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An IL-15 Superagonist, ALT-803, Enhances Antibody-Dependent Cell-Mediated Cytotoxicity Elicited by the Monoclonal Antibody NEO-201 Against Human Carcinoma Cells.

Fantini M, David JM, Wong HC, Annunziata CM, Arlen PM, Tsang KY.

Cancer Biother Radiopharm. 2019 Jan 2. doi: 10.1089/cbr.2018.2628. [Epub ahead of print]


Toxicological evaluation of the biflavonoid, agathisflavone in albino Swiss mice.

Lopes Andrade AW, Dias Ribeiro Figueiredo D, Torequl Islam M, Viana Nunes AM, da Conceição Machado K, da Conceição Machado K, Uddin SJ, Ahmed Shilpi J, Rouf R, de Carvalho Melo-Cavalcante AA, David JM, Mubarak MS, Pereira Costa J.

Biomed Pharmacother. 2019 Feb;110:68-73. doi: 10.1016/j.biopha.2018.11.050. Epub 2018 Nov 19.


Effects of Rodent Thermoregulation on Animal Models in the Research Environment.

Hankenson FC, Marx JO, Gordon CJ, David JM.

Comp Med. 2018 Nov 20. doi: 10.30802/AALAS-CM-18-000049. [Epub ahead of print]


Seasonal variation in the chemical composition of two chemotypes of Lippia alba.

Gomes AF, Almeida MP, Leite MF, Schwaiger S, Stuppner H, Halabalaki M, Amaral JG, David JM.

Food Chem. 2019 Feb 1;273:186-193. doi: 10.1016/j.foodchem.2017.11.089. Epub 2017 Nov 23.


Mineral content in mustard leaves according to the cooking method.

Lima AMS, Dos Santos LO, David JM, Ferreira SLC.

Food Chem. 2019 Feb 1;273:172-177. doi: 10.1016/j.foodchem.2017.12.042. Epub 2017 Dec 13.


Neoadjuvant PET and MRI-based intensity modulated radiotherapy leads to less toxicity and improved pathologic response rates in locally advanced rectal cancer.

David JM, Gresham G, Jabbour SK, Deek M, Thomassian S, Robertson JM, Newman NB, Herman JM, Osipov A, Kabolizadeh P, Tuli R.

J Gastrointest Oncol. 2018 Aug;9(4):641-649. doi: 10.21037/jgo.2018.03.10.


In vitro antioxidant properties of the biflavonoid agathisflavone.

Andrade AWL, Machado KDC, Machado KDC, Figueiredo DDR, David JM, Islam MT, Uddin SJ, Shilpi JA, Costa JP.

Chem Cent J. 2018 Jun 29;12(1):75. doi: 10.1186/s13065-018-0443-0.


Evaluation of warming devices for lateral tail vein blood collection in mice (Mus musculus).

David JM, Chen X.

J Pharmacol Toxicol Methods. 2018 Nov - Dec;94(Pt 1):87-93. doi: 10.1016/j.vascn.2018.06.002. Epub 2018 Jun 15. No abstract available.


In vitro ovicidal and larvicidal activities of some saponins and flavonoids against parasitic nematodes of goats.

Santos ACV, Santos FO, Lima HG, Silva GDD, Uzêda RS, Dias ÊR, Branco A, Cardoso KV, David JM, Botura MB, Costa SL, Batatinha MJM.

Parasitology. 2018 Dec;145(14):1884-1889. doi: 10.1017/S0031182018000689. Epub 2018 May 21.


Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity.

Dos Santos Souza C, Grangeiro MS, Lima Pereira EP, Dos Santos CC, da Silva AB, Sampaio GP, Ribeiro Figueiredo DD, David JM, David JP, da Silva VDA, Butt AM, Lima Costa S.

Neurotoxicology. 2018 Mar;65:85-97. doi: 10.1016/j.neuro.2018.02.001. Epub 2018 Feb 6.


Postoperative chemoradiotherapy in patients with head and neck cancer aged 70 or older with positive margins or extranodal extension and the influence of nodal classification.

Yoshida EJ, Luu M, David JM, Kim S, Mita A, Scher K, Shiao SL, Tighiouart M, Ho AS, Zumsteg ZS.

Head Neck. 2018 Jun;40(6):1228-1236. doi: 10.1002/hed.25100. Epub 2018 Feb 8.


Preclinical Characterization of a Novel Monoclonal Antibody NEO-201 for the Treatment of Human Carcinomas.

Fantini M, David JM, Saric O, Dubeykovskiy A, Cui Y, Mavroukakis SA, Bristol A, Annunziata CM, Tsang KY, Arlen PM.

Front Immunol. 2018 Jan 4;8:1899. doi: 10.3389/fimmu.2017.01899. eCollection 2017.


Absence of toxicity in Swiss mice following treatment with 7-acetoxy-4-aryl-3,4-dihydrocoumarin: Acute and repeated-dose toxicity study.

Saldanha GB, Saldanha GB, de Sousa MRSC, Oliveira GLDS, da Silva APDSCL, David JM, David JP.

Regul Toxicol Pharmacol. 2018 Apr;94:75-82. doi: 10.1016/j.yrtph.2018.01.003. Epub 2018 Jan 13.


A novel bifunctional anti-PD-L1/TGF-β Trap fusion protein (M7824) efficiently reverts mesenchymalization of human lung cancer cells.

David JM, Dominguez C, McCampbell KK, Gulley JL, Schlom J, Palena C.

Oncoimmunology. 2017 Jul 13;6(10):e1349589. doi: 10.1080/2162402X.2017.1349589. eCollection 2017.


Facility Volume and Survival in Nasopharyngeal Carcinoma.

Yoshida EJ, Luu M, David JM, Kim S, Mita A, Scher K, Shiao SL, Tighiouart M, Lee NY, Ho AS, Zumsteg ZS.

Int J Radiat Oncol Biol Phys. 2018 Feb 1;100(2):408-417. doi: 10.1016/j.ijrobp.2017.09.038. Epub 2017 Sep 28.


Neutralization of IL-8 decreases tumor PMN-MDSCs and reduces mesenchymalization of claudin-low triple-negative breast cancer.

Dominguez C, McCampbell KK, David JM, Palena C.

JCI Insight. 2017 Nov 2;2(21). pii: 94296. doi: 10.1172/jci.insight.94296. [Epub ahead of print]


Do contamination of and exposure to chicken meat and water drive the temporal dynamics of Campylobacter cases?

David JM, Pollari F, Pintar KDM, Nesbitt A, Butler AJ, Ravel A.

Epidemiol Infect. 2017 Nov;145(15):3191-3203. doi: 10.1017/S0950268817002199. Epub 2017 Oct 12.


Brachyury-YAP Regulatory Axis Drives Stemness and Growth in Cancer.

Shah SR, David JM, Tippens ND, Mohyeldin A, Martinez-Gutierrez JC, Ganaha S, Schiapparelli P, Hamilton DH, Palena C, Levchenko A, Quiñones-Hinojosa A.

Cell Rep. 2017 Oct 10;21(2):495-507. doi: 10.1016/j.celrep.2017.09.057.


Epithelial-mesenchymal transition and inflammation at the site of the primary tumor.

Dominguez C, David JM, Palena C.

Semin Cancer Biol. 2017 Dec;47:177-184. doi: 10.1016/j.semcancer.2017.08.002. Epub 2017 Aug 18. Review.


Combined high-intensity local treatment and systemic therapy in metastatic head and neck squamous cell carcinoma: An analysis of the National Cancer Data Base.

Zumsteg ZS, Luu M, Yoshida EJ, Kim S, Tighiouart M, David JM, Shiao SL, Mita AC, Scher KS, Sherman EJ, Lee NY, Ho AS.

Cancer. 2017 Dec 1;123(23):4583-4593. doi: 10.1002/cncr.30933. Epub 2017 Aug 17.


Terpene Esters from Natural Products: Synthesis and Evaluation of Cytotoxic Activity.

Victor MM, David JM, Sakukuma MCK, Costa-Lotufo LV, Moura AF, Araújo AJ.

An Acad Bras Cienc. 2017 Jul-Sep;89(3):1369-1379. doi: 10.1590/0001-3765201720160780. Epub 2017 Aug 14.


Treatment at high-volume facilities and academic centers is independently associated with improved survival in patients with locally advanced head and neck cancer.

David JM, Ho AS, Luu M, Yoshida EJ, Kim S, Mita AC, Scher KS, Shiao SL, Tighiouart M, Zumsteg ZS.

Cancer. 2017 Oct 15;123(20):3933-3942. doi: 10.1002/cncr.30843. Epub 2017 Jun 22.


Betulinic Acid from Zizyphus Joazeiro Bark Using Focused Microwave-Assisted Extraction and Response Surface Methodology.

Fonseca FCS, Reis LCB, Dos Santos JDG, Branco CRC, Ferreira SLDC, David JM, Branco A.

Pharmacogn Mag. 2017 Apr-Jun;13(50):226-229. doi: 10.4103/0973-1296.204565. Epub 2017 Apr 18.


Identification and characterization of enhancer agonist human cytotoxic T-cell epitopes of the human papillomavirus type 16 (HPV16) E6/E7.

Tsang KY, Fantini M, Fernando RI, Palena C, David JM, Hodge JW, Gabitzsch ES, Jones FR, Schlom J.

Vaccine. 2017 May 2;35(19):2605-2611. doi: 10.1016/j.vaccine.2017.03.025. Epub 2017 Apr 4.


Bergenin from Peltophorum dubium: Isolation, Characterization, and Antioxidant Activities in Non-Biological Systems and Erythrocytes.

de Oliveira GAL, da Silva Oliveira GL, Nicolau LAD, Mafud AC, Batista LF, Mascarenhas YP, de Sousa LKM, David JM, Pinto LS, Alves CQ, Medeiros JVR.

Med Chem. 2017;13(6):592-603. doi: 10.2174/1573406413666170306120152.


Development of Cancer Vaccines Targeting Brachyury, a Transcription Factor Associated with Tumor Epithelial-Mesenchymal Transition.

Hamilton DH, David JM, Dominguez C, Palena C.

Cells Tissues Organs. 2017;203(2):128-138. doi: 10.1159/000446495. Epub 2017 Feb 20. Review.


Impact of concomitant chemoradiation on survival for patients with T1-2N1 head and neck cancer.

Zumsteg ZS, Kim S, David JM, Yoshida EJ, Tighiouart M, Shiao SL, Scher K, Mita A, Sherman EJ, Lee NY, Ho AS.

Cancer. 2017 May 1;123(9):1555-1565. doi: 10.1002/cncr.30508. Epub 2016 Dec 21.


Pharmacological and immunological targeting of tumor mesenchymalization.

David JM, Dominguez C, Palena C.

Pharmacol Ther. 2017 Feb;170:212-225. doi: 10.1016/j.pharmthera.2016.11.011. Epub 2016 Dec 1. Review.


Poligalen, a new coumarin from Polygala boliviensis, reduces the release of TNF and IL-6 independent of NF-kB downregulation.

Silva DF, Alves CQ, Brandão HN, David JM, David JP, Silva RL, Franchin M, Cunha TM, Martins FT, Oliveira CM.

Fitoterapia. 2016 Sep;113:139-43. doi: 10.1016/j.fitote.2016.07.021. Epub 2016 Aug 2.


The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance.

David JM, Dominguez C, Hamilton DH, Palena C.

Vaccines (Basel). 2016 Jun 24;4(3). pii: E22. doi: 10.3390/vaccines4030022. Review.


Detection and Quantification of Rotenoids from Clitoria fairchildiana and its Lipids Profile.

Santos RA, David JM, David JP.

Nat Prod Commun. 2016 May;11(5):631-2.


Targeting Estrogen Receptor Signaling with Fulvestrant Enhances Immune and Chemotherapy-Mediated Cytotoxicity of Human Lung Cancer.

Hamilton DH, Griner LM, Keller JM, Hu X, Southall N, Marugan J, David JM, Ferrer M, Palena C.

Clin Cancer Res. 2016 Dec 15;22(24):6204-6216. Epub 2016 Jun 7.


IL-8 signaling is involved in resistance of lung carcinoma cells to erlotinib.

Fernando RI, Hamilton DH, Dominguez C, David JM, McCampbell KK, Palena C.

Oncotarget. 2016 Jul 5;7(27):42031-42044. doi: 10.18632/oncotarget.9662.


MUC1 upregulation promotes immune resistance in tumor cells undergoing brachyury-mediated epithelial-mesenchymal transition.

David JM, Hamilton DH, Palena C.

Oncoimmunology. 2016 Jan 6;5(4):e1117738. eCollection 2016 Apr.


Pre-clinical toxicology of garcinielliptone FC, a tautomeric pair of polyprenylated benzophenone, isolated from Platonia insignis Mart seeds.

da Silva AP, Oliveira GL, Medeiros SC, Sousa AM, Lopes Lda S, David JM, da Costa Junior JS, de Freitas RM.

Phytomedicine. 2016 May 15;23(5):477-82. doi: 10.1016/j.phymed.2016.02.013. Epub 2016 Mar 8.


Antinoceptive and Anti-inflammatory Activities of the Ethanolic Extract, Fractions and Flavones Isolated from Mimosa tenuiflora (Willd.) Poir (Leguminosae).

Cruz MP, Andrade CM, Silva KO, de Souza EP, Yatsuda R, Marques LM, David JP, David JM, Napimoga MH, Clemente-Napimoga JT.

PLoS One. 2016 Mar 8;11(3):e0150839. doi: 10.1371/journal.pone.0150839. eCollection 2016.


Soy Isoflavones Promote Radioprotection of Normal Lung Tissue by Inhibition of Radiation-Induced Activation of Macrophages and Neutrophils.

Abernathy LM, Fountain MD, Rothstein SE, David JM, Yunker CK, Rakowski J, Lonardo F, Joiner MC, Hillman GG.

J Thorac Oncol. 2015 Dec;10(12):1703-12. doi: 10.1097/JTO.0000000000000677.


The generation and analyses of a novel combination of recombinant adenovirus vaccines targeting three tumor antigens as an immunotherapeutic.

Gabitzsch ES, Tsang KY, Palena C, David JM, Fantini M, Kwilas A, Rice AE, Latchman Y, Hodge JW, Gulley JL, Madan RA, Heery CR, Balint JP Jr, Jones FR, Schlom J.

Oncotarget. 2015 Oct 13;6(31):31344-59. doi: 10.18632/oncotarget.5181.


A Scientific Software Product Line for the Bioinformatics domain.

Costa GC, Braga R, David JM, Campos F.

J Biomed Inform. 2015 Aug;56:239-64. doi: 10.1016/j.jbi.2015.05.014. Epub 2015 Jun 14.


Cytotoxicity of the diterpene 14-O-methyl-ryanodanol from Erythroxylum passerinum in an astrocytic cells model.

Menezes-Filho Nde J, Souza Cdos S, Costa TC, Da Silva VD, Ribeiro CS, Barreiros ML, Costa JF, David JM, David JP, Costa SL.

Nat Prod Commun. 2014 Sep;9(9):1245-8.


Comprehensive bioimaging with fluorinated nanoparticles using breathable liquids.

Kurczy ME, Zhu ZJ, Ivanisevic J, Schuyler AM, Lalwani K, Santidrian AF, David JM, Giddabasappa A, Roberts AJ, Olivos HJ, O'Brien PJ, Franco L, Fields MW, Paris LP, Friedlander M, Johnson CH, Epstein AA, Gendelman HE, Wood MR, Felding BH, Patti GJ, Spilker ME, Siuzdak G.

Nat Commun. 2015 Jan 20;6:5998. doi: 10.1038/ncomms6998.


Gramicidin A: A New Mission for an Old Antibiotic.

David JM, Rajasekaran AK.

J Kidney Cancer VHL. 2015 Jan 18;2(1):15-24. doi: 10.15586/jkcvhl.2015.21. eCollection 2015.


Cardiovascular effects of a labdenic diterpene isolated from Moldenhawera nutans in conscious, spontaneously hypertensive rats.

de Barros Correia Junior CA, Bezerra de Siqueira RJ, Leal Interaminense LF, Alves-Santos TR, Duarte GP, David JM, David JP, Magalhães PJ, Lahlou S.

Pharm Biol. 2015 Apr;53(4):582-7. doi: 10.3109/13880209.2014.934964. Epub 2014 Dec 9.


α2-Adrenergic blockade mimics the enhancing effect of chronic stress on breast cancer progression.

Lamkin DM, Sung HY, Yang GS, David JM, Ma JC, Cole SW, Sloan EK.

Psychoneuroendocrinology. 2015 Jan;51:262-70. doi: 10.1016/j.psyneuen.2014.10.004. Epub 2014 Oct 12.


In vitro effects of arylhydrocoumarin on free radicals and oxidative stress in erythrocytes and Saccharomyces cerevisiae.

de Freitas RL, Oliveira GL, de Freitas RM, Barreiros AL, David JP, Alves CQ, Pinto CR, David JM.

Curr Pharm Biotechnol. 2014;15(11):1069-82.


Mikania glomerata: Phytochemical, Pharmacological, and Neurochemical Study.

Santana LC, Brito MR, Oliveira GL, Citó AM, Alves CQ, David JP, David JM, de Freitas RM.

Evid Based Complement Alternat Med. 2014;2014:710410. doi: 10.1155/2014/710410. Epub 2014 Aug 18.


Determination of Flavanones in Orange Juices Obtained from Different Sources by HPLC/DAD.

Silva LC, David JM, Borges Rdos S, Ferreira SL, David JP, Dos Reis PS, Bruns RE.

J Anal Methods Chem. 2014;2014:296838. doi: 10.1155/2014/296838. Epub 2014 Aug 7.


Wilms' tumor protein induces an epithelial-mesenchymal hybrid differentiation state in clear cell renal cell carcinoma.

Sampson VB, David JM, Puig I, Patil PU, de Herreros AG, Thomas GV, Rajasekaran AK.

PLoS One. 2014 Jul 15;9(7):e102041. doi: 10.1371/journal.pone.0102041. eCollection 2014.


Association of diffuse idiopathic skeletal hyperostosis and aortic valve sclerosis.

Orden AO, David JM, Díaz RP, Nardi NN, Ejarque AC, Yöchler AB.

Medicina (B Aires). 2014;74(3):205-9.


Behavioral and neurochemical studies in mice pretreated with garcinielliptone FC in pilocarpine-induced seizures.

da Silva AP, Lopes JS, Vieira Pde S, Pinheiro EE, da Silva ML, Silva Filho JC, da Costa JS Jr, David JM, de Freitas RM.

Pharmacol Biochem Behav. 2014 Sep;124:305-10. doi: 10.1016/j.pbb.2014.05.021. Epub 2014 Jun 6.

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