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Items: 1 to 50 of 98

1.

Simultaneous profiling of sexually transmitted bacterial pathogens, microbiome, and concordant host response in cervical samples using whole transcriptome sequencing analysis.

O'Connell CM, Brochu H, Girardi J, Harrell E, Jones A, Darville T, Seña AC, Peng X.

Microb Cell. 2019 Jan 24;6(3):177-183. doi: 10.15698/mic2019.03.672.

2.

Cervical Cytokines Associated With Chlamydia trachomatis Susceptibility and Protection.

Poston TB, Lee DE, Darville T, Zhong W, Dong L, O'Connell CM, Wiesenfeld HC, Hillier SL, Sempowski GD, Zheng X.

J Infect Dis. 2019 Jun 19;220(2):330-339. doi: 10.1093/infdis/jiz087.

PMID:
30820577
3.

Anti-chlamydia IgG and IgA are insufficient to prevent endometrial chlamydia infection in women, and increased anti-chlamydia IgG is associated with enhanced risk for incident infection.

Darville T, Albritton HL, Zhong W, Dong L, O'Connell CM, Poston TB, Quayle AJ, Goonetilleke N, Wiesenfeld HC, Hillier SL, Zheng X.

Am J Reprod Immunol. 2019 May;81(5):e13103. doi: 10.1111/aji.13103. Epub 2019 Mar 18.

PMID:
30784128
4.

Susceptibility of endometrial isolates recovered from women with clinical pelvic inflammatory disease or histological endometritis to antimicrobial agents.

Petrina MAB, Cosentino LA, Wiesenfeld HC, Darville T, Hillier SL.

Anaerobe. 2019 Apr;56:61-65. doi: 10.1016/j.anaerobe.2019.02.005. Epub 2019 Feb 10.

PMID:
30753898
5.

Mixed Chlamydia trachomatis Peptide Antigens Provide a Specific and Sensitive Single-Well Colorimetric Enzyme-Linked Immunosorbent Assay for Detection of Human Anti-C. trachomatis Antibodies.

Rahman KS, Darville T, Wiesenfeld HC, Hillier SL, Kaltenboeck B.

mSphere. 2018 Nov 7;3(6). pii: e00484-18. doi: 10.1128/mSphere.00484-18.

6.

Gene Expression Signatures Can Aid Diagnosis of Sexually Transmitted Infection-Induced Endometritis in Women.

Zheng X, O'Connell CM, Zhong W, Poston TB, Wiesenfeld HC, Hillier SL, Trent M, Gaydos C, Tseng G, Taylor BD, Darville T.

Front Cell Infect Microbiol. 2018 Sep 20;8:307. doi: 10.3389/fcimb.2018.00307. eCollection 2018.

7.

Comprehensive Molecular Serology of Human Chlamydia trachomatis Infections by Peptide Enzyme-Linked Immunosorbent Assays.

Rahman KS, Darville T, Russell AN, O'Connell CM, Wiesenfeld HC, Hillier SL, Lee DE, Kaltenboeck B.

mSphere. 2018 Aug 1;3(4). pii: e00253-18. doi: 10.1128/mSphere.00253-18.

8.

Discovery of Human-Specific Immunodominant Chlamydia trachomatis B Cell Epitopes.

Rahman KS, Darville T, Russell AN, O'Connell CM, Wiesenfeld HC, Hillier SL, Chowdhury EU, Juan YC, Kaltenboeck B.

mSphere. 2018 Aug 1;3(4). pii: e00246-18. doi: 10.1128/mSphere.00246-18.

9.

T Cell-Independent Gamma Interferon and B Cells Cooperate To Prevent Mortality Associated with Disseminated Chlamydia muridarum Genital Tract Infection.

Poston TB, O'Connell CM, Girardi J, Sullivan JE, Nagarajan UM, Marinov A, Scurlock AM, Darville T.

Infect Immun. 2018 Jun 21;86(7). pii: e00143-18. doi: 10.1128/IAI.00143-18. Print 2018 Jul.

10.

Risk factors for Mycoplasma genitalium endometritis and incident infection: a secondary data analysis of the T cell Response Against Chlamydia (TRAC) Study.

Taylor BD, Zheng X, O'Connell CM, Wiesenfeld HC, Hillier SL, Darville T.

Sex Transm Infect. 2018 Sep;94(6):414-420. doi: 10.1136/sextrans-2017-053376. Epub 2018 Mar 21.

11.

Discovery of Blood Transcriptional Endotypes in Women with Pelvic Inflammatory Disease.

Zheng X, O'Connell CM, Zhong W, Nagarajan UM, Tripathy M, Lee D, Russell AN, Wiesenfeld H, Hillier S, Darville T.

J Immunol. 2018 Apr 15;200(8):2941-2956. doi: 10.4049/jimmunol.1701658. Epub 2018 Mar 12.

12.

National Institute of Allergy and Infectious Diseases workshop report: "Chlamydia vaccines: The way forward".

Zhong G, Brunham RC, de la Maza LM, Darville T, Deal C.

Vaccine. 2017 Oct 31. pii: S0264-410X(17)31483-4. doi: 10.1016/j.vaccine.2017.10.075. [Epub ahead of print]

PMID:
29097007
13.

A Chlamydia-Specific TCR-Transgenic Mouse Demonstrates Th1 Polyfunctionality with Enhanced Effector Function.

Poston TB, Qu Y, Girardi J, O'Connell CM, Frazer LC, Russell AN, Wall M, Nagarajan UM, Darville T.

J Immunol. 2017 Oct 15;199(8):2845-2854. doi: 10.4049/jimmunol.1700914. Epub 2017 Aug 30.

14.

Status of vaccine research and development of vaccines for Chlamydia trachomatis infection.

Poston TB, Gottlieb SL, Darville T.

Vaccine. 2017 Jan 19. pii: S0264-410X(17)30042-7. doi: 10.1016/j.vaccine.2017.01.023. [Epub ahead of print]

PMID:
28111145
15.

Whole-Exome Sequencing to Identify Novel Biological Pathways Associated With Infertility After Pelvic Inflammatory Disease.

Taylor BD, Zheng X, Darville T, Zhong W, Konganti K, Abiodun-Ojo O, Ness RB, O'Connell CM, Haggerty CL.

Sex Transm Dis. 2017 Jan;44(1):35-41.

16.

Identification of Chlamydia trachomatis Antigens Recognized by T Cells From Highly Exposed Women Who Limit or Resist Genital Tract Infection.

Russell AN, Zheng X, O'Connell CM, Wiesenfeld HC, Hillier SL, Taylor BD, Picard MD, Flechtner JB, Zhong W, Frazer LC, Darville T.

J Infect Dis. 2016 Dec 15;214(12):1884-1892. Epub 2016 Oct 12.

17.

A Quality Assessment of a Collaborative Model of a Pediatric Antimicrobial Stewardship Program.

Nguyen-Ha PT, Howrie D, Crowley K, Vetterly CG, McGhee W, Berry D, Ferguson E, Polischuk E, Brooks MM, Goff J, Stillwell T, Darville T, Thompson AE, Levin JE, Michaels MG, Green M.

Pediatrics. 2016 May;137(5). pii: e20150316. doi: 10.1542/peds.2015-0316. Epub 2016 Apr 6.

18.

Chlamydia trachomatis: Protective Adaptive Responses and Prospects for a Vaccine.

Poston TB, Darville T.

Curr Top Microbiol Immunol. 2018;412:217-237. doi: 10.1007/82_2016_6. Review.

PMID:
27033698
19.

Analysis of Factors Driving Incident and Ascending Infection and the Role of Serum Antibody in Chlamydia trachomatis Genital Tract Infection.

Russell AN, Zheng X, O'Connell CM, Taylor BD, Wiesenfeld HC, Hillier SL, Zhong W, Darville T.

J Infect Dis. 2016 Feb 15;213(4):523-31. doi: 10.1093/infdis/jiv438. Epub 2015 Sep 7.

20.

Comparable Genital Tract Infection, Pathology, and Immunity in Rhesus Macaques Inoculated with Wild-Type or Plasmid-Deficient Chlamydia trachomatis Serovar D.

Qu Y, Frazer LC, O'Connell CM, Tarantal AF, Andrews CW Jr, O'Connor SL, Russell AN, Sullivan JE, Poston TB, Vallejo AN, Darville T.

Infect Immun. 2015 Oct;83(10):4056-67. doi: 10.1128/IAI.00841-15. Epub 2015 Jul 27.

21.

Correction: Role of Neutrophils in IL-17-Dependent Immunity to Mucosal Candidiasis.

Huppler AR, Conti HR, Hernández-Santos N, Darville T, Biswas PS, Gaffen SL.

J Immunol. 2015 Feb 1;194(3):1382. doi: 10.4049/jimmunol.1490053. No abstract available.

22.

Cross-sectional analysis of Toll-like receptor variants and bacterial vaginosis in African-American women with pelvic inflammatory disease.

Taylor BD, Darville T, Ferrell RE, Ness RB, Kelsey SF, Haggerty CL.

Sex Transm Infect. 2014 Nov;90(7):563-6. doi: 10.1136/sextrans-2014-051524. Epub 2014 May 21.

PMID:
24848367
23.

Steroids alone or as adjunctive therapy with doxycycline fail to improve oviduct damage in mice infected with Chlamydia muridarum.

Corr TE, Sullivan J, Frazer LC, Andrews CW Jr, O'Connell CM, Darville T.

Clin Vaccine Immunol. 2014 Jun;21(6):824-30. doi: 10.1128/CVI.00006-14. Epub 2014 Apr 2.

24.

Frequency of Chlamydia trachomatis-specific T cell interferon-γ and interleukin-17 responses in CD4-enriched peripheral blood mononuclear cells of sexually active adolescent females.

Barral R, Desai R, Zheng X, Frazer LC, Sucato GS, Haggerty CL, O'Connell CM, Zurenski MA, Darville T.

J Reprod Immunol. 2014 Jun;103:29-37. doi: 10.1016/j.jri.2014.01.002. Epub 2014 Feb 1.

25.

Role of neutrophils in IL-17-dependent immunity to mucosal candidiasis.

Huppler AR, Conti HR, Hernández-Santos N, Darville T, Biswas PS, Gaffen SL.

J Immunol. 2014 Feb 15;192(4):1745-52. doi: 10.4049/jimmunol.1302265. Epub 2014 Jan 17. Erratum in: J Immunol. 2015 Feb 1;194(3):1382.

26.
27.

IL-23 induces IL-22 and IL-17 production in response to Chlamydia muridarum genital tract infection, but the absence of these cytokines does not influence disease pathogenesis.

Frazer LC, Scurlock AM, Zurenski MA, Riley MM, Mintus M, Pociask DA, Sullivan JE, Andrews CW Jr, Darville T.

Am J Reprod Immunol. 2013 Dec;70(6):472-84. doi: 10.1111/aji.12171.

28.

CD4+ T cell expression of MyD88 is essential for normal resolution of Chlamydia muridarum genital tract infection.

Frazer LC, Sullivan JE, Zurenski MA, Mintus M, Tomasak TE, Prantner D, Nagarajan UM, Darville T.

J Immunol. 2013 Oct 15;191(8):4269-79. doi: 10.4049/jimmunol.1301547. Epub 2013 Sep 13.

29.

Recognition and treatment of chlamydial infections from birth to adolescence.

Darville T.

Adv Exp Med Biol. 2013;764:109-22. Review.

PMID:
23654060
30.

Does bacterial vaginosis cause pelvic inflammatory disease?

Taylor BD, Darville T, Haggerty CL.

Sex Transm Dis. 2013 Feb;40(2):117-22. doi: 10.1097/OLQ.0b013e31827c5a5b. Review.

PMID:
23324974
31.

Chlamydia trachomatis infection may increase the risk of preeclampsia.

Haggerty CL, Panum I, Uldum SA, Bass DC, Olsen J, Darville T, Eastman JM, Simhan HN, Roberts JM, Ness RB.

Pregnancy Hypertens. 2013 Jan;3(1):28-33. doi: 10.1016/j.preghy.2012.09.002. Epub 2012 Sep 28.

PMID:
26105737
32.

Racial variation in toll-like receptor variants among women with pelvic inflammatory disease.

Taylor BD, Darville T, Ferrell RE, Ness RB, Haggerty CL.

J Infect Dis. 2013 Mar 15;207(6):940-6. doi: 10.1093/infdis/jis922. Epub 2012 Dec 18.

33.

The recall response induced by genital challenge with Chlamydia muridarum protects the oviduct from pathology but not from reinfection.

Riley MM, Zurenski MA, Frazer LC, O'Connell CM, Andrews CW Jr, Mintus M, Darville T.

Infect Immun. 2012 Jun;80(6):2194-203. doi: 10.1128/IAI.00169-12. Epub 2012 Mar 19.

34.

Plasmid-cured Chlamydia caviae activates TLR2-dependent signaling and retains virulence in the guinea pig model of genital tract infection.

Frazer LC, Darville T, Chandra-Kuntal K, Andrews CW Jr, Zurenski M, Mintus M, AbdelRahman YM, Belland RJ, Ingalls RR, O'Connell CM.

PLoS One. 2012;7(1):e30747. doi: 10.1371/journal.pone.0030747. Epub 2012 Jan 24.

35.

Variants in toll-like receptor 1 and 4 genes are associated with Chlamydia trachomatis among women with pelvic inflammatory disease.

Taylor BD, Darville T, Ferrell RE, Kammerer CM, Ness RB, Haggerty CL.

J Infect Dis. 2012 Feb 15;205(4):603-9. doi: 10.1093/infdis/jir822. Epub 2012 Jan 11.

36.

The role of Chlamydia trachomatis polymorphic membrane proteins in inflammation and sequelae among women with pelvic inflammatory disease.

Taylor BD, Darville T, Tan C, Bavoil PM, Ness RB, Haggerty CL.

Infect Dis Obstet Gynecol. 2011;2011:989762. doi: 10.1155/2011/989762. Epub 2011 Oct 19.

37.

Enhanced neutrophil longevity and recruitment contribute to the severity of oviduct pathology during Chlamydia muridarum infection.

Frazer LC, O'Connell CM, Andrews CW Jr, Zurenski MA, Darville T.

Infect Immun. 2011 Oct;79(10):4029-41. doi: 10.1128/IAI.05535-11. Epub 2011 Aug 8.

38.

Chlamydial infection increases gonococcal colonization in a novel murine coinfection model.

Vonck RA, Darville T, O'Connell CM, Jerse AE.

Infect Immun. 2011 Apr;79(4):1566-77. doi: 10.1128/IAI.01155-10. Epub 2011 Jan 18.

39.

Toll-like receptor 2 activation by Chlamydia trachomatis is plasmid dependent, and plasmid-responsive chromosomal loci are coordinately regulated in response to glucose limitation by C. trachomatis but not by C. muridarum.

O'Connell CM, AbdelRahman YM, Green E, Darville HK, Saira K, Smith B, Darville T, Scurlock AM, Meyer CR, Belland RJ.

Infect Immun. 2011 Mar;79(3):1044-56. doi: 10.1128/IAI.01118-10. Epub 2011 Jan 3.

40.

Interleukin-17 contributes to generation of Th1 immunity and neutrophil recruitment during Chlamydia muridarum genital tract infection but is not required for macrophage influx or normal resolution of infection.

Scurlock AM, Frazer LC, Andrews CW Jr, O'Connell CM, Foote IP, Bailey SL, Chandra-Kuntal K, Kolls JK, Darville T.

Infect Immun. 2011 Mar;79(3):1349-62. doi: 10.1128/IAI.00984-10. Epub 2010 Dec 13.

41.

Microbial correlates of delayed care for pelvic inflammatory disease.

Taylor BD, Ness RB, Darville T, Haggerty CL.

Sex Transm Dis. 2011 May;38(5):434-8. doi: 10.1097/OLQ.0b013e3181ffa7c7.

42.
43.

Infectivity acts as in vivo selection for maintenance of the chlamydial cryptic plasmid.

Russell M, Darville T, Chandra-Kuntal K, Smith B, Andrews CW Jr, O'Connell CM.

Infect Immun. 2011 Jan;79(1):98-107. doi: 10.1128/IAI.01105-10. Epub 2010 Oct 25.

44.

Pathogenesis of genital tract disease due to Chlamydia trachomatis.

Darville T, Hiltke TJ.

J Infect Dis. 2010 Jun 15;201 Suppl 2:S114-25. Review.

45.

Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection.

Prantner D, Darville T, Nagarajan UM.

J Immunol. 2010 Mar 1;184(5):2551-60. doi: 10.4049/jimmunol.0903704. Epub 2010 Jan 27.

46.

Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages.

Prantner D, Darville T, Sikes JD, Andrews CW Jr, Brade H, Rank RG, Nagarajan UM.

Infect Immun. 2009 Dec;77(12):5334-46. doi: 10.1128/IAI.00883-09. Epub 2009 Oct 5.

47.

Two different homing pathways involving integrin β7 and E-selectin significantly influence trafficking of CD4 cells to the genital tract following Chlamydia muridarum infection.

Kelly KA, Chan AM, Butch A, Darville T.

Am J Reprod Immunol. 2009 Jun;61(6):438-45. doi: 10.1111/j.1600-0897.2009.00704.x. Epub 2009 Apr 22.

48.

The combination of the gastrointestinal integrin (α4β7) and selectin ligand enhances T-Cell migration to the reproductive tract during infection with Chlamydia trachomatis.

Kelly KA, Wiley D, Wiesmeier E, Briskin M, Butch A, Darville T.

Am J Reprod Immunol. 2009 Jun;61(6):446-52. doi: 10.1111/j.1600-0897.2009.00705.x. Epub 2009 Apr 22.

49.

Chronic granulomatous disease in an adolescent with recurrent impetigo and cholecystectomy.

Scholnicoff ET, MacGinnitie AJ, Lin PL, Darville T.

Pediatr Infect Dis J. 2009 Mar;28(3):255-7. doi: 10.1097/INF.0b013e31818dd99f.

PMID:
19165129
50.

Type I interferon signaling exacerbates Chlamydia muridarum genital infection in a murine model.

Nagarajan UM, Prantner D, Sikes JD, Andrews CW Jr, Goodwin AM, Nagarajan S, Darville T.

Infect Immun. 2008 Oct;76(10):4642-8. doi: 10.1128/IAI.00629-08. Epub 2008 Jul 28.

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