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Items: 27


CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation.

Seibert M, Kr├╝ger M, Watson NA, Sen O, Daum JR, Slotman JA, Braun T, Houtsmuller AB, Gorbsky GJ, Jacob R, Kracht M, Higgins JMG, Schmitz ML.

J Cell Biol. 2019 Apr 1;218(4):1164-1181. doi: 10.1083/jcb.201806057. Epub 2019 Feb 14.


Multiple determinants and consequences of cohesion fatigue in mammalian cells.

Sapkota H, Wasiak E, Daum JR, Gorbsky GJ.

Mol Biol Cell. 2018 Aug 1;29(15):1811-1824. doi: 10.1091/mbc.E18-05-0315. Epub 2018 May 30. Erratum in: Mol Biol Cell. 2018 Oct 15;29(21):2601.


Predictive bioinformatics identifies novel regulators of proliferation in a cancer stem cell model.

Fields E, Wren JD, Georgescu C, Daum JR, Gorbsky GJ.

Stem Cell Res. 2018 Jan;26:1-7. doi: 10.1016/j.scr.2017.11.009. Epub 2017 Nov 21.


GTSE1 regulates spindle microtubule dynamics to control Aurora B kinase and Kif4A chromokinesin on chromosome arms.

Tipton AR, Wren JD, Daum JR, Siefert JC, Gorbsky GJ.

J Cell Biol. 2017 Oct 2;216(10):3117-3132. doi: 10.1083/jcb.201610012. Epub 2017 Aug 18.


Live-cell fluorescence imaging for phenotypic analysis of mitosis.

Sivakumar S, Daum JR, Gorbsky GJ.

Methods Mol Biol. 2014;1170:549-62. doi: 10.1007/978-1-4939-0888-2_31.


The spindle and kinetochore-associated (Ska) complex enhances binding of the anaphase-promoting complex/cyclosome (APC/C) to chromosomes and promotes mitotic exit.

Sivakumar S, Daum JR, Tipton AR, Rankin S, Gorbsky GJ.

Mol Biol Cell. 2014 Mar;25(5):594-605. doi: 10.1091/mbc.E13-07-0421. Epub 2014 Jan 8.


Haspin inhibitors reveal centromeric functions of Aurora B in chromosome segregation.

Wang F, Ulyanova NP, Daum JR, Patnaik D, Kateneva AV, Gorbsky GJ, Higgins JM.

J Cell Biol. 2012 Oct 15;199(2):251-68. doi: 10.1083/jcb.201205106.


Cohesion fatigue induces chromatid separation in cells delayed at metaphase.

Daum JR, Potapova TA, Sivakumar S, Daniel JJ, Flynn JN, Rankin S, Gorbsky GJ.

Curr Biol. 2011 Jun 21;21(12):1018-24. doi: 10.1016/j.cub.2011.05.032. Epub 2011 Jun 9.


Histone H3 Thr-3 phosphorylation by Haspin positions Aurora B at centromeres in mitosis.

Wang F, Dai J, Daum JR, Niedzialkowska E, Banerjee B, Stukenberg PT, Gorbsky GJ, Higgins JM.

Science. 2010 Oct 8;330(6001):231-5. doi: 10.1126/science.1189435. Epub 2010 Aug 12.


The dynamics of DNA topoisomerase IIalpha in living cells.

Daum JR, Mo YY, Gorbsky GJ.

Methods Mol Biol. 2009;582:233-44. doi: 10.1007/978-1-60761-340-4_18.


Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.

Daum JR, Wren JD, Daniel JJ, Sivakumar S, McAvoy JN, Potapova TA, Gorbsky GJ.

Curr Biol. 2009 Sep 15;19(17):1467-72. doi: 10.1016/j.cub.2009.07.017. Epub 2009 Jul 30.


A high throughput, whole cell screen for small molecule inhibitors of the mitotic spindle checkpoint identifies OM137, a novel Aurora kinase inhibitor.

DeMoe JH, Santaguida S, Daum JR, Musacchio A, Gorbsky GJ.

Cancer Res. 2009 Feb 15;69(4):1509-16. doi: 10.1158/0008-5472.CAN-08-3133. Epub 2009 Feb 3.


Fine tuning the cell cycle: activation of the Cdk1 inhibitory phosphorylation pathway during mitotic exit.

Potapova TA, Daum JR, Byrd KS, Gorbsky GJ.

Mol Biol Cell. 2009 Mar;20(6):1737-48. doi: 10.1091/mbc.E08-07-0771. Epub 2009 Jan 21.


Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1.

Pouwels J, Kukkonen AM, Lan W, Daum JR, Gorbsky GJ, Stukenberg T, Kallio MJ.

Cell Cycle. 2007 Jul 1;6(13):1579-85. Epub 2007 May 16.


The reversibility of mitotic exit in vertebrate cells.

Potapova TA, Daum JR, Pittman BD, Hudson JR, Jones TN, Satinover DL, Stukenberg PT, Gorbsky GJ.

Nature. 2006 Apr 13;440(7086):954-8.


Polo-like kinase 1 creates the tension-sensing 3F3/2 phosphoepitope and modulates the association of spindle-checkpoint proteins at kinetochores.

Ahonen LJ, Kallio MJ, Daum JR, Bolton M, Manke IA, Yaffe MB, Stukenberg PT, Gorbsky GJ.

Curr Biol. 2005 Jun 21;15(12):1078-89.


The highly conserved Ndc80 complex is required for kinetochore assembly, chromosome congression, and spindle checkpoint activity.

McCleland ML, Gardner RD, Kallio MJ, Daum JR, Gorbsky GJ, Burke DJ, Stukenberg PT.

Genes Dev. 2003 Jan 1;17(1):101-14.


The dephosphorylated form of the anaphase-promoting complex protein Cdc27/Apc3 concentrates on kinetochores and chromosome arms in mitosis.

Topper LM, Campbell MS, Tugendreich S, Daum JR, Burke DJ, Hieter P, Gorbsky GJ.

Cell Cycle. 2002 Jul-Aug;1(4):282-92.


The 3F3/2 anti-phosphoepitope antibody binds the mitotically phosphorylated anaphase-promoting complex/cyclosome.

Daum JR, Tugendreich S, Topper LM, Jorgensen PM, Hoog C, Hieter P, Gorbsky GJ.

Curr Biol. 2000 Nov 30;10(23):R850-2. No abstract available.


The spindle checkpoint of Saccharomyces cerevisiae responds to separable microtubule-dependent events.

Daum JR, Gomez-Ospina N, Winey M, Burke DJ.

Curr Biol. 2000 Nov 2;10(21):1375-8.


Kinetochore "memory" of spindle checkpoint signaling in lysed mitotic cells.

Campbell MS, Daum JR, Gersch MS, Nicklas RB, Gorbsky GJ.

Cell Motil Cytoskeleton. 2000 Jun;46(2):146-56.


Protein dynamics at the kinetochore: cell cycle regulation of the metaphase to anaphase transition.

Gorbsky GJ, Kallio M, Daum JR, Topper LM.

FASEB J. 1999 Dec;13 Suppl 2:S231-4.


Immunotoxicology of cadmium and mercury on B-lymphocytes--I. Effects on lymphocyte function.

Daum JR, Shepherd DM, Noelle RJ.

Int J Immunopharmacol. 1993 Apr;15(3):383-94.


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