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Toll-like receptor 2 and toll-like receptor 4 responses regulate neutrophil infiltration into the junctional epithelium and significantly contribute to the composition of the oral microbiota.

Chang AM, Liu Q, Hajjar AM, Greer A, McLean JS, Darveau RP.

J Periodontol. 2019 May 21. doi: 10.1002/JPER.18-0719. [Epub ahead of print]


Identification of PGN_1123 as the Gene Encoding Lipid A Deacylase, an Enzyme Required for Toll-Like Receptor 4 Evasion, in Porphyromonas gingivalis.

Jain S, Chang AM, Singh M, McLean JS, Coats SR, Kramer RW, Darveau RP.

J Bacteriol. 2019 May 8;201(11). pii: e00683-18. doi: 10.1128/JB.00683-18. Print 2019 Jun 1.


Detection and function of lipopolysaccharide and its purified lipid A after treatment with auxiliary chemical substances and calcium hydroxide dressings used in root canal treatment.

Marinho ACS, To TT, Darveau RP, Gomes BPFA.

Int Endod J. 2018 Oct;51(10):1118-1129. doi: 10.1111/iej.12920. Epub 2018 Apr 2.


The promotion of nephropathy by Porphyromonas gingivalis lipopolysaccharide via toll-like receptors.

Kajiwara K, Takata S, To TT, Takara K, Hatakeyama Y, Tamaoki S, Darveau RP, Ishikawa H, Sawa Y.

Diabetol Metab Syndr. 2017 Sep 22;9:73. doi: 10.1186/s13098-017-0271-8. eCollection 2017.


3LPS-binding protein and its interactions with P. gingivalis LPS modulate pro-inflammatory response and Toll-like receptor signaling in human oral keratinocytes.

Ding PH, Darveau RP, Wang CY, Jin L.

PLoS One. 2017 Apr 6;12(4):e0173223. doi: 10.1371/journal.pone.0173223. eCollection 2017. Erratum in: PLoS One. 2017 May 1;12 (5):e0176996.


Heterogeneous Porphyromonas gingivalis LPS modulates immuno-inflammatory response, antioxidant defense and cytoskeletal dynamics in human gingival fibroblasts.

Herath TDK, Darveau RP, Seneviratne CJ, Wang CY, Wang Y, Jin L.

Sci Rep. 2016 Aug 19;6:29829. doi: 10.1038/srep29829.


Cardiolipins Act as a Selective Barrier to Toll-Like Receptor 4 Activation in the Intestine.

Coats SR, Hashim A, Paramonov NA, To TT, Curtis MA, Darveau RP.

Appl Environ Microbiol. 2016 Jun 30;82(14):4264-78. doi: 10.1128/AEM.00463-16. Print 2016 Jul 15.


Comparison of Fusobacterium nucleatum and Porphyromonas gingivalis Lipopolysaccharides Clinically Isolated from Root Canal Infection in the Induction of Pro-Inflammatory Cytokines Secretion.

Martinho FC, Leite FR, Nóbrega LM, Endo MS, Nascimento GG, Darveau RP, Gomes BP.

Braz Dent J. 2016 Mar-Apr;27(2):202-7. doi: 10.1590/0103-6440201600572.


Draft Genome Sequence of Low-Passage Clinical Isolate Porphyromonas gingivalis MP4-504.

To TT, Liu Q, Watling M, Bumgarner RE, Darveau RP, McLean JS.

Genome Announc. 2016 Apr 7;4(2). pii: e00256-16. doi: 10.1128/genomeA.00256-16.


Site-Specific Neutrophil Migration and CXCL2 Expression in Periodontal Tissue.

Greer A, Irie K, Hashim A, Leroux BG, Chang AM, Curtis MA, Darveau RP.

J Dent Res. 2016 Jul;95(8):946-52. doi: 10.1177/0022034516641036. Epub 2016 Mar 24.


Introduction to the Mark Wilson Conference Special Issue.

Progulske-Fox A, Fine DH, Darveau RP, Fletcher HM.

Mol Oral Microbiol. 2016 Feb;31(1):1-2. doi: 10.1111/omi.12148. No abstract available.


Subgingival Plaque in Periodontal Health Antagonizes at Toll-Like Receptor 4 and Inhibits E-Selectin Expression on Endothelial Cells.

To TT, Gümüş P, Nizam N, Buduneli N, Darveau RP.

Infect Immun. 2015 Oct 19;84(1):120-6. doi: 10.1128/IAI.00693-15. Print 2016 Jan.


Microbial protection and virulence in periodontal tissue as a function of polymicrobial communities: symbiosis and dysbiosis.

Roberts FA, Darveau RP.

Periodontol 2000. 2015 Oct;69(1):18-27. doi: 10.1111/prd.12087. Review.


Impact of Oral Commensal Bacteria on Degradation of Periodontal Connective Tissue in Mice.

Irie K, Tomofuji T, Ekuni D, Morita M, Shimazaki Y, Darveau RP.

J Periodontol. 2015 Jul;86(7):899-905. doi: 10.1902/jop.2015.150006. Epub 2015 Apr 16.


Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation.

Slocum C, Coats SR, Hua N, Kramer C, Papadopoulos G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA.

PLoS Pathog. 2014 Jul 10;10(7):e1004215. doi: 10.1371/journal.ppat.1004215. eCollection 2014 Jul.


Porphyromonas gingivalis neutrophil manipulation: risk factor for periodontitis?

Darveau RP.

Trends Microbiol. 2014 Aug;22(8):428-9. doi: 10.1016/j.tim.2014.06.006. Epub 2014 Jul 4.


Impact of the Oral Commensal Flora on Alveolar Bone Homeostasis.

Irie K, Novince CM, Darveau RP.

J Dent Res. 2014 Aug;93(8):801-6. doi: 10.1177/0022034514540173. Epub 2014 Jun 16.


The Interaction of Implant Luting Cements and Oral Bacteria Linked to Peri-Implant Disease: An In Vitro Analysis of Planktonic and Biofilm Growth--A Preliminary Study.

Raval NC, Wadhwani CP, Jain S, Darveau RP.

Clin Implant Dent Relat Res. 2015 Dec;17(6):1029-35. doi: 10.1111/cid.12235. Epub 2014 Jun 6.


Porphyromonas gingivalis lipid A phosphatase activity is critical for colonization and increasing the commensal load in the rabbit ligature model.

Zenobia C, Hasturk H, Nguyen D, Van Dyke TE, Kantarci A, Darveau RP.

Infect Immun. 2014 Feb;82(2):650-9. doi: 10.1128/IAI.01136-13. Epub 2013 Nov 25.


TLR signaling that induces weak inflammatory response and SHIP1 enhances osteogenic functions.

Muthukuru M, Darveau RP.

Bone Res. 2014 Nov 11;2:14031. doi: 10.1038/boneres.2014.31. eCollection 2014.


Whole-blood cultures from patients with chronic periodontitis respond differently to Porphyromonas gingivalis but not Escherichia coli lipopolysaccharide.

Nogueira-Filho G, Rosa BT, Santos PF, Tunes UR, Freire SM, Meyer R, Darveau RP.

J Periodontol. 2014 Feb;85(2):e18-23. doi: 10.1902/jop.2013.120735. Epub 2013 Sep 3.


The N-terminus of CD14 acts to bind apoptotic cells and confers rapid-tethering capabilities on non-myeloid cells.

Thomas L, Bielemeier A, Lambert PA, Darveau RP, Marshall LJ, Devitt A.

PLoS One. 2013 Jul 30;8(7):e70691. doi: 10.1371/journal.pone.0070691. Print 2013.


Defensins and LL-37: a review of function in the gingival epithelium.

Greer A, Zenobia C, Darveau RP.

Periodontol 2000. 2013 Oct;63(1):67-79. doi: 10.1111/prd.12028. Review.


Naturally occurring low biological reactivity lipopolysaccharides as vaccine adjuvants.

Darveau RP, Chilton PM.

Expert Rev Vaccines. 2013 Jul;12(7):707-9. doi: 10.1586/14760584.2013.811181. No abstract available.


Adjuvant activity of naturally occurring monophosphoryl lipopolysaccharide preparations from mucosa-associated bacteria.

Chilton PM, Hadel DM, To TT, Mitchell TC, Darveau RP.

Infect Immun. 2013 Sep;81(9):3317-25. doi: 10.1128/IAI.01150-12. Epub 2013 Jun 24.


Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis.

Zenobia C, Luo XL, Hashim A, Abe T, Jin L, Chang Y, Jin ZC, Sun JX, Hajishengallis G, Curtis MA, Darveau RP.

Cell Microbiol. 2013 Aug;15(8):1419-26. doi: 10.1111/cmi.12127. Epub 2013 Mar 22.


A novel class of lipoprotein lipase-sensitive molecules mediates Toll-like receptor 2 activation by Porphyromonas gingivalis.

Jain S, Coats SR, Chang AM, Darveau RP.

Infect Immun. 2013 Apr;81(4):1277-86. doi: 10.1128/IAI.01036-12. Epub 2013 Feb 4.


In vitro microbiologic evaluation of PTFE and cotton as spacer materials.

Paranjpe A, Jain S, Alibhai KJ, Wadhwani CP, Darveau RP, Johnson JD.

Quintessence Int. 2012 Sep;43(8):703-7.


The keystone-pathogen hypothesis.

Hajishengallis G, Darveau RP, Curtis MA.

Nat Rev Microbiol. 2012 Oct;10(10):717-25. doi: 10.1038/nrmicro2873. Epub 2012 Sep 3. Review.


Porphyromonas gingivalis as a potential community activist for disease.

Darveau RP, Hajishengallis G, Curtis MA.

J Dent Res. 2012 Sep;91(9):816-20. doi: 10.1177/0022034512453589. Epub 2012 Jul 6.


Porphyromonas gingivalis LPS stimulates the expression of LPS-binding protein in human oral keratinocytes in vitro.

Ding PH, Wang CY, Darveau RP, Jin L.

Innate Immun. 2013 Feb;19(1):66-75. doi: 10.1177/1753425912450348. Epub 2012 Jun 26.


Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement.

Hajishengallis G, Liang S, Payne MA, Hashim A, Jotwani R, Eskan MA, McIntosh ML, Alsam A, Kirkwood KL, Lambris JD, Darveau RP, Curtis MA.

Cell Host Microbe. 2011 Nov 17;10(5):497-506. doi: 10.1016/j.chom.2011.10.006. Epub 2011 Oct 27.


The relationship of the oral microbiotia to periodontal health and disease.

Curtis MA, Zenobia C, Darveau RP.

Cell Host Microbe. 2011 Oct 20;10(4):302-6. doi: 10.1016/j.chom.2011.09.008. Review.


Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts.

Herath TD, Wang Y, Seneviratne CJ, Lu Q, Darveau RP, Wang CY, Jin L.

J Clin Periodontol. 2011 Aug;38(8):694-701. doi: 10.1111/j.1600-051X.2011.01741.x.


Temperature-dependent modulation of Porphyromonas gingivalis lipid A structure and interaction with the innate host defenses.

Curtis MA, Percival RS, Devine D, Darveau RP, Coats SR, Rangarajan M, Tarelli E, Marsh PD.

Infect Immun. 2011 Mar;79(3):1187-93. doi: 10.1128/IAI.00900-10. Epub 2011 Jan 10.


Microbial shift and periodontitis.

Berezow AB, Darveau RP.

Periodontol 2000. 2011 Feb;55(1):36-47. doi: 10.1111/j.1600-0757.2010.00350.x. Review. No abstract available.


The lipid A phosphate position determines differential host Toll-like receptor 4 responses to phylogenetically related symbiotic and pathogenic bacteria.

Coats SR, Berezow AB, To TT, Jain S, Bainbridge BW, Banani KP, Darveau RP.

Infect Immun. 2011 Jan;79(1):203-10. doi: 10.1128/IAI.00937-10. Epub 2010 Oct 25.


Contribution of Porphyromonas gingivalis lipopolysaccharide to periodontitis.

Jain S, Darveau RP.

Periodontol 2000. 2010 Oct;54(1):53-70. doi: 10.1111/j.1600-0757.2009.00333.x. Review. No abstract available.


Differential host response to LPS variants in amniochorion and the TLR4/MD-2 system in Macaca nemestrina.

Chang J, Jain S, Carl DJ, Paolella L, Darveau RP, Gravett MG, Adams Waldorf KM.

Placenta. 2010 Sep;31(9):811-7. doi: 10.1016/j.placenta.2010.06.010.


Periodontitis: a polymicrobial disruption of host homeostasis.

Darveau RP.

Nat Rev Microbiol. 2010 Jul;8(7):481-90. doi: 10.1038/nrmicro2337. Review.


Human Toll-like receptor 4 responses to P. gingivalis are regulated by lipid A 1- and 4'-phosphatase activities.

Coats SR, Jones JW, Do CT, Braham PH, Bainbridge BW, To TT, Goodlett DR, Ernst RK, Darveau RP.

Cell Microbiol. 2009 Nov;11(11):1587-99. doi: 10.1111/j.1462-5822.2009.01349.x. Epub 2009 Jun 13.


The structurally similar, penta-acylated lipopolysaccharides of Porphyromonas gingivalis and Bacteroides elicit strikingly different innate immune responses.

Berezow AB, Ernst RK, Coats SR, Braham PH, Karimi-Naser LM, Darveau RP.

Microb Pathog. 2009 Aug;47(2):68-77. doi: 10.1016/j.micpath.2009.04.015. Epub 2009 May 19.


The oral microbial consortium's interaction with the periodontal innate defense system.

Darveau RP.

DNA Cell Biol. 2009 Aug;28(8):389-95. doi: 10.1089/dna.2009.0864. Review.


TGF-beta1 Inhibits TLR-mediated odontoblast responses to oral bacteria.

Horst OV, Tompkins KA, Coats SR, Braham PH, Darveau RP, Dale BA.

J Dent Res. 2009 Apr;88(4):333-8. doi: 10.1177/0022034509334846.


Bacteria modulate host-cell responses by capitalizing on the lipid raft structure.

Darveau RP.

Future Microbiol. 2009 Mar;4(2):155-7. doi: 10.2217/17460913.4.2.155.


Effects of oral commensal and pathogenic bacteria on human dendritic cells.

Chino T, Santer DM, Giordano D, Chen C, Li C, Chen CH, Darveau RP, Clark EA.

Oral Microbiol Immunol. 2009 Apr;24(2):96-103. doi: 10.1111/j.1399-302X.2008.00478.x.

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