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Items: 36


PTSD Biomarker Database: deep dive metadatabase for PTSD biomarkers, visualizations and analysis tools.

Domingo-Fernández D, Provost A, Kodamullil AT, Marín-Llaó J, Lasseter H, Diaz K, Daskalakis NP, Lancashire L, Hofmann-Apitius M, Haas M.

Database (Oxford). 2019 Jan 1;2019. pii: baz081. doi: 10.1093/database/baz081.


Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction.

Vaz-Silva J, Gomes P, Jin Q, Zhu M, Zhuravleva V, Quintremil S, Meira T, Silva J, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL.

EMBO J. 2018 Oct 15;37(20). pii: e99084. doi: 10.15252/embj.201899084. Epub 2018 Aug 30.


Cell-type-specific interrogation of CeA Drd2 neurons to identify targets for pharmacological modulation of fear extinction.

McCullough KM, Daskalakis NP, Gafford G, Morrison FG, Ressler KJ.

Transl Psychiatry. 2018 Aug 22;8(1):164. doi: 10.1038/s41398-018-0190-y.


Recent Genetics and Epigenetics Approaches to PTSD.

Daskalakis NP, Rijal CM, King C, Huckins LM, Ressler KJ.

Curr Psychiatry Rep. 2018 Apr 5;20(5):30. doi: 10.1007/s11920-018-0898-7. Review.


Noncoding RNAs: Stress, Glucocorticoids, and Posttraumatic Stress Disorder.

Daskalakis NP, Provost AC, Hunter RG, Guffanti G.

Biol Psychiatry. 2018 May 15;83(10):849-865. doi: 10.1016/j.biopsych.2018.01.009. Epub 2018 Jan 31. Review.


Longitudinal changes in glucocorticoid receptor exon 1F methylation and psychopathology after military deployment.

Schür RR, Boks MP, Rutten BPF, Daskalakis NP, de Nijs L, van Zuiden M, Kavelaars A, Heijnen CJ, Joëls M, Kahn RS, Geuze E, Vermetten E, Vinkers CH.

Transl Psychiatry. 2017 Jul 25;7(7):e1181. doi: 10.1038/tp.2017.150.


Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder.

Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, Kenis G, Viechtbauer W, van den Hove D, Schraut KG, Lesch KP, Kleinman JE, Hyde TM, Weinberger DR, Schalkwyk L, Lunnon K, Mill J, Cohen H, Yehuda R, Baker DG, Maihofer AX, Nievergelt CM, Geuze E, Boks MPM.

Mol Psychiatry. 2018 May;23(5):1145-1156. doi: 10.1038/mp.2017.120. Epub 2017 Jun 20.


Oxytocin improves behavioral and electrophysiological deficits in a novel Shank3-deficient rat.

Harony-Nicolas H, Kay M, du Hoffmann J, Klein ME, Bozdagi-Gunal O, Riad M, Daskalakis NP, Sonar S, Castillo PE, Hof PR, Shapiro ML, Baxter MG, Wagner S, Buxbaum JD.

Elife. 2017 Jan 31;6. pii: e18904. doi: 10.7554/eLife.18904.


New translational perspectives for blood-based biomarkers of PTSD: From glucocorticoid to immune mediators of stress susceptibility.

Daskalakis NP, Cohen H, Nievergelt CM, Baker DG, Buxbaum JD, Russo SJ, Yehuda R.

Exp Neurol. 2016 Oct;284(Pt B):133-140. doi: 10.1016/j.expneurol.2016.07.024. Epub 2016 Jul 29. Review.


Early Life Stress Effects on Glucocorticoid-BDNF Interplay in the Hippocampus.

Daskalakis NP, De Kloet ER, Yehuda R, Malaspina D, Kranz TM.

Front Mol Neurosci. 2015 Nov 16;8:68. doi: 10.3389/fnmol.2015.00068. eCollection 2015. Review.


Defeat stress in rodents: From behavior to molecules.

Hammels C, Pishva E, De Vry J, van den Hove DL, Prickaerts J, van Winkel R, Selten JP, Lesch KP, Daskalakis NP, Steinbusch HW, van Os J, Kenis G, Rutten BP.

Neurosci Biobehav Rev. 2015 Dec;59:111-40. doi: 10.1016/j.neubiorev.2015.10.006. Epub 2015 Oct 22. Review.


Holocaust Exposure Induced Intergenerational Effects on FKBP5 Methylation.

Yehuda R, Daskalakis NP, Bierer LM, Bader HN, Klengel T, Holsboer F, Binder EB.

Biol Psychiatry. 2016 Sep 1;80(5):372-80. doi: 10.1016/j.biopsych.2015.08.005. Epub 2015 Aug 12.


Early maternal influences on stress circuitry: implications for resilience and susceptibility to physical and mental disorders.

Daskalakis NP, Yehuda R.

Front Endocrinol (Lausanne). 2015 Jan 14;5:244. doi: 10.3389/fendo.2014.00244. eCollection 2014. No abstract available.


Schizophrenia in the spectrum of gene-stress interactions: the FKBP5 example.

Daskalakis NP, Binder EB.

Schizophr Bull. 2015 Mar;41(2):323-9. doi: 10.1093/schbul/sbu189. Epub 2015 Jan 14. Review.


Site-specific methylation changes in the glucocorticoid receptor exon 1F promoter in relation to life adversity: systematic review of contributing factors.

Daskalakis NP, Yehuda R.

Front Neurosci. 2014 Nov 21;8:369. doi: 10.3389/fnins.2014.00369. eCollection 2014. Review.


Immediate Effects of Maternal Deprivation on the (Re)Activity of the HPA-Axis Differ in CD1 and C57Bl/6J Mouse Pups.

Daskalakis NP, Enthoven L, Schoonheere E, de Kloet ER, Oitzl MS.

Front Endocrinol (Lausanne). 2014 Nov 5;5:190. doi: 10.3389/fendo.2014.00190. eCollection 2014.


Glucocorticoid-related predictors and correlates of post-traumatic stress disorder treatment response in combat veterans.

Yehuda R, Pratchett LC, Elmes MW, Lehrner A, Daskalakis NP, Koch E, Makotkine I, Flory JD, Bierer LM.

Interface Focus. 2014 Oct 6;4(5):20140048. doi: 10.1098/rsfs.2014.0048.


Principles for developing animal models of military PTSD.

Daskalakis NP, Yehuda R.

Eur J Psychotraumatol. 2014 Aug 14;5. doi: 10.3402/ejpt.v5.23825. eCollection 2014.


Expression profiling associates blood and brain glucocorticoid receptor signaling with trauma-related individual differences in both sexes.

Daskalakis NP, Cohen H, Cai G, Buxbaum JD, Yehuda R.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13529-34. doi: 10.1073/pnas.1401660111. Epub 2014 Aug 11.


Maternal Age at Holocaust Exposure and Maternal PTSD Independently Influence Urinary Cortisol Levels in Adult Offspring.

Bader HN, Bierer LM, Lehrner A, Makotkine I, Daskalakis NP, Yehuda R.

Front Endocrinol (Lausanne). 2014 Jul 4;5:103. doi: 10.3389/fendo.2014.00103. eCollection 2014.


Elevation of 11β-hydroxysteroid dehydrogenase type 2 activity in Holocaust survivor offspring: evidence for an intergenerational effect of maternal trauma exposure.

Bierer LM, Bader HN, Daskalakis NP, Lehrner AL, Makotkine I, Seckl JR, Yehuda R.

Psychoneuroendocrinology. 2014 Oct;48:1-10. doi: 10.1016/j.psyneuen.2014.06.001. Epub 2014 Jun 7.


Influences of maternal and paternal PTSD on epigenetic regulation of the glucocorticoid receptor gene in Holocaust survivor offspring.

Yehuda R, Daskalakis NP, Lehrner A, Desarnaud F, Bader HN, Makotkine I, Flory JD, Bierer LM, Meaney MJ.

Am J Psychiatry. 2014 Aug;171(8):872-880. doi: 10.1176/appi.ajp.2014.13121571.


Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with posttraumatic stress disorder.

Yehuda R, Flory JD, Bierer LM, Henn-Haase C, Lehrner A, Desarnaud F, Makotkine I, Daskalakis NP, Marmar CR, Meaney MJ.

Biol Psychiatry. 2015 Feb 15;77(4):356-64. doi: 10.1016/j.biopsych.2014.02.006. Epub 2014 Feb 17.


Maternal PTSD associates with greater glucocorticoid sensitivity in offspring of Holocaust survivors.

Lehrner A, Bierer LM, Passarelli V, Pratchett LC, Flory JD, Bader HN, Harris IR, Bedi A, Daskalakis NP, Makotkine I, Yehuda R.

Psychoneuroendocrinology. 2014 Feb;40:213-20. doi: 10.1016/j.psyneuen.2013.11.019. Epub 2013 Dec 1.


Early experience of a novel-environment in isolation primes a fearful phenotype characterized by persistent amygdala activation.

Daskalakis NP, Diamantopoulou A, Claessens SE, Remmers E, Tjälve M, Oitzl MS, Champagne DL, de Kloet ER.

Psychoneuroendocrinology. 2014 Jan;39:39-57. doi: 10.1016/j.psyneuen.2013.09.021. Epub 2013 Sep 27.


Epigenetic Biomarkers as Predictors and Correlates of Symptom Improvement Following Psychotherapy in Combat Veterans with PTSD.

Yehuda R, Daskalakis NP, Desarnaud F, Makotkine I, Lehrner AL, Koch E, Flory JD, Buxbaum JD, Meaney MJ, Bierer LM.

Front Psychiatry. 2013 Sep 27;4:118. doi: 10.3389/fpsyt.2013.00118. eCollection 2013.


Endocrine aspects of post-traumatic stress disorder and implications for diagnosis and treatment.

Daskalakis NP, Lehrner A, Yehuda R.

Endocrinol Metab Clin North Am. 2013 Sep;42(3):503-13. doi: 10.1016/j.ecl.2013.05.004. Review.


Animal models in translational studies of PTSD.

Daskalakis NP, Yehuda R, Diamond DM.

Psychoneuroendocrinology. 2013 Sep;38(9):1895-911. doi: 10.1016/j.psyneuen.2013.06.006. Epub 2013 Jul 8. Review.


The three-hit concept of vulnerability and resilience: toward understanding adaptation to early-life adversity outcome.

Daskalakis NP, Bagot RC, Parker KJ, Vinkers CH, de Kloet ER.

Psychoneuroendocrinology. 2013 Sep;38(9):1858-73. doi: 10.1016/j.psyneuen.2013.06.008. Epub 2013 Jul 7. Review.


Early handling modulates outcome of neonatal dexamethasone exposure.

Claessens SE, Daskalakis NP, Oitzl MS, de Kloet ER.

Horm Behav. 2012 Sep;62(4):433-41. doi: 10.1016/j.yhbeh.2012.07.011. Epub 2012 Aug 6.


Drawings reflect a new dimension of the psychological impact of long-term remission of Cushing's syndrome.

Tiemensma J, Daskalakis NP, van der Veen EM, Ramondt S, Richardson SK, Broadbent E, Romijn JA, Pereira AM, Biermasz NR, Kaptein AA.

J Clin Endocrinol Metab. 2012 Sep;97(9):3123-31. doi: 10.1210/jc.2012-1235. Epub 2012 Jun 20.


Testing the cumulative stress and mismatch hypotheses of psychopathology in a rat model of early-life adversity.

Daskalakis NP, Oitzl MS, Schächinger H, Champagne DL, de Kloet ER.

Physiol Behav. 2012 Jul 16;106(5):707-21. doi: 10.1016/j.physbeh.2012.01.015. Epub 2012 Jan 28.


The newborn rat's stress system readily habituates to repeated and prolonged maternal separation, while continuing to respond to stressors in context dependent fashion.

Daskalakis NP, Claessens SE, Laboyrie JJ, Enthoven L, Oitzl MS, Champagne DL, de Kloet ER.

Horm Behav. 2011 Jul;60(2):165-76. doi: 10.1016/j.yhbeh.2011.04.003. Epub 2011 May 3.


Development of individual differences in stress responsiveness: an overview of factors mediating the outcome of early life experiences.

Claessens SE, Daskalakis NP, van der Veen R, Oitzl MS, de Kloet ER, Champagne DL.

Psychopharmacology (Berl). 2011 Mar;214(1):141-54. doi: 10.1007/s00213-010-2118-y. Epub 2010 Dec 18. Review.


Cortisol rapidly disrupts prepulse inhibition in healthy men.

Richter S, Schulz A, Zech CM, Oitzl MS, Daskalakis NP, Blumenthal TD, Schächinger H.

Psychoneuroendocrinology. 2011 Jan;36(1):109-14. doi: 10.1016/j.psyneuen.2010.07.002. Epub 2010 Aug 3.


Environmental and tactile stimulation modulates the neonatal handling effect on adult rat spatial memory.

Daskalakis NP, Kaperoni M, Koros C, de Kloet ER, Kitraki E.

Int J Dev Neurosci. 2009 Dec;27(8):747-55. doi: 10.1016/j.ijdevneu.2009.08.013. Epub 2009 Aug 29.


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