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Items: 1 to 50 of 55

1.

Divergent and regioselective synthesis of 1,2,4- and 1,2,5-trisubstituted imidazoles.

Delest B, Nshimyumukiza P, Fasbender O, Tinant B, Marchand-Brynaert J, Darro F, Robiette R.

J Org Chem. 2008 Sep 5;73(17):6816-23. doi: 10.1021/jo801256b. Epub 2008 Aug 6.

PMID:
18681408
2.

Amaryllidaceae isocarbostyril alkaloids and their derivatives as promising antitumor agents.

Ingrassia L, Lefranc F, Mathieu V, Darro F, Kiss R.

Transl Oncol. 2008 Mar;1(1):1-13.

3.

UNBS5162, a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers.

Mijatovic T, Mahieu T, Bruyère C, De Nève N, Dewelle J, Simon G, Dehoux MJ, van der Aar E, Haibe-Kains B, Bontempi G, Decaestecker C, Van Quaquebeke E, Darro F, Kiss R.

Neoplasia. 2008 Jun;10(6):573-86.

4.

The Amaryllidaceae isocarbostyril narciclasine induces apoptosis by activation of the death receptor and/or mitochondrial pathways in cancer cells but not in normal fibroblasts.

Dumont P, Ingrassia L, Rouzeau S, Ribaucour F, Thomas S, Roland I, Darro F, Lefranc F, Kiss R.

Neoplasia. 2007 Sep;9(9):766-76.

5.

Cardiotonic steroids on the road to anti-cancer therapy.

Mijatovic T, Van Quaquebeke E, Delest B, Debeir O, Darro F, Kiss R.

Biochim Biophys Acta. 2007 Sep;1776(1):32-57. Epub 2007 Jul 4. Review.

PMID:
17706876
6.

2,2,2-Trichloro-N-({2-[2-(dimethylamino)ethyl]-1,3-dioxo-2,3-dihydro-1H-benzo[de]isoquinolin- 5-yl}carbamoyl)acetamide (UNBS3157), a novel nonhematotoxic naphthalimide derivative with potent antitumor activity.

Van Quaquebeke E, Mahieu T, Dumont P, Dewelle J, Ribaucour F, Simon G, Sauvage S, Gaussin JF, Tuti J, El Yazidi M, Van Vynckt F, Mijatovic T, Lefranc F, Darro F, Kiss R.

J Med Chem. 2007 Aug 23;50(17):4122-34. Epub 2007 Jul 21.

PMID:
17658777
7.

The alpha1 subunit of the sodium pump could represent a novel target to combat non-small cell lung cancers.

Mijatovic T, Roland I, Van Quaquebeke E, Nilsson B, Mathieu A, Van Vynckt F, Darro F, Blanco G, Facchini V, Kiss R.

J Pathol. 2007 Jun;212(2):170-9.

PMID:
17471453
8.

New terpenoids from two Indonesian marine sponges.

Salmoun M, Braekman JC, Dewelle J, Darro F, Kiss R, De Voogd NJ, Van Soest RW.

Nat Prod Res. 2007 Feb;21(2):149-55.

PMID:
17365702
9.

New calamenene sesquiterpenes from Tarenna madagascariensis.

Salmoun M, Braekman JC, Ranarivelo Y, Rasamoelisendra R, Ralambomanana D, Dewelle J, Darro F, Kiss R.

Nat Prod Res. 2007 Feb;21(2):111-20.

PMID:
17365697
10.

Anti-galectin compounds as potential anti-cancer drugs.

Ingrassia L, Camby I, Lefranc F, Mathieu V, Nshimyumukiza P, Darro F, Kiss R.

Curr Med Chem. 2006;13(29):3513-27. Review.

PMID:
17168720
11.

Cardenolide-induced lysosomal membrane permeabilization demonstrates therapeutic benefits in experimental human non-small cell lung cancers.

Mijatovic T, Mathieu V, Gaussin JF, De Nève N, Ribaucour F, Van Quaquebeke E, Dumont P, Darro F, Kiss R.

Neoplasia. 2006 May;8(5):402-12.

12.

A lactosylated steroid contributes in vivo therapeutic benefits in experimental models of mouse lymphoma and human glioblastoma.

Ingrassia L, Nshimyumukiza P, Dewelle J, Lefranc F, Wlodarczak L, Thomas S, Dielie G, Chiron C, Zedde C, Tisnès P, van Soest R, Braekman JC, Darro F, Kiss R.

J Med Chem. 2006 Mar 9;49(5):1800-7.

PMID:
16509595
13.

The cardenolide UNBS1450 is able to deactivate nuclear factor kappaB-mediated cytoprotective effects in human non-small cell lung cancer cells.

Mijatovic T, Op De Beeck A, Van Quaquebeke E, Dewelle J, Darro F, de Launoit Y, Kiss R.

Mol Cancer Ther. 2006 Feb;5(2):391-9.

14.

Are syngeneic mouse tumor models still valuable experimental models in the field of anti-cancer drug discovery?

Darro F, Decaestecker C, Gaussin JF, Mortier S, Van Ginckel R, Kiss R.

Int J Oncol. 2005 Sep;27(3):607-16.

PMID:
16077908
15.
16.

Identification of a novel cardenolide (2''-oxovoruscharin) from Calotropis procera and the hemisynthesis of novel derivatives displaying potent in vitro antitumor activities and high in vivo tolerance: structure-activity relationship analyses.

Van Quaquebeke E, Simon G, André A, Dewelle J, El Yazidi M, Bruyneel F, Tuti J, Nacoulma O, Guissou P, Decaestecker C, Braekman JC, Kiss R, Darro F.

J Med Chem. 2005 Feb 10;48(3):849-56.

PMID:
15689169
18.

Synthesis and in vitro antitumor activity of ring C and D-substituted phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine.

Delfourne E, Kiss R, Le Corre L, Dujols F, Bastide J, Collignon F, Lesur B, Frydman A, Darro F.

Bioorg Med Chem. 2004 Aug 1;12(15):3987-94.

PMID:
15246075
19.

Synthesis and in vitro antitumor activity of an isomer of the marine pyridoacridine alkaloid ascididemin and related compounds.

Delfourne E, Kiss R, Le Corre L, Merza J, Bastide J, Frydman A, Darro F.

Bioorg Med Chem. 2003 Oct 1;11(20):4351-6.

PMID:
13129571
20.

Synthesis and in vitro antitumor activity of phenanthrolin-7-one derivatives, analogues of the marine pyridoacridine alkaloids ascididemin and meridine: structure-activity relationship.

Delfourne E, Kiss R, Le Corre L, Dujols F, Bastide J, Collignon F, Lesur B, Frydman A, Darro F.

J Med Chem. 2003 Jul 31;46(16):3536-45.

PMID:
12877592
21.

Synthesis and in vitro antitumor activity of novel ring D analogues of the marine pyridoacridine ascididemin: structure-activity relationship.

Delfourne E, Darro F, Portefaix P, Galaup C, Bayssade S, Bouteillé A, Le Corre L, Bastide J, Collignon F, Lesur B, Frydman A, Kiss R.

J Med Chem. 2002 Aug 15;45(17):3765-71.

PMID:
12166949
22.

Galectin-1 modulates human glioblastoma cell migration into the brain through modifications to the actin cytoskeleton and levels of expression of small GTPases.

Camby I, Belot N, Lefranc F, Sadeghi N, de Launoit Y, Kaltner H, Musette S, Darro F, Danguy A, Salmon I, Gabius HJ, Kiss R.

J Neuropathol Exp Neurol. 2002 Jul;61(7):585-96.

PMID:
12125737
24.

Synthesis and cytotoxic evaluation of analogues of the marine pyridoacridine amphimedine.

Brahic C, Darro F, Belloir M, Bastide J, Kiss R, Delfourne E.

Bioorg Med Chem. 2002 Sep;10(9):2845-53.

PMID:
12110304
25.

3-Aryl-2-quinolone derivatives: synthesis and characterization of in vitro and in vivo antitumor effects with emphasis on a new therapeutical target connected with cell migration.

Joseph B, Darro F, Béhard A, Lesur B, Collignon F, Decaestecker C, Frydman A, Guillaumet G, Kiss R.

J Med Chem. 2002 Jun 6;45(12):2543-55.

PMID:
12036363
26.

Synthesis and cytotoxicity on sensitive and doxorubicin-resistant cell lines of new pyrrolo[2,1-c][1,4]benzodiazepines related to anthramycin.

Langlois N, Rojas-Rousseau A, Gaspard C, Werner GH, Darro F, Kiss R.

J Med Chem. 2001 Oct 25;44(22):3754-7.

PMID:
11606141
27.

Synthesis and characterization of the antitumor activities of analogues of meridine, a marine pyridoacridine alkaloid.

Delfourne E, Darro F, Bontemps-Subielos N, Decaestecker C, Bastide J, Frydman A, Kiss R.

J Med Chem. 2001 Sep 27;44(20):3275-82.

PMID:
11563926
28.

The levels of retinoid RARbeta receptors correlate with galectin-1, -3 and -8 expression in human cholesteatomas.

Simon P, Decaestecker C, Choufani G, Delbrouck C, Danguy A, Salmon I, Zick Y, Kaltner H, Hassid S, Gabius HJ, Kiss R, Darro F.

Hear Res. 2001 Jun;156(1-2):1-9.

PMID:
11377877
29.
30.

Characterization of TNP-470-induced modifications to cell functions in HUVEC and cancer cells.

Farinelle S, Malonne H, Chaboteaux C, Decaestecker C, Dedecker R, Gras T, Darro F, Fontaine J, Atassi G, Kiss R.

J Pharmacol Toxicol Methods. 2000 Jan-Feb;43(1):15-24.

PMID:
11091126
31.

Characterization of steroid hormone sensitivity in human breast cancers maintained ex vivo under organotypical culture conditions.

Darro F, Schwarz G Jr, Pétein M, Schwarz S, Chaboteaux C, Nogaret JM, Decaestecker C, Salmon I, Kiss R.

J Cancer Res Clin Oncol. 2000 May;126(5):257-62.

PMID:
10815760
32.

Grading dysplasia in colorectal adenomas by means of the quantitative binding pattern determination of Arachis hypogaea, Dolichos biflorus, Amaranthus caudatus, Maackia amurensis, and Sambucus nigra agglutinins.

Bronckart Y, Nagy N, Decaestecker C, Bouckaert Y, Remmelink M, Gielen I, Hittelet A, Darro F, Pector JC, Yeaton P, Danguy A, Kiss R, Salmon I.

Hum Pathol. 1999 Oct;30(10):1178-91.

PMID:
10534165
33.

Characterization of biological features and chemosensitivity of a new experimental lung metastasis model originating from the MXT mouse mammary adenocarcinoma.

Farinelle S, Dedecker R, Malonne H, Werry J, Darro F, Kiss R.

Anticancer Res. 1999 Mar-Apr;19(2A):1171-80.

PMID:
10368671
34.
35.

In vitro influence of lectins and neoglycoconjugates on the growth of three human sarcoma cell lines.

Remmelink M, Darro F, Decaestecker C, De Decker R, Bovin NV, Gebhart M, Kaltner H, Gabius HJ, Kiss R, Salmon I, Danguy A.

J Cancer Res Clin Oncol. 1999;125(5):275-85.

PMID:
10359132
36.

In vitro motility evaluation of aggregated cancer cells by means of automatic image processing.

De Hauwer C, Darro F, Camby I, Kiss R, Van Ham P, Decaesteker C.

Cytometry. 1999 May 1;36(1):1-10.

PMID:
10331621
37.

Galectin fingerprinting in tumor diagnosis. Differential expression of galectin-3 and galectin-3 binding sites, but not galectin-1, in benign vs malignant uterine smooth muscle tumors.

Schwarz G Jr, Remmelink M, Decaestecker C, Gielen I, Budel V, Burchert M, Darro F, Danguy A, Gabius HJ, Salmon I, Kiss R.

Am J Clin Pathol. 1999 May;111(5):623-31.

PMID:
10230352
38.

Growth inhibition of human in vitro and mouse in vitro and in vivo mammary tumor models by retinoids in comparison with tamoxifen and the RU-486 anti-progestagen.

Darro F, Cahen P, Vianna A, Decaestecker C, Nogaret JM, Leblond B, Chaboteaux C, Ramos C, Pétein M, Budel V, Schoofs A, Pourrias B, Kiss R.

Breast Cancer Res Treat. 1998 Sep;51(1):39-55.

PMID:
9877028
39.

Setting up of an original computer-assisted methodology to characterize in vitro drug-induced anti-angiogenic effects.

Farinelle S, Dehauwer C, Darro F, Decaestecker C, Fontaine J, Pasteels JL, Van Ham P, Atassi G, Kiss R.

Int J Mol Med. 1998 Nov;2(5):545-53.

PMID:
9858650
40.

Gastrin inhibits motility, decreases cell death levels and increases proliferation in human glioblastoma cell lines.

De Hauwer C, Camby I, Darro F, Migeotte I, Decaestecker C, Verbeek C, Danguy A, Pasteels JL, Brotchi J, Salmon I, Van Ham P, Kiss R.

J Neurobiol. 1998 Nov 15;37(3):373-82.

PMID:
9828043
41.

The in vitro influence of eight hormones and growth factors on the proliferation of eight sarcoma cell lines.

Remmelink M, Decaestecker C, Darro F, Goldschmidt D, Gebhart M, Pasteels JL, Kiss R, Salmon I.

J Cancer Res Clin Oncol. 1998;124(3-4):155-64.

PMID:
9619741
42.

Direct relationship between hormone sensitivity level and growth pattern. Evidence in 18 gastrointestinal neoplastic cell lines.

Kiss R, Decaestecker C, Camby I, Darro F, Salmon I, Danguy A, Pasteels JL, Yeaton P.

Anal Quant Cytol Histol. 1998 Apr;20(2):133-43.

PMID:
9569971
43.

Correlation between gender and cytomorphonuclear characteristics in human melanomas and in vitro evidence of sex steroid-induced modifications in the morphonuclear characteristics of three human melanoma cell lines.

Loréa P, Decaestecker C, Goldschmidt D, Renard N, André J, Lipski D, Van den Heule B, Salmon I, Darro F, Kiss R.

Melanoma Res. 1997 Oct;7(5):382-92.

PMID:
9429221
44.

In vitro characterization of lectin-induced alterations on the proliferative activity of three human melanoma cell lines.

Loréa P, Goldschmidt D, Darro F, Salmon I, Bovin N, Gabius HJ, Kiss R, Danguy A.

Melanoma Res. 1997 Oct;7(5):353-63.

PMID:
9429218
45.

Ploidy level determination and quantitative chromatin pattern description in pregnancy-associated breast cancers.

Budel V, Gasperin P, Hatschbach S, Cavalcanti TC, Pétein M, Decaestecker C, Darro F, Salmon I, Kiss R.

Breast Cancer Res Treat. 1997 Sep;45(2):109-20.

PMID:
9342436
46.

In vitro characterisation of soft tissue tumor chemosensitivity.

Remmelink M, Salmon I, Delville JP, Goldschmidt D, Capel P, Gebhart M, Pasteels JL, Kiss R, Darro F.

Anticancer Res. 1997 May-Jun;17(3C):2009-17.

PMID:
9216658
47.

Dynamic characterization of glioblastoma cell motility.

De Hauwer C, Camby I, Darro F, Decaestecker C, Gras T, Salmon I, Kiss R, Van Ham P.

Biochem Biophys Res Commun. 1997 Mar 17;232(2):267-72.

PMID:
9125161
49.
50.

In vitro characterization of prolactin-induced effects on proliferation in the neoplastic LNCaP, DU145, and PC3 models of the human prostate.

Janssen T, Darro F, Petein M, Raviv G, Pasteels JL, Kiss R, Schulman CC.

Cancer. 1996 Jan 1;77(1):144-9.

PMID:
8630922

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