Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 66

1.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

2.

Desensitization of human CRF2(a) receptor signaling governed by agonist potency and βarrestin2 recruitment.

Hauger RL, Olivares-Reyes JA, Braun S, Hernandez-Aranda J, Hudson CC, Gutknecht E, Dautzenberg FM, Oakley RH.

Regul Pept. 2013 Sep 10;186:62-76. doi: 10.1016/j.regpep.2013.06.009. Epub 2013 Jun 29.

3.

Pharmacological characterization of JNJ-40068782, a new potent, selective, and systemically active positive allosteric modulator of the mGlu2 receptor and its radioligand [3H]JNJ-40068782.

Lavreysen H, Langlois X, Ahnaou A, Drinkenburg W, te Riele P, Biesmans I, Van der Linden I, Peeters L, Megens A, Wintmolders C, Cid JM, Trabanco AA, Andrés JI, Dautzenberg FM, Lütjens R, Macdonald G, Atack JR.

J Pharmacol Exp Ther. 2013 Sep;346(3):514-27. doi: 10.1124/jpet.113.204990. Epub 2013 Jun 13.

PMID:
23766542
4.

Structure-activity relationships of 2-arylamido-5,7-dihydro-4H-thieno[2,3-c]pyran-3-carboxamide derivatives as cannabinoid receptor agonists and their analgesic action.

Thur Y, Bhalerao A, Munshi Z, Pansare N, Mann K, Hanauer G, Kley HP, Nappe S, Weiss-Haljiti C, Ostermann C, Zitt C, Schaefer M, Mondal D, Ali Siddiki A, Armugam V, Gudaghe V, Gupta M, Rayudu P, Dautzenberg FM, Das Sarma K.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7314-21. doi: 10.1016/j.bmcl.2012.10.087. Epub 2012 Oct 25.

PMID:
23147076
5.

Molecular and cell signaling targets for PTSD pathophysiology and pharmacotherapy.

Hauger RL, Olivares-Reyes JA, Dautzenberg FM, Lohr JB, Braun S, Oakley RH.

Neuropharmacology. 2012 Feb;62(2):705-14. doi: 10.1016/j.neuropharm.2011.11.007. Epub 2011 Nov 25. Review.

6.

Contribution of melanin-concentrating hormone (MCH1) receptor to thermoregulation and sleep stabilization: evidence from MCH1 (-/-) mice.

Ahnaou A, Dautzenberg FM, Huysmans H, Steckler T, Drinkenburg WH.

Behav Brain Res. 2011 Mar 17;218(1):42-50. doi: 10.1016/j.bbr.2010.11.019. Epub 2010 Nov 11.

PMID:
21074567
7.

Corticotropin-releasing factor receptors induce calcium mobilization through cross-talk with Gq-coupled receptors.

Gutknecht E, Vauquelin G, Dautzenberg FM.

Eur J Pharmacol. 2010 Sep 10;642(1-3):1-9. doi: 10.1016/j.ejphar.2010.05.027. Epub 2010 Jun 8.

PMID:
20594969
8.

Role of CRF receptor signaling in stress vulnerability, anxiety, and depression.

Hauger RL, Risbrough V, Oakley RH, Olivares-Reyes JA, Dautzenberg FM.

Ann N Y Acad Sci. 2009 Oct;1179:120-43. doi: 10.1111/j.1749-6632.2009.05011.x. Review.

9.

Corticotropin releasing factor-induced ERK phosphorylation in AtT20 cells occurs via a cAMP-dependent mechanism requiring EPAC2.

Van Kolen K, Dautzenberg FM, Verstraeten K, Royaux I, De Hoogt R, Gutknecht E, Peeters PJ.

Neuropharmacology. 2010 Jan;58(1):135-44. doi: 10.1016/j.neuropharm.2009.06.022. Epub 2009 Jun 30. Erratum in: Neuropharmacology. 2010 Feb;58(2):559. Dautzenberg, Frank M [added].

PMID:
19573542
10.

Molecular mechanisms of corticotropin-releasing factor receptor-induced calcium signaling.

Gutknecht E, Van der Linden I, Van Kolen K, Verhoeven KF, Vauquelin G, Dautzenberg FM.

Mol Pharmacol. 2009 Mar;75(3):648-57. doi: 10.1124/mol.108.050427. Epub 2008 Dec 19.

PMID:
19098121
11.

Modulation of group II metabotropic glutamate receptor (mGlu2) elicits common changes in rat and mice sleep-wake architecture.

Ahnaou A, Dautzenberg FM, Geys H, Imogai H, Gibelin A, Moechars D, Steckler T, Drinkenburg WH.

Eur J Pharmacol. 2009 Jan 28;603(1-3):62-72. doi: 10.1016/j.ejphar.2008.11.018. Epub 2008 Nov 17.

PMID:
19046965
12.

Molecular Properties of the CRF Receptor.

Spiess J, Dautzenberg FM, Sydow S, Hauger RL, Rühmann A, Blank T, Radulovic J.

Trends Endocrinol Metab. 1998 May-Jun;9(4):140-5.

PMID:
18406257
13.

Therapeutic potential of group III metabotropic glutamate receptors.

Lavreysen H, Dautzenberg FM.

Curr Med Chem. 2008;15(7):671-84. Review.

PMID:
18336281
14.

Blocking melanin-concentrating hormone MCH1 receptor affects rat sleep-wake architecture.

Ahnaou A, Drinkenburg WH, Bouwknecht JA, Alcazar J, Steckler T, Dautzenberg FM.

Eur J Pharmacol. 2008 Jan 28;579(1-3):177-88. Epub 2007 Oct 23.

PMID:
18062961
15.
16.

Nociceptive and behavioural sensitisation by protein kinase Cepsilon signalling in the CNS.

Van Kolen K, Pullan S, Neefs JM, Dautzenberg FM.

J Neurochem. 2008 Jan;104(1):1-13. Epub 2007 Oct 30. Review.

17.

Carboxyl-terminal and intracellular loop sites for CRF1 receptor phosphorylation and beta-arrestin-2 recruitment: a mechanism regulating stress and anxiety responses.

Oakley RH, Olivares-Reyes JA, Hudson CC, Flores-Vega F, Dautzenberg FM, Hauger RL.

Am J Physiol Regul Integr Comp Physiol. 2007 Jul;293(1):R209-22. Epub 2007 Mar 15.

18.

Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets.

Hauger RL, Risbrough V, Brauns O, Dautzenberg FM.

CNS Neurol Disord Drug Targets. 2006 Aug;5(4):453-79. Review.

19.

Corticotropin-releasing factor receptor antagonists in affective disorders and drug dependence-- an update.

Steckler T, Dautzenberg FM.

CNS Neurol Disord Drug Targets. 2006 Apr;5(2):147-65. Review.

PMID:
16611089
20.

Urocortins of the South African clawed frog, Xenopus laevis: conservation of structure and function in tetrapod evolution.

Boorse GC, Crespi EJ, Dautzenberg FM, Denver RJ.

Endocrinology. 2005 Nov;146(11):4851-60. Epub 2005 Jul 21.

PMID:
16037378
21.

Irreversible binding kinetics of neuropeptide Y ligands to Y2 but not to Y1 and Y5 receptors.

Dautzenberg FM, Neysari S.

Pharmacology. 2005 Dec;75(1):21-9. Epub 2005 May 20.

PMID:
15908753
23.

Stimulation of neuropeptide Y-mediated calcium responses in human SMS-KAN neuroblastoma cells endogenously expressing Y2 receptors by co-expression of chimeric G proteins.

Dautzenberg FM.

Biochem Pharmacol. 2005 May 15;69(10):1493-9. Erratum in: Biochem Pharmacol. 2005 Sep 1;70(5):809.

PMID:
15857613
24.
25.

Molecular cloning and functional expression of the mouse CRF2(a) receptor splice variant.

Dautzenberg FM, Higelin J, Wille S, Brauns O.

Regul Pept. 2004 Sep 15;121(1-3):89-97.

PMID:
15256278
27.
28.

Mediation of corticotropin releasing factor type 1 receptor phosphorylation and desensitization by protein kinase C: a possible role in stress adaptation.

Hauger RL, Olivares-Reyes JA, Braun S, Catt KJ, Dautzenberg FM.

J Pharmacol Exp Ther. 2003 Aug;306(2):794-803. Epub 2003 May 6.

PMID:
12734388
29.

Corticotropin-releasing hormone (CRH) expression and protein kinase A mediated CRH receptor signalling in an immortalized hypothalamic cell line.

Kasckow J, Mulchahey JJ, Aguilera G, Pisarska M, Nikodemova M, Chen HC, Herman JP, Murphy EK, Liu Y, Rizvi TA, Dautzenberg FM, Sheriff S.

J Neuroendocrinol. 2003 May;15(5):521-9.

PMID:
12694378
30.

International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands.

Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM.

Pharmacol Rev. 2003 Mar;55(1):21-6. Review.

PMID:
12615952
31.

Novel hexahydrospiro[piperidine-4,1'-pyrrolo[3,4-c]pyrroles]: highly selective small-molecule nociceptin/orphanin FQ receptor agonists.

Kolczewski S, Adam G, Cesura AM, Jenck F, Hennig M, Oberhauser T, Poli SM, Rössler F, Röver S, Wichmann J, Dautzenberg FM.

J Med Chem. 2003 Jan 16;46(2):255-64.

PMID:
12519064
32.

GRK3 regulation during CRF- and urocortin-induced CRF1 receptor desensitization.

Dautzenberg FM, Wille S, Braun S, Hauger RL.

Biochem Biophys Res Commun. 2002 Nov 1;298(3):303-8.

PMID:
12413940
33.
34.

The highly selective CRF(2) receptor antagonist K41498 binds to presynaptic CRF(2) receptors in rat brain.

Lawrence AJ, Krstew EV, Dautzenberg FM, Rühmann A.

Br J Pharmacol. 2002 Jul;136(6):896-904.

35.
36.
37.

The CRF peptide family and their receptors: yet more partners discovered.

Dautzenberg FM, Hauger RL.

Trends Pharmacol Sci. 2002 Feb;23(2):71-7. Review.

PMID:
11830263
38.

Interaction of neuropeptide Y and corticotropin-releasing factor signaling pathways in AR-5 amygdalar cells.

Sheriff S, Dautzenberg FM, Mulchahey JJ, Pisarska M, Hauger RL, Chance WT, Balasubramaniam A, Kasckow JW.

Peptides. 2001 Dec;22(12):2083-9.

PMID:
11786194
39.

Pharmacological characterization of the novel nonpeptide orphanin FQ/nociceptin receptor agonist Ro 64-6198: rapid and reversible desensitization of the ORL1 receptor in vitro and lack of tolerance in vivo.

Dautzenberg FM, Wichmann J, Higelin J, Py-Lang G, Kratzeisen C, Malherbe P, Kilpatrick GJ, Jenck F.

J Pharmacol Exp Ther. 2001 Aug;298(2):812-9.

PMID:
11454946
40.

Molecular biology of the CRH receptors-- in the mood.

Dautzenberg FM, Kilpatrick GJ, Hauger RL, Moreau J.

Peptides. 2001 May;22(5):753-60. Review.

PMID:
11337088
41.

GRK3 mediates desensitization of CRF1 receptors: a potential mechanism regulating stress adaptation.

Dautzenberg FM, Braun S, Hauger RL.

Am J Physiol Regul Integr Comp Physiol. 2001 Apr;280(4):R935-46.

43.

High-affinity, non-peptide agonists for the ORL1 (orphanin FQ/nociceptin) receptor.

Röver S, Adam G, Cesura AM, Galley G, Jenck F, Monsma FJ Jr, Wichmann J, Dautzenberg FM.

J Med Chem. 2000 Apr 6;43(7):1329-38.

PMID:
10753470
44.

Different binding modes of amphibian and human corticotropin-releasing factor type 1 and type 2 receptors: evidence for evolutionary differences.

Dautzenberg FM, Py-Lang G, Higelin J, Fischer C, Wright MB, Huber G.

J Pharmacol Exp Ther. 2001 Jan;296(1):113-20.

PMID:
11123370
45.

125I-Antisauvagine-30: a novel and specific high-affinity radioligand for the characterization of corticotropin-releasing factor type 2 receptors.

Higelin J, Py-Lang G, Paternoster C, Ellis GJ, Patel A, Dautzenberg FM.

Neuropharmacology. 2001;40(1):114-22.

PMID:
11077077
46.
47.

Evidence for the abundant expression of arginine 185 containing human CRF(2alpha) receptors and the role of position 185 for receptor-ligand selectivity.

Dautzenberg FM, Huber G, Higelin J, Py-Lang G, Kilpatrick GJ.

Neuropharmacology. 2000 Jun 8;39(8):1368-76.

PMID:
10818253
48.

A synthetic agonist at the orphanin FQ/nociceptin receptor ORL1: anxiolytic profile in the rat.

Jenck F, Wichmann J, Dautzenberg FM, Moreau JL, Ouagazzal AM, Martin JR, Lundstrom K, Cesura AM, Poli SM, Roever S, Kolczewski S, Adam G, Kilpatrick G.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43.

49.
50.

Rapid agonist-induced phosphorylation of the human CRF receptor, type 1: a potential mechanism for homologous desensitization.

Hauger RL, Smith RD, Braun S, Dautzenberg FM, Catt KJ.

Biochem Biophys Res Commun. 2000 Feb 16;268(2):572-6.

PMID:
10679245

Supplemental Content

Loading ...
Support Center