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Items: 1 to 50 of 51

1.

Use of standardized SCID-hu Thy/Liv mouse model for preclinical efficacy testing of anti-human immunodeficiency virus type 1 compounds.

Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V, Datema R, Charpiot B, Seifert J, Kaneshima H, McCune JM.

Antimicrob Agents Chemother. 1996 Mar;40(3):755-62.

2.

Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry.

Datema R, Rabin L, Hincenbergs M, Moreno MB, Warren S, Linquist V, Rosenwirth B, Seifert J, McCune JM.

Antimicrob Agents Chemother. 1996 Mar;40(3):750-4.

3.

The molecular target of bicyclams, potent inhibitors of human immunodeficiency virus replication.

de Vreese K, Kofler-Mongold V, Leutgeb C, Weber V, Vermeire K, Schacht S, Anné J, de Clercq E, Datema R, Werner G.

J Virol. 1996 Feb;70(2):689-96.

4.

Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog.

Rosenwirth B, Billich A, Datema R, Donatsch P, Hammerschmid F, Harrison R, Hiestand P, Jaksche H, Mayer P, Peichl P, et al.

Antimicrob Agents Chemother. 1994 Aug;38(8):1763-72.

5.

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100.

De Clercq E, Yamamoto N, Pauwels R, Balzarini J, Witvrouw M, De Vreese K, Debyser Z, Rosenwirth B, Peichl P, Datema R, et al.

Antimicrob Agents Chemother. 1994 Apr;38(4):668-74.

6.

Synthesis and antiviral activity of 2'-substituted 9-[2-(phosphonomethoxy)ethyl]guanine analogues.

Yu KL, Bronson JJ, Yang H, Patick A, Alam M, Brankovan V, Datema R, Hitchcock MJ, Martin JC.

J Med Chem. 1993 Sep 17;36(19):2726-38.

PMID:
8410987
7.

Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine.

Yu KL, Bronson JJ, Yang H, Patick A, Alam M, Brankovan V, Datema R, Hitchcock MJ, Martin JC.

J Med Chem. 1992 Aug 7;35(16):2958-69.

PMID:
1323678
9.

Selective induction of discrete epitopes of herpes simplex virus type 1-specified glycoprotein C by interference with terminal steps in glycosylation.

Olofsson S, Sjöblom I, Glorioso JC, Jeansson S, Datema R.

J Gen Virol. 1991 Aug;72 ( Pt 8):1959-65.

PMID:
1714943
10.

Early events of HIV infection as targets for antiviral agents.

Datema R.

Ann N Y Acad Sci. 1990;616:155-60. Review. No abstract available.

PMID:
2078016
11.

Inhibition of HIV-1 reverse transcriptase by 5'-triphosphates of 5-substituted uridine analogs.

Tao PZ, Johansson NG, Stening G, Oberg B, Datema R.

Antiviral Res. 1989 Dec;12(5-6):269-78.

PMID:
2483878
12.
13.

Comparison of foscarnet and foscarnet esters as anti-influenza virus agents.

Strid S, Ekström C, Datema R.

Chemotherapy. 1989;35(1):69-76.

PMID:
2524368
14.

An analysis of the inhibition of replication of HIV and MuLV by some 3'-blocked pyrimidine analogs.

Bazin H, Chattopadhyaya J, Datema R, Ericson AC, Gilljam G, Johansson NG, Hansen J, Koshida R, Moelling K, Oberg B, et al.

Biochem Pharmacol. 1989 Jan 1;38(1):109-19.

PMID:
2462876
16.
17.
18.

Limited efficacy of inhibitors of herpes simplex virus DNA synthesis in murine models of recrudescent disease.

Kristofferson A, Ericson AC, Sohl-Akerlund A, Datema R.

J Gen Virol. 1988 Jun;69 ( Pt 6):1157-66.

PMID:
2838569
19.

Incorporation into nucleic acids of the antiherpes guanosine analog buciclovir, and effects on DNA and protein synthesis.

Stenberg K, Lundström M, Olofsson S, Datema R.

Biochem Pharmacol. 1988 May 15;37(10):1925-31.

PMID:
2837218
20.

Host cell-induced differences in O-glycosylation of herpes simplex virus gC-1. I. Structures of nonsialylated HPA- and PNA-binding carbohydrates.

Lundström M, Olofsson S, Jeansson S, Lycke E, Datema R, Månsson JE.

Virology. 1987 Dec;161(2):385-94.

PMID:
2825412
21.

Glucose trimming and mannose trimming affect different phases of the maturation of Sindbis virus in infected BHK cells.

McDowell W, Romero PA, Datema R, Schwarz RT.

Virology. 1987 Nov;161(1):37-44.

PMID:
2960074
22.

The effects of topical foscarnet in a new model of herpes simplex skin infection.

van Genderen J, Wolthuis OL, Ariens AT, Ericson AC, Datema R.

J Antimicrob Chemother. 1987 Oct;20(4):547-56.

PMID:
2960644
23.

Critical determinants of antiherpes efficacy of buciclovir and related acyclic guanosine analogs.

Datema R, Ericson AC, Field HJ, Larsson A, Stenberg K.

Antiviral Res. 1987 Jul;7(6):303-16. Review.

PMID:
2823702
24.

Inhibitors of protein glycosylation and glycoprotein processing in viral systems.

Datema R, Olofsson S, Romero PA.

Pharmacol Ther. 1987;33(2-3):221-86. Review. No abstract available.

PMID:
3310033
25.

Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir.

Larsson A, Stenberg K, Ericson AC, Haglund U, Yisak WA, Johansson NG, Oberg B, Datema R.

Antimicrob Agents Chemother. 1986 Oct;30(4):598-605.

26.
27.

Efficacy of the acyclic guanosine analog buciclovir [(R)-9-(3,4-dihydroxybutyl)guanine] in experimental genital herpes.

Lundgren B, Ericson AC, Berg M, Datema R.

Antimicrob Agents Chemother. 1986 Feb;29(2):294-7.

31.

Antiherpes effects and pharmacokinetic properties of 9-(4-hydroxybutyl) guanine and the (R) and (S) enantiomers of 9-(3,4-dihydroxybutyl)guanine.

Ericson AC, Larsson A, Aoki FY, Yisak WA, Johansson NG, Oberg B, Datema R.

Antimicrob Agents Chemother. 1985 May;27(5):753-9.

32.

The chemical synthesis and antiviral properties of an acyclovir-phospholipid conjugate.

Welch CJ, Larsson A, Ericson AC, Oberg B, Datema R, Chattopadhyaya J.

Acta Chem Scand B. 1985;39(1):47-54.

PMID:
2984864
33.
34.

An inhibitor of mannosylation of retinyl-phosphate.

Datema R, Schwarz RT.

Biosci Rep. 1984 Mar;4(3):213-21.

PMID:
6202337
35.

On the role of oligosaccharide trimming in the maturation of Sindbis and influenza virus.

Datema R, Romero PA, Rott R, Schwarz RT.

Arch Virol. 1984;81(1-2):25-39.

PMID:
6743024
36.
37.

Purification and characterization of a pig intestinal alpha-limit dextrinase.

Taravel FR, Datema R, Woloszczuk W, Marshall JJ, Whelan WJ.

Eur J Biochem. 1983 Jan 17;130(1):147-53.

38.
39.

Inhibition of formation of complex oligosaccharides by the glucosidase inhibitor bromoconduritol.

Datema R, Romero PA, Legler G, Schwarz RT.

Proc Natl Acad Sci U S A. 1982 Nov;79(22):6787-91.

40.

Inhibition of the dolichol pathway of protein glycosylation.

Schwarz RT, Datema R.

Methods Enzymol. 1982;83:432-43. No abstract available.

PMID:
7098946
41.

The lipid pathway of protein glycosylation and its inhibitors: the biological significance of protein-bound carbohydrates.

Schwarz RT, Datema R.

Adv Carbohydr Chem Biochem. 1982;40:287-379. Review. No abstract available.

PMID:
6188345
42.

Effect of energy depletion on the glycosylation of a viral glycoprotein.

Datema R, Schwarz RT.

J Biol Chem. 1981 Nov 10;256(21):11191-8.

43.

Deoxyglucose inhibition of protein glycosylation: effects of nucleotide deoxysugars on the formation of glucosylated lipid intermediates.

Datema R, Lezica RP, Robbins PW, Schwarz RT.

Arch Biochem Biophys. 1981 Jan;206(1):65-71. No abstract available.

PMID:
7212721
44.
45.

Dolichol-dependent protein glycosylation in a deoxy-glucose-resistant baby-hamster-kidney cell line.

Schwarz RT, Datema R, Hughes RC.

Biochim Biophys Acta. 1980 Aug 13;631(2):386-91.

PMID:
7407253
48.

Inhibition of glycosylation of viral glycoproteins.

Schwarz RT, Schmidt MF, Datema R.

Biochem Soc Trans. 1979 Apr;7(2):322-6. No abstract available.

PMID:
428638
50.

The hyphal wall of Mucor mucedo. 2. Hexosamine-containing polymers.

Datema R, Wessels JG, van den Ende H.

Eur J Biochem. 1977 Nov 1;80(2):621-6.

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