Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 136


Mutual action by Gγ and Gβ for optimal activation of GIRK channels in a channel subunit-specific manner.

Tabak G, Keren-Raifman T, Kahanovitch U, Dascal N.

Sci Rep. 2019 Jan 24;9(1):508. doi: 10.1038/s41598-018-36833-y.


Protein kinase C enhances plasma membrane expression of cardiac L-type calcium channel, CaV1.2.

Raifman TK, Kumar P, Haase H, Klussmann E, Dascal N, Weiss S.

Channels (Austin). 2017 Nov 2;11(6):604-615. doi: 10.1080/19336950.2017.1369636. Epub 2017 Sep 21.


Lithium reduces the span of G protein-activated K+ (GIRK) channel inhibition in hippocampal neurons.

Dascal N, Rubinstein M.

Bipolar Disord. 2017 Nov;19(7):568-574. doi: 10.1111/bdi.12536. Epub 2017 Sep 12.


Collision coupling in the GABAB receptor-G protein-GIRK signaling cascade.

Kahanovitch U, Berlin S, Dascal N.

FEBS Lett. 2017 Sep;591(18):2816-2825. doi: 10.1002/1873-3468.12756. Epub 2017 Aug 21.


Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit.

Oz S, Pankonien I, Belkacemi A, Flockerzi V, Klussmann E, Haase H, Dascal N.

J Physiol. 2017 May 15;595(10):3181-3202. doi: 10.1113/JP274015. Epub 2017 Mar 23.


Interactions between N and C termini of α1C subunit regulate inactivation of CaV1.2 L-type Ca(2+) channel.

Benmocha Guggenheimer A, Almagor L, Tsemakhovich V, Tripathy DR, Hirsch JA, Dascal N.

Channels (Austin). 2016;10(1):55-68. doi: 10.1080/19336950.2015.1108499.


A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ.

Yakubovich D, Berlin S, Kahanovitch U, Rubinstein M, Farhy-Tselnicker I, Styr B, Keren-Raifman T, Dessauer CW, Dascal N.

PLoS Comput Biol. 2015 Nov 6;11(11):e1004598. doi: 10.1371/journal.pcbi.1004598. eCollection 2015 Nov.


The Roles of Gβγ and Gα in Gating and Regulation of GIRK Channels.

Dascal N, Kahanovitch U.

Int Rev Neurobiol. 2015;123:27-85. doi: 10.1016/bs.irn.2015.06.001. Epub 2015 Jul 26. Review.


Molecular Aspects of Modulation of L-type Calcium Channels by Protein Kinase C.

Weiss S, Dascal N.

Curr Mol Pharmacol. 2015;8(1):43-53. Review.


Recruitment of Gβγ controls the basal activity of G-protein coupled inwardly rectifying potassium (GIRK) channels: crucial role of distal C terminus of GIRK1.

Kahanovitch U, Tsemakhovich V, Berlin S, Rubinstein M, Styr B, Castel R, Peleg S, Tabak G, Dessauer CW, Ivanina T, Dascal N.

J Physiol. 2014 Dec 15;592(24):5373-90. doi: 10.1113/jphysiol.2014.283218. Epub 2014 Nov 10.


Dual regulation of G proteins and the G-protein-activated K+ channels by lithium.

Farhy Tselnicker I, Tsemakhovich V, Rishal I, Kahanovitch U, Dessauer CW, Dascal N.

Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):5018-23. doi: 10.1073/pnas.1316425111. Epub 2014 Mar 17.


Conserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition response.

Edelheit O, Ben-Shahar R, Dascal N, Hanukoglu A, Hanukoglu I.

FEBS J. 2014 Apr;281(8):2097-111. doi: 10.1111/febs.12765. Epub 2014 Mar 17.


Regulation of cardiac L-type Ca²⁺ channel CaV1.2 via the β-adrenergic-cAMP-protein kinase A pathway: old dogmas, advances, and new uncertainties.

Weiss S, Oz S, Benmocha A, Dascal N.

Circ Res. 2013 Aug 16;113(5):617-31. doi: 10.1161/CIRCRESAHA.113.301781.


SK4 Ca2+ activated K+ channel is a critical player in cardiac pacemaker derived from human embryonic stem cells.

Weisbrod D, Peretz A, Ziskind A, Menaker N, Oz S, Barad L, Eliyahu S, Itskovitz-Eldor J, Dascal N, Khananshvili D, Binah O, Attali B.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):E1685-94. doi: 10.1073/pnas.1221022110. Epub 2013 Apr 15.


Competitive and non-competitive regulation of calcium-dependent inactivation in CaV1.2 L-type Ca2+ channels by calmodulin and Ca2+-binding protein 1.

Oz S, Benmocha A, Sasson Y, Sachyani D, Almagor L, Lee A, Hirsch JA, Dascal N.

J Biol Chem. 2013 May 3;288(18):12680-91. doi: 10.1074/jbc.M113.460949. Epub 2013 Mar 25.


Early infantile epileptic encephalopathy associated with a high voltage gated calcium channelopathy.

Edvardson S, Oz S, Abulhijaa FA, Taher FB, Shaag A, Zenvirt S, Dascal N, Elpeleg O.

J Med Genet. 2013 Feb;50(2):118-23. doi: 10.1136/jmedgenet-2012-101223.


Molecular basis of the facilitation of the heterooligomeric GIRK1/GIRK4 complex by cAMP dependent protein kinase.

Treiber F, Rosker C, Keren-Raifman T, Steinecker B, Gorischek A, Dascal N, Schreibmayer W.

Biochim Biophys Acta. 2013 Apr;1828(4):1214-21. doi: 10.1016/j.bbamem.2012.12.016. Epub 2013 Jan 7.


Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of Gβγ and protein kinase C.

Weiss S, Keren-Raifman T, Oz S, Ben Mocha A, Haase H, Dascal N.

Channels (Austin). 2012 Nov-Dec;6(6):426-37. doi: 10.4161/chan.22016. Epub 2012 Sep 18.


Ca(V)1.2 I-II linker structure and Timothy syndrome.

Almagor L, Chomsky-Hecht O, Ben-Mocha A, Hendin-Barak D, Dascal N, Hirsch JA.

Channels (Austin). 2012 Nov-Dec;6(6):468-72. doi: 10.4161/chan.22078. Epub 2012 Sep 18.


The role of a voltage-dependent Ca2+ channel intracellular linker: a structure-function analysis.

Almagor L, Chomsky-Hecht O, Ben-Mocha A, Hendin-Barak D, Dascal N, Hirsch JA.

J Neurosci. 2012 May 30;32(22):7602-13. doi: 10.1523/JNEUROSCI.5727-11.2012.


Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cavβ₂.

Pankonien I, Otto A, Dascal N, Morano I, Haase H.

Biochem Biophys Res Commun. 2012 May 4;421(2):184-9. doi: 10.1016/j.bbrc.2012.03.132. Epub 2012 Apr 4.


Two distinct aspects of coupling between Gα(i) protein and G protein-activated K+ channel (GIRK) revealed by fluorescently labeled Gα(i3) protein subunits.

Berlin S, Tsemakhovich VA, Castel R, Ivanina T, Dessauer CW, Keren-Raifman T, Dascal N.

J Biol Chem. 2011 Sep 23;286(38):33223-35. doi: 10.1074/jbc.M111.271056. Epub 2011 Jul 27.


CaBP1 regulates voltage-dependent inactivation and activation of Ca(V)1.2 (L-type) calcium channels.

Oz S, Tsemakhovich V, Christel CJ, Lee A, Dascal N.

J Biol Chem. 2011 Apr 22;286(16):13945-53. doi: 10.1074/jbc.M110.198424. Epub 2011 Mar 7.


Identification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesis.

Edelheit O, Hanukoglu I, Dascal N, Hanukoglu A.

Am J Physiol Renal Physiol. 2011 Apr;300(4):F887-97. doi: 10.1152/ajprenal.00648.2010. Epub 2011 Jan 5.


Further characterization of regulation of Ca(V)2.2 by stargazin.

Tselnicker I, Dascal N.

Channels (Austin). 2010 Sep-Oct;4(5):351-4. doi: 10.4161/chan.4.5.13504.


A novel mutation in the HCN4 gene causes symptomatic sinus bradycardia in Moroccan Jews.

Laish-Farkash A, Glikson M, Brass D, Marek-Yagel D, Pras E, Dascal N, Antzelevitch C, Nof E, Reznik H, Eldar M, Luria D.

J Cardiovasc Electrophysiol. 2010 Dec;21(12):1365-72. doi: 10.1111/j.1540-8167.2010.01844.x.


Stargazin modulates neuronal voltage-dependent Ca(2+) channel Ca(v)2.2 by a Gbetagamma-dependent mechanism.

Tselnicker I, Tsemakhovich VA, Dessauer CW, Dascal N.

J Biol Chem. 2010 Jul 2;285(27):20462-71. doi: 10.1074/jbc.M110.121277. Epub 2010 Apr 30.


Anion-sensitive regions of L-type CaV1.2 calcium channels expressed in HEK293 cells.

Babai N, Kanevsky N, Dascal N, Rozanski GJ, Singh DP, Fatma N, Thoreson WB.

PLoS One. 2010 Jan 6;5(1):e8602. doi: 10.1371/journal.pone.0008602.


Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC.

Edelheit O, Hanukoglu I, Shriki Y, Tfilin M, Dascal N, Gillis D, Hanukoglu A.

J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):84-8. doi: 10.1016/j.jsbmb.2010.01.002. Epub 2010 Jan 12.


G alpha(i) and G betagamma jointly regulate the conformations of a G betagamma effector, the neuronal G protein-activated K+ channel (GIRK).

Berlin S, Keren-Raifman T, Castel R, Rubinstein M, Dessauer CW, Ivanina T, Dascal N.

J Biol Chem. 2010 Feb 26;285(9):6179-85. doi: 10.1074/jbc.M109.085944. Epub 2009 Dec 16.


N terminus of type 5 adenylyl cyclase scaffolds Gs heterotrimer.

Sadana R, Dascal N, Dessauer CW.

Mol Pharmacol. 2009 Dec;76(6):1256-64. doi: 10.1124/mol.109.058370. Epub 2009 Sep 25.


Characterization of the calmodulin-binding site in the N terminus of CaV1.2.

Benmocha A, Almagor L, Oz S, Hirsch JA, Dascal N.

Channels (Austin). 2009 Sep-Oct;3(5):337-42. Epub 2009 Sep 29.


Divergent regulation of GIRK1 and GIRK2 subunits of the neuronal G protein gated K+ channel by GalphaiGDP and Gbetagamma.

Rubinstein M, Peleg S, Berlin S, Brass D, Keren-Raifman T, Dessauer CW, Ivanina T, Dascal N.

J Physiol. 2009 Jul 15;587(Pt 14):3473-91. doi: 10.1113/jphysiol.2009.173229. Epub 2009 May 26.


Renin-aldosterone response, urinary Na/K ratio and growth in pseudohypoaldosteronism patients with mutations in epithelial sodium channel (ENaC) subunit genes.

Hanukoglu A, Edelheit O, Shriki Y, Gizewska M, Dascal N, Hanukoglu I.

J Steroid Biochem Mol Biol. 2008 Sep;111(3-5):268-74. doi: 10.1016/j.jsbmb.2008.06.013. Epub 2008 Jun 26.


Amplitude histogram-based method of analysis of patch clamp recordings that involve extreme changes in channel activity levels.

Yakubovich D, Rishal I, Dessauer CW, Dascal N.

J Mol Neurosci. 2009 Mar;37(3):201-11. doi: 10.1007/s12031-008-9117-z. Epub 2008 Jul 12.


Voltage clamp recordings from Xenopus oocytes.

Dascal N.

Curr Protoc Neurosci. 2001 May;Chapter 6:Unit 6.12. doi: 10.1002/0471142301.ns0612s10.


Molecular mechanisms that control initiation and termination of physiological depolarization-evoked transmitter release.

Kupchik YM, Rashkovan G, Ohana L, Keren-Raifman T, Dascal N, Parnas H, Parnas I.

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4435-40. doi: 10.1073/pnas.0708540105. Epub 2008 Mar 7.


An inactivation gate in the selectivity filter of KCNQ1 potassium channels.

Gibor G, Yakubovich D, Rosenhouse-Dantsker A, Peretz A, Schottelndreier H, Seebohm G, Dascal N, Logothetis DE, Paas Y, Attali B.

Biophys J. 2007 Dec 15;93(12):4159-72. Epub 2007 Aug 17.


Point mutation in the HCN4 cardiac ion channel pore affecting synthesis, trafficking, and functional expression is associated with familial asymptomatic sinus bradycardia.

Nof E, Luria D, Brass D, Marek D, Lahat H, Reznik-Wolf H, Pras E, Dascal N, Eldar M, Glikson M.

Circulation. 2007 Jul 31;116(5):463-70. Epub 2007 Jul 23.


Galphai3 primes the G protein-activated K+ channels for activation by coexpressed Gbetagamma in intact Xenopus oocytes.

Rubinstein M, Peleg S, Berlin S, Brass D, Dascal N.

J Physiol. 2007 May 15;581(Pt 1):17-32. Epub 2007 Feb 8.


Movement of 'gating charge' is coupled to ligand binding in a G-protein-coupled receptor.

Ben-Chaim Y, Chanda B, Dascal N, Bezanilla F, Parnas I, Parnas H.

Nature. 2006 Nov 2;444(7115):106-9. Epub 2006 Oct 25.


Coupling of GABAB receptor GABAB2 subunit to G proteins: evidence from Xenopus oocyte and baby hamster kidney cell expression system.

Uezono Y, Kanaide M, Kaibara M, Barzilai R, Dascal N, Sumikawa K, Taniyama K.

Am J Physiol Cell Physiol. 2006 Jan;290(1):C200-7. Epub 2005 Aug 24.


Kinetic modeling of Na(+)-induced, Gbetagamma-dependent activation of G protein-gated K(+) channels.

Yakubovich D, Rishal I, Dascal N.

J Mol Neurosci. 2005;25(1):7-19.


Gbetagamma-dependent and Gbetagamma-independent basal activity of G protein-activated K+ channels.

Rishal I, Porozov Y, Yakubovich D, Varon D, Dascal N.

J Biol Chem. 2005 Apr 29;280(17):16685-94. Epub 2005 Feb 23.


G protein-activated K+ channels: a reporter for rapid activation of G proteins by lysophosphatidic acid in Xenopus oocytes.

Itzhaki Van-Ham I, Peleg S, Dascal N, Shapira H, Oron Y.

FEBS Lett. 2004 Apr 23;564(1-2):157-60.


Galphai1 and Galphai3 differentially interact with, and regulate, the G protein-activated K+ channel.

Ivanina T, Varon D, Peleg S, Rishal I, Porozov Y, Dessauer CW, Keren-Raifman T, Dascal N.

J Biol Chem. 2004 Apr 23;279(17):17260-8. Epub 2004 Feb 12.


Intracellular Na+ inhibits voltage-dependent N-type Ca2+ channels by a G protein betagamma subunit-dependent mechanism.

Blumenstein Y, Maximyuk OP, Lozovaya N, Yatsenko NM, Kanevsky N, Krishtal O, Dascal N.

J Physiol. 2004 Apr 1;556(Pt 1):121-34. Epub 2004 Jan 23.


Modulation of cardiac Ca2+ channel by Gq-activating neurotransmitters reconstituted in Xenopus oocytes.

Weiss S, Doan T, Bernstein KE, Dascal N.

J Biol Chem. 2004 Mar 26;279(13):12503-10. Epub 2004 Jan 13.

Supplemental Content

Loading ...
Support Center