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When you're strange: Unusual features of the MUTYH glycosylase and implications in cancer.

Raetz AG, David SS.

DNA Repair (Amst). 2019 Jun 8;80:16-25. doi: 10.1016/j.dnarep.2019.05.005. [Epub ahead of print] Review.


Evolution of Base Excision Repair in Entamoeba histolytica is shaped by gene loss, gene duplication, and lateral gene transfer.

Trasviña-Arenas CH, David SS, Delaye L, Azuara-Liceaga E, Brieba LG.

DNA Repair (Amst). 2019 Apr;76:76-88. doi: 10.1016/j.dnarep.2019.02.009. Epub 2019 Feb 22.


Targeting Base Excision Repair Glycosylases with DNA Containing Transition State Mimics Prepared via Click Chemistry.

Yuen PK, Green SA, Ashby J, Lay KT, Santra A, Chen X, Horvath MP, David SS.

ACS Chem Biol. 2019 Jan 18;14(1):27-36. doi: 10.1021/acschembio.8b00771. Epub 2019 Jan 2.


The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.

Nuñez NN, Khuu C, Babu CS, Bertolani SJ, Rajavel AN, Spear JE, Armas JA, Wright JD, Siegel JB, Lim C, David SS.

J Am Chem Soc. 2018 Oct 17;140(41):13260-13271. doi: 10.1021/jacs.8b06923. Epub 2018 Oct 8.



David SS.

Methods Enzymol. 2018;599:xv-xvii. doi: 10.1016/S0076-6879(18)30010-7. No abstract available.


Cellular Assays for Studying the Fe-S Cluster Containing Base Excision Repair Glycosylase MUTYH and Homologs.

Majumdar C, Nuñez NN, Raetz AG, Khuu C, David SS.

Methods Enzymol. 2018;599:69-99. doi: 10.1016/bs.mie.2017.12.006. Epub 2018 Jan 10.


Fe-S Clusters and MutY Base Excision Repair Glycosylases: Purification, Kinetics, and DNA Affinity Measurements.

Nuñez NN, Majumdar C, Lay KT, David SS.

Methods Enzymol. 2018;599:21-68. doi: 10.1016/bs.mie.2017.11.035. Epub 2018 Jan 10.


Selective base excision repair of DNA damage by the non-base-flipping DNA glycosylase AlkC.

Shi R, Mullins EA, Shen XX, Lay KT, Yuen PK, David SS, Rokas A, Eichman BF.

EMBO J. 2018 Jan 4;37(1):63-74. doi: 10.15252/embj.201797833. Epub 2017 Oct 20.


Structure-Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase.

Manlove AH, McKibbin PL, Doyle EL, Majumdar C, Hamm ML, David SS.

ACS Chem Biol. 2017 Sep 15;12(9):2335-2344. doi: 10.1021/acschembio.7b00389. Epub 2017 Aug 8.


Sulfur K-Edge XAS Studies of the Effect of DNA Binding on the [Fe4S4] Site in EndoIII and MutY.

Ha Y, Arnold AR, Nuñez NN, Bartels PL, Zhou A, David SS, Barton JK, Hedman B, Hodgson KO, Solomon EI.

J Am Chem Soc. 2017 Aug 23;139(33):11434-11442. doi: 10.1021/jacs.7b03966. Epub 2017 Aug 10.


Piecewise Structural Equation Model (SEM) Disentangles the Environmental Conditions Favoring Diatom Diazotroph Associations (DDAs) in the Western Tropical North Atlantic (WTNA).

Stenegren M, Berg C, Padilla CC, David SS, Montoya JP, Yager PL, Foster RA.

Front Microbiol. 2017 May 9;8:810. doi: 10.3389/fmicb.2017.00810. eCollection 2017.


Electrochemistry of the [4Fe4S] Cluster in Base Excision Repair Proteins: Tuning the Redox Potential with DNA.

Bartels PL, Zhou A, Arnold AR, Nuñez NN, Crespilho FN, David SS, Barton JK.

Langmuir. 2017 Mar 14;33(10):2523-2530. doi: 10.1021/acs.langmuir.6b04581. Epub 2017 Mar 2.


Repair of 8-oxoG:A mismatches by the MUTYH glycosylase: Mechanism, metals and medicine.

Banda DM, Nuñez NN, Burnside MA, Bradshaw KM, David SS.

Free Radic Biol Med. 2017 Jun;107:202-215. doi: 10.1016/j.freeradbiomed.2017.01.008. Epub 2017 Jan 10. Review.


Base Excision Repair of N6-Deoxyadenosine Adducts of 1,3-Butadiene.

Wickramaratne S, Banda DM, Ji S, Manlove AH, Malayappan B, Nuñez NN, Samson L, Campbell C, David SS, Tretyakova N.

Biochemistry. 2016 Nov 1;55(43):6070-6081. Epub 2016 Oct 21.


Prehospital trauma care in South India: A glance through the last 15 years.

Adhikari DD, Florence B, David SS.

J Family Med Prim Care. 2016 Jan-Mar;5(1):195-6. doi: 10.4103/2249-4863.184669. No abstract available.


Structure and stereochemistry of the base excision repair glycosylase MutY reveal a mechanism similar to retaining glycosidases.

Woods RD, O'Shea VL, Chu A, Cao S, Richards JL, Horvath MP, David SS.

Nucleic Acids Res. 2016 Jan 29;44(2):801-10. doi: 10.1093/nar/gkv1469. Epub 2015 Dec 15.


The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions.

Mullins EA, Shi R, Parsons ZD, Yuen PK, David SS, Igarashi Y, Eichman BF.

Nature. 2015 Nov 12;527(7577):254-8. doi: 10.1038/nature15728. Epub 2015 Oct 28.


Permissive hypotension in a head-injured multi-trauma patient: Controversies and contradictions.

Senthilkumaran S, David SS, Manikam R, Thirumalaikolundusubramanian P.

J Anaesthesiol Clin Pharmacol. 2015 Jul-Sep;31(3):428-9. doi: 10.4103/0970-9185.161745. No abstract available.


DNMT1 and Cancer: An Electrifying Link.

Nuñez NN, Manlove AH, David SS.

Chem Biol. 2015 Jul 23;22(7):810-1. doi: 10.1016/j.chembiol.2015.07.004.


Cricothyroidotomy and ventilation: physics and physiology.

Senthilkumaran S, David SS, Jena NN, Thirumalaikolundusubramanian P.

J Emerg Med. 2014 Nov;47(5):e131. doi: 10.1016/j.jemermed.2013.08.147. Epub 2014 Sep 8. No abstract available.


Concern, counseling and consent for bariatric surgery.

SenthilKumaran S, David SS, Menezes RG, Thirumalaikolundusubramanian P.

Indian J Nephrol. 2014 Jul;24(4):263-4. doi: 10.4103/0971-4065.133045. No abstract available.


Microscopic mechanism of DNA damage searching by hOGG1.

Rowland MM, Schonhoft JD, McKibbin PL, David SS, Stivers JT.

Nucleic Acids Res. 2014 Aug;42(14):9295-303. doi: 10.1093/nar/gku621. Epub 2014 Jul 12.


Continuous versus intermittent methylene blue administration: which spin will win?

Senthilkumaran S, David SS, Manikam R, Thirumalaikolundusubramanian P.

Indian J Crit Care Med. 2014 Jun;18(6):407-8. doi: 10.4103/0972-5229.133953. No abstract available.


A zinc linchpin motif in the MUTYH glycosylase interdomain connector is required for efficient repair of DNA damage.

Engstrom LM, Brinkmeyer MK, Ha Y, Raetz AG, Hedman B, Hodgson KO, Solomon EI, David SS.

J Am Chem Soc. 2014 Jun 4;136(22):7829-32. doi: 10.1021/ja502942d. Epub 2014 May 23.


Henna leaf ingestion and intravascular hemolysis: the missing link.

Senthilkumaran S, David SS, Menezes RG, Thirumalaikolundusubramanian P.

Saudi J Kidney Dis Transpl. 2014 May;25(3):667-8. No abstract available.


Acute myocardial infarction and cocaine toxicity: One step closer.

Senthilkumaran S, David SS, Jena NN, Menezes RG, Thirumalaikolundusubramanian P.

Indian J Crit Care Med. 2014 Feb;18(2):118. doi: 10.4103/0972-5229.126091. No abstract available.


Limitations and consumer aspects of point-of-care in snake envenomation.

Senthilkumaran S, David SS, Jena NN, Thirumalaikolundusubramanian P.

Emerg Med Australas. 2014 Apr;26(2):208. doi: 10.1111/1742-6723.12161. Epub 2013 Nov 18. No abstract available.


Acute myocardial infarction triggered by bee sting: an alternative view.

Senthilkumaran S, David SS, Menezes RG, Thirumalaikolundusubramanian P.

Emerg Med Australas. 2013 Dec;25(6):615. doi: 10.1111/1742-6723.12140. Epub 2013 Oct 11. No abstract available.


Need for parenteral pyridoxine: A clarion call.

Senthilkumaran S, David SS, Menezes RG, Thirumalaikolundusubramanian P.

Indian J Nephrol. 2013 Jul;23(4):324-5. doi: 10.4103/0971-4065.114501. No abstract available.


Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair.

McKibbin PL, Fleming AM, Towheed MA, Van Houten B, Burrows CJ, David SS.

J Am Chem Soc. 2013 Sep 18;135(37):13851-61. doi: 10.1021/ja4059469. Epub 2013 Sep 5.


Atropine resistant bradycardia and hyperkalemia: our experiences.

Senthilkumaran S, David SS, Manikam R, Thirumalaikolundusubramanian P.

Am J Emerg Med. 2013 Sep;31(9):1415. doi: 10.1016/j.ajem.2013.06.020. Epub 2013 Jul 29. No abstract available.


Epinephrine-induced myocardial infarction in severe anaphylaxis: is β-blocker a bad actor or bystander?

Senthilkumaran S, David SS, Jena NN, Thirumalaikolundusubramanian P.

Am J Emerg Med. 2013 Sep;31(9):1410. doi: 10.1016/j.ajem.2013.04.027. Epub 2013 Jun 29. No abstract available.


Role of fresh-frozen plasma in angioedema: progress and problems.

Senthilkumaran S, David SS, Menezes RG, Thirumalaikolundusubramanian P.

Eur J Emerg Med. 2013 Aug;20(4):292-3. doi: 10.1097/MEJ.0b013e328360d8b6. No abstract available.


Energy drinks overdose and metabolic abnormalities--a double whammy!

Senthilkumaran S, David SS, Balamurugan N, Thirumalaikolundusubramanian P.

Am J Emerg Med. 2013 Jun;31(6):984. doi: 10.1016/j.ajem.2013.02.016. Epub 2013 Apr 18. No abstract available.


C-reactive protein value in organophosphate-poisoned patients - Promises and pitfalls.

Senthilkumaran S, David SS, Menezes RG, Thirumalaikolundusubramanian P.

Clin Toxicol (Phila). 2013 Feb;51(2):121. doi: 10.3109/15563650.2013.765011. Epub 2013 Jan 29. No abstract available.


Gas-phase studies of substrates for the DNA mismatch repair enzyme MutY.

Michelson AZ, Rozenberg A, Tian Y, Sun X, Davis J, Francis AW, O'Shea VL, Halasyam M, Manlove AH, David SS, Lee JK.

J Am Chem Soc. 2012 Dec 5;134(48):19839-50. doi: 10.1021/ja309082k. Epub 2012 Nov 26.


Cancer-associated variants and a common polymorphism of MUTYH exhibit reduced repair of oxidative DNA damage using a GFP-based assay in mammalian cells.

Raetz AG, Xie Y, Kundu S, Brinkmeyer MK, Chang C, David SS.

Carcinogenesis. 2012 Nov;33(11):2301-9. doi: 10.1093/carcin/bgs270. Epub 2012 Aug 26.


An iron-sulfur cluster loop motif in the Archaeoglobus fulgidus uracil-DNA glycosylase mediates efficient uracil recognition and removal.

Engstrom LM, Partington OA, David SS.

Biochemistry. 2012 Jun 26;51(25):5187-97. doi: 10.1021/bi3000462. Epub 2012 Jun 12.


NEIL1 binding to DNA containing 2'-fluorothymidine glycol stereoisomers and the effect of editing.

Onizuka K, Yeo J, David SS, Beal PA.

Chembiochem. 2012 Jun 18;13(9):1338-48. doi: 10.1002/cbic.201200139. Epub 2012 May 25.


Catalytic contributions of key residues in the adenine glycosylase MutY revealed by pH-dependent kinetics and cellular repair assays.

Brinkmeyer MK, Pope MA, David SS.

Chem Biol. 2012 Feb 24;19(2):276-86. doi: 10.1016/j.chembiol.2011.11.011.


Direct fluorescence monitoring of DNA base excision repair.

Ono T, Wang S, Koo CK, Engstrom L, David SS, Kool ET.

Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1689-92. doi: 10.1002/anie.201108135. Epub 2012 Jan 12. No abstract available.


Surprising repair activities of nonpolar analogs of 8-oxoG expose features of recognition and catalysis by base excision repair glycosylases.

McKibbin PL, Kobori A, Taniguchi Y, Kool ET, David SS.

J Am Chem Soc. 2012 Jan 25;134(3):1653-61. doi: 10.1021/ja208510m. Epub 2012 Jan 9.


Profiling base excision repair glycosylases with synthesized transition state analogs.

Chu AM, Fettinger JC, David SS.

Bioorg Med Chem Lett. 2011 Sep 1;21(17):4969-72. doi: 10.1016/j.bmcl.2011.05.085. Epub 2011 May 30.


RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1.

Yeo J, Goodman RA, Schirle NT, David SS, Beal PA.

Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20715-9. doi: 10.1073/pnas.1009231107. Epub 2010 Nov 10.


Bioscavenger therapy for organophosphate poisoning - an open-labeled pilot randomized trial comparing fresh frozen plasma or albumin with saline in acute organophosphate poisoning in humans.

Pichamuthu K, Jerobin J, Nair A, John G, Kamalesh J, Thomas K, Jose A, Fleming JJ, Zachariah A, David SS, Daniel D, Peter JV.

Clin Toxicol (Phila). 2010 Oct;48(8):813-9. doi: 10.3109/15563650.2010.518970. Epub 2010 Oct 6.


Ser 524 is a phosphorylation site in MUTYH and Ser 524 mutations alter 8-oxoguanine (OG): a mismatch recognition.

Kundu S, Brinkmeyer MK, Eigenheer RA, David SS.

DNA Repair (Amst). 2010 Oct 5;9(10):1026-37. doi: 10.1016/j.dnarep.2010.07.002. Epub 2010 Aug 17.


Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine.

Dias-Santagata D, Akhavanfard S, David SS, Vernovsky K, Kuhlmann G, Boisvert SL, Stubbs H, McDermott U, Settleman J, Kwak EL, Clark JW, Isakoff SJ, Sequist LV, Engelman JA, Lynch TJ, Haber DA, Louis DN, Ellisen LW, Borger DR, Iafrate AJ.

EMBO Mol Med. 2010 May;2(5):146-58. doi: 10.1002/emmm.201000070.


Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts.

Zhao X, Krishnamurthy N, Burrows CJ, David SS.

Biochemistry. 2010 Mar 2;49(8):1658-66. doi: 10.1021/bi901852q.


Morphometric analysis and clinical application of the working dimensions of cricothyroid membrane in south Indian adults: with special relevance to surgical cricothyroidotomy.

Prithishkumar IJ, David SS.

Emerg Med Australas. 2010 Feb;22(1):13-20. doi: 10.1111/j.1742-6723.2009.01245.x. Epub 2009 Dec 1.


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