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Items: 26

1.

Integrated analysis of genomics, longitudinal metabolomics, and Alzheimer's risk factors among 1,111 cohort participants.

Darst BF, Lu Q, Johnson SC, Engelman CD.

Genet Epidemiol. 2019 Sep;43(6):657-674. doi: 10.1002/gepi.22211. Epub 2019 May 18.

PMID:
31104335
2.

KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD.

Erickson CM, Schultz SA, Oh JM, Darst BF, Ma Y, Norton D, Betthauser T, Gallagher CL, Carlsson CM, Bendlin BB, Asthana S, Hermann BP, Sager MA, Blennow K, Zetterberg H, Engelman CD, Christian BT, Johnson SC, Dubal DB, Okonkwo OC.

Neurology. 2019 Apr 16;92(16):e1878-e1889. doi: 10.1212/WNL.0000000000007323. Epub 2019 Mar 13.

PMID:
30867273
3.

Carrier frequency estimation of Zellweger spectrum disorder using ExAC database and bioinformatics tools.

Vasiljevic E, Ye Z, Pavelec DM, Darst BF, Engelman CD, Baker MW.

Genet Med. 2019 Sep;21(9):1969-1976. doi: 10.1038/s41436-019-0468-3. Epub 2019 Mar 8.

PMID:
30846882
4.

Longitudinal plasma metabolomics of aging and sex.

Darst BF, Koscik RL, Hogan KJ, Johnson SC, Engelman CD.

Aging (Albany NY). 2019 Feb 24;11(4):1262-1282. doi: 10.18632/aging.101837.

5.

The gut microbiota-derived metabolite trimethylamine N-oxide is elevated in Alzheimer's disease.

Vogt NM, Romano KA, Darst BF, Engelman CD, Johnson SC, Carlsson CM, Asthana S, Blennow K, Zetterberg H, Bendlin BB, Rey FE.

Alzheimers Res Ther. 2018 Dec 22;10(1):124. doi: 10.1186/s13195-018-0451-2.

6.

Using recursive feature elimination in random forest to account for correlated variables in high dimensional data.

Darst BF, Malecki KC, Engelman CD.

BMC Genet. 2018 Sep 17;19(Suppl 1):65. doi: 10.1186/s12863-018-0633-8.

7.

The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer's Prevention.

Engelman CD, Darst BF, Bilgel M, Vasiljevic E, Koscik RL, Jedynak BM, Johnson SC.

Neurobiol Aging. 2018 Jun;66:177.e1-177.e5. doi: 10.1016/j.neurobiolaging.2017.12.025. Epub 2017 Dec 29.

8.

BDNF Val66Met predicts cognitive decline in the Wisconsin Registry for Alzheimer's Prevention.

Boots EA, Schultz SA, Clark LR, Racine AM, Darst BF, Koscik RL, Carlsson CM, Gallagher CL, Hogan KJ, Bendlin BB, Asthana S, Sager MA, Hermann BP, Christian BT, Dubal DB, Engelman CD, Johnson SC, Okonkwo OC.

Neurology. 2017 May 30;88(22):2098-2106. doi: 10.1212/WNL.0000000000003980. Epub 2017 May 3.

9.

Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD.

Schultz SA, Boots EA, Darst BF, Zetterberg H, Blennow K, Edwards DF, Koscik RL, Carlsson CM, Gallagher CL, Bendlin BB, Asthana S, Sager MA, Hogan KJ, Hermann BP, Cook DB, Johnson SC, Engelman CD, Okonkwo OC.

Neurology. 2017 Apr 25;88(17):1650-1658. doi: 10.1212/WNL.0000000000003862. Epub 2017 Mar 24.

10.

Macrovascular and microvascular cerebral blood flow in adults at risk for Alzheimer's disease.

Clark LR, Berman SE, Rivera-Rivera LA, Hoscheidt SM, Darst BF, Engelman CD, Rowley HA, Carlsson CM, Asthana S, Turski P, Wieben O, Johnson SC.

Alzheimers Dement (Amst). 2017 Jan 23;7:48-55. doi: 10.1016/j.dadm.2017.01.002. eCollection 2017.

11.

Patient perspectives on whole-genome sequencing for undiagnosed diseases.

Boeldt DL, Cheung C, Ariniello L, Darst BF, Topol S, Schork NJ, Philis-Tsimikas A, Torkamani A, Fortmann AL, Bloss CS.

Per Med. 2017 Jan;14(1):17-25. doi: 10.2217/pme-2016-0050. Epub 2016 Nov 30.

PMID:
29749824
12.

Prioritization of family member sequencing for the detection of rare variants.

Sippy R, Kolesar JM, Darst BF, Engelman CD.

BMC Proc. 2016 Oct 18;10(Suppl 7):227-231. eCollection 2016.

13.

Transmission and decorrelation methods for detecting rare variants using sequencing data from related individuals.

Darst BF, Engelman CD.

BMC Proc. 2016 Oct 18;10(Suppl 7):203-207. eCollection 2016.

14.

Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.

Darst BF, Koscik RL, Racine AM, Oh JM, Krause RA, Carlsson CM, Zetterberg H, Blennow K, Christian BT, Bendlin BB, Okonkwo OC, Hogan KJ, Hermann BP, Sager MA, Asthana S, Johnson SC, Engelman CD.

J Alzheimers Dis. 2017;55(2):473-484.

15.

Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.

Eicher JD, Montgomery AM, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst T, Frazier J, Kaufmann WE, Keating B, Kenet T, Kennedy D, Mostofsky S, Murray SS, Sowell ER, Bartsch H, Kuperman JM, Brown TT, Hagler DJ Jr, Dale AM, Jernigan TL, Gruen JR; Pediatric Imaging Neurocognition Genetics Study.

Brain Imaging Behav. 2016 Mar;10(1):272-82. doi: 10.1007/s11682-015-9392-6.

16.

A genome sequencing program for novel undiagnosed diseases.

Bloss CS, Zeeland AA, Topol SE, Darst BF, Boeldt DL, Erikson GA, Bethel KJ, Bjork RL, Friedman JR, Hwynn N, Patay BA, Pockros PJ, Scott ER, Simon RA, Williams GW, Schork NJ, Topol EJ, Torkamani A.

Genet Med. 2015 Dec;17(12):995-1001. doi: 10.1038/gim.2015.21. Epub 2015 Mar 19. Erratum in: Genet Med. 2015 Jun;17(6):515.

17.

Heritability of cognitive traits among siblings with a parental history of Alzheimer's disease.

Darst BF, Koscik RL, Hermann BP, La Rue A, Sager MA, Johnson SC, Engelman CD.

J Alzheimers Dis. 2015;45(4):1149-55. doi: 10.3233/JAD-142658.

18.

Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults.

Rana BK, Darst BF, Bloss C, Shih PA, Depp C, Nievergelt CM, Allison M, Parsons JK, Schork N, Jeste DV.

Am J Geriatr Psychiatry. 2014 Oct;22(10):997-1006.e5. doi: 10.1016/j.jagp.2014.03.009. Epub 2014 Mar 26.

19.

Genome-wide association study of shared components of reading disability and language impairment.

Eicher JD, Powers NR, Miller LL, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst T, Frazier J, Kaufmann WE, Keating B, Kenet T, Kennedy D, Mostofsky S, Murray SS, Sowell ER, Bartsch H, Kuperman JM, Brown TT, Hagler DJ Jr, Dale AM, Jernigan TL, St Pourcain B, Davey Smith G, Ring SM, Gruen JR; Pediatric Imaging, Neurocognition, and Genetics Study.

Genes Brain Behav. 2013 Nov;12(8):792-801. doi: 10.1111/gbb.12085. Epub 2013 Oct 9.

20.

Evidence for the role of EPHX2 gene variants in anorexia nervosa.

Scott-Van Zeeland AA, Bloss CS, Tewhey R, Bansal V, Torkamani A, Libiger O, Duvvuri V, Wineinger N, Galvez L, Darst BF, Smith EN, Carson A, Pham P, Phillips T, Villarasa N, Tisch R, Zhang G, Levy S, Murray S, Chen W, Srinivasan S, Berenson G, Brandt H, Crawford S, Crow S, Fichter MM, Halmi KA, Johnson C, Kaplan AS, La Via M, Mitchell JE, Strober M, Rotondo A, Treasure J, Woodside DB, Bulik CM, Keel P, Klump KL, Lilenfeld L, Plotnicov K, Topol EJ, Shih PB, Magistretti P, Bergen AW, Berrettini W, Kaye W, Schork NJ.

Mol Psychiatry. 2014 Jun;19(6):724-32. doi: 10.1038/mp.2013.91. Epub 2013 Sep 3.

21.

Perceptions of genetic counseling services in direct-to-consumer personal genomic testing.

Darst BF, Madlensky L, Schork NJ, Topol EJ, Bloss CS.

Clin Genet. 2013 Oct;84(4):335-9. doi: 10.1111/cge.12166. Epub 2013 May 13.

PMID:
23590221
22.

Impact of direct-to-consumer genomic testing at long term follow-up.

Bloss CS, Wineinger NE, Darst BF, Schork NJ, Topol EJ.

J Med Genet. 2013 Jun;50(6):393-400. doi: 10.1136/jmedgenet-2012-101207. Epub 2013 Apr 4.

PMID:
23559530
23.

Characteristics of genomic test consumers who spontaneously share results with their health care provider.

Darst BF, Madlensky L, Schork NJ, Topol EJ, Bloss CS.

Health Commun. 2014;29(1):105-8. doi: 10.1080/10410236.2012.717216. Epub 2013 Feb 5.

24.

Long-term influence of normal variation in neonatal characteristics on human brain development.

Walhovd KB, Fjell AM, Brown TT, Kuperman JM, Chung Y, Hagler DJ Jr, Roddey JC, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Schork NJ, Darst BF, Casey BJ, Chang L, Ernst TM, Frazier J, Gruen JR, Kaufmann WE, Murray SS, van Zijl P, Mostofsky S, Dale AM; Pediatric Imaging, Neurocognition, and Genetics Study.

Proc Natl Acad Sci U S A. 2012 Dec 4;109(49):20089-94. doi: 10.1073/pnas.1208180109. Epub 2012 Nov 19.

25.

Multimodal imaging of the self-regulating developing brain.

Fjell AM, Walhovd KB, Brown TT, Kuperman JM, Chung Y, Hagler DJ Jr, Venkatraman V, Roddey JC, Erhart M, McCabe C, Akshoomoff N, Amaral DG, Bloss CS, Libiger O, Darst BF, Schork NJ, Casey BJ, Chang L, Ernst TM, Gruen JR, Kaufmann WE, Kenet T, Frazier J, Murray SS, Sowell ER, van Zijl P, Mostofsky S, Jernigan TL, Dale AM; Pediatric Imaging, Neurocognition, and Genetics Study.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19620-5. doi: 10.1073/pnas.1208243109. Epub 2012 Nov 12.

26.

Direct-to-consumer personalized genomic testing.

Bloss CS, Darst BF, Topol EJ, Schork NJ.

Hum Mol Genet. 2011 Oct 15;20(R2):R132-41. doi: 10.1093/hmg/ddr349. Epub 2011 Aug 9. Review.

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