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Intra-arterial stem cell therapy modulates neuronal calcineurin and confers neuroprotection after ischemic stroke.

Saraf J, Sarmah D, Vats K, Kaur H, Pravalika K, Wanve M, Kalia K, Borah A, Dave KR, Yavagal DR, Bhattacharya P.

Int J Neurosci. 2019 Jun 15:1-10. doi: 10.1080/00207454.2019.1633315. [Epub ahead of print]


Blockade of Acid-Sensing Ion Channels Attenuates Recurrent Hypoglycemia-Induced Potentiation of Ischemic Brain Damage in Treated Diabetic Rats.

Rehni AK, Shukla V, Perez-Pinzon MA, Dave KR.

Neuromolecular Med. 2019 May 27. doi: 10.1007/s12017-019-08546-6. [Epub ahead of print]


Preclinical Evaluation of Safety and Biodistribution of Red Cell Microparticles: A Novel Hemostatic Agent.

Rehni AK, Shukla V, Navarro Quero H, Bidot C Jr, Haase CR, Crane EAA, Patel SG, Koch S, Ahn YS, Jy W, Dave KR.

J Cardiovasc Pharmacol Ther. 2019 Apr 29:1074248419838512. doi: 10.1177/1074248419838512. [Epub ahead of print]


Basal and Evoked Neurotransmitter Levels in Parkin, DJ-1, PINK1 and LRRK2 Knockout Rat Striatum.

Creed RB, Menalled L, Casey B, Dave KD, Janssens HB, Veinbergs I, van der Hart M, Rassoulpour A, Goldberg MS.

Neuroscience. 2019 Jun 15;409:169-179. doi: 10.1016/j.neuroscience.2019.04.033. Epub 2019 Apr 25.


Evolving Evidence of Calreticulin as a Pharmacological Target in Neurological Disorders.

Kotian V, Sarmah D, Kaur H, Kesharwani R, Verma G, Mounica L, Veeresh P, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P.

ACS Chem Neurosci. 2019 May 6. doi: 10.1021/acschemneuro.9b00158. [Epub ahead of print]


Interplay between Mitophagy and Inflammasomes in Neurological Disorders.

Kesharwani R, Sarmah D, Kaur H, Mounika L, Verma G, Pabbala V, Kotian V, Kalia K, Borah A, Dave KR, Yavagal DR, Bhattacharya P.

ACS Chem Neurosci. 2019 May 15;10(5):2195-2208. doi: 10.1021/acschemneuro.9b00117. Epub 2019 Apr 8.


Specificity of extended O-aryloxycarbonyl hydroxamates as inhibitors of a class C β-lactamase.

Malico AA, Dave K, Adediran SA, Pratt RF.

Bioorg Med Chem. 2019 Apr 1;27(7):1430-1436. doi: 10.1016/j.bmc.2019.02.023. Epub 2019 Feb 12.


Chromomycin, an antibiotic produced by Streptomyces flaviscleroticus might play a role in the resistance to oxidative stress and is essential for viability in stationary phase.

Prajapati D, Kumari N, Dave K, Chatupale V, Pohnerkar J.

Environ Microbiol. 2019 Feb;21(2):814-826. doi: 10.1111/1462-2920.14515. Epub 2019 Jan 14.


Neuronal Exosome-Derived Human Tau is Toxic to Recipient Mouse Neurons in vivo.

Winston CN, Aulston B, Rockenstein EM, Adame A, Prikhodko O, Dave KN, Mishra P, Rissman RA, Yuan SH.

J Alzheimers Dis. 2019;67(2):541-553. doi: 10.3233/JAD-180776.


Trigonelline therapy confers neuroprotection by reduced glutathione mediated myeloperoxidase expression in animal model of ischemic stroke.

Pravalika K, Sarmah D, Kaur H, Vats K, Saraf J, Wanve M, Kalia K, Borah A, Yavagal DR, Dave KR, Bhattacharya P.

Life Sci. 2019 Jan 1;216:49-58. doi: 10.1016/j.lfs.2018.11.014. Epub 2018 Nov 7.


A Proposed Roadmap for Parkinson's Disease Proof of Concept Clinical Trials Investigating Compounds Targeting Alpha-Synuclein.

Merchant KM, Cedarbaum JM, Brundin P, Dave KD, Eberling J, Espay AJ, Hutten SJ, Javidnia M, Luthman J, Maetzler W, Menalled L, Reimer AN, Stoessl AJ, Weiner DM; and The Michael J. Fox Foundation Alpha Synuclein Clinical Path Working Group.

J Parkinsons Dis. 2019;9(1):31-61. doi: 10.3233/JPD-181471.


Resveratrol Preconditioning Induces Genomic and Metabolic Adaptations within the Long-Term Window of Cerebral Ischemic Tolerance Leading to Bioenergetic Efficiency.

Khoury N, Xu J, Stegelmann SD, Jackson CW, Koronowski KB, Dave KR, Young JI, Perez-Pinzon MA.

Mol Neurobiol. 2019 Jun;56(6):4549-4565. doi: 10.1007/s12035-018-1380-6. Epub 2018 Oct 20.


Therapeutic spectrum of interferon-β in ischemic stroke.

Wanve M, Kaur H, Sarmah D, Saraf J, Pravalika K, Vats K, Kalia K, Borah A, Yavagal DR, Dave KR, Bhattacharya P.

J Neurosci Res. 2019 Feb;97(2):116-127. doi: 10.1002/jnr.24333. Epub 2018 Oct 15. Review.


Feasibility and Safety of Multicenter Tissue and Biofluid Sampling for α-Synuclein in Parkinson's Disease: The Systemic Synuclein Sampling Study (S4).

Chahine LM, Beach TG, Seedorff N, Caspell-Garcia C, Coffey CS, Brumm M, Adler CH, Serrano GE, Linder C, Mosovsky S, Foroud T, Riss H, Ecklund D, Seibyl J, Jennings D, Arnedo V, Riley L, Dave KD, Mollenhauer B; Systemic sSynuclein Sampling study.

J Parkinsons Dis. 2018;8(4):517-527. doi: 10.3233/JPD-181434.


Contribution of allelic imbalance to colorectal cancer.

Palin K, Pitkänen E, Turunen M, Sahu B, Pihlajamaa P, Kivioja T, Kaasinen E, Välimäki N, Hänninen UA, Cajuso T, Aavikko M, Tuupanen S, Kilpivaara O, van den Berg L, Kondelin J, Tanskanen T, Katainen R, Grau M, Rauanheimo H, Plaketti RM, Taira A, Sulo P, Hartonen T, Dave K, Schmierer B, Botla S, Sokolova M, Vähärautio A, Gladysz K, Ongen H, Dermitzakis E, Bramsen JB, Ørntoft TF, Andersen CL, Ristimäki A, Lepistö A, Renkonen-Sinisalo L, Mecklin JP, Taipale J, Aaltonen LA.

Nat Commun. 2018 Sep 10;9(1):3664. doi: 10.1038/s41467-018-06132-1.


Antibody-based methods for the measurement of α-synuclein concentration in human cerebrospinal fluid - method comparison and round robin study.

Mollenhauer B, Bowman FD, Drake D, Duong J, Blennow K, El-Agnaf O, Shaw LM, Masucci J, Taylor P, Umek RM, Dunty JM, Smith CL, Stoops E, Vanderstichele H, Schmid AW, Moniatte M, Zhang J, Kruse N, Lashuel HA, Teunissen C, Schubert T, Dave KD, Hutten SJ, Zetterberg H.

J Neurochem. 2019 Apr;149(1):126-138. doi: 10.1111/jnc.14569. Epub 2018 Nov 13.


Immunohistochemical Method and Histopathology Judging for the Systemic Synuclein Sampling Study (S4).

Beach TG, Serrano GE, Kremer T, Canamero M, Dziadek S, Sade H, Derkinderen P, Corbillé AG, Letournel F, Munoz DG, White CL 3rd, Schneider J, Crary JF, Sue LI, Adler CH, Glass MJ, Intorcia AJ, Walker JE, Foroud T, Coffey CS, Ecklund D, Riss H, Goßmann J, König F, Kopil CM, Arnedo V, Riley L, Linder C, Dave KD, Jennings D, Seibyl J, Mollenhauer B, Chahine L; Systemic Synuclein Sampling Study (S4) .

J Neuropathol Exp Neurol. 2018 Sep 1;77(9):793-802. doi: 10.1093/jnen/nly056.


A Friend or Foe: Calcineurin across the Gamut of Neurological Disorders.

Saraf J, Bhattacharya P, Kalia K, Borah A, Sarmah D, Kaur H, Dave KR, Yavagal DR.

ACS Cent Sci. 2018 Jul 25;4(7):805-819. doi: 10.1021/acscentsci.8b00230. Epub 2018 Jun 27. Review.


Novel Targets for Parkinson's Disease: Addressing Different Therapeutic Paradigms and Conundrums.

Rane P, Sarmah D, Bhute S, Kaur H, Goswami A, Kalia K, Borah A, Dave KR, Sharma N, Bhattacharya P.

ACS Chem Neurosci. 2019 Jan 16;10(1):44-57. doi: 10.1021/acschemneuro.8b00180. Epub 2018 Jul 11.


Pharmacokinetics of Human Red Blood Cell Microparticles Prepared Using High-Pressure Extrusion Method.

Jy W, Rehni AK, Bidot C Jr, Navarro-Quero H, Haase CR, Koch S, Ahn YS, Dave KR.

Front Pharmacol. 2018 Jun 11;9:599. doi: 10.3389/fphar.2018.00599. eCollection 2018.


Mitochondrial Dysfunction in Stroke: Implications of Stem Cell Therapy.

Sarmah D, Kaur H, Saraf J, Vats K, Pravalika K, Wanve M, Kalia K, Borah A, Kumar A, Wang X, Yavagal DR, Dave KR, Bhattacharya P.

Transl Stroke Res. 2018 Jun 20. doi: 10.1007/s12975-018-0642-y. [Epub ahead of print] Review.


Exposure to hypoglycemia and risk of stroke.

Smith L, Chakraborty D, Bhattacharya P, Sarmah D, Koch S, Dave KR.

Ann N Y Acad Sci. 2018 Nov;1431(1):25-34. doi: 10.1111/nyas.13872. Epub 2018 Jun 19. Review.


Inflammasomes in stroke: a triggering role for acid-sensing ion channels.

Vats K, Sarmah D, Kaur H, Wanve M, Kalia K, Borah A, Dave KR, Yavagal DR, Bhattacharya P.

Ann N Y Acad Sci. 2018 Nov;1431(1):14-24. doi: 10.1111/nyas.13852. Epub 2018 Jun 19. Review.


Ameliorative potential of conditioning on ischemia-reperfusion injury in diabetes.

Rehni AK, Dave KR.

Cond Med. 2018;1(3):105-115. Epub 2018 Apr 20.


Noncoding RNAs in ischemic stroke: time to translate.

Kaur H, Sarmah D, Saraf J, Vats K, Kalia K, Borah A, Yavagal DR, Dave KR, Ghosh Z, Bhattacharya P.

Ann N Y Acad Sci. 2018 Jun;1421(1):19-36. doi: 10.1111/nyas.13612. Epub 2018 Apr 23. Review.


FDA Approval Summary: Niraparib for the Maintenance Treatment of Patients with Recurrent Ovarian Cancer in Response to Platinum-Based Chemotherapy.

Ison G, Howie LJ, Amiri-Kordestani L, Zhang L, Tang S, Sridhara R, Pierre V, Charlab R, Ramamoorthy A, Song P, Li F, Yu J, Manheng W, Palmby TR, Ghosh S, Horne HN, Lee EY, Philip R, Dave K, Chen XH, Kelly SL, Janoria KG, Banerjee A, Eradiri O, Dinin J, Goldberg KB, Pierce WF, Ibrahim A, Kluetz PG, Blumenthal GM, Beaver JA, Pazdur R.

Clin Cancer Res. 2018 Sep 1;24(17):4066-4071. doi: 10.1158/1078-0432.CCR-18-0042. Epub 2018 Apr 12.


Impact of Hypoglycemia on Brain Metabolism During Diabetes.

Rehni AK, Dave KR.

Mol Neurobiol. 2018 Dec;55(12):9075-9088. doi: 10.1007/s12035-018-1044-6. Epub 2018 Apr 10. Review.


Recurrent Hypoglycemia Exacerbates Cerebral Ischemic Damage in Diabetic Rats via Enhanced Post-Ischemic Mitochondrial Dysfunction.

Shukla V, Fuchs P, Liu A, Cohan CH, Dong C, Wright CB, Perez-Pinzon MA, Dave KR.

Transl Stroke Res. 2019 Feb;10(1):78-90. doi: 10.1007/s12975-018-0622-2. Epub 2018 Mar 22.


Acidosis mediates recurrent hypoglycemia-induced increase in ischemic brain injury in treated diabetic rats.

Rehni AK, Shukla V, Perez-Pinzon MA, Dave KR.

Neuropharmacology. 2018 Jun;135:192-201. doi: 10.1016/j.neuropharm.2018.03.016. Epub 2018 Mar 15.


The breast cancer antigen 5T4 interacts with Rab11, and is a target and regulator of Rab11 mediated trafficking.

Harris JL, Dave K, Gorman J, Khanna KK.

Int J Biochem Cell Biol. 2018 Jun;99:28-37. doi: 10.1016/j.biocel.2018.03.002. Epub 2018 Mar 13.


Pressure- and heat-induced protein unfolding in bacterial cells: crowding vs. sticking.

Chen T, Dave K, Gruebele M.

FEBS Lett. 2018 Apr;592(8):1357-1365. doi: 10.1002/1873-3468.13025. Epub 2018 Mar 22.


Primary Psychiatric Disorder Masking the Diagnosis of Neuropsychiatric Lupus in a Patient with Altered Mental Status: A Case Report.

Perez O, Dave K, Almanzar A, Prodhan T, Concepion L.

Cureus. 2017 Oct 23;9(10):e1793. doi: 10.7759/cureus.1793.


Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents.

Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VMY, Martinez TN, Dave KD.

J Parkinsons Dis. 2018;8(2):303-322. doi: 10.3233/JPD-171248.


Myeloperoxidase and Neurological Disorder: A Crosstalk.

Pravalika K, Sarmah D, Kaur H, Wanve M, Saraf J, Kalia K, Borah A, Yavagal DR, Dave KR, Bhattacharya P.

ACS Chem Neurosci. 2018 Mar 21;9(3):421-430. doi: 10.1021/acschemneuro.7b00462. Epub 2018 Feb 2. Review.


Potential link between post-acute ischemic stroke exposure to hypoglycemia and hemorrhagic transformation.

Klingbeil KD, Koch S, Dave KR.

Int J Stroke. 2017 Jan 1:1747493017743797. doi: 10.1177/1747493017743797. [Epub ahead of print]


Dendritic polymers for dermal drug delivery.

Dave K, Krishna Venuganti VV.

Ther Deliv. 2017 Dec;8(12):1077-1096. doi: 10.4155/tde-2017-0091. Review.


Ischemic Preconditioning Protects Astrocytes against Oxygen Glucose Deprivation Via the Nuclear Erythroid 2-Related Factor 2 Pathway.

Narayanan SV, Dave KR, Perez-Pinzon MA.

Transl Stroke Res. 2018 Apr;9(2):99-109. doi: 10.1007/s12975-017-0574-y. Epub 2017 Nov 4.


Mesenchymal Stem Cell Therapy in Ischemic Stroke: A Meta-analysis of Preclinical Studies.

Sarmah D, Agrawal V, Rane P, Bhute S, Watanabe M, Kalia K, Ghosh Z, Dave KR, Yavagal DR, Bhattacharya P.

Clin Pharmacol Ther. 2018 Jun;103(6):990-998. doi: 10.1002/cpt.927. Epub 2017 Dec 14. Review.


Impact of an integrated medicines management service on preventable medicines-related readmission to hospital: a descriptive study.

Barnett NL, Dave K, Athwal D, Parmar P, Kaher S, Ward C.

Eur J Hosp Pharm Sci Pract. 2017 Nov;24(6):327-331. doi: 10.1136/ejhpharm-2016-000984. Epub 2016 Nov 1.


Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell.

Sarmah D, Kaur H, Saraf J, Pravalika K, Goswami A, Kalia K, Borah A, Wang X, Dave KR, Yavagal DR, Bhattacharya P.

Transl Stroke Res. 2018 Aug;9(4):356-374. doi: 10.1007/s12975-017-0580-0. Epub 2017 Oct 26. Review.


Neuronal SIRT1 (Silent Information Regulator 2 Homologue 1) Regulates Glycolysis and Mediates Resveratrol-Induced Ischemic Tolerance.

Koronowski KB, Khoury N, Saul I, Loris ZB, Cohan CH, Stradecki-Cohan HM, Dave KR, Young JI, Perez-Pinzon MA.

Stroke. 2017 Nov;48(11):3117-3125. doi: 10.1161/STROKEAHA.117.018562. Epub 2017 Oct 10.


Therapeutic approaches to target alpha-synuclein pathology.

Brundin P, Dave KD, Kordower JH.

Exp Neurol. 2017 Dec;298(Pt B):225-235. doi: 10.1016/j.expneurol.2017.10.003. Epub 2017 Oct 4. Review.


Stroke Management: An Emerging Role of Nanotechnology.

Sarmah D, Saraf J, Kaur H, Pravalika K, Tekade RK, Borah A, Kalia K, Dave KR, Bhattacharya P.

Micromachines (Basel). 2017 Aug 28;8(9). pii: E262. doi: 10.3390/mi8090262. Review.


Soft tissue laceration caused by lower extremity intraosseous access insertion in an obese patient.

Bromberg R, Dave K, Mankodi D, Danckers M.

BMJ Case Rep. 2017 Jul 24;2017. pii: bcr-2017-220069. doi: 10.1136/bcr-2017-220069. No abstract available.


Physical Exercise Improves Cognitive Outcomes in 2 Models of Transient Cerebral Ischemia.

Stradecki-Cohan HM, Youbi M, Cohan CH, Saul I, Garvin AA, Perez E, Dave KR, Wright CB, Sacco RL, Perez-Pinzon MA.

Stroke. 2017 Aug;48(8):2306-2309. doi: 10.1161/STROKEAHA.117.017296. Epub 2017 Jun 29.


Feasibility of Focused Beam Reflectance Measurement (FBRM) for Analysis of Pharmaceutical Suspensions in Preclinical Development.

Dave K, Luner PE, Forness C, Baker D, Jankovsky C, Chen S.

AAPS PharmSciTech. 2018 Jan;19(1):155-165. doi: 10.1208/s12249-017-0819-9. Epub 2017 Jun 21.


Chemoprevention of Breast Cancer by Transdermal Delivery of α-Santalol through Breast Skin and Mammary Papilla (Nipple).

Dave K, Alsharif FM, Islam S, Dwivedi C, Perumal O.

Pharm Res. 2017 Sep;34(9):1897-1907. doi: 10.1007/s11095-017-2198-z. Epub 2017 Jun 6.


Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth.

Dave K, Sur I, Yan J, Zhang J, Kaasinen E, Zhong F, Blaas L, Li X, Kharazi S, Gustafsson C, De Paepe A, Månsson R, Taipale J.

Elife. 2017 Jun 6;6. pii: e23382. doi: 10.7554/eLife.23382.


Impact of Dendrimers on Solubility of Hydrophobic Drug Molecules.

Choudhary S, Gupta L, Rani S, Dave K, Gupta U.

Front Pharmacol. 2017 May 16;8:261. doi: 10.3389/fphar.2017.00261. eCollection 2017. Review.

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