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Items: 23


Deficiency in the DNA repair protein ERCC1 triggers a link between senescence and apoptosis in human fibroblasts and mouse skin.

Kim DE, Dollé MET, Vermeij WP, Gyenis A, Vogel K, Hoeijmakers JHJ, Wiley CD, Davalos AR, Hasty P, Desprez PY, Campisi J.

Aging Cell. 2019 Nov 18:e13072. doi: 10.1111/acel.13072. [Epub ahead of print]


Restored immune cell functions upon clearance of senescence in the irradiated splenic environment.

Palacio L, Goyer ML, Maggiorani D, Espinosa A, Villeneuve N, Bourbonnais S, Moquin-Beaudry G, Le O, Demaria M, Davalos AR, Decaluwe H, Beauséjour C.

Aging Cell. 2019 Aug;18(4):e12971. doi: 10.1111/acel.12971. Epub 2019 May 31.


Alarmin Detection in Senescent Cells.

Kim DE, Davalos AR.

Methods Mol Biol. 2019;1896:71-81. doi: 10.1007/978-1-4939-8931-7_8.


Small-molecule MDM2 antagonists attenuate the senescence-associated secretory phenotype.

Wiley CD, Schaum N, Alimirah F, Lopez-Dominguez JA, Orjalo AV, Scott G, Desprez PY, Benz C, Davalos AR, Campisi J.

Sci Rep. 2018 Feb 5;8(1):2410. doi: 10.1038/s41598-018-20000-4.


Non-catalytic Roles for XPG with BRCA1 and BRCA2 in Homologous Recombination and Genome Stability.

Trego KS, Groesser T, Davalos AR, Parplys AC, Zhao W, Nelson MR, Hlaing A, Shih B, Rydberg B, Pluth JM, Tsai MS, Hoeijmakers JHJ, Sung P, Wiese C, Campisi J, Cooper PK.

Mol Cell. 2016 Feb 18;61(4):535-546. doi: 10.1016/j.molcel.2015.12.026. Epub 2016 Jan 28.


MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.

Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, Curran SC, Davalos AR, Wilson-Edell KA, Liu S, Limbad C, Demaria M, Li P, Hubbard GB, Ikeno Y, Javors M, Desprez PY, Benz CC, Kapahi P, Nelson PS, Campisi J.

Nat Cell Biol. 2015 Aug;17(8):1049-61. doi: 10.1038/ncb3195. Epub 2015 Jul 6.


Development of a highly potent, selective, and cell-active inhibitor of cysteine cathepsin L-A hybrid design approach.

Dana D, De S, Rathod P, Davalos AR, Novoa DA, Paroly S, Torres VM, Afzal N, Lankalapalli RS, Rotenberg SA, Chang EJ, Subramaniam G, Kumar S.

Chem Commun (Camb). 2014 Sep 25;50(74):10875-8. doi: 10.1039/c4cc04037f. Epub 2014 Aug 4.


p53-dependent release of Alarmin HMGB1 is a central mediator of senescent phenotypes.

Davalos AR, Kawahara M, Malhotra GK, Schaum N, Huang J, Ved U, Beausejour CM, Coppe JP, Rodier F, Campisi J.

J Cell Biol. 2013 May 13;201(4):613-29. doi: 10.1083/jcb.201206006. Epub 2013 May 6.


Development of cell-active non-peptidyl inhibitors of cysteine cathepsins.

Dana D, Davalos AR, De S, Rathod P, Gamage RK, Huestis J, Afzal N, Zavlanov Y, Paroly SS, Rotenberg SA, Subramaniam G, Mark KJ, Chang EJ, Kumar S.

Bioorg Med Chem. 2013 Jun 1;21(11):2975-87. doi: 10.1016/j.bmc.2013.03.062. Epub 2013 Apr 2.


The autophagy-senescence connection in chemotherapy: must tumor cells (self) eat before they sleep?

Goehe RW, Di X, Sharma K, Bristol ML, Henderson SC, Valerie K, Rodier F, Davalos AR, Gewirtz DA.

J Pharmacol Exp Ther. 2012 Dec;343(3):763-78. doi: 10.1124/jpet.112.197590. Epub 2012 Aug 27.


Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation.

Zou Y, Zhang N, Ellerby LM, Davalos AR, Zeng X, Campisi J, Desprez PY.

Biochem Biophys Res Commun. 2012 Sep 14;426(1):100-5. doi: 10.1016/j.bbrc.2012.08.043. Epub 2012 Aug 14.


Design, synthesis, and evaluation of 2-(arylsulfonyl)oxiranes as cell-permeable covalent inhibitors of protein tyrosine phosphatases.

Dana D, Das TK, Kumar I, Davalos AR, Mark KJ, Ramai D, Chang EJ, Talele TT, Kumar S.

Chem Biol Drug Des. 2012 Oct;80(4):489-99. doi: 10.1111/j.1747-0285.2012.01437.x. Epub 2012 Jul 25.


The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome.

Trego KS, Chernikova SB, Davalos AR, Perry JJ, Finger LD, Ng C, Tsai MS, Yannone SM, Tainer JA, Campisi J, Cooper PK.

Cell Cycle. 2011 Jun 15;10(12):1998-2007. Epub 2011 Jun 15.


DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion.

Rodier F, Muñoz DP, Teachenor R, Chu V, Le O, Bhaumik D, Coppé JP, Campeau E, Beauséjour CM, Kim SH, Davalos AR, Campisi J.

J Cell Sci. 2011 Jan 1;124(Pt 1):68-81. doi: 10.1242/jcs.071340. Epub 2010 Nov 30.


Senescent cells as a source of inflammatory factors for tumor progression.

Davalos AR, Coppe JP, Campisi J, Desprez PY.

Cancer Metastasis Rev. 2010 Jun;29(2):273-83. doi: 10.1007/s10555-010-9220-9. Review.


Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

Rodier F, Coppé JP, Patil CK, Hoeijmakers WA, Muñoz DP, Raza SR, Freund A, Campeau E, Davalos AR, Campisi J.

Nat Cell Biol. 2009 Aug;11(8):973-9. doi: 10.1038/ncb1909. Epub 2009 Jul 13. Erratum in: Nat Cell Biol. 2009 Oct;11(10):1272. Dosage error in article text.


Telomere dysfunction and cell survival: roles for distinct TIN2-containing complexes.

Kim SH, Davalos AR, Heo SJ, Rodier F, Zou Y, Beausejour C, Kaminker P, Yannone SM, Campisi J.

J Cell Biol. 2008 May 5;181(3):447-60. doi: 10.1083/jcb.200710028. Epub 2008 Apr 28.


The XIST noncoding RNA functions independently of BRCA1 in X inactivation.

Xiao C, Sharp JA, Kawahara M, Davalos AR, Difilippantonio MJ, Hu Y, Li W, Cao L, Buetow K, Ried T, Chadwick BP, Deng CX, Panning B.

Cell. 2007 Mar 9;128(5):977-89.


ATR and ATM-dependent movement of BLM helicase during replication stress ensures optimal ATM activation and 53BP1 focus formation.

Davalos AR, Kaminker P, Hansen RK, Campisi J.

Cell Cycle. 2004 Dec;3(12):1579-86. Epub 2004 Dec 4.


TIN2 mediates functions of TRF2 at human telomeres.

Kim SH, Beausejour C, Davalos AR, Kaminker P, Heo SJ, Campisi J.

J Biol Chem. 2004 Oct 15;279(42):43799-804. Epub 2004 Aug 3.


Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress.

Rubio MA, Davalos AR, Campisi J.

Exp Cell Res. 2004 Aug 1;298(1):17-27.


Semaphorin 3F gene from human 3p21.3 suppresses tumor formation in nude mice.

Xiang R, Davalos AR, Hensel CH, Zhou XJ, Tse C, Naylor SL.

Cancer Res. 2002 May 1;62(9):2637-43.

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