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Safety and Adverse Events after Targeted Lung Denervation for Symptomatic Moderate to Severe COPD (AIRFLOW): A Multicenter Randomized Controlled Trial.

Slebos DJ, Shah PL, Herth FJ, Pison C, Schumann C, Hübner RH, Bonta PI, Kessler R, Gesierich W, Darwiche K, Lamprecht B, Perez T, Skowasch D, Deslee G, Marceau A, Sciurba FC, Gosens R, Hartman JE, Srikanthan K, Duller M, Valipour A; AIRFLOW-2 Trial Study Group.

Am J Respir Crit Care Med. 2019 Aug 12. doi: 10.1164/rccm.201903-0624OC. [Epub ahead of print]


Bleeding risk of transbronchial cryobiopsy compared to transbronchial forceps biopsy in interstitial lung disease - a prospective, randomized, multicentre cross-over trial.

Hetzel J, Eberhardt R, Petermann C, Gesierich W, Darwiche K, Hagmeyer L, Muche R, Kreuter M, Lewis R, Ehab A, Boeckeler M, Haentschel M.

Respir Res. 2019 Jul 5;20(1):140. doi: 10.1186/s12931-019-1091-1.


Bronchial Thermoplasty Including the Middle Lobe Bronchus Significantly Improves Lung Function and Quality of Life in Patients Suffering from Severe Asthma.

Eisenmann S, Schütte W, Funke F, Oezkan F, Islam S, Darwiche K.

Lung. 2019 Aug;197(4):493-499. doi: 10.1007/s00408-019-00240-5. Epub 2019 May 27.


A Prospective, Randomized Trial for the Comparison of 19-G and 22-G Endobronchial Ultrasound-Guided Transbronchial Aspiration Needles; Introducing a Novel End Point of Sample Weight Corrected for Blood Content.

Wolters C, Darwiche K, Franzen D, Hager T, Bode-Lesnievska B, Kneuertz PJ, He K, Koenig M, Freitag L, Wei L, Eisenmann S, Taube C, Weinreich G, Oezkan F.

Clin Lung Cancer. 2019 May;20(3):e265-e273. doi: 10.1016/j.cllc.2019.02.019. Epub 2019 Mar 4.


Cytology Versus Histology in the Primary Diagnosis of Lymphoma Located in the Mediastinum.

Plönes T, Mardanzai K, Gafencu D, Viehof J, Hager T, Theegarten D, Dührsen U, Darwiche K, Taube C, Aigner C.

Ann Thorac Surg. 2019 Jul;108(1):244-248. doi: 10.1016/j.athoracsur.2019.02.030. Epub 2019 Mar 20.


Machine learning-based predictors for immune checkpoint inhibitor therapy of non-small-cell lung cancer.

Wiesweg M, Mairinger F, Reis H, Goetz M, Walter RFH, Hager T, Metzenmacher M, Eberhardt WEE, McCutcheon A, Köster J, Stuschke M, Aigner C, Darwiche K, Schmid KW, Rahmann S, Schuler M.

Ann Oncol. 2019 Apr 1;30(4):655-657. doi: 10.1093/annonc/mdz049. No abstract available.


Impact of RAS mutation subtype on clinical outcome-a cross-entity comparison of patients with advanced non-small cell lung cancer and colorectal cancer.

Wiesweg M, Kasper S, Worm K, Herold T, Reis H, Sara L, Metzenmacher M, Abendroth A, Darwiche K, Aigner C, Wedemeyer HH, Helfritz FA, Stuschke M, Schumacher B, Markus P, Paul A, Rahmann S, Schmid KW, Schuler M.

Oncogene. 2019 Apr;38(16):2953-2966. doi: 10.1038/s41388-018-0634-0. Epub 2018 Dec 19.


Clinical management of lung volume reduction in end stage emphysema patients.

Darwiche K, Aigner C.

J Thorac Dis. 2018 Aug;10(Suppl 23):S2732-S2737. doi: 10.21037/jtd.2018.02.69. Review.


Rapid and Highly Sensitive Detection of Therapeutically Relevant Oncogenic Driver Mutations in EBUS-TBNA Specimens From Patients With Lung Adenocarcinoma.

Oezkan F, Herold T, Darwiche K, Eberhardt WEE, Worm K, Christoph DC, Wiesweg M, Freitag L, Schmid KW, Theegarten D, Hager T, Koenig MJ, He K, Taube C, Schuler M, Breitenbuecher F.

Clin Lung Cancer. 2018 Nov;19(6):e879-e884. doi: 10.1016/j.cllc.2018.08.016. Epub 2018 Aug 22.


[Rebiopsy for Patients with Lung Cancer - Joint Opinion from both the Endoscopic and Thoracic Oncology Sections of the German Society of Pneumology (DGP)].

Brückl WM, Ficker JH, Tiemann M, Schumann C, Reinmuth N, Heigener D, Schütte W, Eberhardt R, Darwiche K, Wagner M.

Pneumologie. 2018 Sep;72(9):617-623. doi: 10.1055/a-0632-9174. Epub 2018 Aug 2. Review. German.


Endobronchialer Ultraschall (EBUS) – ein Update 2017.

Darwiche K, Özkan F, Wolters C, Eisenmann S.

Ultraschall Med. 2018 Oct;39(5):566-567. doi: 10.1055/a-0629-5580. Epub 2018 Jul 4. German. No abstract available.


MET Expression in Advanced Non-Small-Cell Lung Cancer: Effect on Clinical Outcomes of Chemotherapy, Targeted Therapy, and Immunotherapy.

Reis H, Metzenmacher M, Goetz M, Savvidou N, Darwiche K, Aigner C, Herold T, Eberhardt WE, Skiba C, Hense J, Virchow I, Westerwick D, Bogner S, Ting S, Kasper S, Stuschke M, Nensa F, Herrmann K, Hager T, Schmid KW, Schuler M, Wiesweg M.

Clin Lung Cancer. 2018 Jul;19(4):e441-e463. doi: 10.1016/j.cllc.2018.03.010. Epub 2018 Mar 17.


Endobronchial Ultrasound (EBUS) - Update 2017.

Darwiche K, Özkan F, Wolters C, Eisenmann S.

Ultraschall Med. 2018 Feb;39(1):14-38. doi: 10.1055/s-0043-125092. Epub 2018 Feb 7. Review.


Transbronchial Cryobiopsies for the Diagnosis of Diffuse Parenchymal Lung Diseases: Expert Statement from the Cryobiopsy Working Group on Safety and Utility and a Call for Standardization of the Procedure.

Hetzel J, Maldonado F, Ravaglia C, Wells AU, Colby TV, Tomassetti S, Ryu JH, Fruchter O, Piciucchi S, Dubini A, Cavazza A, Chilosi M, Sverzellati N, Valeyre D, Leduc D, Walsh SLF, Gasparini S, Hetzel M, Hagmeyer L, Haentschel M, Eberhardt R, Darwiche K, Yarmus LB, Torrego A, Krishna G, Shah PL, Annema JT, Herth FJF, Poletti V.

Respiration. 2018;95(3):188-200. doi: 10.1159/000484055. Epub 2018 Jan 9.


Prognostic value of MIB-1 proliferation index in solitary fibrous tumors of the pleura implemented in a new score - a multicenter study.

Diebold M, Soltermann A, Hottinger S, Haile SR, Bubendorf L, Komminoth P, Jochum W, Grobholz R, Theegarten D, Berezowska S, Darwiche K, Oezkan F, Kohler M, Franzen DP.

Respir Res. 2017 Dec 16;18(1):210. doi: 10.1186/s12931-017-0693-8.


[Endobronchial Ultrasound (EBUS) - an Update 2017].

Darwiche K, Özkan F, Wolters C, Eisenmann S.

Pneumologie. 2017 Nov;71(11):798-812. doi: 10.1055/s-0043-103034. Epub 2017 Nov 13. Review. German.


A Multicenter Randomized Controlled Trial of Zephyr Endobronchial Valve Treatment in Heterogeneous Emphysema (TRANSFORM).

Kemp SV, Slebos DJ, Kirk A, Kornaszewska M, Carron K, Ek L, Broman G, Hillerdal G, Mal H, Pison C, Briault A, Downer N, Darwiche K, Rao J, Hübner RH, Ruwwe-Glosenkamp C, Trosini-Desert V, Eberhardt R, Herth FJ, Derom E, Malfait T, Shah PL, Garner JL, Ten Hacken NH, Fallouh H, Leroy S, Marquette CH; TRANSFORM Study Team *.

Am J Respir Crit Care Med. 2017 Dec 15;196(12):1535-1543. doi: 10.1164/rccm.201707-1327OC.


Towards Individualized Tracheobronchial Stents: Technical, Practical and Legal Considerations.

Freitag L, Gördes M, Zarogoulidis P, Darwiche K, Franzen D, Funke F, Hohenforst-Schmidt W, Dutau H.

Respiration. 2017;94(5):442-456. doi: 10.1159/000479164. Epub 2017 Sep 7.


Heart dose exposure as prognostic marker after radiotherapy for resectable stage IIIA/B non-small-cell lung cancer: secondary analysis of a randomized trial.

Guberina M, Eberhardt W, Stuschke M, Gauler T, Heinzelmann F, Cheufou D, Kimmich M, Friedel G, Schmidberger H, Darwiche K, Jendrossek V, Schuler M, Stamatis G, Pöttgen C.

Ann Oncol. 2017 May 1;28(5):1084-1089. doi: 10.1093/annonc/mdx069.


Prospects of gene therapy for pulmonary diseases: progress and limitations.

Karponi G, Zogas N, Domvri K, Zarogoulidis P, Trakada G, Roumeliotis S, Hohenforst-Schmidt W, Darwiche K, Freitag L, Zarogoulidis K.

Med Chem. 2017 Feb 9. doi: 10.2174/1573406413666170209122131. [Epub ahead of print]


Tissue is the issue and tissue competition. Re-biopsy for mutation T790: where and why?

Zarogoulidis P, Gaga M, Huang H, Darwiche K, Rapti A, Hohenforst-Schmidt W.

Clin Transl Med. 2017 Dec;6(1):6. doi: 10.1186/s40169-017-0135-8. Epub 2017 Jan 18.


Bronchoscopic Lung Volume Reduction with Endobronchial Valves in Low-FEV1 Patients.

Darwiche K, Karpf-Wissel R, Eisenmann S, Aigner C, Welter S, Zarogoulidis P, Hohenforst-Schmidt W, Freitag L, Oezkan F.

Respiration. 2016;92(6):414-419. Epub 2016 Nov 12.


Endobronchial Valve Therapy in Patients with Homogeneous Emphysema. Results from the IMPACT Study.

Valipour A, Slebos DJ, Herth F, Darwiche K, Wagner M, Ficker JH, Petermann C, Hubner RH, Stanzel F, Eberhardt R; IMPACT Study Team.

Am J Respir Crit Care Med. 2016 Nov 1;194(9):1073-1082.


High Prevalence of Concomitant Oncogene Mutations in Prospectively Identified Patients with ROS1-Positive Metastatic Lung Cancer.

Wiesweg M, Eberhardt WEE, Reis H, Ting S, Savvidou N, Skiba C, Herold T, Christoph DC, Meiler J, Worm K, Kasper S, Theegarten D, Hense J, Hager T, Darwiche K, Oezkan F, Aigner C, Welter S, Kühl H, Stuschke M, Schmid KW, Schuler M.

J Thorac Oncol. 2017 Jan;12(1):54-64. doi: 10.1016/j.jtho.2016.08.137. Epub 2016 Aug 27.


[Sufficient high frequency jet ventilation during a period of 2.5 h - Airway management during resection of a tracheaesophageal fistula and tracheal resection].

Kampe S, Rocha M, Darwiche K, Ebmeyer U, Georgios S.

Anasthesiol Intensivmed Notfallmed Schmerzther. 2016 Jun;51(6):368-71. doi: 10.1055/s-0041-110265. Epub 2016 Jun 30. German.


Standardized Uptake Decrease on [18F]-Fluorodeoxyglucose Positron Emission Tomography After Neoadjuvant Chemotherapy Is a Prognostic Classifier for Long-Term Outcome After Multimodality Treatment: Secondary Analysis of a Randomized Trial for Resectable Stage IIIA/B Non-Small-Cell Lung Cancer.

Pöttgen C, Gauler T, Bellendorf A, Guberina M, Bockisch A, Schwenzer N, Heinzelmann F, Cordes S, Schuler MH, Welter S, Stamatis G, Friedel G, Darwiche K, Jöckel KH, Eberhardt W, Stuschke M.

J Clin Oncol. 2016 Jul 20;34(21):2526-33. doi: 10.1200/JCO.2015.65.5167. Epub 2016 May 31.


In Reply.

Stang A, Kowall B, Schuler M, Darwiche K, Kühl H, Jöckel KH.

Dtsch Arztebl Int. 2016 Apr 29;113(17):297-8. doi: 10.3238/arztebl.2016.0297b. No abstract available.


Tyrosine Kinase Inhibitors for the Elderly.

Hohenforst-Schmidt W, Zarogoulidis P, Steinheimer M, Benhassen N, Tsiouda T, Baka S, Yarmus L, Stratakos G, Organtzis J, Pataka A, Tsakiridis K, Karapantzos I, Karapantzou C, Darwiche K, Zissimopoulos A, Pitsiou G, Zarogoulidis K, Man YG, Rittger H.

J Cancer. 2016 Mar 21;7(6):687-93. doi: 10.7150/jca.14819. eCollection 2016. Review.


Radial Endobronchial Ultrasound (EBUS) Guided Suction Catheter-Biopsy in Histological Diagnosis of Peripheral Pulmonary Lesions.

Zaric B, Stojsic V, Carapic V, Kovacevic T, Stojanovic G, Panjkovic M, Kioumis I, Darwiche K, Zarogoulidis K, Stratakos G, Tsavlis D, Hohenforst-Schmidt W, Pitsiou G, Zissimopoulos A, Sachpekidis N, Karapantzos I, Karapantzou C, Zarogoulidis P, Perin B.

J Cancer. 2016 Jan 1;7(1):7-13. doi: 10.7150/jca.13081. eCollection 2016.


Circulating U2 small nuclear RNA fragments as a diagnostic and prognostic biomarker in lung cancer patients.

Köhler J, Schuler M, Gauler TC, Nöpel-Dünnebacke S, Ahrens M, Hoffmann AC, Kasper S, Nensa F, Gomez B, Hahnemann M, Breitenbuecher F, Cheufou D, Özkan F, Darwiche K, Hoiczyk M, Reis H, Welter S, Eberhardt WE, Eisenacher M, Teschler H, Stamatis G, Schmiegel W, Hahn SA, Baraniskin A.

J Cancer Res Clin Oncol. 2016 Apr;142(4):795-805. doi: 10.1007/s00432-015-2095-y. Epub 2015 Dec 19.


Biodegradable Airway Stents - Bench to Bedside: A Comprehensive Review.

Dutau H, Musani AI, Laroumagne S, Darwiche K, Freitag L, Astoul P.

Respiration. 2015;90(6):512-21. doi: 10.1159/000442054. Epub 2015 Nov 28. Review.


EGFR-TKIs in adjuvant treatment of lung cancer: to give or not to give?

Milovancev A, Stojsic V, Zaric B, Kovacevic T, Sarcev T, Perin B, Zarogoulidis K, Tsirgogianni K, Freitag L, Darwiche K, Tsavlis D, Zissimopoulos A, Stratakos G, Zarogoulidis P.

Onco Targets Ther. 2015 Oct 13;8:2915-21. doi: 10.2147/OTT.S91627. eCollection 2015. Review.


OSNA: A Fast Molecular Test Based on CK19 mRNA Concentration for Assessment of EBUS-TBNA Samples in Lung Cancer Patients.

Oezkan F, Khan AM, Hager T, Freitag L, Christoph D, Darwiche K.

Clin Lung Cancer. 2016 May;17(3):198-204. doi: 10.1016/j.cllc.2015.09.001. Epub 2015 Sep 21.


Lung Cancer Screening Using Low Dose CT Scanning in Germany. Extrapolation of results from the National Lung Screening Trial.

Stang A, Schuler M, Kowall B, Darwiche K, Kühl H, Jöckel KH.

Dtsch Arztebl Int. 2015 Sep 18;112(38):637-44. doi: 10.3238/arztebl.2015.0637.


DDMC-p53 gene therapy with or without cisplatin and microwave ablation.

Hohenforst-Schmidt W, Zarogoulidis P, Stopek J, Vogl T, Hübner F, Turner JF, Browning R, Zarogoulidis K, Drevelegas A, Drevelegas K, Darwiche K, Freitag L, Rittger H.

Onco Targets Ther. 2015 May 20;8:1165-73. doi: 10.2147/OTT.S83794. eCollection 2015.


Transtracheal single-point stent fixation in posttracheotomy tracheomalacia under cone-beam computer tomography guidance by transmural suturing with the Berci needle - a perspective on a new tool to avoid stent migration of Dumon stents.

Hohenforst-Schmidt W, Linsmeier B, Zarogoulidis P, Freitag L, Darwiche K, Browning R, Turner JF, Huang H, Li Q, Vogl T, Zarogoulidis K, Brachmann J, Rittger H.

Ther Clin Risk Manag. 2015 May 22;11:837-50. doi: 10.2147/TCRM.S83230. eCollection 2015.


Defining the role of tyrosine kinase inhibitors in early stage non-small cell lung cancer.

Lampaki S, Lazaridis G, Zarogoulidis K, Kioumis I, Papaiwannou A, Tsirgogianni K, Karavergou A, Tsiouda T, Karavasilis V, Yarmus L, Darwiche K, Freitag L, Sakkas A, Kantzeli A, Baka S, Hohenforst-Schmidt W, Zarogoulidis P.

J Cancer. 2015 May 7;6(6):568-74. doi: 10.7150/jca.11893. eCollection 2015. Review.


[Tracheal injuries, fistulae from bronchial stump and bronchial anastomoses and recurrent laryngeal nerve paralysis : management of complications in thoracic surgery].

Welter S, Cheufou D, Darwiche K, Stamatis G.

Chirurg. 2015 May;86(5):410-8. doi: 10.1007/s00104-014-2862-3. Review. German.


Could Somatostatin Enhance the Outcomes of Chemotherapeutic Treatment in SCLC?

Domvri K, Bougiouklis D, Zarogoulidis P, Porpodis K, Xristoforidis M, Liaka A, Eleutheriadou E, Lampaki S, Lazaridis G, Organtzis J, Kyriazis G, Hohenforst-Schmidt W, Tsirgogianni K, Karavasilis V, Baka S, Darwiche K, Freitag L, Trakada G, Zarogoulidis K.

J Cancer. 2015 Feb 23;6(4):360-6. doi: 10.7150/jca.11308. eCollection 2015.


Exhaled volatile organic compounds discriminate patients with chronic obstructive pulmonary disease from healthy subjects.

Besa V, Teschler H, Kurth I, Khan AM, Zarogoulidis P, Baumbach JI, Sommerwerck U, Freitag L, Darwiche K.

Int J Chron Obstruct Pulmon Dis. 2015 Feb 23;10:399-406. doi: 10.2147/COPD.S76212. eCollection 2015.


HER2 expression and markers of phosphoinositide-3-kinase pathway activation define a favorable subgroup of metastatic pulmonary adenocarcinomas.

Reis H, Herold T, Ting S, Worm K, Huber U, Christoph DC, Eberhardt WE, Kostbade K, Kasper S, Stamatis G, Welter S, Darwiche K, Karpf-Wissel R, Theegarten D, Schmid KW, Schuler M, Wiesweg M.

Lung Cancer. 2015 Apr;88(1):34-41. doi: 10.1016/j.lungcan.2015.02.002. Epub 2015 Feb 7.


Functional bronchoscopy: development of a new bronchoscopic method for real-time gas exchange assessment of lobes and lung segments.

Freitag L, Lenkens D, Zarogoulidis P, Karpf-Wissel R, Hang H, Darwiche K.

Respiration. 2014;88(6):469-77. doi: 10.1159/000368087. Epub 2014 Nov 28.


Hemoptysis in primary pulmonary amyloidoma treated with intrabronchial arterial coiling.

Oezkan F, Khan AM, Freitag L, Montag M, Hahn S, Berliner PJ, Darwiche K.

Am J Respir Crit Care Med. 2014 Dec 1;190(11):1311-4. doi: 10.1164/rccm.201406-1009IM. No abstract available.


Efficient utilization of EBUS-TBNA samples for both diagnosis and molecular analyses.

Oezkan F, Khan A, Zarogoulidis P, Hohenforst-Schmidt W, Theegarten D, Yasufuku K, Nakajima T, Freitag L, Darwiche K.

Onco Targets Ther. 2014 Nov 10;7:2061-5. doi: 10.2147/OTT.S72974. eCollection 2014.


Experimentation with aerosol bonsetan, pirfenidone, treprostinil and sidenafil.

Huang H, Zarogoulidis P, Lampaki S, Organtzis J, Petridis D, Porpodis K, Papaiwannou A, Karageorgiou V, Pitsiou G, Kioumis I, Hohenforst-Schmidt W, Li Q, Darwiche K, Freitag L, Rapti A, Zarogoulidis K.

J Thorac Dis. 2014 Oct;6(10):1411-9. doi: 10.3978/j.issn.2072-1439.2014.08.38.


Short- and Mid-Term Changes in Lung Function after Bilateral Pulmonary Metastasectomy.

Welter S, Cheufou D, Zahin M, Kampe S, Darwiche K, Weinreich G, Stamatis G.

Thorac Cardiovasc Surg. 2016 Mar;64(2):139-45. doi: 10.1055/s-0034-1383828. Epub 2014 Jul 28.


[Role of pretherapeutic biomarkers in lung cancer with special regards to bronchoscopic procedures].

Darwiche K, Özkan F, Ting S, Johnen G, Brüning T, Soltermann A, Huber LC, Christoph DC, Freitag L, Franzen D.

Pneumologie. 2014 Nov;68(11):719-26. doi: 10.1055/s-0034-1377299. Epub 2014 Jul 8. Review. German.


Neuroendocrine tumors of the bronchopulmonary system (typical and atypical carcinoid tumors): current strategies in diagnosis and treatment. Conclusions of an expert meeting February 2011 in Weimar, Germany.

Hörsch D, Schmid KW, Anlauf M, Darwiche K, Denecke T, Baum RP, Spitzweg C, Grohé C, Presselt N, Stremmel C, Heigener DF, Serke M, Kegel T, Pavel M, Waller CF, Deppermann KM, Arnold R, Huber RM, Weber MM, Hoffmann H.

Oncol Res Treat. 2014;37(5):266-76. doi: 10.1159/000362430. Epub 2014 Apr 14. Review.


"Denervation" of autonomous nervous system in idiopathic pulmonary arterial hypertension by low-dose radiation: a case report with an unexpected outcome.

Hohenforst-Schmidt W, Zarogoulidis P, Oezkan F, Mahnkopf C, Grabenbauer G, Kreczy A, Bartunek R, Darwiche K, Freitag L, Li Q, Huang H, Vogl T, Lepilvert P, Tsiouda T, Tsakiridis K, Zarogoulidis K, Brachmann J.

Ther Clin Risk Manag. 2014 Mar 27;10:207-15. doi: 10.2147/TCRM.S58705. eCollection 2014.


Cone Beam Computertomography (CBCT) in Interventional Chest Medicine - High Feasibility for Endobronchial Realtime Navigation.

Hohenforst-Schmidt W, Zarogoulidis P, Vogl T, Turner JF, Browning R, Linsmeier B, Huang H, Li Q, Darwiche K, Freitag L, Simoff M, Kioumis I, Zarogoulidis K, Brachmann J.

J Cancer. 2014 Mar 9;5(3):231-41. doi: 10.7150/jca.8834. eCollection 2014.

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