 Aug 9;24(2):324-31. doi: 10.1016/j.cmet.2016.07.001. Epub 2016 Jul 28.


Corrigendum: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate.

Pacold ME, Brimacombe KR, Chan SH, Rohde JM, Lewis CA, Swier LJ, Possemato R, Chen WW, Sullivan LB, Fiske BP, Cho S, Freinkman E, Birsoy K, Abu MR, Shaul YD, Liu CM, Zhou M, Koh MJ, Chung H, Davidson SM, Luengo A, Wang AQ, Xu X, Yasgar A, Liu L, Rai G, Westover KD, Heiden MG, Shen M, Gray NS, Boxer MB, Sabatini DM.

Nat Chem Biol. 2016 Jul 19;12(8):656. doi: 10.1038/nchembio0816-656. No abstract available.


Co-dependence of the neural and humoral pathways in the mechanism of remote ischemic conditioning.

Pickard JM, Davidson SM, Hausenloy DJ, Yellon DM.

Basic Res Cardiol. 2016 Jul;111(4):50. doi: 10.1007/s00395-016-0568-z. Epub 2016 Jun 23.


9th Hatter Biannual Meeting: position document on ischaemia/reperfusion injury, conditioning and the ten commandments of cardioprotection.

Bell RM, Bøtker HE, Carr RD, Davidson SM, Downey JM, Dutka DP, Heusch G, Ibanez B, Macallister R, Stoppe C, Ovize M, Redington A, Walker JM, Yellon DM.

Basic Res Cardiol. 2016 Jul;111(4):41. doi: 10.1007/s00395-016-0558-1. Epub 2016 May 10. Review.


Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma.

Dayton TL, Gocheva V, Miller KM, Israelsen WJ, Bhutkar A, Clish CB, Davidson SM, Luengo A, Bronson RT, Jacks T, Vander Heiden MG.

Genes Dev. 2016 May 1;30(9):1020-33. doi: 10.1101/gad.278549.116. Epub 2016 Apr 28.

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