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Characterisation of the Selective Reduced Uteroplacental Perfusion (sRUPP) Model of Preeclampsia.

Morton JS, Levasseur J, Ganguly E, Quon A, Kirschenman R, Dyck JRB, Fraser GM, Davidge ST.

Sci Rep. 2019 Jul 2;9(1):9565. doi: 10.1038/s41598-019-45959-6.


Advanced maternal age and the impact on maternal and offspring cardiovascular health.

Cooke CM, Davidge ST.

Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H387-H394. doi: 10.1152/ajpheart.00045.2019. Epub 2019 Jun 14.


Sex-Specific Effects of Nanoparticle-Encapsulated MitoQ (nMitoQ) Delivery to the Placenta in a Rat Model of Fetal Hypoxia.

Ganguly E, Aljunaidy MM, Kirschenman R, Spaans F, Morton JS, Phillips TEJ, Case CP, Cooke CM, Davidge ST.

Front Physiol. 2019 May 24;10:562. doi: 10.3389/fphys.2019.00562. eCollection 2019.


Low altitude simulation without hypoxia improves left ventricular function after myocardial infarction by reducing ventricular afterload.

Shahid A, Patel VB, Morton JS, Stenson TH, Davidge ST, Oudit GY, McMurtry MS.

PLoS One. 2019 May 31;14(5):e0215814. doi: 10.1371/journal.pone.0215814. eCollection 2019.


Blunted sympathetic neurovascular transduction during normotensive pregnancy.

Steinback CD, Fraser GM, Usselman CW, Reyes LM, Julian CG, Stickland MK, Chari RS, Khurana R, Davidge ST, Davenport MH.

J Physiol. 2019 Jul;597(14):3687-3696. doi: 10.1113/JP277714. Epub 2019 Jun 13.


Egg white hydrolysate enhances insulin sensitivity in high-fat diet-induced insulin-resistant rats via Akt activation.

Jahandideh F, Zani SCC, Son M, Proctor SD, Davidge ST, Chan CB, Wu J.

Br J Nutr. 2019 Jul 14;122(1):14-24. doi: 10.1017/S0007114519000837. Epub 2019 Jun 18.


Egg White-Derived Antihypertensive Peptide IRW (Ile-Arg-Trp) Reduces Blood Pressure in Spontaneously Hypertensive Rats via the ACE2/Ang (1-7)/Mas Receptor Axis.

Liao W, Fan H, Davidge ST, Wu J.

Mol Nutr Food Res. 2019 May;63(9):e1900063. doi: 10.1002/mnfr.201900063. Epub 2019 Apr 10.


Cardiovascular Health of Offspring of Diabetic Mothers From the Fetal Through Late-Infancy Stages.

Do V, Al-Hashmi H, Ojala T, Jain V, Colen T, Goncalvez-Alvarez S, Davidge ST, Al-Rajaa N, Serrano-Lomelin J, Stickland MK, Hornberger LK.

JACC Cardiovasc Imaging. 2019 May;12(5):932-934. doi: 10.1016/j.jcmg.2018.10.016. Epub 2018 Dec 12. No abstract available.


Alterations in vascular function by syncytiotrophoblast extracellular vesicles via lectin-like oxidized low-density lipoprotein receptor-1 in mouse uterine arteries.

Spaans F, Quon A, Rowe SR, Morton JS, Kirschenman R, Sawamura T, Tannetta DS, Sargent IL, Davidge ST.

Clin Sci (Lond). 2018 Nov 13;132(21):2369-2381. doi: 10.1042/CS20180639. Print 2018 Nov 15.


Egg White-Derived Tripeptide IRW (Ile-Arg-Trp) Is an Activator of Angiotensin Converting Enzyme 2.

Liao W, Bhullar KS, Chakrabarti S, Davidge ST, Wu J.

J Agric Food Chem. 2018 Oct 31;66(43):11330-11336. doi: 10.1021/acs.jafc.8b03501. Epub 2018 Oct 22.


Sex-specific effects of advanced maternal age on cardiovascular function in aged adult rat offspring.

Shah A, Cooke CM, Kirschenman RD, Quon AL, Morton JS, Care AS, Davidge ST.

Am J Physiol Heart Circ Physiol. 2018 Dec 1;315(6):H1724-H1734. doi: 10.1152/ajpheart.00375.2018. Epub 2018 Oct 5.


Effect of high dose folic acid supplementation in pregnancy on pre-eclampsia (FACT): double blind, phase III, randomised controlled, international, multicentre trial.

Wen SW, White RR, Rybak N, Gaudet LM, Robson S, Hague W, Simms-Stewart D, Carroli G, Smith G, Fraser WD, Wells G, Davidge ST, Kingdom J, Coyle D, Fergusson D, Corsi DJ, Champagne J, Sabri E, Ramsay T, Mol BWJ, Oudijk MA, Walker MC; FACT Collaborating Group.

BMJ. 2018 Sep 12;362:k3478. doi: 10.1136/bmj.k3478.


Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes.

Chakrabarti S, Jahandideh F, Davidge ST, Wu J.

J Agric Food Chem. 2018 Oct 3;66(39):10179-10187. doi: 10.1021/acs.jafc.8b02051. Epub 2018 Sep 20.


Increased susceptibility to cardiovascular disease in offspring born from dams of advanced maternal age.

Cooke CM, Shah A, Kirschenman RD, Quon AL, Morton JS, Care AS, Davidge ST.

J Physiol. 2018 Dec;596(23):5807-5821. doi: 10.1113/JP275472. Epub 2018 Jun 21.


Reduction in Regulatory T Cells in Early Pregnancy Causes Uterine Artery Dysfunction in Mice.

Care AS, Bourque SL, Morton JS, Hjartarson EP, Robertson SA, Davidge ST.

Hypertension. 2018 Jul;72(1):177-187. doi: 10.1161/HYPERTENSIONAHA.118.10858. Epub 2018 May 21.


Maternal treatment with a placental-targeted antioxidant (MitoQ) impacts offspring cardiovascular function in a rat model of prenatal hypoxia.

Aljunaidy MM, Morton JS, Kirschenman R, Phillips T, Case CP, Cooke CM, Davidge ST.

Pharmacol Res. 2018 Aug;134:332-342. doi: 10.1016/j.phrs.2018.05.006. Epub 2018 May 17.


Maternal Physical Activity Is Associated With Improved Blood Pressure Regulation During Late Pregnancy.

Sobierajski FM, Purdy GM, Usselman CW, Skow RJ, James MA, Chari RS, Khurana R, Stickland MK, Davidge ST, Devolin M, Steinback CD, Davenport MH.

Can J Cardiol. 2018 Apr;34(4):485-491. doi: 10.1016/j.cjca.2018.01.021. Epub 2018 Jan 31.


Foetal growth restriction in mice modifies postnatal airway responsiveness in an age and sex-dependent manner.

Wang KCW, Larcombe AN, Berry LJ, Morton JS, Davidge ST, James AL, Noble PB.

Clin Sci (Lond). 2018 Jan 25;132(2):273-284. doi: 10.1042/CS20171554. Print 2018 Jan 31.


The role of the tumor necrosis factor (TNF)-related weak inducer of apoptosis (TWEAK) in offspring exposed to prenatal hypoxia.

Reyes LM, Shah A, Quon A, Morton JS, Davidge ST.

J Dev Orig Health Dis. 2018 Dec;9(6):661-669. doi: 10.1017/S2040174417001003. Epub 2017 Dec 18.


Activity of muscle sympathetic neurons during normotensive pregnancy.

Schmidt SML, Usselman CW, Martinek E, Stickland MK, Julian CG, Chari R, Khurana R, Davidge ST, Davenport MH, Steinback CD.

Am J Physiol Regul Integr Comp Physiol. 2018 Feb 1;314(2):R153-R160. doi: 10.1152/ajpregu.00121.2016. Epub 2017 Oct 18.


Egg white hydrolysate shows insulin mimetic and sensitizing effects in 3T3-F442A pre-adipocytes.

Jahandideh F, Chakrabarti S, Davidge ST, Wu J.

PLoS One. 2017 Oct 3;12(10):e0185653. doi: 10.1371/journal.pone.0185653. eCollection 2017.


Treating the placenta to prevent adverse effects of gestational hypoxia on fetal brain development.

Phillips TJ, Scott H, Menassa DA, Bignell AL, Sood A, Morton JS, Akagi T, Azuma K, Rogers MF, Gilmore CE, Inman GJ, Grant S, Chung Y, Aljunaidy MM, Cooke CL, Steinkraus BR, Pocklington A, Logan A, Collett GP, Kemp H, Holmans PA, Murphy MP, Fulga TA, Coney AM, Akashi M, Davidge ST, Case CP.

Sci Rep. 2017 Aug 22;7(1):9079. doi: 10.1038/s41598-017-06300-1.


Cardiovascular susceptibility to in vivo ischemic myocardial injury in male and female rat offspring exposed to prenatal hypoxia.

Shah A, Matsumura N, Quon A, Morton JS, Dyck JRB, Davidge ST.

Clin Sci (Lond). 2017 Aug 10;131(17):2303-2317. doi: 10.1042/CS20171122. Print 2017 Sep 1.


Prenatal hypoxia and placental oxidative stress: linkages to developmental origins of cardiovascular disease.

Aljunaidy MM, Morton JS, Cooke CM, Davidge ST.

Am J Physiol Regul Integr Comp Physiol. 2017 Oct 1;313(4):R395-R399. doi: 10.1152/ajpregu.00245.2017. Epub 2017 Aug 9. Review.


Muscle sympathetic nerve activity and volume-regulating factors in healthy pregnant and nonpregnant women.

Charkoudian N, Usselman CW, Skow RJ, Staab JS, Julian CG, Stickland MK, Chari RS, Khurana R, Davidge ST, Davenport MH, Steinback CD.

Am J Physiol Heart Circ Physiol. 2017 Oct 1;313(4):H782-H787. doi: 10.1152/ajpheart.00312.2017. Epub 2017 Jul 21.


Advanced Maternal Age Worsens Postpartum Vascular Function.

Morton JS, Care AS, Kirschenman R, Cooke CL, Davidge ST.

Front Physiol. 2017 Jun 30;8:465. doi: 10.3389/fphys.2017.00465. eCollection 2017.


Syncytiotrophoblast extracellular vesicles impair rat uterine vascular function via the lectin-like oxidized LDL receptor-1.

Spaans F, Kao CK, Morton JS, Quon AL, Sawamura T, Tannetta DS, Sargent IL, Davidge ST.

PLoS One. 2017 Jul 3;12(7):e0180364. doi: 10.1371/journal.pone.0180364. eCollection 2017.


Pre-gravid predictors of new onset hypertension in pregnancy - Results from a pre-conception cohort study in China.

Wen SW, Tan H, Retnakaran R, Shen M, Zhou S, Xie RH, Smith GN, Davidge ST, Trasler J, Walker MC.

Eur J Obstet Gynecol Reprod Biol. 2017 Jul;214:140-144. doi: 10.1016/j.ejogrb.2017.05.008. Epub 2017 May 12. No abstract available.


Increased heterogeneity of airway calibre in adult rats after hypoxia-induced intrauterine growth restriction.

Wang KCW, Morton JS, Davidge ST, Larcombe AN, James AL, Donovan GM, Noble PB.

Respirology. 2017 Oct;22(7):1329-1335. doi: 10.1111/resp.13071. Epub 2017 May 17.


The Effects of Myo-Inositol and B and D Vitamin Supplementation in the db/+ Mouse Model of Gestational Diabetes Mellitus.

Plows JF, Budin F, Andersson RA, Mills VJ, Mace K, Davidge ST, Vickers MH, Baker PN, Silva-Zolezzi I, Stanley JL.

Nutrients. 2017 Feb 15;9(2). pii: E141. doi: 10.3390/nu9020141.


Mechanisms of Uterine Artery Dysfunction in Pregnancy Complications.

Morton JS, Care AS, Davidge ST.

J Cardiovasc Pharmacol. 2017 Jun;69(6):343-359. doi: 10.1097/FJC.0000000000000468.


Postnatal resveratrol supplementation improves cardiovascular function in male and female intrauterine growth restricted offspring.

Shah A, Quon A, Morton JS, Davidge ST.

Physiol Rep. 2017 Jan;5(2). pii: e13109. doi: 10.14814/phy2.13109.


Loss of smooth muscle cell disintegrin and metalloproteinase 17 transiently suppresses angiotensin II-induced hypertension and end-organ damage.

Shen M, Morton J, Davidge ST, Kassiri Z.

J Mol Cell Cardiol. 2017 Feb;103:11-21. doi: 10.1016/j.yjmcc.2016.12.001. Epub 2016 Dec 16.


Maternal vascular responses to hypoxia in a rat model of intrauterine growth restriction.

Aljunaidy MM, Morton JS, Cooke CL, Davidge ST.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1068-R1075. doi: 10.1152/ajpregu.00119.2016. Epub 2016 Oct 19.


Postpartum Vascular Dysfunction in the Reduced Uteroplacental Perfusion Model of Preeclampsia.

Brennan L, Morton JS, Quon A, Davidge ST.

PLoS One. 2016 Sep 22;11(9):e0162487. doi: 10.1371/journal.pone.0162487. eCollection 2016.


Modulatory Effects of Egg White Ovotransferrin-Derived Tripeptide IRW (Ile-Arg-Trp) on Vascular Smooth Muscle Cells against Angiotensin II Stimulation.

Liao W, Chakrabarti S, Davidge ST, Wu J.

J Agric Food Chem. 2016 Oct 5;64(39):7342-7347. Epub 2016 Sep 27.


Serum Folate Shows an Inverse Association with Blood Pressure in a Cohort of Chinese Women of Childbearing Age: A Cross-Sectional Study.

Shen M, Tan H, Zhou S, Retnakaran R, Smith GN, Davidge ST, Trasler J, Walker MC, Wen SW.

PLoS One. 2016 May 16;11(5):e0155801. doi: 10.1371/journal.pone.0155801. eCollection 2016.


Perinatal Resveratrol Supplementation to Spontaneously Hypertensive Rat Dams Mitigates the Development of Hypertension in Adult Offspring.

Care AS, Sung MM, Panahi S, Gragasin FS, Dyck JR, Davidge ST, Bourque SL.

Hypertension. 2016 May;67(5):1038-44. doi: 10.1161/HYPERTENSIONAHA.115.06793. Epub 2016 Feb 29.


In Utero Origins of Hypertension: Mechanisms and Targets for Therapy.

Morton JS, Cooke CL, Davidge ST.

Physiol Rev. 2016 Apr;96(2):549-603. doi: 10.1152/physrev.00015.2015. Review.


Mechanism of vascular dysfunction due to circulating factors in women with pre-eclampsia.

Kao CK, Morton JS, Quon AL, Reyes LM, Lopez-Jaramillo P, Davidge ST.

Clin Sci (Lond). 2016 Apr 1;130(7):539-49. doi: 10.1042/CS20150678. Epub 2016 Jan 5.


Antioxidant Peptides Identified from Ovotransferrin by the ORAC Method Did Not Show Anti-Inflammatory and Antioxidant Activities in Endothelial Cells.

Jahandideh F, Chakrabarti S, Davidge ST, Wu J.

J Agric Food Chem. 2016 Jan 13;64(1):113-9. doi: 10.1021/acs.jafc.5b04230. Epub 2015 Dec 31.


Sildenafil Therapy Normalizes the Aberrant Metabolomic Profile in the Comt(-/-) Mouse Model of Preeclampsia/Fetal Growth Restriction.

Stanley JL, Sulek K, Andersson IJ, Davidge ST, Kenny LC, Sibley CP, Mandal R, Wishart DS, Broadhurst DI, Baker PN.

Sci Rep. 2015 Dec 15;5:18241. doi: 10.1038/srep18241.


Analysis of G-Protein Coupled Receptor 30 (GPR30) on Endothelial Inflammation.

Chakrabarti S, Davidge ST.

Methods Mol Biol. 2016;1366:503-516. doi: 10.1007/978-1-4939-3127-9_39.


Reduced uterine perfusion pressure decreases functional capillary density in skeletal muscle.

Fraser GM, Morton JS, Schmidt SM, Bourque S, Davidge ST, Davenport MH, Steinback CD.

Am J Physiol Heart Circ Physiol. 2015 Dec 15;309(12):H2002-7. doi: 10.1152/ajpheart.00641.2015. Epub 2015 Oct 16.


Effect of resveratrol on metabolic and cardiovascular function in male and female adult offspring exposed to prenatal hypoxia and a high-fat diet.

Shah A, Reyes LM, Morton JS, Fung D, Schneider J, Davidge ST.

J Physiol. 2016 Mar 1;594(5):1465-82. doi: 10.1113/JP271133. Epub 2015 Nov 4.


Aerobic exercise training reduces cardiac function in adult male offspring exposed to prenatal hypoxia.

Reyes LM, Kirschenman R, Quon A, Morton JS, Shah A, Davidge ST.

Am J Physiol Regul Integr Comp Physiol. 2015 Sep;309(5):R489-98. doi: 10.1152/ajpregu.00201.2015. Epub 2015 Jul 8.


Egg ovotransferrin-derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats.

Majumder K, Liang G, Chen Y, Guan L, Davidge ST, Wu J.

Mol Nutr Food Res. 2015 Sep;59(9):1735-44. doi: 10.1002/mnfr.201500050. Epub 2015 Jun 26.


Effect of advanced maternal age on pregnancy outcomes and vascular function in the rat.

Care AS, Bourque SL, Morton JS, Hjartarson EP, Davidge ST.

Hypertension. 2015 Jun;65(6):1324-30. doi: 10.1161/HYPERTENSIONAHA.115.05167. Epub 2015 Apr 27.


The vascular effects of sodium tanshinone IIA sulphonate in rodent and human pregnancy.

Morton JS, Andersson IJ, Cheung PY, Baker P, Davidge ST.

PLoS One. 2015 Mar 26;10(3):e0121897. doi: 10.1371/journal.pone.0121897. eCollection 2015.


Vascular effects of aerobic exercise training in rat adult offspring exposed to hypoxia-induced intrauterine growth restriction.

Reyes LM, Morton JS, Kirschenman R, DeLorey DS, Davidge ST.

J Physiol. 2015 Apr 15;593(8):1913-29. doi: 10.1113/jphysiol.2014.288449. Epub 2015 Feb 19.

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