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Neonatal Injury Increases Gut Permeability by Epigenetically Suppressing E-Cadherin in Adulthood.

Kline KT, Lian H, Zhong XS, Luo X, Winston JH, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li Q.

J Immunol. 2020 Feb 15;204(4):980-989. doi: 10.4049/jimmunol.1900639. Epub 2019 Dec 30.


Sulforaphane Bioavailability and Chemopreventive Activity in Men Presenting for Biopsy of the Prostate Gland: A Randomized Controlled Trial.

Zhang Z, Garzotto M, Davis EW 2nd, Mori M, Stoller WA, Farris PE, Wong CP, Beaver LM, Thomas GV, Williams DE, Dashwood RH, Hendrix DA, Ho E, Shannon J.

Nutr Cancer. 2020;72(1):74-87. doi: 10.1080/01635581.2019.1619783. Epub 2019 Jun 1.


Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition.

Rajendran P, Johnson G, Li L, Chen YS, Dashwood M, Nguyen N, Ulusan A, Ertem F, Zhang M, Li J, Sun D, Huang Y, Wang S, Leung HC, Lieberman D, Beaver L, Ho E, Bedford M, Chang K, Vilar E, Dashwood R.

Cancer Res. 2019 Mar 1;79(5):918-927. doi: 10.1158/0008-5472.CAN-18-2003. Epub 2019 Jan 14.


p53-dependent autophagic degradation of TET2 modulates cancer therapeutic resistance.

Zhang J, Tan P, Guo L, Gong J, Ma J, Li J, Lee M, Fang S, Jing J, Johnson G, Sun D, Cao WM, Dashwood R, Han L, Zhou Y, Dong WG, Huang Y.

Oncogene. 2019 Mar;38(11):1905-1919. doi: 10.1038/s41388-018-0524-5. Epub 2018 Nov 2.


Broccoli Sprouts Delay Prostate Cancer Formation and Decrease Prostate Cancer Severity with a Concurrent Decrease in HDAC3 Protein Expression in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice.

Beaver LM, Lӧhr CV, Clarke JD, Glasser ST, Watson GW, Wong CP, Zhang Z, Williams DE, Dashwood RH, Shannon J, Thuillier P, Ho E.

Curr Dev Nutr. 2017 Dec 26;2(3):nzy002. doi: 10.1093/cdn/nzy002. eCollection 2018 Mar.


Neonatal Colonic Inflammation Epigenetically Aggravates Epithelial Inflammatory Responses to Injury in Adult Life.

Zhong XS, Winston JH, Luo X, Kline KT, Nayeem SZ, Cong Y, Savidge TC, Dashwood RH, Powell DW, Li Q.

Cell Mol Gastroenterol Hepatol. 2018 Mar 9;6(1):65-78. doi: 10.1016/j.jcmgh.2018.02.014. eCollection 2018.


Measuring Histone Deacetylase Inhibition in the Brain.

Reddy DS, Wu X, Golub VM, Dashwood WM, Dashwood RH.

Curr Protoc Pharmacol. 2018 Jun;81(1):e41. doi: 10.1002/cpph.41. Epub 2018 Jun 7.


Heterocyclic Analogs of Sulforaphane Trigger DNA Damage and Impede DNA Repair in Colon Cancer Cells: Interplay of HATs and HDACs.

Okonkwo A, Mitra J, Johnson GS, Li L, Dashwood WM, Hegde ML, Yue C, Dashwood RH, Rajendran P.

Mol Nutr Food Res. 2018 Sep;62(18):e1800228. doi: 10.1002/mnfr.201800228. Epub 2018 Jul 19.


Untargeted Metabolomic Screen Reveals Changes in Human Plasma Metabolite Profiles Following Consumption of Fresh Broccoli Sprouts.

Housley L, Magana AA, Hsu A, Beaver LM, Wong CP, Stevens JF, Choi J, Jiang Y, Bella D, Williams DE, Maier CS, Shannon J, Dashwood RH, Ho E.

Mol Nutr Food Res. 2018 Oct;62(19):e1700665. doi: 10.1002/mnfr.201700665. Epub 2018 Feb 23.


Accurate quantification of PGE2 in the polyposis in rat colon (Pirc) model by surrogate analyte-based UPLC-MS/MS.

Yun C, Dashwood WM, Kwong LN, Gao S, Yin T, Ling Q, Singh R, Dashwood RH, Hu M.

J Pharm Biomed Anal. 2018 Jan 30;148:42-50. doi: 10.1016/j.jpba.2017.07.025. Epub 2017 Jul 25.


Streptococcus gallolyticus subsp. gallolyticus promotes colorectal tumor development.

Kumar R, Herold JL, Schady D, Davis J, Kopetz S, Martinez-Moczygemba M, Murray BE, Han F, Li Y, Callaway E, Chapkin RS, Dashwood WM, Dashwood RH, Berry T, Mackenzie C, Xu Y.

PLoS Pathog. 2017 Jul 13;13(7):e1006440. doi: 10.1371/journal.ppat.1006440. eCollection 2017 Jul.


The phytochemical 3,3'-diindolylmethane decreases expression of AR-controlled DNA damage repair genes through repressive chromatin modifications and is associated with DNA damage in prostate cancer cells.

Palomera-Sanchez Z, Watson GW, Wong CP, Beaver LM, Williams DE, Dashwood RH, Ho E.

J Nutr Biochem. 2017 Sep;47:113-119. doi: 10.1016/j.jnutbio.2017.05.005. Epub 2017 May 25.


A miRNA signature for an environmental heterocyclic amine defined by a multi-organ carcinogenicity bioassay in the rat.

Chen YS, Wang R, Dashwood WM, Löhr CV, Williams DE, Ho E, Mertens-Talcott S, Dashwood RH.

Arch Toxicol. 2017 Oct;91(10):3415-3425. doi: 10.1007/s00204-017-1945-6. Epub 2017 Mar 13.


Divergent roles of p120-catenin isoforms linked to altered cell viability, proliferation, and invasiveness in carcinogen-induced rat skin tumors.

Wang R, Chen YS, Dashwood WM, Li Q, Löhr CV, Fischer K, Ho E, Williams DE, Dashwood RH.

Mol Carcinog. 2017 Jul;56(7):1733-1742. doi: 10.1002/mc.22630. Epub 2017 Mar 6.


Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer.

Beaver LM, Kuintzle R, Buchanan A, Wiley MW, Glasser ST, Wong CP, Johnson GS, Chang JH, Löhr CV, Williams DE, Dashwood RH, Hendrix DA, Ho E.

J Nutr Biochem. 2017 Apr;42:72-83. doi: 10.1016/j.jnutbio.2017.01.001. Epub 2017 Jan 12.


Towards High Capacity Li-ion Batteries Based on Silicon-Graphene Composite Anodes and Sub-micron V-doped LiFePO4 Cathodes.

Loveridge MJ, Lain MJ, Johnson ID, Roberts A, Beattie SD, Dashwood R, Darr JA, Bhagat R.

Sci Rep. 2016 Nov 29;6:37787. doi: 10.1038/srep37787.


A functional pseudogene, NMRAL2P, is regulated by Nrf2 and serves as a coactivator of NQO1 in sulforaphane-treated colon cancer cells.

Johnson GS, Li J, Beaver LM, Dashwood WM, Sun D, Rajendran P, Williams DE, Ho E, Dashwood RH.

Mol Nutr Food Res. 2017 Apr;61(4). doi: 10.1002/mnfr.201600769. Epub 2017 Jan 3.


Oncogenic targets Mmp7, S100a9, Nppb and Aldh1a3 from transcriptome profiling of FAP and Pirc adenomas are downregulated in response to tumor suppression by Clotam.

Ertem FU, Zhang W, Chang K, Mohaiza Dashwood W, Rajendran P, Sun D, Abudayyeh A, Vilar E, Abdelrahim M, Dashwood RH.

Int J Cancer. 2017 Jan 15;140(2):460-468. doi: 10.1002/ijc.30458. Epub 2016 Oct 18.


Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.

Wang R, Kang Y, Löhr CV, Fischer KA, Bradford CS, Johnson G, Dashwood WM, Williams DE, Ho E, Dashwood RH.

Cancer Lett. 2016 Oct 28;381(2):341-8. doi: 10.1016/j.canlet.2016.08.008. Epub 2016 Aug 15.


Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126/PI3K/AKT/mTOR axis in vitro and in vivo.

Kim H, Banerjee N, Barnes RC, Pfent CM, Talcott ST, Dashwood RH, Mertens-Talcott SU.

Mol Carcinog. 2017 Jan;56(1):197-207. doi: 10.1002/mc.22484. Epub 2016 Apr 6.


Comparison of anti-inflammatory mechanisms of mango (Mangifera Indica L.) and pomegranate (Punica Granatum L.) in a preclinical model of colitis.

Kim H, Banerjee N, Ivanov I, Pfent CM, Prudhomme KR, Bisson WH, Dashwood RH, Talcott ST, Mertens-Talcott SU.

Mol Nutr Food Res. 2016 Sep;60(9):1912-23. doi: 10.1002/mnfr.201501008. Epub 2016 May 23.


Dibenzo[def,p]chrysene transplacental carcinogenesis in wild-type, Cyp1b1 knockout, and CYP1B1 humanized mice.

Madeen EP, Löhr CV, You H, Siddens LK, Krueger SK, Dashwood RH, Gonzalez FJ, Baird WM, Ho E, Bramer L, Waters KM, Williams DE.

Mol Carcinog. 2017 Jan;56(1):163-171. doi: 10.1002/mc.22480. Epub 2016 Mar 17.


Development of a murine colonoscopic polypectomy model (with videos).

Ertem F, Dashwood WM, Rajendran P, Raju G, Rashid A, Dashwood R.

Gastrointest Endosc. 2016 Jun;83(6):1272-6. doi: 10.1016/j.gie.2015.11.030. Epub 2015 Nov 30.


HDAC6 activity is not required for basal autophagic flux in metastatic prostate cancer cells.

Watson GW, Wickramasekara S, Fang Y, Maier CS, Williams DE, Dashwood RH, Perez VI, Ho E.

Exp Biol Med (Maywood). 2016 Jun;241(11):1177-85. doi: 10.1177/1535370215618518. Epub 2015 Dec 6.


Assessment of global proteome in LNCaP cells by 2D-RP/RP LC-MS/MS following sulforaphane exposure.

Watson GW, Wickramasekara S, Maier CS, Williams DE, Dashwood RH, Ho E.

EuPA Open Proteom. 2015 Dec;9:34-40. Epub 2015 Aug 10.


Immunohistochemical characterization of intestinal neoplasia in zebrafish Danio rerio indicates epithelial origin.

Paquette CE, Kent ML, Peterson TS, Wang R, Dashwood RH, Löhr CV.

Dis Aquat Organ. 2015 Oct 27;116(3):191-7. doi: 10.3354/dao02924.


A hypermorphic epithelial β-catenin mutation facilitates intestinal tumorigenesis in mice in response to compounding WNT-pathway mutations.

Buchert M, Rohde F, Eissmann M, Tebbutt N, Williams B, Tan CW, Owen A, Hirokawa Y, Gnann A, Orend G, Orner G, Dashwood RH, Heath JK, Ernst M, Janssen KP.

Dis Model Mech. 2015 Nov;8(11):1361-73. doi: 10.1242/dmm.019844. Epub 2015 Aug 6.


Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.

Rajendran P, Dashwood WM, Li L, Kang Y, Kim E, Johnson G, Fischer KA, Löhr CV, Williams DE, Ho E, Yamamoto M, Lieberman DA, Dashwood RH.

Clin Epigenetics. 2015 Sep 18;7:102. doi: 10.1186/s13148-015-0132-y. eCollection 2015.


Histone and Non-Histone Targets of Dietary Deacetylase Inhibitors.

Kim E, Bisson WH, Löhr CV, Williams DE, Ho E, Dashwood RH, Rajendran P.

Curr Top Med Chem. 2016;16(7):714-31. Review.


Analysis of autophagic flux in response to sulforaphane in metastatic prostate cancer cells.

Watson GW, Wickramasekara S, Fang Y, Palomera-Sanchez Z, Maier CS, Williams DE, Dashwood RH, Perez VI, Ho E.

Mol Nutr Food Res. 2015 Oct;59(10):1954-61. doi: 10.1002/mnfr.201500283. Epub 2015 Aug 13.


Epigenetic Regulation by Sulforaphane: Opportunities for Breast and Prostate Cancer Chemoprevention.

Atwell LL, Beaver LM, Shannon J, Williams DE, Dashwood RH, Ho E.

Curr Pharmacol Rep. 2015 Apr 1;1(2):102-111.


The role of microRNA in nutritional control.

Nolte-'t Hoen EN, Van Rooij E, Bushell M, Zhang CY, Dashwood RH, James WP, Harris C, Baltimore D.

J Intern Med. 2015 Aug;278(2):99-109. doi: 10.1111/joim.12372. Epub 2015 May 19.


Absorption and chemopreventive targets of sulforaphane in humans following consumption of broccoli sprouts or a myrosinase-treated broccoli sprout extract.

Atwell LL, Hsu A, Wong CP, Stevens JF, Bella D, Yu TW, Pereira CB, Löhr CV, Christensen JM, Dashwood RH, Williams DE, Shannon J, Ho E.

Mol Nutr Food Res. 2015 Mar;59(3):424-33. doi: 10.1002/mnfr.201400674. Epub 2015 Jan 22.


SUV39H1/H3K9me3 attenuates sulforaphane-induced apoptotic signaling in PC3 prostate cancer cells.

Watson GW, Wickramasekara S, Palomera-Sanchez Z, Black C, Maier CS, Williams DE, Dashwood RH, Ho E.

Oncogenesis. 2014 Dec 8;3:e131. doi: 10.1038/oncsis.2014.47.


HDAC8 and STAT3 repress BMF gene activity in colon cancer cells.

Kang Y, Nian H, Rajendran P, Kim E, Dashwood WM, Pinto JT, Boardman LA, Thibodeau SN, Limburg PJ, Löhr CV, Bisson WH, Williams DE, Ho E, Dashwood RH.

Cell Death Dis. 2014 Oct 16;5:e1476. doi: 10.1038/cddis.2014.422.


Heterogeneous reactions of particulate matter-bound PAHs and NPAHs with NO3/N2O5, OH radicals, and O3 under simulated long-range atmospheric transport conditions: reactivity and mutagenicity.

Jariyasopit N, Zimmermann K, Schrlau J, Arey J, Atkinson R, Yu TW, Dashwood RH, Tao S, Simonich SL.

Environ Sci Technol. 2014 Sep 2;48(17):10155-64. doi: 10.1021/es5015407. Epub 2014 Aug 13.


Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention.

Beaver LM, Buchanan A, Sokolowski EI, Riscoe AN, Wong CP, Chang JH, Löhr CV, Williams DE, Dashwood RH, Ho E.

Mol Nutr Food Res. 2014 Oct;58(10):2001-13. doi: 10.1002/mnfr.201400269. Epub 2014 Aug 5.


Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells.

Wong CP, Hsu A, Buchanan A, Palomera-Sanchez Z, Beaver LM, Houseman EA, Williams DE, Dashwood RH, Ho E.

PLoS One. 2014 Jan 22;9(1):e86787. doi: 10.1371/journal.pone.0086787. eCollection 2014.


Novel nitro-PAH formation from heterogeneous reactions of PAHs with NO2, NO3/N2O5, and OH radicals: prediction, laboratory studies, and mutagenicity.

Jariyasopit N, McIntosh M, Zimmermann K, Arey J, Atkinson R, Cheong PH, Carter RG, Yu TW, Dashwood RH, Massey Simonich SL.

Environ Sci Technol. 2014;48(1):412-9. doi: 10.1021/es4043808. Epub 2013 Dec 19.


Metabolism and cancer: old and new players.

Cerella C, Michiels C, Dashwood RH, Surh YJ, Diederich M.

Int J Cell Biol. 2013;2013:293201. doi: 10.1155/2013/293201. Epub 2013 Jun 23. No abstract available.


The epigenome as a potential mediator of cancer and disease prevention in prenatal development.

Kaur P, Shorey LE, Ho E, Dashwood RH, Williams DE.

Nutr Rev. 2013 Jul;71(7):441-57. doi: 10.1111/nure.12030. Epub 2013 May 15. Review.


HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates.

Rajendran P, Kidane AI, Yu TW, Dashwood WM, Bisson WH, Löhr CV, Ho E, Williams DE, Dashwood RH.

Epigenetics. 2013 Jun;8(6):612-23. doi: 10.4161/epi.24710. Epub 2013 Apr 26.


Differential modulation of dibenzo[def,p]chrysene transplacental carcinogenesis: maternal diets rich in indole-3-carbinol versus sulforaphane.

Shorey LE, Madeen EP, Atwell LL, Ho E, Löhr CV, Pereira CB, Dashwood RH, Williams DE.

Toxicol Appl Pharmacol. 2013 Jul 1;270(1):60-9. doi: 10.1016/j.taap.2013.02.016. Epub 2013 Apr 6.


A role for low-abundance miRNAs in colon cancer: the miR-206/Krüppel-like factor 4 (KLF4) axis.

Parasramka MA, Dashwood WM, Wang R, Saeed HH, Williams DE, Ho E, Dashwood RH.

Clin Epigenetics. 2012 Sep 24;4(1):16. doi: 10.1186/1868-7083-4-16.


Nutritional regulation of epigenetic changes.

Romagnolo DF, Dashwood R, Stover PJ, Waterland RA, Ziegler TR.

Adv Nutr. 2012 Sep 1;3(5):749-50. doi: 10.3945/an.112.002675. No abstract available.


Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer.

Wang R, Löhr CV, Fischer K, Dashwood WM, Greenwood JA, Ho E, Williams DE, Ashktorab H, Dashwood MR, Dashwood RH.

Int J Cancer. 2013 Mar 1;132(5):1004-12. doi: 10.1002/ijc.27762. Epub 2012 Aug 24.


3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells.

Beaver LM, Yu TW, Sokolowski EI, Williams DE, Dashwood RH, Ho E.

Toxicol Appl Pharmacol. 2012 Sep 15;263(3):345-51. doi: 10.1016/j.taap.2012.07.007. Epub 2012 Jul 16.


MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach.

Parasramka MA, Dashwood WM, Wang R, Abdelli A, Bailey GS, Williams DE, Ho E, Dashwood RH.

Mol Nutr Food Res. 2012 Aug;56(8):1259-69. doi: 10.1002/mnfr.201200117. Epub 2012 May 29.


3,3'-Diindolylmethane induces G1 arrest and apoptosis in human acute T-cell lymphoblastic leukemia cells.

Shorey LE, Hagman AM, Williams DE, Ho E, Dashwood RH, Benninghoff AD.

PLoS One. 2012;7(4):e34975. doi: 10.1371/journal.pone.0034975. Epub 2012 Apr 13.


Dietary factors and epigenetic regulation for prostate cancer prevention.

Ho E, Beaver LM, Williams DE, Dashwood RH.

Adv Nutr. 2011 Nov;2(6):497-510. doi: 10.3945/an.111.001032. Epub 2011 Nov 3. Review.

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