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Items: 1 to 50 of 165


Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing.

Garcia B, Lee J, Edraki A, Hidalgo-Reyes Y, Erwood S, Mir A, Trost CN, Seroussi U, Stanley SY, Cohn RD, Claycomb JM, Sontheimer EJ, Maxwell KL, Davidson AR.

Cell Rep. 2019 Nov 12;29(7):1739-1746.e5. doi: 10.1016/j.celrep.2019.10.017.


Anti-CRISPR-Associated Proteins Are Crucial Repressors of Anti-CRISPR Transcription.

Stanley SY, Borges AL, Chen KH, Swaney DL, Krogan NJ, Bondy-Denomy J, Davidson AR.

Cell. 2019 Sep 5;178(6):1452-1464.e13. doi: 10.1016/j.cell.2019.07.046. Epub 2019 Aug 29.


Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2.

Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna J, Davidson AR, Moraes TF, Wang Y, Maxwell KL.

Nat Commun. 2019 Jun 26;10(1):2806. doi: 10.1038/s41467-019-10577-3.


Phage tail fibre assembly proteins employ a modular structure to drive the correct folding of diverse fibres.

North OI, Sakai K, Yamashita E, Nakagawa A, Iwazaki T, Büttner CR, Takeda S, Davidson AR.

Nat Microbiol. 2019 Oct;4(10):1645-1653. doi: 10.1038/s41564-019-0477-7. Epub 2019 Jun 17.


A Unified Resource for Tracking Anti-CRISPR Names.

Bondy-Denomy J, Davidson AR, Doudna JA, Fineran PC, Maxwell KL, Moineau S, Peng X, Sontheimer EJ, Wiedenheft B.

CRISPR J. 2018 Oct;1:304-305. doi: 10.1089/crispr.2018.0043. No abstract available.


Physicians' perspectives on the treatment of patients with eating disorders in the acute setting.

Davidson AR, Braham S, Dasey L, Reidlinger DP.

J Eat Disord. 2019 Jan 10;7:1. doi: 10.1186/s40337-018-0231-1. eCollection 2019.


Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins.

Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ.

mBio. 2018 Dec 4;9(6). pii: e02321-18. doi: 10.1128/mBio.02321-18.


Type VI secretion system baseplate.

Davidson AR, Maxwell KL.

Nat Microbiol. 2018 Dec;3(12):1330-1331. doi: 10.1038/s41564-018-0311-7. No abstract available.


A common trick for transferring bacterial DNA.

Davidson AR.

Science. 2018 Oct 12;362(6411):152-153. doi: 10.1126/science.aav1723. No abstract available.


Phage Morons Play an Important Role in Pseudomonas aeruginosa Phenotypes.

Tsao YF, Taylor VL, Kala S, Bondy-Denomy J, Khan AN, Bona D, Cattoir V, Lory S, Davidson AR, Maxwell KL.

J Bacteriol. 2018 Oct 23;200(22). pii: e00189-18. doi: 10.1128/JB.00189-18. Print 2018 Nov 15.


Disabling a Type I-E CRISPR-Cas Nuclease with a Bacteriophage-Encoded Anti-CRISPR Protein.

Pawluk A, Shah M, Mejdani M, Calmettes C, Moraes TF, Davidson AR, Maxwell KL.

mBio. 2017 Dec 12;8(6). pii: e01751-17. doi: 10.1128/mBio.01751-17.


Pseudomonas aeruginosa defends against phages through type IV pilus glycosylation.

Harvey H, Bondy-Denomy J, Marquis H, Sztanko KM, Davidson AR, Burrows LL.

Nat Microbiol. 2018 Jan;3(1):47-52. doi: 10.1038/s41564-017-0061-y. Epub 2017 Nov 13.


Anti-CRISPR: discovery, mechanism and function.

Pawluk A, Davidson AR, Maxwell KL.

Nat Rev Microbiol. 2018 Jan;16(1):12-17. doi: 10.1038/nrmicro.2017.120. Epub 2017 Oct 24. Review.


Cheese, phages and anti-CRISPRs.

Davidson AR.

Nat Microbiol. 2017 Oct;2(10):1338-1339. doi: 10.1038/s41564-017-0026-1. No abstract available.


A Broad-Spectrum Inhibitor of CRISPR-Cas9.

Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA.

Cell. 2017 Sep 7;170(6):1224-1233.e15. doi: 10.1016/j.cell.2017.07.037. Epub 2017 Aug 24.


The Discovery, Mechanisms, and Evolutionary Impact of Anti-CRISPRs.

Borges AL, Davidson AR, Bondy-Denomy J.

Annu Rev Virol. 2017 Sep 29;4(1):37-59. doi: 10.1146/annurev-virology-101416-041616. Epub 2017 Jul 27. Review.


Inhibition of CRISPR-Cas systems by mobile genetic elements.

Sontheimer EJ, Davidson AR.

Curr Opin Microbiol. 2017 Jun;37:120-127. doi: 10.1016/j.mib.2017.06.003. Epub 2017 Jun 29. Review.


Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex.

Chowdhury S, Carter J, Rollins MF, Golden SM, Jackson RN, Hoffmann C, Nosaka L, Bondy-Denomy J, Maxwell KL, Davidson AR, Fischer ER, Lander GC, Wiedenheft B.

Cell. 2017 Mar 23;169(1):47-57.e11. doi: 10.1016/j.cell.2017.03.012.


Virology: Phages make a group decision.

Davidson AR.

Nature. 2017 Jan 26;541(7638):466-467. doi: 10.1038/nature21118. Epub 2017 Jan 18. No abstract available.


Naturally Occurring Off-Switches for CRISPR-Cas9.

Pawluk A, Amrani N, Zhang Y, Garcia B, Hidalgo-Reyes Y, Lee J, Edraki A, Shah M, Sontheimer EJ, Maxwell KL, Davidson AR.

Cell. 2016 Dec 15;167(7):1829-1838.e9. doi: 10.1016/j.cell.2016.11.017. Epub 2016 Dec 8.


The solution structure of an anti-CRISPR protein.

Maxwell KL, Garcia B, Bondy-Denomy J, Bona D, Hidalgo-Reyes Y, Davidson AR.

Nat Commun. 2016 Oct 11;7:13134. doi: 10.1038/ncomms13134.


Inactivation of CRISPR-Cas systems by anti-CRISPR proteins in diverse bacterial species.

Pawluk A, Staals RH, Taylor C, Watson BN, Saha S, Fineran PC, Maxwell KL, Davidson AR.

Nat Microbiol. 2016 Jun 13;1(8):16085. doi: 10.1038/nmicrobiol.2016.85.


Baseplate assembly of phage Mu: Defining the conserved core components of contractile-tailed phages and related bacterial systems.

Büttner CR, Wu Y, Maxwell KL, Davidson AR.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):10174-9. doi: 10.1073/pnas.1607966113. Epub 2016 Aug 23.


Accessibility and Availability of Online Information for Orthopedic Surgery Residency Programs.

Davidson AR, Loftis CM, Throckmorton TW, Kelly DM.

Iowa Orthop J. 2016;36:31-6.


Prophages mediate defense against phage infection through diverse mechanisms.

Bondy-Denomy J, Qian J, Westra ER, Buckling A, Guttman DS, Davidson AR, Maxwell KL.

ISME J. 2016 Dec;10(12):2854-2866. doi: 10.1038/ismej.2016.79. Epub 2016 Jun 3.


Foreign DNA acquisition by the I-F CRISPR-Cas system requires all components of the interference machinery.

Vorontsova D, Datsenko KA, Medvedeva S, Bondy-Denomy J, Savitskaya EE, Pougach K, Logacheva M, Wiedenheft B, Davidson AR, Severinov K, Semenova E.

Nucleic Acids Res. 2015 Dec 15;43(22):10848-60. doi: 10.1093/nar/gkv1261. Epub 2015 Nov 19.


Multiple mechanisms for CRISPR-Cas inhibition by anti-CRISPR proteins.

Bondy-Denomy J, Garcia B, Strum S, Du M, Rollins MF, Hidalgo-Reyes Y, Wiedenheft B, Maxwell KL, Davidson AR.

Nature. 2015 Oct 1;526(7571):136-9. doi: 10.1038/nature15254. Epub 2015 Sep 23.


The phage tail tape measure protein, an inner membrane protein and a periplasmic chaperone play connected roles in the genome injection process of E. coli phage HK97.

Cumby N, Reimer K, Mengin-Lecreulx D, Davidson AR, Maxwell KL.

Mol Microbiol. 2015 May;96(3):437-47. doi: 10.1111/mmi.12918. Epub 2015 Jan 30.


Subaxial cervical spine injuries in children and adolescents.

Murphy RF, Davidson AR, Kelly DM, Warner WC Jr, Sawyer JR.

J Pediatr Orthop. 2015 Mar;35(2):136-9. doi: 10.1097/BPO.0000000000000341.


Accessibility and quality of online information for pediatric orthopaedic surgery fellowships.

Davidson AR, Murphy RF, Spence DD, Kelly DM, Warner WC Jr, Sawyer JR.

J Pediatr Orthop. 2014 Dec;34(8):831-4. doi: 10.1097/BPO.0000000000000217.


A new group of phage anti-CRISPR genes inhibits the type I-E CRISPR-Cas system of Pseudomonas aeruginosa.

Pawluk A, Bondy-Denomy J, Cheung VH, Maxwell KL, Davidson AR.

mBio. 2014 Apr 15;5(2):e00896. doi: 10.1128/mBio.00896-14.


HNH proteins are a widespread component of phage DNA packaging machines.

Kala S, Cumby N, Sadowski PD, Hyder BZ, Kanelis V, Davidson AR, Maxwell KL.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6022-7. doi: 10.1073/pnas.1320952111. Epub 2014 Apr 7.


When a virus is not a parasite: the beneficial effects of prophages on bacterial fitness.

Bondy-Denomy J, Davidson AR.

J Microbiol. 2014 Mar;52(3):235-42. doi: 10.1007/s12275-014-4083-3. Epub 2014 Mar 1. Review.


To acquire or resist: the complex biological effects of CRISPR-Cas systems.

Bondy-Denomy J, Davidson AR.

Trends Microbiol. 2014 Apr;22(4):218-25. doi: 10.1016/j.tim.2014.01.007. Epub 2014 Feb 26. Review.


Insights into bacteriophage T5 structure from analysis of its morphogenesis genes and protein components.

Zivanovic Y, Confalonieri F, Ponchon L, Lurz R, Chami M, Flayhan A, Renouard M, Huet A, Decottignies P, Davidson AR, Breyton C, Boulanger P.

J Virol. 2014 Jan;88(2):1162-74. doi: 10.1128/JVI.02262-13. Epub 2013 Nov 6.


Structural and functional studies of gpX of Escherichia coli phage P2 reveal a widespread role for LysM domains in the baseplates of contractile-tailed phages.

Maxwell KL, Fatehi Hassanabad M, Chang T, Paul VD, Pirani N, Bona D, Edwards AM, Davidson AR.

J Bacteriol. 2013 Dec;195(24):5461-8. doi: 10.1128/JB.00805-13. Epub 2013 Oct 4. Erratum in: J Bacteriol. 2014 Jun;196(11):2122. Paul, Vivek D [added].


A shifty chaperone for phage tail assembly.

Maxwell KL, Davidson AR.

J Mol Biol. 2014 Mar 6;426(5):1001-3. doi: 10.1016/j.jmb.2013.08.004. Epub 2013 Aug 9. No abstract available.


The moron comes of age.

Cumby N, Davidson AR, Maxwell KL.

Bacteriophage. 2012 Oct 1;2(4):225-228.


A conserved spiral structure for highly diverged phage tail assembly chaperones.

Pell LG, Cumby N, Clark TE, Tuite A, Battaile KP, Edwards AM, Chirgadze NY, Davidson AR, Maxwell KL.

J Mol Biol. 2013 Jul 24;425(14):2436-49. doi: 10.1016/j.jmb.2013.03.035. Epub 2013 Mar 28.


Tail tip proteins related to bacteriophage λ gpL coordinate an iron-sulfur cluster.

Tam W, Pell LG, Bona D, Tsai A, Dai XX, Edwards AM, Hendrix RW, Maxwell KL, Davidson AR.

J Mol Biol. 2013 Jul 24;425(14):2450-62. doi: 10.1016/j.jmb.2013.03.032. Epub 2013 Mar 28.


Differential dynamic engagement within 24 SH3 domain: peptide complexes revealed by co-linear chemical shift perturbation analysis.

Stollar EJ, Lin H, Davidson AR, Forman-Kay JD.

PLoS One. 2012;7(12):e51282. doi: 10.1371/journal.pone.0051282. Epub 2012 Dec 12.


Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system.

Bondy-Denomy J, Pawluk A, Maxwell KL, Davidson AR.

Nature. 2013 Jan 17;493(7432):429-32. doi: 10.1038/nature11723. Epub 2012 Dec 16.


The CRISPR/Cas adaptive immune system of Pseudomonas aeruginosa mediates resistance to naturally occurring and engineered phages.

Cady KC, Bondy-Denomy J, Heussler GE, Davidson AR, O'Toole GA.

J Bacteriol. 2012 Nov;194(21):5728-38. doi: 10.1128/JB.01184-12. Epub 2012 Aug 10.


Structural and biochemical characterization of phage λ FI protein (gpFI) reveals a novel mechanism of DNA packaging chaperone activity.

Popovic A, Wu B, Arrowsmith CH, Edwards AM, Davidson AR, Maxwell KL.

J Biol Chem. 2012 Sep 14;287(38):32085-95. doi: 10.1074/jbc.M112.378349. Epub 2012 Jul 16.


The bacteriophage HK97 gp15 moron element encodes a novel superinfection exclusion protein.

Cumby N, Edwards AM, Davidson AR, Maxwell KL.

J Bacteriol. 2012 Sep;194(18):5012-9. doi: 10.1128/JB.00843-12. Epub 2012 Jul 13.


The importance of conserved features of yeast actin-binding protein 1 (Abp1p): the conditional nature of essentiality.

Garcia B, Stollar EJ, Davidson AR.

Genetics. 2012 Aug;191(4):1199-211. doi: 10.1534/genetics.112.141739. Epub 2012 Jun 1.


Yeast adaptor protein, Nbp2p, is conserved regulator of fungal Ptc1p phosphatases and is involved in multiple signaling pathways.

Stanger K, Gorelik M, Davidson AR.

J Biol Chem. 2012 Jun 22;287(26):22133-41. doi: 10.1074/jbc.M112.348052. Epub 2012 May 8.


Proteome-wide discovery of evolutionary conserved sequences in disordered regions.

Nguyen Ba AN, Yeh BJ, van Dyk D, Davidson AR, Andrews BJ, Weiss EL, Moses AM.

Sci Signal. 2012 Mar 13;5(215):rs1. doi: 10.1126/scisignal.2002515.


Long noncontractile tail machines of bacteriophages.

Davidson AR, Cardarelli L, Pell LG, Radford DR, Maxwell KL.

Adv Exp Med Biol. 2012;726:115-42. doi: 10.1007/978-1-4614-0980-9_6. Review.


Distinct peptide binding specificities of Src homology 3 (SH3) protein domains can be determined by modulation of local energetics across the binding interface.

Gorelik M, Davidson AR.

J Biol Chem. 2012 Mar 16;287(12):9168-77. doi: 10.1074/jbc.M111.330753. Epub 2012 Jan 25.

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