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Items: 1 to 50 of 162

1.

The Natural Product Eugenol Is an Inhibitor of the Ebola Virus In Vitro.

Lane T, Anantpadma M, Freundlich JS, Davey RA, Madrid PB, Ekins S.

Pharm Res. 2019 May 17;36(7):104. doi: 10.1007/s11095-019-2629-0.

PMID:
31101988
2.

The androgen receptor in the hypothalamus positively regulates hind-limb muscle mass and voluntary physical activity in adult male mice.

Clarke MV, Russell PK, Zajac JD, Davey RA.

J Steroid Biochem Mol Biol. 2019 May;189:187-194. doi: 10.1016/j.jsbmb.2019.02.018. Epub 2019 Mar 8.

PMID:
30853652
3.

Ebola Virus Bayesian Machine Learning Models Enable New in Vitro Leads.

Anantpadma M, Lane T, Zorn KM, Lingerfelt MA, Clark AM, Freundlich JS, Davey RA, Madrid PB, Ekins S.

ACS Omega. 2019 Jan 31;4(1):2353-2361. doi: 10.1021/acsomega.8b02948. Epub 2019 Jan 30.

4.

Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.

Batra J, Hultquist JF, Liu D, Shtanko O, Von Dollen J, Satkamp L, Jang GM, Luthra P, Schwarz TM, Small GI, Arnett E, Anantpadma M, Reyes A, Leung DW, Kaake R, Haas P, Schmidt CB, Schlesinger LS, LaCount DJ, Davey RA, Amarasinghe GK, Basler CF, Krogan NJ.

Cell. 2018 Dec 13;175(7):1917-1930.e13. doi: 10.1016/j.cell.2018.08.044.

PMID:
30550789
5.

Identification of Diaryl-Quinoline Compounds as Entry Inhibitors of Ebola Virus.

Cui Q, Cheng H, Xiong R, Zhang G, Du R, Anantpadma M, Davey RA, Rong L.

Viruses. 2018 Nov 30;10(12). pii: E678. doi: 10.3390/v10120678.

6.

Novel amodiaquine derivatives potently inhibit Ebola virus infection.

Sakurai Y, Sakakibara N, Toyama M, Baba M, Davey RA.

Antiviral Res. 2018 Dec;160:175-182. doi: 10.1016/j.antiviral.2018.10.025. Epub 2018 Nov 3.

PMID:
30395872
7.

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses.

Luthra P, Naidoo J, Pietzsch CA, De S, Khadka S, Anantpadma M, Williams CG, Edwards MR, Davey RA, Bukreyev A, Ready JM, Basler CF.

Antiviral Res. 2018 Oct;158:288-302. doi: 10.1016/j.antiviral.2018.08.012. Epub 2018 Aug 23.

PMID:
30144461
8.

Autophagy-Associated Proteins Control Ebola Virus Internalization Into Host Cells.

Shtanko O, Reyes AN, Jackson WT, Davey RA.

J Infect Dis. 2018 Nov 22;218(suppl_5):S346-S354. doi: 10.1093/infdis/jiy294.

9.

Development of Clinical-Stage Human Monoclonal Antibodies That Treat Advanced Ebola Virus Disease in Nonhuman Primates.

Pascal KE, Dudgeon D, Trefry JC, Anantpadma M, Sakurai Y, Murin CD, Turner HL, Fairhurst J, Torres M, Rafique A, Yan Y, Badithe A, Yu K, Potocky T, Bixler SL, Chance TB, Pratt WD, Rossi FD, Shamblin JD, Wollen SE, Zelko JM, Carrion R Jr, Worwa G, Staples HM, Burakov D, Babb R, Chen G, Martin J, Huang TT, Erlandson K, Willis MS, Armstrong K, Dreier TM, Ward AB, Davey RA, Pitt MLM, Lipsich L, Mason P, Olson W, Stahl N, Kyratsous CA.

J Infect Dis. 2018 Nov 22;218(suppl_5):S612-S626. doi: 10.1093/infdis/jiy285.

10.

Identification of Ellagic Acid from Plant Rhodiola rosea L. as an Anti-Ebola Virus Entry Inhibitor.

Cui Q, Du R, Anantpadma M, Schafer A, Hou L, Tian J, Davey RA, Cheng H, Rong L.

Viruses. 2018 Mar 27;10(4). pii: E152. doi: 10.3390/v10040152.

11.

The androgen receptor in bone marrow progenitor cells negatively regulates fat mass.

Russell PK, Mangiafico S, Fam BC, Clarke MV, Marin ES, Andrikopoulos S, Wiren KM, Zajac JD, Davey RA.

J Endocrinol. 2018 Apr;237(1):15-27. doi: 10.1530/JOE-17-0656. Epub 2018 Jan 31.

PMID:
29386237
12.

Retro-2 and its dihydroquinazolinone derivatives inhibit filovirus infection.

Shtanko O, Sakurai Y, Reyes AN, Noël R, Cintrat JC, Gillet D, Barbier J, Davey RA.

Antiviral Res. 2018 Jan;149:154-163. doi: 10.1016/j.antiviral.2017.11.016. Epub 2017 Nov 22.

13.

ABMA, a small molecule that inhibits intracellular toxins and pathogens by interfering with late endosomal compartments.

Wu Y, Pons V, Goudet A, Panigai L, Fischer A, Herweg JA, Kali S, Davey RA, Laporte J, Bouclier C, Yousfi R, Aubenque C, Merer G, Gobbo E, Lopez R, Gillet C, Cojean S, Popoff MR, Clayette P, Le Grand R, Boulogne C, Tordo N, Lemichez E, Loiseau PM, Rudel T, Sauvaire D, Cintrat JC, Gillet D, Barbier J.

Sci Rep. 2017 Nov 14;7(1):15567. doi: 10.1038/s41598-017-15466-7.

14.

Absence of vitamin D receptor in mature osteoclasts results in altered osteoclastic activity and bone loss.

Starczak Y, Reinke DC, Barratt KR, Ryan JW, Russell PK, Clarke MV, St-Arnaud R, Morris HA, Davey RA, Atkins GJ, Anderson PH.

J Steroid Biochem Mol Biol. 2018 Mar;177:77-82. doi: 10.1016/j.jsbmb.2017.10.022. Epub 2017 Oct 28.

PMID:
29107736
15.

Androgen Action via the Androgen Receptor in Neurons Within the Brain Positively Regulates Muscle Mass in Male Mice.

Davey RA, Clarke MV, Russell PK, Rana K, Seto J, Roeszler KN, How JMY, Chia LY, North K, Zajac JD.

Endocrinology. 2017 Oct 1;158(10):3684-3695. doi: 10.1210/en.2017-00470.

PMID:
28977603
16.

Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer.

Cheung AS, de Rooy C, Levinger I, Rana K, Clarke MV, How JM, Garnham A, McLean C, Zajac JD, Davey RA, Grossmann M.

J Steroid Biochem Mol Biol. 2017 Nov;174:56-64. doi: 10.1016/j.jsbmb.2017.07.029. Epub 2017 Jul 27.

PMID:
28756295
17.

Mechanisms of Filovirus Entry.

Davey RA, Shtanko O, Anantpadma M, Sakurai Y, Chandran K, Maury W.

Curr Top Microbiol Immunol. 2017;411:323-352. doi: 10.1007/82_2017_14. Review.

PMID:
28601947
18.

Reduced bone formation markers, and altered trabecular and cortical bone mineral densities of non-paretic femurs observed in rats with ischemic stroke: A randomized controlled pilot study.

Borschmann KN, Rewell SS, Iuliano S, Ghasem-Zadeh A, Davey RA, Ho H, Skeers PN, Bernhardt J, Howells DW.

PLoS One. 2017 Mar 9;12(3):e0172889. doi: 10.1371/journal.pone.0172889. eCollection 2017.

19.

Inhibitors of retrograde trafficking active against ricin and Shiga toxins also protect cells from several viruses, Leishmania and Chlamydiales.

Gupta N, Noël R, Goudet A, Hinsinger K, Michau A, Pons V, Abdelkafi H, Secher T, Shima A, Shtanko O, Sakurai Y, Cojean S, Pomel S, Liévin-Le Moal V, Leignel V, Herweg JA, Fischer A, Johannes L, Harrison K, Beard PM, Clayette P, Le Grand R, Rayner JO, Rudel T, Vacus J, Loiseau PM, Davey RA, Oswald E, Cintrat JC, Barbier J, Gillet D.

Chem Biol Interact. 2017 Apr 1;267:96-103. doi: 10.1016/j.cbi.2016.10.005. Epub 2016 Oct 3.

PMID:
27712998
20.

Corrigendum: Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining.

Wang B, Kluwe CA, Lungu OI, DeKosky BJ, Kerr SA, Johnson EL, Tanno H, Lee CH, Jung J, Rezigh AB, Carroll SM, Reyes AN, Bentz JR, Villanueva I, Altman AL, Davey RA, Ellington AD, Georgiou G.

Sci Rep. 2016 Jun 10;6:27229. doi: 10.1038/srep27229. No abstract available.

21.

Discovery of a Broad-Spectrum Antiviral Compound That Inhibits Pyrimidine Biosynthesis and Establishes a Type 1 Interferon-Independent Antiviral State.

Chung DH, Golden JE, Adcock RS, Schroeder CE, Chu YK, Sotsky JB, Cramer DE, Chilton PM, Song C, Anantpadma M, Davey RA, Prodhan AI, Yin X, Zhang X.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4552-62. doi: 10.1128/AAC.00282-16. Print 2016 Aug.

22.

Large-Scale Screening and Identification of Novel Ebola Virus and Marburg Virus Entry Inhibitors.

Anantpadma M, Kouznetsova J, Wang H, Huang R, Kolokoltsov A, Guha R, Lindstrom AR, Shtanko O, Simeonov A, Maloney DJ, Maury W, LaCount DJ, Jadhav A, Davey RA.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):4471-81. doi: 10.1128/AAC.00543-16. Print 2016 Aug.

23.

Androgen Receptor Structure, Function and Biology: From Bench to Bedside.

Davey RA, Grossmann M.

Clin Biochem Rev. 2016 Feb;37(1):3-15. Review.

24.

Treatment of blood with a pathogen reduction technology using ultraviolet light and riboflavin inactivates Ebola virus in vitro.

Cap AP, Pidcoke HF, Keil SD, Staples HM, Anantpadma M, Carrion R Jr, Davey RA, Frazer-Abel A, Taylor AL, Gonzales R, Patterson JL, Goodrich RP.

Transfusion. 2016 Mar;56 Suppl 1:S6-15. doi: 10.1111/trf.13393.

25.

Sex-related differences in the skeletal phenotype of aged vitamin D receptor global knockout mice.

Ryan JW, Starczak Y, Tsangari H, Sawyer RK, Davey RA, Atkins GJ, Morris HA, Anderson PH.

J Steroid Biochem Mol Biol. 2016 Nov;164:361-368. doi: 10.1016/j.jsbmb.2015.12.005. Epub 2015 Dec 9.

PMID:
26690785
26.

Interferon-γ Inhibits Ebola Virus Infection.

Rhein BA, Powers LS, Rogers K, Anantpadma M, Singh BK, Sakurai Y, Bair T, Miller-Hunt C, Sinn P, Davey RA, Monick MM, Maury W.

PLoS Pathog. 2015 Nov 12;11(11):e1005263. doi: 10.1371/journal.ppat.1005263. eCollection 2015.

27.

Machine learning models identify molecules active against the Ebola virus in vitro.

Ekins S, Freundlich JS, Clark AM, Anantpadma M, Davey RA, Madrid P.

Version 3. F1000Res. 2015 Oct 20 [revised 2017 Jan 1];4:1091. doi: 10.12688/f1000research.7217.3. eCollection 2015.

28.

Facile Discovery of a Diverse Panel of Anti-Ebola Virus Antibodies by Immune Repertoire Mining.

Wang B, Kluwe CA, Lungu OI, DeKosky BJ, Kerr SA, Johnson EL, Tanno H, Lee CH, Jung J, Rezigh AB, Carroll SM, Reyes AN, Bentz JR, Villanueva I, Altman AL, Davey RA, Ellington AD, Georgiou G.

Sci Rep. 2015 Sep 10;5:13926. doi: 10.1038/srep13926. Erratum in: Sci Rep. 2016 Jun 10;6:27229.

29.

Wnt Signaling Inhibits Osteoclast Differentiation by Activating Canonical and Noncanonical cAMP/PKA Pathways.

Weivoda MM, Ruan M, Hachfeld CM, Pederson L, Howe A, Davey RA, Zajac JD, Kobayashi Y, Williams BO, Westendorf JJ, Khosla S, Oursler MJ.

J Bone Miner Res. 2016 Jan;31(1):65-75. doi: 10.1002/jbmr.2599. Epub 2015 Aug 19.

30.

A Role for the Calcitonin Receptor to Limit Bone Loss During Lactation in Female Mice by Inhibiting Osteocytic Osteolysis.

Clarke MV, Russell PK, Findlay DM, Sastra S, Anderson PH, Skinner JP, Atkins GJ, Zajac JD, Davey RA.

Endocrinology. 2015 Sep;156(9):3203-14. doi: 10.1210/en.2015-1345. Epub 2015 Jul 2.

PMID:
26135836
31.

Osteoclast TGF-β Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation.

Weivoda MM, Ruan M, Pederson L, Hachfeld C, Davey RA, Zajac JD, Westendorf JJ, Khosla S, Oursler MJ.

J Bone Miner Res. 2016 Jan;31(1):76-85. doi: 10.1002/jbmr.2586. Epub 2015 Aug 6.

32.

The androgen receptor has no direct antiresorptive actions in mouse osteoclasts.

Sinnesael M, Jardi F, Deboel L, Laurent MR, Dubois V, Zajac JD, Davey RA, Carmeliet G, Claessens F, Vanderschueren D.

Mol Cell Endocrinol. 2015 Aug 15;411:198-206. doi: 10.1016/j.mce.2015.04.030. Epub 2015 May 6.

PMID:
25958043
33.

An Intrinsically Disordered Peptide from Ebola Virus VP35 Controls Viral RNA Synthesis by Modulating Nucleoprotein-RNA Interactions.

Leung DW, Borek D, Luthra P, Binning JM, Anantpadma M, Liu G, Harvey IB, Su Z, Endlich-Frazier A, Pan J, Shabman RS, Chiu W, Davey RA, Otwinowski Z, Basler CF, Amarasinghe GK.

Cell Rep. 2015 Apr 21;11(3):376-89. doi: 10.1016/j.celrep.2015.03.034. Epub 2015 Apr 9.

34.

Ebola virus. Two-pore channels control Ebola virus host cell entry and are drug targets for disease treatment.

Sakurai Y, Kolokoltsov AA, Chen CC, Tidwell MW, Bauta WE, Klugbauer N, Grimm C, Wahl-Schott C, Biel M, Davey RA.

Science. 2015 Feb 27;347(6225):995-8. doi: 10.1126/science.1258758.

35.

Identification of factors regulating MET receptor endocytosis by high-throughput siRNA screening.

Gaziova I, Davey RA, Elferink LA.

Methods Mol Biol. 2015;1270:381-94. doi: 10.1007/978-1-4939-2309-0_26.

PMID:
25702130
36.

pH-Dependent entry of chikungunya virus fusion into mosquito cells.

Nuckols JT, McAuley AJ, Huang YJ, Horne KM, Higgs S, Davey RA, Vanlandingham DL.

Virol J. 2014 Dec 5;11:215. doi: 10.1186/s12985-014-0215-y.

37.

Androgen receptor action in osteoblasts in male mice is dependent on their stage of maturation.

Russell PK, Clarke MV, Cheong K, Anderson PH, Morris HA, Wiren KM, Zajac JD, Davey RA.

J Bone Miner Res. 2015 May;30(5):809-23. doi: 10.1002/jbmr.2413.

38.

Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names.

Kuhn JH, Andersen KG, Bào Y, Bavari S, Becker S, Bennett RS, Bergman NH, Blinkova O, Bradfute S, Brister JR, Bukreyev A, Chandran K, Chepurnov AA, Davey RA, Dietzgen RG, Doggett NA, Dolnik O, Dye JM, Enterlein S, Fenimore PW, Formenty P, Freiberg AN, Garry RF, Garza NL, Gire SK, Gonzalez JP, Griffiths A, Happi CT, Hensley LE, Herbert AS, Hevey MC, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson JC, Johnson KM, Kindrachuk J, Klenk HD, Kobinger G, Kochel TJ, Lackemeyer MG, Lackner DF, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Omilabu SA, Palacios G, Panchal RG, Park DJ, Patterson JL, Paweska JT, Peters CJ, Pettitt J, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Sabeti PC, Sealfon R, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST.

Viruses. 2014 Sep 26;6(9):3663-82. doi: 10.3390/v6093663.

39.

Postinhibitory rebound neurons and networks are disrupted in retrovirus-induced spongiform neurodegeneration.

Li Y, Davey RA, Sivaramakrishnan S, Lynch WP.

J Neurophysiol. 2014 Aug 1;112(3):683-704. doi: 10.1152/jn.00227.2014. Epub 2014 May 14.

40.

Crimean-Congo hemorrhagic fever virus entry into host cells occurs through the multivesicular body and requires ESCRT regulators.

Shtanko O, Nikitina RA, Altuntas CZ, Chepurnov AA, Davey RA.

PLoS Pathog. 2014 Sep 18;10(9):e1004390. doi: 10.1371/journal.ppat.1004390. eCollection 2014 Sep.

41.

Discovery of a novel compound with anti-venezuelan equine encephalitis virus activity that targets the nonstructural protein 2.

Chung DH, Jonsson CB, Tower NA, Chu YK, Sahin E, Golden JE, Noah JW, Schroeder CE, Sotsky JB, Sosa MI, Cramer DE, McKellip SN, Rasmussen L, White EL, Schmaljohn CS, Julander JG, Smith JM, Filone CM, Connor JH, Sakurai Y, Davey RA.

PLoS Pathog. 2014 Jun 26;10(6):e1004213. doi: 10.1371/journal.ppat.1004213. eCollection 2014 Jun.

42.

In silico derived small molecules bind the filovirus VP35 protein and inhibit its polymerase cofactor activity.

Brown CS, Lee MS, Leung DW, Wang T, Xu W, Luthra P, Anantpadma M, Shabman RS, Melito LM, MacMillan KS, Borek DM, Otwinowski Z, Ramanan P, Stubbs AJ, Peterson DS, Binning JM, Tonelli M, Olson MA, Davey RA, Ready JM, Basler CF, Amarasinghe GK.

J Mol Biol. 2014 May 15;426(10):2045-58. doi: 10.1016/j.jmb.2014.01.010. Epub 2014 Feb 1.

43.

Blunted sympathoinhibitory responses in obesity-related hypertension are due to aberrant central but not peripheral signalling mechanisms.

How JM, Wardak SA, Ameer SI, Davey RA, Sartor DM.

J Physiol. 2014 Apr 1;592(7):1705-20. doi: 10.1113/jphysiol.2013.269670. Epub 2014 Feb 3.

44.

Human androgen deficiency: insights gained from androgen receptor knockout mouse models.

Rana K, Davey RA, Zajac JD.

Asian J Androl. 2014 Mar-Apr;16(2):169-77. doi: 10.4103/1008-682X.122590. Review.

45.

Normal phenotype in conditional androgen receptor (AR) exon 3-floxed neomycin-negative male mice.

Rana K, Clarke MV, Zajac JD, Davey RA, MacLean HE.

Endocr Res. 2014;39(3):130-5. doi: 10.3109/07435800.2013.864303. Epub 2014 Jan 27.

PMID:
24467187
46.

Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA.

Kuhn JH, Bào Y, Bavari S, Becker S, Bradfute S, Brauburger K, Rodney Brister J, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Hoenen T, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Volchkova VA, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST.

Arch Virol. 2014 May;159(5):1229-37. doi: 10.1007/s00705-013-1877-2. Epub 2013 Nov 5.

47.

Role of the phosphatidylserine receptor TIM-1 in enveloped-virus entry.

Moller-Tank S, Kondratowicz AS, Davey RA, Rennert PD, Maury W.

J Virol. 2013 Aug;87(15):8327-41. doi: 10.1128/JVI.01025-13. Epub 2013 May 22.

48.

A systematic screen of FDA-approved drugs for inhibitors of biological threat agents.

Madrid PB, Chopra S, Manger ID, Gilfillan L, Keepers TR, Shurtleff AC, Green CE, Iyer LV, Dilks HH, Davey RA, Kolokoltsov AA, Carrion R Jr, Patterson JL, Bavari S, Panchal RG, Warren TK, Wells JB, Moos WH, Burke RL, Tanga MJ.

PLoS One. 2013;8(4):e60579. doi: 10.1371/journal.pone.0060579. Epub 2013 Apr 5.

49.

Calcitonin: physiology or fantasy?

Davey RA, Findlay DM.

J Bone Miner Res. 2013 May;28(5):973-9. doi: 10.1002/jbmr.1869.

50.

Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae.

Kuhn JH, Bao Y, Bavari S, Becker S, Bradfute S, Brister JR, Bukreyev AA, Caì Y, Chandran K, Davey RA, Dolnik O, Dye JM, Enterlein S, Gonzalez JP, Formenty P, Freiberg AN, Hensley LE, Honko AN, Ignatyev GM, Jahrling PB, Johnson KM, Klenk HD, Kobinger G, Lackemeyer MG, Leroy EM, Lever MS, Lofts LL, Mühlberger E, Netesov SV, Olinger GG, Palacios G, Patterson JL, Paweska JT, Pitt L, Radoshitzky SR, Ryabchikova EI, Saphire EO, Shestopalov AM, Smither SJ, Sullivan NJ, Swanepoel R, Takada A, Towner JS, van der Groen G, Volchkov VE, Wahl-Jensen V, Warren TK, Warfield KL, Weidmann M, Nichol ST.

Arch Virol. 2013 Jun;158(6):1425-32. doi: 10.1007/s00705-012-1594-2. Epub 2013 Jan 29. No abstract available.

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