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Items: 18


Live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine with dmLT adjuvant protects human volunteers against virulent experimental ETEC challenge.

Harro C, Louis Bourgeois A, Sack D, Walker R, DeNearing B, Brubaker J, Maier N, Fix A, Dally L, Chakraborty S, Clements JD, Saunders I, Darsley MJ.

Vaccine. 2019 Mar 28;37(14):1978-1986. doi: 10.1016/j.vaccine.2019.02.025. Epub 2019 Feb 21.


Human Experimental Challenge With Enterotoxigenic Escherichia coli Elicits Immune Responses to Canonical and Novel Antigens Relevant to Vaccine Development.

Chakraborty S, Randall A, Vickers TJ, Molina D, Harro CD, DeNearing B, Brubaker J, Sack DA, Bourgeois AL, Felgner PL, Liang X, Mani S, Wenzel H, Townsend RR, Gilmore PE, Darsley MJ, Rasko DA, Fleckenstein JM.

J Infect Dis. 2018 Sep 22;218(9):1436-1446. doi: 10.1093/infdis/jiy312.


Development of a fast-dissolving tablet formulation of a live attenuated enterotoxigenic E. coli vaccine candidate.

Lal M, Priddy S, Bourgeois L, Walker R, Pebley W, Brown J, Desai J, Darsley MJ, Kristensen D, Chen D.

Vaccine. 2013 Oct 1;31(42):4759-64. doi: 10.1016/j.vaccine.2013.08.010. Epub 2013 Aug 17.


The oral, live attenuated enterotoxigenic Escherichia coli vaccine ACE527 reduces the incidence and severity of diarrhea in a human challenge model of diarrheal disease.

Darsley MJ, Chakraborty S, DeNearing B, Sack DA, Feller A, Buchwaldt C, Bourgeois AL, Walker R, Harro CD.

Clin Vaccine Immunol. 2012 Dec;19(12):1921-31. doi: 10.1128/CVI.00364-12. Epub 2012 Oct 3.


Generation and characterization of a live attenuated enterotoxigenic Escherichia coli combination vaccine expressing six colonization factors and heat-labile toxin subunit B.

Turner AK, Stephens JC, Beavis JC, Greenwood J, Gewert C, Randall R, Freeman D, Darsley MJ.

Clin Vaccine Immunol. 2011 Dec;18(12):2128-35. doi: 10.1128/CVI.05345-11. Epub 2011 Oct 12.


A combination vaccine consisting of three live attenuated enterotoxigenic Escherichia coli strains expressing a range of colonization factors and heat-labile toxin subunit B is well tolerated and immunogenic in a placebo-controlled double-blind phase I trial in healthy adults.

Harro C, Sack D, Bourgeois AL, Walker R, DeNearing B, Feller A, Chakraborty S, Buchwaldt C, Darsley MJ.

Clin Vaccine Immunol. 2011 Dec;18(12):2118-27. doi: 10.1128/CVI.05342-11. Epub 2011 Oct 12.


Caught in the act: in vivo development of macrolide resistance to Campylobacter jejuni infection.

Lindow JC, Poly F, Tribble DR, Guerry P, Carmolli MP, Baqar S, Porter CK, Pierce KK, Darsley MJ, Sadigh KS, Dill EA; Campylobacter Study Team, Kirkpatrick BD.

J Clin Microbiol. 2010 Aug;48(8):3012-5. doi: 10.1128/JCM.00768-10. Epub 2010 Jun 16.


Construction and phase I clinical evaluation of the safety and immunogenicity of a candidate enterotoxigenic Escherichia coli vaccine strain expressing colonization factor antigen CFA/I.

Turner AK, Beavis JC, Stephens JC, Greenwood J, Gewert C, Thomas N, Deary A, Casula G, Daley A, Kelly P, Randall R, Darsley MJ.

Infect Immun. 2006 Feb;74(2):1062-71.


Attenuated Salmonella enterica serovar Typhi expressing urease effectively immunizes mice against Helicobacter pylori challenge as part of a heterologous mucosal priming-parenteral boosting vaccination regimen.

Londoño-Arcila P, Freeman D, Kleanthous H, O'Dowd AM, Lewis S, Turner AK, Rees EL, Tibbitts TJ, Greenwood J, Monath TP, Darsley MJ.

Infect Immun. 2002 Sep;70(9):5096-106.


Construction and characterization of genetically defined aro omp mutants of enterotoxigenic Escherichia coli and preliminary studies of safety and immunogenicity in humans.

Turner AK, Terry TD, Sack DA, Londoño-Arcila P, Darsley MJ.

Infect Immun. 2001 Aug;69(8):4969-79. Erratum in: Infect Immun 2001 Oct;69(10):6564.


Spectrophotometric quantitation of silver in X-ray film images and silver-stained electrophoresis gel bands.

Sanchez RI, Darsley MJ, Martin MT.

Anal Biochem. 1995 Jan 1;224(1):190-4.


Aspects of antibody-catalyzed primary amide hydrolysis.

Titmas RC, Angeles TS, Sugasawara R, Aman N, Darsley MJ, Blackburn G, Martin MT.

Appl Biochem Biotechnol. 1994 May-Jun;47(2-3):277-90; discussion 291-2.


Isoabzymes: structurally and mechanistically similar catalytic antibodies from the same immunization.

Angeles TS, Smith RG, Darsley MJ, Sugasawara R, Sanchez RI, Kenten J, Schultz PG, Martin MT.

Biochemistry. 1993 Nov 16;32(45):12128-35.


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